المؤلفون: Brindavanam, Narasimha Baba^{1, 1}, Goraya, Gurinderjit Singh², Singh, Santosh Pal¹, Bhatt, Jayesh³, Paradva, Bhagirath³, Poptani, Rakesh³, Vadodaria, Viral³, Mahato, Arun Kumar Roy³, Vijaykumar, V.³

المصدر: Medicinal Plants - International Journal of Phytomedicines and Related Industries 14(4):648-657. 2022

المؤلفون: Guo, Xuanming, Asthana, Pallavi, Zhai, Lixiang, Cheng, Ka Wing, Gurung, Susma, Huang, Jiangang, Wu, Jiayan, Zhang, Yijing, Mahato, Arun Kumar, Saarma, Mart, Ustav, Mart, Kwan, Hiu Yee, Lyu, Aiping, Chan, Kui Ming, Xu, Pingyi, Bian, Zhao-Xiang, Wong, Hoi Leong Xavier

المساهمون: Institute of Biotechnology, Mart Saarma / Principal Investigator

مصطلحات موضوعية: Recombinant leptin, Glucose-tolerance, Weight-loss, Receptor, Gdf15, Resistance, Malaria, System, Islet, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: The presented work was kindly supported by the General Research Fund (12102020 and 22104123) (Wong HLX), Health and Medical Research Fund (08793626) (Wong HLX), Excellent Young Scientist Fund by National Natural Science Foundation of China (32322091) (Wong HLX) and Innovation and Technology Fund (ITS/058/22MS) (Wong HLX).; Guo , X , Asthana , P , Zhai , L , Cheng , K W , Gurung , S , Huang , J , Wu , J , Zhang , Y , Mahato , A K , Saarma , M , Ustav , M , Kwan , H Y , Lyu , A , Chan , K M , Xu , P , Bian , Z-X & Wong , H L X 2024 , ' Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis ' , Nature Communications , vol. 15 , 1034 . https://doi.org/10.1038/s41467-024-45452-3; ORCID: /0000-0001-5543-7160/work/156157546; http://hdl.handle.net/10138/573428; 6ee211f4-a4ad-461d-b973-aa5075029bdb; 001156769400017

الاتاحة: http://hdl.handle.net/10138/573428

المؤلفون: Badoni, Subhashini, Rawat, Deepshikha, Mahato, Arun Kumar, Jangwan, Nitish Singh, Ashraf, Ghulam Md, Alexiou, Athanasios, Tayeb, Haythum O., Alghamdi, Badrah S., Papadakis, Marios, Singh, Mamta F.

المساهمون: King Abdulaziz University

المصدر: Chemistry & Biodiversity ; ISSN 1612-1872 1612-1880

الاتاحة: http://dx.doi.org/10.1002/cbdv.202301888
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202301888

المؤلفون: Haider, Malik Salman, Mahato, Arun Kumar, Kotliarova, Anastasiia, Forster, Stefan, Böttcher, Bettina, Stahlhut, Philipp, Sidorova, Yulia, Luxenhofer, Robert

المساهمون: Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Joint Activities, Helsinki Institute of Life Science HiLIFE, Divisions of Faculty of Pharmacy, Helsinki Institute of Sustainability Science (HELSUS), Polymers, Department of Chemistry, Faculty of Science

مصطلحات موضوعية: DELIVERY-SYSTEMS, SOLUBILITY PARAMETERS, POLYMERIC MICELLES, BLOCK-COPOLYMERS, SOLUBLE DRUGS, GDNF FAMILY, POLY(2-OXAZOLINE)S, FORMULATIONS, RECEPTOR, NANOCARRIERS, Chemical sciences

وصف الملف: application/pdf

Relation: M.S.H. is grateful to the higher education commission of Pakistan and German academic exchange services (HECDAAD Pakistan) for the award of his Ph.D. scholarship. Y.S. acknowledges financial support from the Academy of Finland (grant numbers 1325555 and N 1333697). This work was supported by Deutsche Forschungsgemeinschaft (DFG), German Research Foundation Project no. 398461692 awarded to R.L. We also thank Jan Weichhold for providing technical support during XRD measurements. We are grateful to Paula Collin for her excellent technical assistance with cell-based assays and to Pharmidex Pharmaceutical Services Ltd. (U.K.) for the measurement of the plasma and brain concentration of BT44. We further thank the NMR core facility supported by University of Helsinki, Biocenter Finland and Helsinki Institute of Life Science (HiLIFE) for verification of the structure of BT44. The table of contents graphic for this article was created with BioRender.com.; Haider , M S , Mahato , A K , Kotliarova , A , Forster , S , Böttcher , B , Stahlhut , P , Sidorova , Y & Luxenhofer , R 2023 , ' Biological Activity In Vitro, Absorption, BBB Penetration, and Tolerability of Nanoformulation of BT44 : RET Agonist with Disease-Modifying Potential for the Treatment of Neurodegeneration ' , Biomacromolecules , vol. 24 , no. 10 , pp. 4348–4365 . https://doi.org/10.1021/acs.biomac.2c00761; ORCID: /0000-0001-5567-7404/work/147400682; http://hdl.handle.net/10138/567397; 7f827a91-32f5-46ae-b1e8-ea84fea7b39a; 85139829855; 000869074200001

الاتاحة: http://hdl.handle.net/10138/567397

المؤلفون: Allam, Parbej, Shakya, Smriti, Yadav, Vijay, KC, Shradha, Sedai, Hari, Poddar, Elisha, Shrestha, Suraj, KC, Niranjan, Mahato, Arun Kumar

المصدر: Annals of Medicine & Surgery ; volume 85, issue 10, page 5105-5109 ; ISSN 2049-0801

الاتاحة: http://dx.doi.org/10.1097/ms9.0000000000001129
https://journals.lww.com/10.1097/MS9.0000000000001129

المؤلفون: Haider, Malik Salman, Mahato, Arun Kumar, Kotliarova, Anastasiia, Forster, Stefan, Böttcher, Bettina, Stahlhut, Philipp, Sidorova, Yulia, Luxenhofer, Robert

المساهمون: Deutscher Akademischer Austauschdienst, Higher Education Commision, Pakistan, Academy of Finland

المصدر: Biomacromolecules ; volume 24, issue 10, page 4348-4365 ; ISSN 1525-7797 1526-4602

الاتاحة: http://dx.doi.org/10.1021/acs.biomac.2c00761
https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.2c00761

المؤلفون: Ajmal, Mohammad, Mahato, Arun Kumar, Khan, Mausin, Rawat, Shivani, Husain, Asif, Almalki, Emad Bakheet, Alzahrani, Mohammed Ahmed, Haque, Anzarul, Hakme, Mohammed Japer Mohammed, Albalawi, Ahmed Suleman, Rashid, Mohammad

المصدر: Chemistry & Biodiversity; Jul2024, Vol. 21 Issue 7, p1-29, 29p

المؤلفون: Shanthi, Nithya, Arora, Khushbu, Pant, Himani, Soni, Komal, Gupta, Geetika, Chandra, Gaurav, Mahato, Arun Kumar

المصدر: Current Nanomedicine ; volume 15 ; ISSN 2468-1873

الاتاحة: http://dx.doi.org/10.2174/0124681873314206241023034855

المؤلفون: Shanthi, Nithya, Mittal, Heena, Kumar, Manish, Mahato, Arun Kumar, Mishra, Brahmeshwar

المصدر: Current Nanomedicine ; volume 14, issue 2, page 143-154 ; ISSN 2468-1873

الاتاحة: http://dx.doi.org/10.2174/0124681873276409231213115328
https://www.eurekaselect.com/article/download?doi=10.2174/0124681873276409231213115328
https://www.eurekaselect.com/225818/article

المؤلفون: Renko, Juho-Matti, Mahato, Arun Kumar, Visnapuu, Tanel, Valkonen, Konsta, Karelson, Mati, Voutilainen, Merja H., Saarma, Mart, Tuominen, Raimo K., Sidorova, Yulia A.

المساهمون: Regenerative pharmacology group, Regenerative Neuroscience, Division of Pharmacology and Pharmacotherapy, Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Drug Research Program, Divisions of Faculty of Pharmacy, Mart Saarma / Principal Investigator

مصطلحات موضوعية: BT44, RET agonist, glial cell line-derived neurotrophic factor, receptor tyrosine kinase RET, AKT pathway, MAPK pathway, rat 6-hydroxydopamine (6-OHDA) model, neuroprotection, Parkinson's disease, RECEPTOR TYROSINE KINASE, NEUROTROPHIC FACTOR, PARKINSONS-DISEASE, FUNCTIONAL RECOVERY, GDNF FAMILY, IN-VITRO, SUBSTANTIA-NIGRA, LESION MODEL, GENE-THERAPY, DOUBLE-BLIND, Neurosciences

وصف الملف: application/pdf

Relation: This work was supported by FP7-HEALTH-2013-INNOVATION-1 GA N602919, FP7-PEOPLE-2013-IAPP GA N612275, Gene Code Ltd., Lundbeck Foundation, Sigrid Jusélius Foundation (MS), Parkinson’s UK Innovation grant - K-1408 (MS and YAS), Academy of Finland Project Grant 1325555 (YAS). Academy of Finland Grants 126744, 309708 and 314233 (MV). Centre of Excellence in Molecular Cell Engineering, Estonia, 2014-2020.4.01.15-013 (MK), Finnish Parkinson’s Foundation fellowship (AKM) and The Finnish Funding Agency for Innovation (Tekes, 3iRegeneration, Project 40395/13) (RKT and MS).; Renko , J-M , Mahato , A K , Visnapuu , T , Valkonen , K , Karelson , M , Voutilainen , M H , Saarma , M , Tuominen , R K & Sidorova , Y A 2021 , ' Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats ' , Journal of Parkinson's disease , vol. 11 , no. 3 , pp. 1023-1046 . https://doi.org/10.3233/JPD-202400; ORCID: /0000-0002-9614-1988/work/99386290; ORCID: /0000-0001-5543-7160/work/99387628; http://hdl.handle.net/10138/333936; 54e9b2ee-4d2b-4b8e-afbc-dfd914eeb6cc; 000683027900011

الاتاحة: http://hdl.handle.net/10138/333936

المؤلفون: Ardashov, Oleg V., Pavlova, Alla V., Mahato, Arun Kumar, Sidorova, Yulia, Morozova, Ekaterina A., Korchagina, Dina V., Salnikov, Georgi E., Genaev, Alexander M., Patrusheva, Oksana S., Li-Zhulanov, Nikolay S., Tolstikova, Tat'yana G., Volcho, Konstantin P., Salakhutdinov, Nariman. F.

المساهمون: Institute of Biotechnology

مصطلحات موضوعية: Parkinson's disease, neurorestoration, MAPK signaling ERK pathway, dopamine neurons, tyrosine hydroxylase, NEUROTROPHIC FACTOR, PROTEIN-KINASE, ANIMAL-MODELS, GDNF, DERIVATIVES, RECEPTOR, CYCLOHEX-3-ENE-1,2-DIOL, GFR-ALPHA-1, SELEGILINE, MANAGEMENT, Neurosciences

وصف الملف: application/pdf

Relation: Current work was financially supported by FP7-PEOPLE-2013-IAPP GA N612275, Parkinson's UK Innovation Grant K-1408 and Russian Foundation for Basic Research (Grant No 19-03-00071a). We thank Jenni Montonen and Elena Burtovskaia for their excellent assistance with experimental procedures. We thank Prof. Mart Saarma for critical comments to this paper.; Ardashov , O V , Pavlova , A V , Mahato , A K , Sidorova , Y , Morozova , E A , Korchagina , D V , Salnikov , G E , Genaev , A M , Patrusheva , O S , Li-Zhulanov , N S , Tolstikova , T G , Volcho , K P & Salakhutdinov , N F 2019 , ' A Novel Small Molecule Supports the Survival of Cultured Dopamine Neurons and May Restore the Dopaminergic Innervation of the Brain in the MPTP Mouse Model of Parkinson's Disease ' , ACS chemical neuroscience , vol. 10 , no. 10 , pp. 4337-4349 . https://doi.org/10.1021/acschemneuro.9b00396; http://hdl.handle.net/10138/322044; 4701bf34-8253-483b-a462-1942d69e4980; 000491219000017

الاتاحة: http://hdl.handle.net/10138/322044

المؤلفون: Viisanen, Hanna, Nuotio, Ulpukka, Kambur, Oleg, Mahato, Arun Kumar, Jokinen, Viljami, Lilius, Tuomas, Li, Wei, Santos, Hélder A, Karelson, Mati, Rauhala, Pekka, Kalso, Eija, Sidorova, Yulia A

المساهمون: Department of Pharmacology, Faculty of Medicine, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, Institute of Biotechnology, HUSLAB, Medicum, Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Nanomedicines and Biomedical Engineering, Helsinki One Health (HOH), Divisions of Faculty of Pharmacy, Helsinki Institute of Life Science HiLIFE, Pekka Rauhala / Principal Investigator, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Helsinki University Hospital Area

مصطلحات موضوعية: ARTEMIN, GDNF, GDNF family ligands, GFR-ALPHA-1, GOOD STATISTICAL PRACTICE, GUIDELINES, Glial cell line-derived neurotrophic factor, NEURONS, NEUROTROPHIC FACTOR, PAIN, RECEPTOR, RET agonist, SPINAL NERVE LIGATION, diabetes mellitus, diabetic neuropathy, neuropathic pain, neuropathy, receptor tyrosine kinase RET, Neurosciences, Neurology and psychiatry

وصف الملف: application/pdf

Relation: Viisanen , H , Nuotio , U , Kambur , O , Mahato , A K , Jokinen , V , Lilius , T , Li , W , Santos , H A , Karelson , M , Rauhala , P , Kalso , E & Sidorova , Y A 2020 , ' Novel RET agonist for the treatment of experimental neuropathies ' , Molecular pain , vol. 16 , 1744806920950866 . https://doi.org/10.1177/1744806920950866; RIS: urn:989CF69CD1F7E1CAEA95BA2C1E779E7A; ORCID: /0000-0003-2036-3522/work/80576319; ORCID: /0000-0002-6997-9611/work/80578846; ORCID: /0000-0001-7850-6309/work/103469474; http://hdl.handle.net/10138/319451; b4a7fa72-b172-46ea-82e7-1c987c3564e3; 000563365700001

الاتاحة: http://hdl.handle.net/10138/319451

المؤلفون: Mahato, Arun Kumar, Kopra, Jaakko, Renko, Juho-Matti, Visnapuu, Tanel, Korhonen, Ilari, Pulkkinen, Nita, Bespalov, Maxim M., Domanskyi, Andrii, Ronken, Eric, Piepponen, T. Petteri, Voutilainen, Merja H., Tuominen, Raimo K., Karelson, Mati, Sidorova, Yulia A., Saarma, Mart

المساهمون: Institute of Biotechnology, Helsinki Institute of Life Science HiLIFE, Division of Pharmacology and Pharmacotherapy, Regenerative pharmacology group, Regenerative Neuroscience, Centre of Excellence in Stem Cell Metabolism, STEMM - Stem Cells and Metabolism Research Program, Drug Research Program, Timo Petteri Piepponen / Principal Investigator, Mart Saarma / Principal Investigator

مصطلحات موضوعية: Clustered Regularly Interspaced Short Palindromic Repeats, CRISPR associated protein 9, dopamine neurons, glial cell line-derived neurotrophic factor (GDNF), Parkinson's disease, receptor tyrosine kinase RET agonist, PARKINSONS-DISEASE, SUBSTANTIA-NIGRA, DOUBLE-BLIND, GENE DELIVERY, FACTOR GDNF, NEURTURIN, MODEL, NEUROPROTECTION, GFR-ALPHA-1, INFUSION, Neurosciences

وصف الملف: application/pdf

Relation: The current work was financially supported by FP7-HEALTH-2013-INNOVATION-1 GA N602919, FP7-PEOPLE-2013-IAPP GA N612275, Genecode Ltd, Lundbeck Foundation, Sigrid Juselius Foundation (all to M.S.), Parkinson's UK Innovation Grant K-1408 to M.S. and Y.A.S., Academy of Finland Project Grant 1325555 to Y.A.S., Academy of Finland Grants 293392 and 319195 to A.D., Academy of Finland Grants 126744, 309708 and 314233 to M.H.V. Centre of Excellence in Molecular Cell Engineering, Estonia, 2014-2020.4.01.15-013, Grant PUT582 from the Estonian Research Council to M.K., Finnish Parkinson's Foundation fellowship to A.K.M., and The Finnish Funding Agency for Innovation (TEKES, 3iRegeneration, Project 40395/13) to R.K.T. and M.S.; Mahato , A K , Kopra , J , Renko , J-M , Visnapuu , T , Korhonen , I , Pulkkinen , N , Bespalov , M M , Domanskyi , A , Ronken , E , Piepponen , T P , Voutilainen , M H , Tuominen , R K , Karelson , M , Sidorova , Y A & Saarma , M 2020 , ' Glial cell line-derived neurotrophic factor receptor REarranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo ' , Movement Disorders , vol. 35 , no. 2 , pp. 245-255 . https://doi.org/10.1002/mds.27943; ORCID: /0000-0002-2318-1612/work/71512044; ORCID: /0000-0002-9614-1988/work/71512624; ORCID: /0000-0001-5543-7160/work/71513963; ORCID: /0000-0002-8754-5753/work/71513967; ORCID: /0000-0002-4872-3326/work/159449492; http://hdl.handle.net/10138/320194; 2c976ce8-60e8-425a-ac32-4b2372b20aca; 000502663800001

الاتاحة: http://hdl.handle.net/10138/320194

المؤلفون: Datta, Ashim, Mahato, Arun Kumar Roy, Nisha, Priyanka, Jat, H.S., Sharma, Parbodh Chander

المصدر: European Journal of Environment and Earth Sciences ; volume 1, issue 3 ; ISSN 2684-446X

الاتاحة: http://dx.doi.org/10.24018/ejgeo.2020.1.3.24
https://www.ej-geo.org/index.php/ejgeo/article/download/24/10

المؤلفون: Mahato, Arun Kumar, Kopra, Jaakko, Renko, Juho‐Matti, Visnapuu, Tanel, Korhonen, Ilari, Pulkkinen, Nita, Bespalov, Maxim M., Domanskyi, Andrii, Ronken, Eric, Piepponen, T. Petteri, Voutilainen, Merja H., Tuominen, Raimo K., Karelson, Mati, Sidorova, Yulia A., Saarma, Mart

المساهمون: Eesti Teadusagentuur, Lundbeckfonden, Sigrid Juséliuksen Säätiö, Academy of Finland

المصدر: Movement Disorders ; volume 35, issue 2, page 245-255 ; ISSN 0885-3185 1531-8257

الاتاحة: http://dx.doi.org/10.1002/mds.27943
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmds.27943
https://onlinelibrary.wiley.com/doi/pdf/10.1002/mds.27943
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/mds.27943

المؤلفون: Kumar, Manish, Shanthi, Nithya, Mahato, Arun Kumar, Soni, Shashank, Rajnikanth, P.S.

المصدر: Heliyon ; volume 5, issue 5, page e01688 ; ISSN 2405-8440

الاتاحة: http://dx.doi.org/10.1016/j.heliyon.2019.e01688
https://api.elsevier.com/content/article/PII:S2405844018381106?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2405844018381106?httpAccept=text/plain

المؤلفون: Gajjar, Dipmala, Mahato, Arun Kumar Roy, Sorathia, Kalpesh

المصدر: Advances in Zoology and Botany ; volume 11, issue 5, page 336-349 ; ISSN 2331-5083 2331-5091

الاتاحة: http://dx.doi.org/10.13189/azb.2023.110502

المؤلفون: Haider, Malik Salman, Mahato, Arun Kumar, Kotliarova, Anastasiia, Forster, Stefan, Böttcher, Bettina, Stahlhut, Philipp, Sidorova, Yulia, Luxenhofer, Robert

المصدر: Biomacromolecules; 10/9/2023, Vol. 24 Issue 10, p4348-4365, 18p

المؤلفون: Saha, Supriyo, Prinsa, Jakhmola, Vikash, Mahato, Arun Kumar, Srivastava, Saloni, Dobhal, Kiran, Kawsar, Sarkar M. A.

المصدر: Philippine Journal of Science; Oct2023, Vol. 152 Issue 5, p1953-1988, 36p

مصطلحات موضوعية: ZIKA virus infections, INFLUENZA A virus, H3N2 subtype, RNA viruses, ZIKA virus, ZOONOSES

المؤلفون: Mahato, Arun Kumar

المساهمون: University of Helsinki, Faculty of Biological and Environmental Sciences, Institute of Biotechnology, HiLIFE, Doctoral Programme Brain and Mind, Helsingin yliopisto, bio- ja ympäristötieteellinen tiedekunta, Aivot ja mieli tohtoriohjelma (B&M), Helsingfors universitet, bio- och miljövetenskapliga fakulteten, Doktorandprogrammet i hjärn- och medvetandeforskning, Kokaia, Zaal, Sidorova, Yulia, Saarma, Mart

مصطلحات موضوعية: physiology and Neuroscience

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1593::a3a73a83820ad7df6d428276fd2d1a3d
http://hdl.handle.net/10138/350003