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المؤلفون: Wei Li, Georgina N. Masoud
المصدر: Acta Pharmaceutica Sinica B, Vol 5, Iss 5, Pp 378-389 (2015)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: MAPK/ERK pathway, IPAS, inhibitory PAS, TAD, transactivation domains, HIF-1α, hypoxia-inducible factor-1α, Angiogenesis, MTs, microtubules, EMSA, electrophoretic mobility shift assay, Hsp90, heat shock protein 90, ODDD, oxygen dependent degradation domain, GLUT3, glucose transporter 3, Luc, luciferase, HRE, hypoxia response elements, PKM, pyruvate kinase M, HDAC, histone deacetylase, Review, MNK, MAP kinase interacting kinase, Bioinformatics, Metastasis, CAC, circulating angiogenic cells, AKt, protein kinase B, ERK, extracellular signal-regulated kinase, PCAF, p300/CBP associated factor, Top I, topoisomerase I, Raf, rapidly accelerated fibrosarcoma, General Pharmacology, Toxicology and Pharmaceutics, HK2, hexokinase 2, CPTs, camptothecins, GA, geldanamycin, NOS, nitric oxide synthase, N, asparagine residue, DFO, deferoxamine, PI3K, phosphatidyl inositol-4,5-bisphosphate-3-kinase, pVHL, von Hippel-Lindau protein, ELISA, enzyme-linked immunosorbent assay, LDHA, lactate dehydrogenase, LRP1, VEGF, vascular endothelial growth factor, 3. Good health, ChIP, chromatin immunoprecipitation, eIF-4E, eukaryotic translation initiation factor 4E, C-MYC, myelocytomatosis virus oncogene cellular homolog, C-TAD, COOH-terminal TAD, AhR, aryl hydrocarbon receptor, Mdm2, RCC, renal cell carcinoma, medicine.symptom, P, proline residue, HK1, hexokinase 1, GLUTs, glucose transporters, bHLH, basic-helix-loop-helix, Cancer drug discovery and development, PAS, Per and Sim, HIF-1α, GLUT1, glucose transporter 1, mTOR, mammalian target of rapamycin, Biology, ARNT, aryl hydrocarbon nuclear translocator, IGF-BP3, IGF-factor-binding protein 3, FIH-1, factor inhibiting HIF-1, RT-PCR, reverse transcription polymerase chain reaction, medicine, HTS, high throughput screens, ID2, DNA-binding protein inhibitor, PHDs, prolyl-4-hydroxylases, TGF-α, transforming growth factor α, Protein kinase B, PI3K/AKT/mTOR pathway, EGF, epidermal growth factor, SIRT 1, Sirtuin 1, IGF2, insulin-like growth factor 2, lcsh:RM1-950, Hypoxia (medical), medicine.disease, ARD-1, arrest-defective-1, LRP1, LDL-receptor-related protein 1, TPT, topotecan, HPH, HIF-1 prolyl hydroxylases, CoCl2, cobalt chloride, lcsh:Therapeutics. Pharmacology, Ras, rat sarcoma, TGF-β3, transforming growth factor beta3, GAs, geldanamycins, MAPK, mitogen-activated protein kinases, N-TAD, NH2-terminal TAD, MEK, MAPK/ERK kinase, biology.protein, LEP, leptin, IGF-BP2, IGF-factor-binding protein 2, HIF-1α inhibitors, ADM, adrenomedullin, EPO, erythropoietin, K, lysine residue, Mdm2, mouse double minute 2 homolog, 4E-BP1, eukaryotic translation initiation factor 4E (eIF-4E) binding protein p70 S6 kinase (S6K)