يعرض 1 - 20 نتائج من 46 نتيجة بحث عن '"Macaulay, Stuart"', وقت الاستعلام: 0.49s تنقيح النتائج
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    Relation: https://acuresearchbank.acu.edu.au/item/876vx/associations-of-neighborhood-environment-with-brain-imaging-outcomes-in-the-australian-imaging-biomarkers-and-lifestyle-cohort; https://doi.org/10.1016/j.jalz.2016.06.2364; Cerin, Ester, Rainey-Smith, Stephanie R., Ames, David, Lautenschlager, Nicola T., Macaulay, Stuart Lance, Fowler, Chris J., Robertson, Jane M., Rowe, Christopher C., Maruff, Paul Thomas, Martins, Ralph N., Masters, Colin L. and Ellis, Kathryn A. (2017). Associations of neighborhood environment with brain imaging outcomes in the Australian imaging, biomarkers and lifestyle cohort. Alzheimer's and Dementia. 13(4), pp. 388 - 398. https://doi.org/10.1016/j.jalz.2016.06.2364

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    Academic Journal

    مصطلحات موضوعية: AIBL, Alzheimer’s disease, Australia, Mediterranean diet, MCI

    Relation: https://acuresearchbank.acu.edu.au/item/8523z/adherence-to-a-mediterranean-diet-and-alzheimer-s-disease-risk-in-an-australian-population; https://doi.org/10.1038/tp.2012.91; Gardener, Samantha L., Gu, Yian, Rainey-Smith, Stephanie R., Keogh, Jennifer B., Clifton, Peter Marshall, Mathieson, S. L., Taddei, Kevin, Mondal, Alinda, Ward, Vanessa K., Scarmeas, Nikolaos, Barnes, Margaret, Ellis, Kathryn A., Head, Richard, Masters, Colin L., Ames, David, Macaulay, Stuart Lance, Rowe, Christopher C., Szoeke, Cassandra and Martins, Ralph N. (2012). Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry. https://doi.org/10.1038/tp.2012.91

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    Electronic Resource

    المصدر: Research outputs 2014 to 2021

    مصطلحات الفهرس: Find It@ECU(opens in a new window)|View at Publisher| CSV export | Download | Add to List | More... Journal of Alzheimer's Disease Volume 46, Issue 4, 26 June 2015, Pages 1079-1089 Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer's Disease Trials: An AIBL Study (Article) Burnham, S.C.ap, Raghavan, N.bp, Wilson, W.c, Baker, D.d, Ropacki, M.T.e, Novak, G.b, Ames, D.fg, Ellis, K.f, Martins, R.N.hi, Maruff, P.j, Masters, C.L.k, Romano, Rowe, C.C.lm, Savage, G.n, Macaulay, S.L.o, Narayan, V.A.b a DPF, CSIRO, Private Bag 5, Wembley, WA, Australia b Janssen Research and Development, Raritan, NJ, United States c CSIRO Digital Productivity Flagship, North Ryde, NSW, Australia View additional affiliations View references (33) Abstract Background: There is a growing consensus that disease-modifying therapies must be given at the prodromal or preclinical stages of Alzheimer's disease (AD) to be effective. A major unmet need is to develop and validate sensitive measures to track disease progression in these populations. Objective: To generate novel statistically-derived composites from standard scores, which have increased sensitivity in the assessment of change from baseline in prodromal AD. Methods: An empirically based method was employed to generate domain specific, global, and cognitive-functional novel composites. The novel composites were compared and contrasted with each other, as well as standard scores for their ability to track change from baseline. The longitudinal characteristics and power to detect decline of the measures were evaluated. Data from participants in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study characterized as mild cognitively impaired with high neocortical amyloid-β burden were utilized for the study. Results: The best performing standard scores were CDR Sum-of-Boxes and MMSE. The statistically-derived novel composites performed better than the standard scores from which they were derived. The domain-specific composites generally did not perform as well as the global composites or the cognitive-functional composites. Conclusion: A systematic method was employed to generate novel statistically-derived composite measures from standard scores. Composites comprised of measures including function and multiple cognitive domains appeared to best capture change from baseline. These composites may be useful to assess progression or lack thereof in prodromal AD. However, the results should be replicated and validated using an independent clinical sample before implementation in a clinical trial. © 2015 - IOS Press and the authors. All rights reserved. Author keywords Alzheimer's disease; clinical marker; clinical trial; mild cognitive impairment; prodromal stage, Medicine and Health Sciences, text

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