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المؤلفون: Huihuang Yan, Khashayarsha Khazaie, Gianrico Farrugia, Sabriya A. Syed, Michelle Wehling-Henricks, Makoto Kuro-o, Simon J. Gibbons, Sergiy M. Kvasha, David T. Asuzu, Rea A. Nagy, Eduardo N. Chini, Mahendra Pal Singh, Yujiro Hayashi, David R. Linden, James G. Tidball, Gabriella B. Gajdos, Michael R. Bardsley, Jair Machado Espindola Netto, Siva Arumugam Saravanaperumal, Todd A. Kellogg, Tamas Ordog, Yoshitaka Toyomasu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: PE, R-phycoerythrin, Male, 0301 basic medicine, CL.CASP3, cleaved caspase 3, Aging, Cell cycle checkpoint, BrdU, 5-bromo-2′-deoxyuridine, DMSO, dimethyl sulfoxide, Mice, 0302 clinical medicine, APC, allophycocyanin, ERK, extracellular signal-regulated kinase, GSEA, gene set enrichment analysis, GEO, Gene Expression Omnibus, NES, normalized enrichment score, TRP53, transformation related protein 53, Wnt Signaling Pathway, Klotho, ANOVA, analysis of variance, Cellular Senescence, Original Research, SA-β-gal, senescence-associated beta-galactosidase, KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Stomach, EdU, 5-ethynyl-2′-deoxyuridine, Gastroenterology, Wnt signaling pathway, MTS, methyltetrazolium salt, ICC, interstitial cells of Cajal, Middle Aged, CDKN1A, cyclin-dependent kinase inhibitor 1a, Up-Regulation, Cell biology, CTNNB1, catenin beta 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Models, Animal, symbols, Female, 030211 gastroenterology & hepatology, ANO1, anoctamin-1, RPKM, reads per kilobase of transcript per million mapped reads, Stem cell, Compliance, Senescence, SESN, sestrin, tsTAg, tsA58-mutant SV40 large T antigen, Adenomatous Polyposis Coli Protein, FDR Q, false discovery rate Q value, Mice, Transgenic, KLF4, Kruppel-like factor 4, Biology, DDR, DNA damage response, PI, propidium iodide, Young Adult, 03 medical and health sciences, symbols.namesake, Cyclin D1, RT-qPCR, real-time quantitative reverse-transcription polymerase chain reaction, Stem Cell, MEK, mitogen-activated protein kinase kinase, Animals, Humans, Kinase activity, lcsh:RC799-869, Klotho Proteins, CCND1, cyclin D1, Hepatology, WB, Western immunoblotting, RNA-seq, RNA sequencing, Cell Cycle Checkpoints, Interstitial Cells of Cajal, CDKN1B, cyclin-dependent kinase inhibitor 2B, WT, wild-type, Interstitial cell of Cajal, 030104 developmental biology, siRNA, small interfering RNA, ETV1, ets variant 1, ICC-SC, interstitial cells of Cajal stem cells, lcsh:Diseases of the digestive system. Gastroenterology, Tumor Suppressor Protein p53, MYC, myelocytomatosis oncogene, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Alice P. Sowton, Andrew J. Murray, Simon James Tunster, Erica D. Watson, Ben D. McNally, Nisha Padmanabhan, Julian L. Griffin, Antonio Murgia, Aisha Yusuf
المساهمون: Medical Research Council, Medical Research Council (MRC), Sowton, Alice [0000-0002-3718-7783], Tunster, Simon [0000-0002-2242-9452], Murray, Andrew [0000-0002-0929-9315], Watson, Erica [0000-0003-4496-2271], Apollo - University of Cambridge Repository, Watson, Erica D [0000-0003-4496-2271]
المصدر: Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports, Vol 23, Iss, Pp-(2020)مصطلحات موضوعية: CE, cholesteryl-ester, LC-MS, liquid chromatography-mass spectrometry, 5-methyl-THF, 5-methyltetrahydofolate, OXPHOS, oxidative phosphorylation, G6pc, glucose 6-phophastase gene, PG, phosphatidylglycerol, 0601 Biochemistry and Cell Biology, Gyg, glycogenin gene, PIP, phosphatidylinositol phosphate(s), Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha gene, chemistry.chemical_compound, Isca1, iron‑sulfur cluster assembly 1 gene, PC, phosphatidylcholine, 0302 clinical medicine, Endocrinology, Nonalcoholic fatty liver disease, One‑carbon metabolism, PA, phosphatidic acid, lcsh:QH301-705.5, 0303 health sciences, lcsh:R5-920, biology, Glycogen, FCCP, p-trifluoromethoxyphenyl hydrazine, 030305 genetics & heredity, SAM, S-adenosylmethionine, Mthfr, methylenetetrahydrofolate reductase gene, Mtr, methionine synthase gene (also MS), PS, phosphatidylserine, 3. Good health, PL, phospholipid, Gsk3, glycogen synthase kinase gene, RIPA, Radioimmunoprecipitation assay, Agl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase gene, Ndufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene, Liver metabolism, Bhmt, betaine-homocysteine S-methyltransferase gene, Hepatic fuel storage, lcsh:Medicine (General), Gbe1, glycogen branching enzyme 1 gene, Research Paper, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, TAG, triacylglycerol, NASH, non-alcoholic steatohepatitis, Cer, ceramide, PE, phosphatidylethanolamine, PI, phosphatidylinositol, 03 medical and health sciences, Internal medicine, FFA, free fatty acid, Genetics, medicine, JO2, oxygen flux, Glycogen synthase, GSK3A, Molecular Biology, Myc, myelocytomatosis oncogene, 0604 Genetics, Methionine, LPC, lysophosphatidylcholine, SM, sphingomyelin, Ddit3, DNA damage inducible transcript 3 gene, SAH, S-adenosylhomocysteine, Lipid metabolism, (Methionine synthase) reductase, Gys2, glycogen synthase 2 gene, Ugp2, UDP-glucose pyrophophorylase 2 gene, medicine.disease, MTRR, HOAD, 3-hydoxyacyl-CoA dehydrogenase, BCA, bicinchoninic acid, Mtrr, methionine synthase reductase gene (also MSR), chemistry, lcsh:Biology (General), gt, gene-trap, Lipidomics, biology.protein, Mitochondrial function, PAS, periodic acid Schiff, DAG, diacylglycerol, 030217 neurology & neurosurgery, ETS, electron transport system
وصف الملف: application/pdf
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المؤلفون: Sowton, Alice P, Padmanabhan, Nisha, Tunster, Simon J, McNally, Ben D, Murgia, Antonio, Yusuf, Aisha, Griffin, Julian L, Murray, Andrew J, Watson, Erica D
مصطلحات موضوعية: CE, cholesteryl-ester, LC-MS, liquid chromatography-mass spectrometry, 5-methyl-THF, 5-methyltetrahydofolate, OXPHOS, oxidative phosphorylation, G6pc, glucose 6-phophastase gene, PG, phosphatidylglycerol, Gyg, glycogenin gene, PIP, phosphatidylinositol phosphate(s), Cebpa, CCAAT/enhancer binding protein (C/EBP), alpha gene, Isca1, iron‑sulfur cluster assembly 1 gene, PC, phosphatidylcholine, One‑carbon metabolism, PA, phosphatidic acid, FCCP, p-trifluoromethoxyphenyl hydrazine, SAM, S-adenosylmethionine, Mthfr, methylenetetrahydrofolate reductase gene, Mtr, methionine synthase gene (also MS), PS, phosphatidylserine, 3. Good health, PL, phospholipid, Gsk3, glycogen synthase kinase gene, RIPA, Radioimmunoprecipitation assay, Agl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase gene, Ndufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) gene, Liver metabolism, Bhmt, betaine-homocysteine S-methyltransferase gene, Hepatic fuel storage, Gbe1, glycogen branching enzyme 1 gene, Glycogen, NAFLD, non-alcoholic fatty liver disease, TAG, triacylglycerol, NASH, non-alcoholic steatohepatitis, Cer, ceramide, PE, phosphatidylethanolamine, PI, phosphatidylinositol, FFA, free fatty acid, JO2, oxygen flux, Myc, myelocytomatosis oncogene, LPC, lysophosphatidylcholine, SM, sphingomyelin, Ddit3, DNA damage inducible transcript 3 gene, SAH, S-adenosylhomocysteine, Gys2, glycogen synthase 2 gene, Ugp2, UDP-glucose pyrophophorylase 2 gene, HOAD, 3-hydoxyacyl-CoA dehydrogenase, BCA, bicinchoninic acid, Mtrr, methionine synthase reductase gene (also MSR), gt, gene-trap, Lipidomics, Mitochondrial function, PAS, periodic acid Schiff, DAG, diacylglycerol, ETS, electron transport system