المؤلفون: Mark D. Andrews, Kevin N. Dack, Marcel J. de Groot, Maja Lambert, Carl J. Sennbro, Mogens Larsen, Martin Stahlhut

المصدر: Journal of Medicinal Chemistry. 65:8828-8842

مصطلحات موضوعية: Receptors, Interleukin-17, Interleukin-17, Drug Discovery, Antibodies, Monoclonal, Cytokines, Humans, Psoriasis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d2334f68390f08242878bf8c7d2e05
https://doi.org/10.1021/acs.jmedchem.2c00422

المؤلفون: Ivaylo Jivkov Elenkov, Simon Feldbaek Nielsen, Kristina Butković, Sanja Koštrun, Dijana Pesic, Dack Kevin Neil, Tine Skak-Nielsen, Dinko Žiher, Martin Stahlhut, Adriana Petrinić Grba, Vlatka Bencetić Mihaljević, Ana Čikoš, Samra Kapić, Andrea Fajdetić, Renata Rupčić, Gordon Saxty, Maja Lambert, Jasna Padovan, Ivana Ozimec Landek, Karmen Brajša, Dubravko Jelić, Haakan Bladh, Ana Grgičević

المصدر: Journal of Medicinal Chemistry. 64:8354-8383

مصطلحات موضوعية: Male, Macrocyclic Compounds, THP-1 Cells, Anti-Inflammatory Agents, 01 natural sciences, Inflammatory bowel disease, Mice, Structure-Activity Relationship, 03 medical and health sciences, Immune system, In vivo, Psoriasis, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, ADME, 0303 health sciences, Receptors, Interleukin-17, Molecular Structure, Chemistry, Drug discovery, Interleukin-17, medicine.disease, 0104 chemical sciences, Molecular Docking Simulation, proteins, macrocycles, IL 17AM, Il 17RA, chemical structure inhibitors, 010404 medicinal & biomolecular chemistry, Rheumatoid arthritis, Immunology, Molecular Medicine, Interleukin 17, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05f28315da0be7107038b135d157e95
https://doi.org/10.1021/acs.jmedchem.1c00327

المؤلفون: Thomas Vifian, Tatiana G Stilou, Simon Feldbaek Nielsen, Maja Lambert, Jens Christian Højland Larsen, Tine Skak-Nielsen, Anders Soehoel, Pontus Hegardt, Lene M. Hansen, Nina Østergaard Knudsen, Morten Dahl Sørensen, Mogens Larsen, Cecilia Eskilsson, Steen Laursen, Stefan Eirefelt, Henrik Pettersson, Anna Ollerstam

المصدر: Journal of Medicinal Chemistry. 63:14502-14521

مصطلحات موضوعية: 0303 health sciences, Isobenzofuran, Chemistry, Drug discovery, Human skin, Topical treatment, Atopic dermatitis, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Medicine, Target organ, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1fb38d7abc4b9986a9e38e75c9c4ae01
https://doi.org/10.1021/acs.jmedchem.0c00797

المؤلفون: Gitte Pommergaard Pedersen, Line Hollesen Schefe, Manfred Bodenlenz, Christian Janfelt, Frank Sinner, Stefan Eirefelt, André Huss Eriksson, Thomas Birngruber, Maja Lambert, Anne Mette Handler, Fredrik Johansson, Kim Troensegaard Nielsen, Nina Østergaard Knudsen

المصدر: Handler, A M, Eirefelt, S, Lambert, M, Johansson, F, Hollesen Schefe, L, Knudsen, N Ø, Bodenlenz, M, Birngruber, T, Sinner, F, Eriksson, A H, Pedersen, G P, Janfelt, C & Troensegaard Nielsen, K 2021, ' Characterizing Cutaneous Drug Delivery Using Open-Flow Microperfusion and Mass Spectrometry Imaging ', Molecular Pharmaceutics, vol. 18, no. 8, pp. 3063-3072 . https://doi.org/10.1021/acs.molpharmaceut.1c00285

مصطلحات موضوعية: Swine, Drug Compounding, Skin Absorption, Pharmaceutical Science, skin permeation, Human skin, OFM, mass spectrometry imaging, skin penetration, Administration, Cutaneous, Mass spectrometry imaging, Pharmacokinetics, Piperidines, In vivo, Drug Discovery, Animals, Humans, Janus Kinase Inhibitors, MALDI-MSI, Tissue Distribution, Skin, open-flow microperfusion, Tofacitinib, integumentary system, Chemistry, Middle Aged, Molecular Weight, Perfusion, Pyrimidines, Solubility, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Drug delivery, Lipophilicity, drug delivery, Biophysics, Molecular Medicine, Female, Ex vivo

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7afaf40a0d690fd7ebd85237ac597828
https://curis.ku.dk/ws/files/336199777/MolecularPharmaceutics18_3063_3072_2021_preprint.pdf

المؤلفون: Maja Lambert, Stefan Eirefelt, Simon Feldbaek Nielsen, Malene Bertelsen, Jens Christian Højland Larsen, Thomas Birngruber, Frank Sinner, Fredrik Johansson, Joanna Hummer, Line Hollesen Basse

المصدر: Pharmaceutical Research. 37

مصطلحات موضوعية: Keratinocytes, Pyridines, Biopsy, Drug Compounding, Microdialysis, Skin Absorption, Pharmaceutical Science, Human skin, 02 engineering and technology, Pharmacology, Administration, Cutaneous, 030226 pharmacology & pharmacy, Dermatitis, Atopic, 03 medical and health sciences, Clinical Trials, Phase II as Topic, 0302 clinical medicine, Drug Stability, Pharmacokinetics, Interstitial fluid, Acetamides, Cyclic AMP, Humans, Medicine, Pharmacology (medical), PDE4 Inhibitors, Cells, Cultured, Skin, integumentary system, medicine.diagnostic_test, business.industry, Organic Chemistry, Extracellular Fluid, 021001 nanoscience & nanotechnology, Open flow, Therapeutic Equivalency, Pharmacodynamics, Skin biopsy, Molecular Medicine, Biomarker (medicine), Phosphodiesterase 4 Inhibitors, 0210 nano-technology, business, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed590dba8addf44cffbacdc91079596c
https://doi.org/10.1007/s11095-020-02962-1

المؤلفون: Jens, Larsen, Maja, Lambert, Henrik, Pettersson, Thomas, Vifian, Mogens, Larsen, Anna, Ollerstam, Pontus, Hegardt, Cecilia, Eskilsson, Steen, Laursen, Anders, Soehoel, Tine, Skak-Nielsen, Lene M, Hansen, Nina Ø, Knudsen, Stefan, Eirefelt, Morten D, Sørensen, Tatiana G, Stilou, Simon F, Nielsen

المصدر: Journal of medicinal chemistry. 63(23)

مصطلحات موضوعية: Drug Discovery, Animals, Humans, Phosphodiesterase 4 Inhibitors, Dermatitis, Atopic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::91d778dd5cf2a7a2234d7f9358d53149
https://pubmed.ncbi.nlm.nih.gov/33054196

المؤلفون: Sanja Koštrun (2064985), Andrea Fajdetić (2115007), Dijana Pešić (2093464), Karmen Brajša (2065021), Vlatka Bencetić Mihaljević (10941240), Dubravko Jelić (2065006), Adriana Petrinić Grba (10941243), Ivaylo Elenkov (391501), Renata Rupčić (2115004), Samra Kapić (2064979), Ivana Ozimec Landek (10941246), Kristina Butković (2231761), Ana Grgičević (10941249), Dinko Žiher (1400686), Ana Čikoš (1400689), Jasna Padovan (2064982), Gordon Saxty (1668052), Kevin Dack (2148385), Haakan Bladh (10941252), Tine Skak-Nielsen (2728693), Simon Feldbaek Nielsen (10941255), Maja Lambert (2516587), Martin Stahlhut (5158313)

مصطلحات موضوعية: Medicine, Pharmacology, Biotechnology, Ecology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, ring sizes, psoriatic patients, chemical space, vivo PK properties, ADME, drug discovery, phenotypic assays, non-lesion parts, IL -17A modulators, Macrocycle, IL -17A Interaction Interleukin 17, bowel disease, IL -17A, nM range, IL -17

Relation: https://figshare.com/articles/dataset/Macrolide_Inspired_Macrocycles_as_Modulators_of_the_IL-17A_IL-17RA_Interaction/14748996

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00327.s003

المؤلفون: Jerzy W. Jaroszewski, Matthias Witt, Christian A. Olsen, Henrik Franzyk, Maja Lambert

المصدر: Amino Acids. 34:465-471

مصطلحات موضوعية: Circular dichroism, Magnetic Resonance Spectroscopy, Molecular Structure, Peptidomimetic, Stereochemistry, Circular Dichroism, Organic Chemistry, Clinical Biochemistry, Stereoisomerism, Peptoid, Biochemistry, Mass Spectrometry, Folding (chemistry), chemistry.chemical_compound, Solid-phase synthesis, chemistry, Side chain, Peptide synthesis, Peptides, Protein secondary structure, Chromatography, High Pressure Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2a40a563d8a9d84cc1c607da29e27b
https://doi.org/10.1007/s00726-007-0546-8

المؤلفون: Maja Lambert, Steen Honoré Hansen, Majid Sairafianpour, Dan Staerk, Jerzy W. Jaroszewski

المصدر: Journal of Natural Products. 68:1500-1509

مصطلحات موضوعية: Pharmacology, Analyte, Plants, Medicinal, Chromatography, Molecular Structure, Elution, Chemistry, Organic Chemistry, Extraction (chemistry), Pharmaceutical Science, Fabaceae, Iran, Isoflavones, Plant Roots, High-performance liquid chromatography, Analytical Chemistry, NMR spectra database, Complementary and alternative medicine, Polyphenol, Drug Discovery, Molecular Medicine, Solid phase extraction, Nuclear Magnetic Resonance, Biomolecular, Two-dimensional nuclear magnetic resonance spectroscopy, Chromatography, High Pressure Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a792cbd741b80f7f4ed6c8dac4c1a5
https://doi.org/10.1021/np0502037

المؤلفون: Javad Asili, Maja Lambert, Hanne L Ziegler, Jerzy W. Jaroszewski, Ismaiel S Ibrahimi, Matthias Witt, Majid Sairafianpour, Dan Staerk, Gholamreza Asghari

المصدر: Journal of Natural Products. 67:631-637

مصطلحات موضوعية: Erythrocytes, Stereochemistry, Plasmodium falciparum, Pharmaceutical Science, Iran, Biology, Analytical Chemistry, Drug Discovery, medicine, Animals, Lipid bilayer, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, Plants, Medicinal, Molecular Structure, Cell Membrane, Organic Chemistry, Absolute configuration, Cupressaceae, Biological activity, biology.organism_classification, In vitro, Terpenoid, Plant Leaves, Red blood cell, medicine.anatomical_structure, Complementary and alternative medicine, Molecular Medicine, Diterpenes, Two-dimensional nuclear magnetic resonance spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7a9dde58c6901f6c95bb2634631411
https://doi.org/10.1021/np034033e

المؤلفون: Dan Staerk, Maja Lambert, Jerzy W. Jaroszewski

المصدر: Medicinal Plant Biotechnology: From Basic Research to Industrial Applications
University of Copenhagen

مصطلحات موضوعية: Chromatography, Chemistry, Environmental chemistry, Isolation (microbiology), High-performance liquid chromatography

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c779ed7f575f398302b32969d375a953
https://doi.org/10.1002/9783527619771.ch3

المؤلفون: Maja Lambert, Jean-Luc Wolfender, Dan Staerk, S. Brøgger Christensen, Jerzy W. Jaroszewski, Kurt Hostettmann

المصدر: Analytical Chemistry, Vol. 79, No 2 (2007) pp. 727-735

مصطلحات موضوعية: Analyte, Magnetic Resonance Spectroscopy, RESOLUTION NMR-SPECTROSCOPY, THAPSIA-GARGANICA, High-performance liquid chromatography, Analytical Chemistry, HARPAGOPHYTUM-PROCUMBENS, chemistry.chemical_compound, Lactones, STRUCTURE ELUCIDATION, Sample preparation, Solid phase extraction, NUCLEAR-MAGNETIC-RESONANCE, CAPILLARY HPLC, Chromatography, High Pressure Liquid, Thapsia, ddc:615, Biological Products, Chromatography, Chemistry, Elution, Extraction (chemistry), Solid Phase Extraction, LC-NMR, Divinylbenzene, PERFORMANCE LIQUID-CHROMATOGRAPHY, Toluene, SOLID-PHASE EXTRACTION, H-1-NMR SPECTROSCOPY

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6451aae7ef0d0649015692d491432da
https://pubmed.ncbi.nlm.nih.gov/17222043

المؤلفون: Jerzy W. Jaroszewski, Lars Olsen, Maja Lambert

المصدر: The Journal of organic chemistry. 71(25)

مصطلحات موضوعية: Steric effects, Flavonoids, Magnetic Resonance Spectroscopy, Hydrogen bond, Chemical shift, Organic Chemistry, Polyphenols, Ether, Hydrogen Bonding, Anisole, Methylation, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, Phenols, Electronic effect, Proton NMR, Benzene Derivatives, Phenol, Thermodynamics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af148b48559337388cf52de99bc7a7a
https://pubmed.ncbi.nlm.nih.gov/17137372

المؤلفون: Maja Lambert, Ian R. Mellor, Jerzy W. Jaroszewski, Cailean Clarkson

المصدر: Planta medica. 72(15)

مصطلحات موضوعية: Patch-Clamp Techniques, medicine.medical_treatment, Pharmaceutical Science, Flowers, Nicotinic Antagonists, Pharmacology, Biology, Receptors, Nicotinic, Analytical Chemistry, Steroid, chemistry.chemical_compound, Inhibitory Concentration 50, Ganglion type nicotinic receptor, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Cardenolide, Humans, Acetylcholine receptor, Plant Extracts, Organic Chemistry, Apocynaceae, Plant Leaves, Electrophysiology, Cardenolides, Nicotinic agonist, Complementary and alternative medicine, chemistry, Biochemistry, Molecular Medicine, Ionotropic effect, Phytotherapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b9683b1726b885cfdf70a8093adda7
https://pubmed.ncbi.nlm.nih.gov/17054051

المؤلفون: Maja Lambert, Jerzy W. Jaroszewski, Steen Honoré Hansen, Dan Staerk

المصدر: Lambert, M, Stærk, D, Hansen, S H & Jaroszewski, J W 2005, ' HPLC-SPE-NMR hyphenation in natural products research: optimization of analysis of Croton membranaceus extract ', Magnetic Resonance in Chemistry, vol. 43, pp. 771-775 . https://doi.org/10.1002/mrc.1613

مصطلحات موضوعية: Biological Products, Scopoletin, Chromatography, Acetonitriles, Magnetic Resonance Spectroscopy, Plants, Medicinal, Chemistry, Elution, Plant Extracts, Research, Extraction (chemistry), Analytical chemistry, General Chemistry, High-performance liquid chromatography, Sensitivity and Specificity, Cartridge, chemistry.chemical_compound, Automation, Column chromatography, General Materials Science, Solid phase extraction, Croton, Two-dimensional nuclear magnetic resonance spectroscopy, Chromatography, High Pressure Liquid

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a3997bbc4bcebd4a6a992b529f11d6
https://pubmed.ncbi.nlm.nih.gov/16049947