المؤلفون: Cao, Danni, Huang, Peng, Chiu, Yi-Ting, Chen, Chongguang, Wang, Huiqun, Li, Mengchu, Zheng, Yi, Ehlert, Frederick J, Zhang, Yan, Liu-Chen, Lee-Yuan

المصدر: ACS Chemical Neuroscience. 11(19)

مصطلحات موضوعية: Analytical Chemistry, Biochemistry and Cell Biology, Biological Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Neurosciences, Pain Research, Chronic Pain, Analgesics, Opioid, Animals, Bias, Mice, Morphinans, Receptors, Opioid, kappa, Spiro Compounds, kappa opioid receptor, nalfurafine, antipruritic effect, conditioned place aversion, sedation, motor incoordination, κ opioid receptor, Biochemistry and cell biology, Analytical chemistry, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9tn0t6k5

المؤلفون: Koehl, Antoine, Hu, Hongli, Maeda, Shoji, Zhang, Yan, Qu, Qianhui, Paggi, Joseph M, Latorraca, Naomi R, Hilger, Daniel, Dawson, Roger, Matile, Hugues, Schertler, Gebhard FX, Granier, Sebastien, Weis, William I, Dror, Ron O, Manglik, Aashish, Skiniotis, Georgios, Kobilka, Brian K

المصدر: Nature. 558(7711)

مصطلحات موضوعية: Animals, Mice, Inbred BALB C, Humans, Mice, Morphinans, GTP-Binding Protein alpha Subunits, Gi-Go, GTP-Binding Protein alpha Subunits, Gs, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Receptors, Adrenergic, beta-2, Receptors, Opioid, mu, Ligands, Cryoelectron Microscopy, Binding Sites, Substrate Specificity, Female, Protein Stability, Molecular Dynamics Simulation, Inbred BALB C, GTP-Binding Protein alpha Subunits, Gi-Go, Gs, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Receptors, Adrenergic, beta-2, Opioid, mu, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1rb3n024

المؤلفون: Helmut Schmidhammer, Mahmoud Al-Khrasani, Susanna Fürst, Mariana Spetea

المصدر: Molecules; Volume 28; Issue 12; Pages: 4761

مصطلحات موضوعية: pain, analgesia, opioid receptors, peripheral analgesia, peripherally restricted opioids, morphine, morphinans, drug design strategies, structure–activity relationships, opioid side effects

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules28124761

الاتاحة: https://doi.org/10.3390/molecules28124761

المؤلفون: Park, Kun Ho (Kenny)¹, Chen, David Y.-K.¹

المصدر: Chemical Communications. 11/28/2018, Vol. 54 Issue 92, p13018-13021. 4p.

مصطلحات موضوعية: *MORPHINANS, *OXYCODONE, *PIPERIDINE

المؤلفون: Dumitrascuta, Maria¹, Ben Haddou, Tanila¹, Guerrieri, Elena¹, Noha, Stefan M.¹, Schläfer, Lea¹, Schmidhammer, Helmut¹, Spetea, Mariana¹ Mariana.Spetea@uibk.ac.at

المصدر: Journal of Medicinal Chemistry. 11/22/2017, Vol. 60 Issue 22, p9407-9412. 6p.

مصطلحات موضوعية: *MORPHINANS, *OPIOID receptors, *CARBONYL group, *CHEMICAL agonists, *LIGANDS (Biochemistry)

المؤلفون: Yamamoto, Naoshi¹, Okada, Takahiro², Harada, Yukimasa³, Kutsumura, Noriki¹, Imaide, Satomi³, Saitoh, Tsuyoshi¹, Fujii, Hideaki³, Nagase, Hiroshi^1,2,3 nagase.hiroshi.gt@u.tsukuba.ac.jp

المصدر: Tetrahedron. Sep2017, Vol. 73 Issue 39, p5751-5758. 8p.

مصطلحات موضوعية: *GALANTHAMINE, *MORPHINANS, *CHEMICAL synthesis, *HOFMANN rule, *ACETIC acid

المؤلفون: Li, Qiao¹, Wu, Shuanggen¹, Wang, Chaoyun², Yi, Yongjian², Zhou, Wanlai², Wang, Hongying², Li, Fenfang¹, Tan, Zhijian² tanzhijian@caas.cn

المصدر: Process Biochemistry. Jul2017, Vol. 58, p282-288. 7p.

مصطلحات موضوعية: *MORPHINANS, *ULTRASONIC waves, *EXTRACTION (Chemistry), *MENISPERMACEAE, *IONIC liquids, *MICELLAR solutions

المؤلفون: Sounier, Rémy, Mas, Camille, Steyaert, Jan, Laeremans, Toon, Manglik, Aashish, Huang, Weijiao, Kobilka, Brian K, Déméné, Héléne, Granier, Sébastien

المصدر: Nature. 524(7565)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Neurosciences, Brain Disorders, Allosteric Regulation, Animals, Binding Sites, Heterotrimeric GTP-Binding Proteins, Lysine, Mice, Models, Molecular, Morphinans, Nuclear Magnetic Resonance, Biomolecular, Protein Binding, Protein Conformation, Pyrroles, Receptors, Adrenergic, beta-2, Receptors, Opioid, mu, Single-Chain Antibodies, Structure-Activity Relationship, Substrate Specificity, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8cp478nr

المؤلفون: Huang, Weijiao, Manglik, Aashish, Venkatakrishnan, AJ, Laeremans, Toon, Feinberg, Evan N, Sanborn, Adrian L, Kato, Hideaki E, Livingston, Kathryn E, Thorsen, Thor S, Kling, Ralf C, Granier, Sébastien, Gmeiner, Peter, Husbands, Stephen M, Traynor, John R, Weis, William I, Steyaert, Jan, Dror, Ron O, Kobilka, Brian K

المصدر: Nature. 524(7565)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Chemical Sciences, Pharmacology and Pharmaceutical Sciences, Biotechnology, Neurosciences, Generic health relevance, Allosteric Regulation, Animals, Binding Sites, Crystallography, X-Ray, Heterotrimeric GTP-Binding Proteins, Mice, Models, Molecular, Molecular Dynamics Simulation, Morphinans, Protein Stability, Protein Structure, Tertiary, Pyrroles, Receptor, Muscarinic M2, Receptors, Adrenergic, beta-2, Receptors, Opioid, mu, Single-Chain Antibodies, Structure-Activity Relationship, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8ks4p3q1

المؤلفون: Ragen, BJ, Maninger, N, Mendoza, SP, Bales, KL

مصطلحات موضوعية: Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Neurosciences, Substance Misuse, Drug Abuse (NIDA only), 3, 4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Animals, Female, Guanidines, Hydrocortisone, Male, Morphinans, Morphine, Naloxone, Narcotic Antagonists, Pair Bond, Pitheciidae, Receptors, Opioid, kappa, Social Behavior, Vasopressins, titi monkey, mu opioid, pair-bonding, cortisol, monogamy, kappa opioid, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology

URL الوصول: https://escholarship.org/uc/item/8h46c4xm

المؤلفون: Akiyama, Tasuku, Carstens, Mirela Iodi, Piecha, Dorothea, Steppan, Sonja, Carstens, Earl

المصدر: Acta Dermato Venereologica. 95(2)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Animals, Antipruritics, Behavior, Animal, Chloroquine, Disease Models, Animal, Histamine, Ichthyosis, Male, Mechanotransduction, Cellular, Mice, Mice, Inbred C57BL, Morphinans, Pressure, Pruritus, Skin, Spiro Compounds, Time Factors, Clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5vq6q1xw

المؤلفون: Chen, Yuesu, Glotz, Gabriel, Cantillo, David, Kappe, C Oliver

المصدر: Chemistry, 26 (13), 2973 - 2979 (2020-03-02)

مصطلحات موضوعية: N-demethylation, continuous-flow, gas/liquid reaction, opioid, photocatalysis, Analgesics, Morphinans, noroxycodone, Oxycodone, Analgesics/chemistry, Demethylation, Humans, Morphinans/chemistry, Oxycodone/chemistry, Continuous flows, Isolated yield, Organic dye, Reaction conditions, Terminal oxidants, Visible-light irradiation, Catalysis, Organic Chemistry, General Chemistry, Physical, chemical, mathematical & earth Sciences, Chemistry, Physique, chimie, mathématiques & sciences de la terre, Chimie

Relation: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.201905505; urn:issn:0947-6539; urn:issn:1521-3765

URL الوصول: https://orbi.uliege.be/handle/2268/298854

المؤلفون: Yin, Qingqiao¹, Xia, Yuanyu¹ liugangliuxi@163.com, Wang, Guan²

المصدر: Biochemical & Biophysical Research Communications. Sep2016, Vol. 477 Issue 4, p881-886. 6p.

مصطلحات موضوعية: *KIDNEY glomerulus diseases, *MORPHINANS, *HYPERGLYCEMIA, *RHO-associated kinases, *ENDOTHELIAL cells, *KINASE inhibitors, *CELLULAR signal transduction, *THERAPEUTICS

المؤلفون: Davies, Stephen G.¹ steve.davies@chem.ox.ac.uk, Goddard, Euan C.¹, Roberts, Paul M.¹, Russell, Angela J.¹, Smith, Andrew D.¹, Thomson, James E.¹, Withey, Jonathan M.¹

المصدر: Tetrahedron: Asymmetry. Apr2016, Vol. 27 Issue 6, p274-284. 11p.

مصطلحات موضوعية: *MORPHINANS, *ALKALOIDS, *RING formation (Chemistry), *REGIOSELECTIVITY (Chemistry), *FRIEDEL-Crafts reaction, *SUBSTITUENTS (Chemistry), *LEWIS acids

المؤلفون: Mariana Spetea, Helmut Schmidhammer

المصدر: Molecules; Volume 26; Issue 18; Pages: 5677

مصطلحات موضوعية: morphine, morphinans, 14-alkoxymorphinans, opioid agonist, multifunctional opioid ligands, drug design, structure–activity relationships, pain, antinociception, side effects

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules26185677

الاتاحة: https://doi.org/10.3390/molecules26185677

المؤلفون: Cong, Xiaojing^1,2,3, Campomanes, Pablo^1,2,3, Kless, Achim⁴, Schapitz, Inga⁴, Wagener, Markus⁴, Koch, Thomas⁴, Carloni, Paolo^1,2,3 p.carloni@fz-juelich.de

المصدر: PLoS ONE. 8/17/2015, Vol. 10 Issue 8, p1-15. 15p.

مصطلحات موضوعية: *MORPHINANS, *OPIOID receptors, *BINDING sites, *MOLECULAR dynamics, *HYDRATION, *MEMBRANE proteins

المؤلفون: Winzer, Thilo¹, Kern, Marcelo¹, King, Andrew J.¹, Larson, Tony R.¹, Teodor, Roxana I.¹, Donninger, Samantha L.¹, Yi Li¹, Dowle, Adam A.², Cartwright, Jared², Bates, Rachel², Ashford, David², Thomas, Jerry², Walker, Carol³, Bowser, Tim A.³, Graham, Ian A.¹ ian.graham@york.ac.uk

المصدر: Science. 7/17/2015, Vol. 349 Issue 6245, p309-312. 4p.

مصطلحات موضوعية: *MORPHINANS, *BIOSYNTHESIS, *OPIUM poppy, *OXIDOREDUCTASES, *CHIMERIC proteins, *ALKALOIDS, *CYTOCHROME P-450, *METABOLITE analysis

المؤلفون: Yuan, Yunyun¹ yyuan@vcu.edu, Zaidi, Saheem A.¹, Stevens, David L.², Scoggins, Krista L.², Mosier, Philip D.¹, Kellogg, Glen E.¹, Dewey, William L.², Selley, Dana E.², Zhang, Yan¹ yzhang2@vcu.edu

المصدر: Bioorganic & Medicinal Chemistry. Apr2015, Vol. 23 Issue 8, p1701-1715. 15p.

مصطلحات موضوعية: *MORPHINANS, *ALKALOID synthesis, *OPIOID receptors, *LIGANDS (Biochemistry), *PHARMACOLOGY, *BINDING site assay

المؤلفون: Kumar, V.¹ vpathania18@gmail.com, Clark, M. J.² mjclark@umich.edu, Traynor, J. R.² jtraynor@umich.edu, Lewis, J. W.¹ prxjwl@bath.ac.uk, Husbands, S. M.¹ s.m.husbands@bath.ac.uk

المصدر: Bioorganic & Medicinal Chemistry. Aug2014, Vol. 22 Issue 15, p4067-4072. 6p.

مصطلحات موضوعية: *MORPHINANS, *DRUG therapy, *OPIOIDS, *CHEMICAL inhibitors, *LIGANDS (Biochemistry), *PAIN management, *DRUG control

المؤلفون: Diana Atigari, Kelly Paton, Rajendra Uprety, András Váradi, Amy Alder, Brittany Scouller, John Miller, Susruta Majumdar, Bronwyn Kivell

مصطلحات موضوعية: Neurosciences not elsewhere classified, Pharmacology and Pharmaceutical Sciences not elsewhere classified, Psychology not elsewhere classified, Mixed opioid receptor agonist, Neuropathic pain, Paclitaxel, Respiratory depression, Tolerance, Tail-withdrawal, Analgesics, Opioid, Animals, Antineoplastic Agents, Dose-Response Relationship, Drug, Female, Injections, Intraperitoneal, Male, Mice, Inbred C57BL, Morphinans, Neuralgia, Rats, Sprague-Dawley, Receptors, delta, kappa, Neurosciences, Behavioral and Social Science

Relation: https://figshare.com/articles/journal_contribution/The_mixed_kappa_and_delta_opioid_receptor_agonist_MP1104_attenuates_chemotherapy-induced_neuropathic_pain/21637670

الاتاحة: https://doi.org/10.25455/wgtn.21637670
https://figshare.com/articles/journal_contribution/The_mixed_kappa_and_delta_opioid_receptor_agonist_MP1104_attenuates_chemotherapy-induced_neuropathic_pain/21637670