المؤلفون: Imhoff, Mackenzie E. Chapman

مصطلحات موضوعية: Structural biology (incl. macromolecular modelling), Enzymes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1a7d63958874c9007fcf00f0e8c669

المؤلفون: Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Lars Pache, Sebastian Burgstaller-Muehlbacher, Paul D. De Jesus, Peter Teriete, Mitchell V. Hull, Max W. Chang, Jasper Fuk-Woo Chan, Jianli Cao, Vincent Kwok-Man Poon, Kristina M. Herbert, Kuoyuan Cheng, Tu-Trinh H. Nguyen, Andrey Rubanov, Yuan Pu, Courtney Nguyen, Angela Choi, Raveen Rathnasinghe, Michael Schotsaert, Lisa Miorin, Marion Dejosez, Thomas P. Zwaka, Ko-Yung Sit, Luis Martinez-Sobrido, Wen-Chun Liu, Kris M. White, Mackenzie E. Chapman, Emma K. Lendy, Richard J. Glynne, Randy Albrecht, Eytan Ruppin, Andrew D. Mesecar, Jeffrey R. Johnson, Christopher Benner, Ren Sun, Peter G. Schultz, Andrew I. Su, Adolfo García-Sastre, Arnab K. Chatterjee, Kwok-Yung Yuen, Sumit K. Chanda

المصدر: Nature

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Morpholines, Induced Pluripotent Stem Cells, Pneumonia, Viral, Drug Evaluation, Preclinical, Cysteine Proteinase Inhibitors, Virus Replication, Antiviral Agents, Models, Biological, Article, Cell Line, Unit (housing), Small Molecule Libraries, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Pandemic, medicine, Humans, Pandemics, Alanine, Multidisciplinary, Dose-Response Relationship, Drug, SARS-CoV-2, Triazines, business.industry, General surgery, Drug Repositioning, Hydrazones, COVID-19, Reproducibility of Results, Drug Synergism, Virus Internalization, Adenosine Monophosphate, COVID-19 Drug Treatment, Pyrimidines, 030104 developmental biology, Gene Expression Regulation, Cardiothoracic surgery, Alveolar Epithelial Cells, 030220 oncology & carcinogenesis, Quality standard, Coronavirus Infections, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec8b07864daa4712214c5022636c8e8
https://doi.org/10.1038/s41586-020-2577-1

المؤلفون: Mackenzie E. Chapman Imhoff (15349264)

مصطلحات موضوعية: Enzymes, Structural biology (incl. macromolecular modelling), coronavirus, Papain-like protease (PLpro), papain-like protease 2, enzyme kinetics assays, protein purification methods, deubiquitinating enzyme activity, deISGylase Activity, Small-Molecule Inhibitors Targeting, covalent fragment library, non-structural protein 3

Relation: https://figshare.com/articles/thesis/FUNCTIONAL_AND_STRUCTURAL_STUDIES_OF_THE_PAPAIN-LIKE_PROTEASE_ENCODED_IN_CORONAVIRUS_NON-STRUCTURAL_PROTEIN_3/22688422

المؤلفون: Mackenzie E. Chapman, Courtney M. Daczkowski, Arun K. Ghosh, Andrew D. Mesecar

المصدر: Biophysical Journal. 121:191a-192a

مصطلحات موضوعية: Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::16de125bf7b350afffc6d67bf26774d2
https://doi.org/10.1016/j.bpj.2021.11.1792

المؤلفون: Matthew Hackbart, Susan C. Baker, Andrew D. Mesecar, Robert C. Mettelman, Amornrat O'Brien, Kristina R. Kesely, Mackenzie E. Chapman, Yafang Chen, Xufang Deng, Anna M. Mielech

المصدر: Journal of Virology

مصطلحات موضوعية: Models, Molecular, Ubiquitin binding, Protein Conformation, viruses, medicine.medical_treatment, Mutant, coronavirus, Virus Replication, medicine.disease_cause, Mice, Interferon, Coronavirus, 0303 health sciences, Virulence, Chemistry, 030302 biochemistry & molecular biology, Cell biology, 3. Good health, Host-Pathogen Interactions, Interferon Type I, IFN antagonist, Coronavirus Infections, DUB activity, medicine.drug, Immunology, RNA-dependent RNA polymerase, Mutagenesis (molecular biology technique), papain-like protease, Biology, Microbiology, Virus, PLP2, Structure-Activity Relationship, Viral Proteins, 03 medical and health sciences, Virology, medicine, Animals, Amino Acid Sequence, 030304 developmental biology, Murine hepatitis virus, Protease, 030306 microbiology, Macrophages, Ubiquitination, Viral replication, Mutagenesis, Insect Science, Pathogenesis and Immunity, PLP2 structure

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd75448d9cf4433bed1318ea6990959

المؤلفون: Margherita Brindisi, Mackenzie E. Chapman, Arun K. Ghosh, Andrew D. Mesecar, Dana Shahabi

المساهمون: Ghosh, A. K., Brindisi, M., Shahabi, D., Chapman, M. E., Mesecar, A. D.

المصدر: ChemMedChem
Chemmedchem

مصطلحات موضوعية: Models, Molecular, Coronavirus disease 2019 (COVID-19), Chemistry, Pharmaceutical, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Protease Inhibitor, Pneumonia, Viral, coronavirus, protease inhibitors, Reviews, Review, Computational biology, Biology, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Approved drug, Biochemistry, Drug Development, Very Important Paper, Pandemic, Drug Discovery, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Pandemics, Coronavirus, Antiviral Agent, Pharmacology, Coronavirus Infection, 010405 organic chemistry, Drug discovery, Organic Chemistry, Proteolytic enzymes, COVID-19, SARS-CoV, 0104 chemical sciences, coronaviru, 010404 medicinal & biomolecular chemistry, Drug development, Molecular Medicine, Coronavirus Infections, Human

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae109fb298d17dbeb436990703433518

المؤلفون: Richard T. D’Aquila, Sergii Pshenychnyi, Andrew D. Mesecar, Emma K. Lendy, Brandon J. Anson, Mackenzie E. Chapman, Karla J. F. Satchell

مصطلحات موضوعية: Proteases, Broad spectrum, Papain, chemistry.chemical_compound, Chemistry, viruses, medicine, virus diseases, medicine.disease_cause, Virology, Coronavirus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::10bd4fc742f3beae5f1573692a1d4972
https://doi.org/10.21203/rs.3.rs-26344/v1

المؤلفون: Andrew D. Mesecar, Sarah E. St John, Emma K. Lendy, Brandon J. Anson, Mackenzie E. Chapman, Arun K. Ghosh

المصدر: Acta Crystallographica Section A Foundations and Advances. 77:C197-C197

مصطلحات موضوعية: Inorganic Chemistry, Structural Biology, General Materials Science, Physical and Theoretical Chemistry, Condensed Matter Physics, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::219ebb0808afe0bf710fc6c0825034ed
https://doi.org/10.1107/s010876732109485x