المؤلفون: Rachel J. Harding, Justin C. Deme, Johannes F. Hevler, Sem Tamara, Alexander Lemak, Jeffrey P. Cantle, Magdalena M. Szewczyk, Nola Begeja, Siobhan Goss, Xiaobing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B. Carroll, Albert J. R. Heck, Susan M. Lea, Cheryl H. Arrowsmith

المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3642

URL الوصول: https://doaj.org/article/eb1fd59dd9ce42829c1dde1a83e58ffc

المؤلفون: Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/03bef969e65b4b6bb250bb2886960e81

المؤلفون: Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy

المصدر: Redox Biology, Vol 51, Iss , Pp 102282- (2022)

مصطلحات موضوعية: Epigenetics, PRMT5, Oxidative stress, Splicing, Intron retention, ATF4, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722000544; https://doaj.org/toc/2213-2317

URL الوصول: https://doaj.org/article/8c9174ed85e342749dbc2bfff8c4fb40

المؤلفون: Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko, Shawna L. Organ, Jabez Bok, Jessica Sook Yuin Ho, Florence P. H. Gay, Fengling Li, Levi Blazer, Mohammad S. Eram, Levon Halabelian, David Dilworth, Genna M. Luciani, Evelyne Lima-Fernandes, Qin Wu, Peter Loppnau, Nathan Palmer, S. Zakiah A. Talib, Peter J. Brown, Matthieu Schapira, Philipp Kaldis, Ronan C. O’Hagan, Ernesto Guccione, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, John M. Sanders, Solomon D. Kattar, D. Jonathan Bennett, Benjamin Nicholson, Masoud Vedadi

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/38d967925aeb49498c5e1209a2983c26

المؤلفون: Jayme L. Dahlin, Kathryn M. Nelson, Jessica M. Strasser, Dalia Barsyte-Lovejoy, Magdalena M. Szewczyk, Shawna Organ, Matthew Cuellar, Gurpreet Singh, Jonathan H. Shrimp, Nghi Nguyen, Jordan L. Meier, Cheryl H. Arrowsmith, Peter J. Brown, Jonathan B. Baell, Michael A. Walters

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/8ca9ff19d5524b75acdb413bf0ff0f30

المؤلفون: Magdalena M. Szewczyk, Yoshinori Ishikawa, Shawna Organ, Nozomu Sakai, Fengling Li, Levon Halabelian, Suzanne Ackloo, Amber L. Couzens, Mohammad Eram, David Dilworth, Hideto Fukushi, Rachel Harding, Carlo C. dela Seña, Tsukasa Sugo, Kozo Hayashi, David McLeod, Carlos Zepeda, Ahmed Aman, Maria Sánchez-Osuna, Eric Bonneil, Shinji Takagi, Rima Al-Awar, Mike Tyers, Stephane Richard, Masayuki Takizawa, Anne-Claude Gingras, Cheryl H. Arrowsmith, Masoud Vedadi, Peter J. Brown, Hiroshi Nara, Dalia Barsyte-Lovejoy

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/1528be5dba214e53abc1707b3bc5de39

المؤلفون: Rachel J Harding, Ivan Franzoni, Mandeep K Mann, Magdalena M Szewczyk, Bijan Mirabi, Dominic D.G Owens, Suzanne Ackloo, Alexej Scheremetjew, Kevin A. Juarez-Ornelas, Randy Sanichar, Rachel J. Baker, Christian Dank, Peter J. Brown, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Matthieu Schapira, Mark Lautens, Cheryl H. Arrowsmith

مصطلحات موضوعية: HDAC6, open source, chemical probe, chemical tool, ubiquitin, ubiquitin binding domain, UBD

Relation: https://doi.org/10.5281/zenodo.7618094; https://doi.org/10.5281/zenodo.7618095; oai:zenodo.org:7618095

الاتاحة: https://doi.org/10.5281/zenodo.7618095

المؤلفون: Ahmed Fnaiche, Hwai-Chien Chan, Alexis Paquin, Narjara González Suárez, Victoria Vu, Fengling Li, Abdellah Allali-Hassani, Michelle Ada Cao, Magdalena M. Szewczyk, Albina Bolotokova, Frédéric Allemand, Muriel Gelin, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Jean-François Guichou, Borhane Annabi, Alexandre Gagnon

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Developmental Biology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, reduces gene expression, controls cell proliferation, transcript levels, tissue repair, reacts covalently, oxopentyl chain, organ growth, nf2 <, htead2 confirmed, hippo pathway, flufenamic acid, downstream effector, cyr61 <, ctgf <, crystal structure, covalent bond, cell migration

Relation: https://figshare.com/articles/journal_contribution/Development_of_HC-258_a_Covalent_Acrylamide_TEAD_Inhibitor_That_Reduces_Gene_Expression_and_Cell_Migration/24680643

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00386.s001
https://figshare.com/articles/journal_contribution/Development_of_HC-258_a_Covalent_Acrylamide_TEAD_Inhibitor_That_Reduces_Gene_Expression_and_Cell_Migration/24680643

المؤلفون: Ronan P. Hanley, David Y. Nie, John R. Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K. Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M. Szewczyk, Peter J. Brown, Dalia Barsyte-Lovejoy, Laura E. Herring, Gang Greg Wang, Jonathan D. Licht, Masoud Vedadi, Cheryl H. Arrowsmith, Lindsey I. James

المصدر: Journal of the American Chemical Society. 145:8176-8188

مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::95bc98e1fc4dc9f993866f26284bf64e
https://doi.org/10.1021/jacs.3c01421

المؤلفون: Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi

المصدر: Journal of Medicinal Chemistry. 66:5041-5060

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::87d2380cfc1eda17d3f8edf2cae4eb67
https://doi.org/10.1021/acs.jmedchem.2c02132

المؤلفون: Anja Dölle (10794992), Bikash Adhikari (704191), Andreas Krämer (3286917), Janik Weckesser (10794995), Nicola Berner (10794998), Lena-Marie Berger (10795001), Mathias Diebold (10795004), Magdalena M. Szewczyk (3119427), Dalia Barsyte-Lovejoy (1399687), Cheryl H. Arrowsmith (246847), Jakob Gebel (10795007), Frank Löhr (1871500), Volker Dötsch (1910650), Martin Eilers (164041), Stephanie Heinzlmeir (1456441), Bernhard Kuster (3990), Christoph Sotriffer (3544643), Elmar Wolf (164036), Stefan Knapp (244328)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, dysfunctional HMT complexes, WDR 5, upregulated MYC levels, 3K, protein interaction interfaces, WDR 5 interactions, WDR 5 degrader series, influence degradation efficacy, WD-repeat-containing protein 5, RNA, WIN site binding scaffolds

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Evaluation_of_WD-Repeat-Containing_Protein_5_WDR5_Degraders/14587298

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00146.s001

المؤلفون: Yudao Shen (1476319), Fengling Li (176389), Magdalena M. Szewczyk (3119427), Levon Halabelian (710679), Irene Chau (2276365), Mohammad S. Eram (1399684), Carlo Dela Seña (10151727), Kwang-Su Park (10151730), Fanye Meng (8299767), He Chen (104732), Hong Zeng (24161), Aiping Dong (141147), Hong Wu (105254), Viacheslav V. Trush (10429365), David McLeod (2086192), Carlos A. Zepeda-Velázquez (8805626), Robert M. Campbell (2443825), Mary M. Mader (1398535), Brian M. Watson (2521252), Matthieu Schapira (51934), Cheryl H. Arrowsmith (246847), Rima Al-Awar (9985073), Dalia Barsyte-Lovejoy (1399687), H. Ümit Kaniskan (1476325), Peter J. Brown (499896), Masoud Vedadi (210076), Jian Jin (351142)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, PRMT 6 functions, Protein Arginine Methyltransferase ., well-characterized PRMT 6 chemical ., PRMT 6, 6870N, PRMT 6 inhibitor, Cell-Active Allosteric Inhibitor, SGC, IC

Relation: https://figshare.com/articles/journal_contribution/A_First-in-Class_Highly_Selective_and_Cell-Active_Allosteric_Inhibitor_of_Protein_Arginine_Methyltransferase_6/14043573

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02160.s001

المؤلفون: Renato Ferreira de Freitas (1399675), Yanli Liu (198140), Magdalena M. Szewczyk (3119427), Naimee Mehta (4774290), Fengling Li (176389), David McLeod (2086192), Carlos Zepeda-Velázquez (1436509), David Dilworth (5431328), Ronan P. Hanley (7848132), Elisa Gibson (10061704), Peter J. Brown (499896), Rima Al-Awar (9985073), Lindsey I. James (1616749), Cheryl H. Arrowsmith (246847), Dalia Barsyte-Lovejoy (1399687), Jinrong Min (182610), Masoud Vedadi (210076), Matthieu Schapira (51934), Abdellah Allali-Hassani (242023)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Cancer, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, small-molecule antagonist 3 f, NSD 2-PWWP domain, NSD 2, abrogates histone H 3K binding, 3.4 μ M, N-terminal PWWP domain, lysine methyltransferase NSD 2, PWWP 1 domain, NSD 2-targeting chemical probe

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Small-Molecule_Antagonists_of_the_PWWP_Domain_of_NSD2/13678450

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01768.s001

المؤلفون: Victoria, Vu, Magdalena M, Szewczyk, David Y, Nie, Cheryl H, Arrowsmith, Dalia, Barsyte-Lovejoy

المصدر: Annual Review of Biochemistry. 91:61-87

مصطلحات موضوعية: Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9d258b06c28692f7e375086129dc9d
https://doi.org/10.1146/annurev-biochem-032620-105344

المؤلفون: Rachel J. Harding, Ivan Franzoni, Mandeep K. Mann, Magdalena M. Szewczyk, Bijan Mirabi, Dominic D.G Owens, Suzanne Ackloo, Alexej Scheremetjew, Kevin A. Juarez-Ornelas, Randy Sanichar, Rachel J. Baker, Christian Dank, Peter J. Brown, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Matthieu Schapira, Mark Lautens, Cheryl H. Arrowsmith

مصطلحات موضوعية: open source, ubiquitin binding domain, chemical tool, ubiquitin, chemical probe, UBD, HDAC6

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1d88eee8c05d3f84ad9eac6e95b802

المؤلفون: Dominic D.G Owens, Matthew E.R Maitland, Aliakbar Khalili Yazdi, Xiaosheng Song, Martin P. Schwalm, Raquel A.C Machado, Nicolas Bauer, Xu Wang, Magdalena M. Szewczyk, Cheng Dong, Aiping Dong, Peter Loppnau, Matthew F. Calabrese, Matthew S. Dowling, Jisun Lee, Justin I. Montgomery, Thomas N. O’Connell, Chakrapani Subramanyam, Feng Wang, Matthieu Schapira, Stefan Knapp, Masoud Vedadi, Jinrong Min, Gilles A. Lajoie, Dalia Barsyte-Lovejoy, Dafydd R. Owen, Caroline Schild-Poulter, Cheryl H. Arrowsmith

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::756b8bd8412abe2d17623cbc6ce6d79d
https://doi.org/10.1101/2023.01.17.524225

المؤلفون: Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi

المصدر: Nat Chem Biol

مصطلحات موضوعية: Gene isoform, Methyltransferase, Nucleolus, Lysine, Methylation, Article, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, Histone-Lysine N-Methyltransferase, Cell Biology, Nucleosomes, Chromatin, Cell biology, Repressor Proteins, Histone, Enzyme, Molecular Probes, 030220 oncology & carcinogenesis, biology.protein, Multiple Myeloma, Cell Nucleolus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29b52d0f1e30e6d3bd73de3c2a5989b
https://doi.org/10.1038/s41589-021-00898-0

المؤلفون: Aiping Dong, Fengling Li, Alexandre Gagnon, Borhane Annabi, Shuay Abdullayev, Hong Zeng, Masoud Vedadi, Léa Mélin, Victoria Vu, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian, Abdellah Allali-Hassani, Irene Chau, Ahmed Fnaiche, Magdalena M. Szewczyk, Simon Woo, Steven R. LaPlante, Guillermo Senisterra, Narjara Gonzalez Suarez

المصدر: ChemMedChem. 16:2982-3002

مصطلحات موضوعية: Cell division, Cell Survival, Cell, Antineoplastic Agents, Biochemistry, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, Tumor Cells, Cultured, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Transcription factor, Cell Proliferation, Pharmacology, Hippo signaling pathway, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Cell Cycle, Organic Chemistry, TEA Domain Transcription Factors, Flufenamic Acid, Cell biology, CTGF, Flufenamic acid, medicine.anatomical_structure, CYR61, Cancer cell, Molecular Medicine, Drug Screening Assays, Antitumor, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f25b13a6b2f757335ed6a0646f9ff
https://doi.org/10.1002/cmdc.202100432

المؤلفون: Jian Jin, Levon Halabelian, Fengling Li, Masoud Vedadi, Rima Al-awar, Carlo C. dela Seña, Mohammad S. Eram, Aiping Dong, Carlos Zepeda-Velázquez, He Chen, Matthieu Schapira, Robert M. Campbell, Dalia Barsyte-Lovejoy, David McLeod, Cheryl H. Arrowsmith, Hong Zeng, Hong Wu, Yudao Shen, Mary M. Mader, Viacheslav V. Trush, Brian Morgan Watson, Kwang-Su Park, Irene Chau, Fanye Meng, Peter Brown, H. Ümit Kaniskan, Magdalena M. Szewczyk

المصدر: J Med Chem

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, Methyltransferase, Arginine, Stereochemistry, Cell, Allosteric regulation, Crystallography, X-Ray, 01 natural sciences, Article, 03 medical and health sciences, Allosteric Regulation, Drug Discovery, medicine, Humans, Enzyme Inhibitors, IC50, 030304 developmental biology, Benzodiazepinones, 0303 health sciences, Chemistry, Nuclear Proteins, Stereoisomerism, Highly selective, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, medicine.anatomical_structure, Molecular Medicine, Enantiomer, Selectivity, Allosteric Site, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cda514e73beafd941778da58b838824
https://doi.org/10.1021/acs.jmedchem.0c02160

المؤلفون: Jing Liu, Dalia Barsyte-Lovejoy, Aiping Dong, Kwang-Su Park, Fanye Meng, Irene Chau, Jian Jin, Peter Brown, Levon Halabelian, Yudao Shen, He Chen, Fengling Li, Cheryl H. Arrowsmith, Masoud Vedadi, Magdalena M. Szewczyk, Hong Zeng

المصدر: J Med Chem

مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, Methyltransferase, Dose-Response Relationship, Drug, Chemistry, Protein-arginine methyltransferase, Nuclear Proteins, Covalent binding, Cocrystal, Article, Protein Structure, Secondary, HEK293 Cells, Biochemistry, Covalent bond, Drug Discovery, MCF-7 Cells, Humans, Molecular Medicine, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2bf740dd17b33e7cc615e30a9e1316
https://doi.org/10.1021/acs.jmedchem.0c00406