-
1
المؤلفون: Meni Girshengorn, Ofir Israeli, Lilach Cherry, Edith Lupu, Arnon Tal, Rona Levy, Osnat Rosen, Arik Monash, Einat Toister, Yaron Kafri, Arik Makovitzki, Lilach Levin, Irit Simon, Eyal Dor, Ziv Oren, Elad Lerer, Idan Hefetz, Hanan Tzadok, Yaakov Adar, Eyal Epstein, Ophir Hazan
المصدر: Vaccine
مصطلحات موضوعية: PES, polyethersulfone, rVSV-S, recombinant vesicular stomatitis virus-ΔG-spike, COVID-19 Vaccines, MWCO, molecular weight cutoff, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), PFU, plaque-forming units, TMP, transmembrane pressure, ACE2, angiotensin-converting enzyme 2, DSP, downstream process, Article, MEM, minimal essential medium, HF-TFF, hollow fiber-tangential flow filtration, Downstream (manufacturing), rVSV, SFM, serum-free medium, Animals, Humans, hc-DNA, host cell DNA, DO, dissolved oxygen, Pandemics, Infectivity, MOI, multiplicities of infection, Downstream process, General Veterinary, General Immunology and Microbiology, Chemistry, SARS-CoV-2, Public Health, Environmental and Occupational Health, Spike Protein, COVID-19, Endonuclease digestion, Antibodies, Neutralizing, Cell biology, Clarification, MT, multi-tray, Infectious Diseases, Recombinant viral vaccine, Cell culture, Spike Glycoprotein, Coronavirus, Nucleic acid, Molecular Medicine, Hollow fiber, HCP, host cell protein, NTU, nephelometric turbidity units, HR, horseradish peroxidase
-
2
المؤلفون: Willie June Brickey, David Cai, Jenny P.-Y. Ting, Subash Sad
المصدر: The Journal of Biological Chemistry
J Biol Chemمصطلحات موضوعية: Salmonella typhimurium, Programmed cell death, Inflammasomes, Interleukin-1beta, PRR, pattern-recognition receptor, Inflammation, Biology, Biochemistry, NLR, NOD-like receptor, Microbiology, Mice, 03 medical and health sciences, RIPK1, 0302 clinical medicine, BMM, bone-marrow-derived macrophage, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, host-pathogen interactions, T3SS, type III secretion system, innate immunity, Molecular Biology, Pathogen, 030304 developmental biology, MOI, multiplicities of infection, SPI, Salmonella pathogenicity island, ST, Salmonella typhimurium, 0303 health sciences, Innate immune system, Macrophages, Caspase 1, Inflammasome, Cell Biology, 3. Good health, Mice, Inbred C57BL, Chronic infection, inflammation, LB, Luria–Bertani, Salmonella Infections, Additions and Corrections, medicine.symptom, Signal transduction, PAMP, pathogen-associated molecular pattern, 030217 neurology & neurosurgery, Research Article, TLR, Toll-like receptor, medicine.drug
-
3Transduction of modified factor VIII gene improves lentiviral gene therapy efficacy for hemophilia A
المؤلفون: Jie Zheng, Jie Gong, Huyong Zheng, Tsai-Hua Chung, Lung-Ji Chang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: S, supernatants, Genetic enhancement, Biochemistry, WB, Western blotting, BDD, B-domain deleted, Transduction, Genetic, MOI, multiplicities of infection, biology, Immunogenicity, F8-N8, eight specific N-glycosylation sites, gene therapy, LV, lentiviral vector/lentivirus, flF8, full-length F8, Coagulation, Research Article, FVIII, ECs, endothelial cells, AAV, Adeno-associated virus vector, glycosylation, Genetic Vectors, Hemophilia A, vWF, von Willebrand Factor, Viral vector, coIP, coimmunoprecipitation, ER, endoplasmic reticulum, Protein replacement therapy, Von Willebrand factor, hF8, human F8, Humans, mAb, monoclonal antibody, VCN, vector copy number, Molecular Biology, Gene, mHSC, murine/mouse hematopoietic stem cell, F8, factor FVIII, Factor VIII, lentiviral vector, Lentivirus, Genetic Therapy, Cell Biology, aPTT, activated Partial Thromboplastin Time, PRT, protein replacement therapy, HA, hemophilia A, Molecular biology, Transplantation, BM, bone marrow, biology.protein, HSCT, HSC transplantation, gDNA, genomic DNA, qPCR, quantitative PCR, K562 Cells, Abs, antibodies, Hb, hemoglobin, L, lysates