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المؤلفون: Jesús Pérez-Gil, Karin Sørig Hougaard, Ulla Vogel, Yi Y. Zuo, Emilie Da Silva, Jorid B. Sørli
المصدر: Current Research in Toxicology
Da Silva, E, Vogel, U, Hougaard, K S, Pérez-Gil, J, Zuo, Y Y & Sørli, J B 2021, ' An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function ', Current Research in Toxicology, vol. 2, pp. 225-236 . https://doi.org/10.1016/j.crtox.2021.05.005
Current Research in Toxicology, Vol 2, Iss, Pp 225-236 (2021)مصطلحات موضوعية: Lung surfactant, AO, adverse outcome, TEER, trans epithelial electrical resistance, Health, Toxicology and Mutagenesis, KE, key event, Pharmacology, Toxicology, MIE, molecular initiating event, Applied Microbiology and Biotechnology, Article, AOP, adverse outcome pathway, Adverse outcome pathway, Pulmonary surfactant, RA1190-1270, Adverse Outcome Pathway, Expiration, Respiratory system, ARDS, acute respiratory distress syndrome, ComputingMethodologies_COMPUTERGRAPHICS, Nanomaterials, Spray products, EAGMST, Extended Advisory Group on Molecular Screening and Toxicogenomics, Inhalation, Chemistry, Albumin, GHS, Globally Harmonized System of Classification and Labelling of Chemicals, respiratory system, SaO2, percentage of hemoglobin saturated with oxygen, PaO2, dissolved oxygen in the plasma, respiratory tract diseases, New approach methodology, Alternative method, Toxicology. Poisons, Toxicity, Breathing, OECD, Organisation for Economic Cooperation and Development, OI, oxygenation index
وصف الملف: application/pdf
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المؤلفون: Carolyn J. Mattingly, Jolene Wiegers, Thomas C. Wiegers, Daniela Sciaky, Cynthia J. Grondin, Robin J. Johnson, Allan Peter Davis
المصدر: Current Research in Toxicology
Current Research in Toxicology, Vol 2, Iss, Pp 272-281 (2021)مصطلحات موضوعية: Health, Toxicology and Mutagenesis, Disease, Toxicology, computer.software_genre, medicine.disease_cause, Applied Microbiology and Biotechnology, Nicotine, RA1190-1270, Mn, manganese, Pb, lead, CGPD, chemical-gene-phenotype-disease, NAFP, nicotine, acetaldehyde, formaldehyde, particulate matter chemical mixture, P, pyruvaldehyde, Respiratory disease, Database, Vaping, Environmental exposure, Cr, chromium, Zn, zinc, Phenotype, N, nicotine, M, marker/mechanism relationship, E-cigarettes, medicine.anatomical_structure, CTD, Comparative Toxicogenomics Database, MOA, mode-of-action, Juul, medicine.drug, Biology, PM, particulate matter, MIE, molecular initiating event, Article, ROS, reactive oxygen species, medicine, F, formaldehyde, FR, free radicals, ComputingMethodologies_COMPUTERGRAPHICS, A, acetaldehyde, medicine.disease, AC, acetone, nAChR, nicotinic acetylcholine receptor, COPD, chronic obstructive pulmonary disease, Toxicology. Poisons, Ni, nickel, Toxicogenomics, computer, Oxidative stress, C, crotonaldehyde, NAFFCAPP, nicotine, acetaldehyde, formaldehyde, free radicals, crotonaldehyde, acetone, pyruvaldehyde, and particulate matter chemical mixture, Respiratory tract
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المؤلفون: Mathieu Vinken
المساهمون: Liver Connexin and Pannexin Research Group, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Experimental in vitro toxicology and dermato-cosmetology
المصدر: Toxicology
مصطلحات موضوعية: 0301 basic medicine, IFN, gamma interferon gamma, Antagonists & inhibitors, Coronavirus disease 2019 (COVID-19), Toxicology, Bioinformatics, Systemic inflammation, ACE2, angiotensin-converting enzyme 2, Antiviral Agents, MIE, molecular initiating event, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, TNF, alphatumor necrosis factor alpha, Article, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, AO(P), adverse outcome (pathway), Adverse Outcome Pathway, Medicine, Animals, Humans, AOP, Liver injury, Inflammation, business.industry, Mechanism (biology), SARS-CoV-2, Liver Diseases, fungi, COVID-19, Hypoxia (medical), medicine.disease, COVID-19, corona virus disease 2019, COVID-19 Drug Treatment, KE(R), key event (relationship), 030104 developmental biology, CIAO, modelling the pathogenesis of COVID-19 using the AOP framework, Liver, TMPRSS2, transmembrane serine protease 2, Angiotensin-Converting Enzyme 2, Mechanism, medicine.symptom, business, 030217 neurology & neurosurgery
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المؤلفون: Jessica Budde, Oleg Brinster, Fan Yu, Lukasz Czekala, Roman Wieczorek, Matthew Stevenson, Kathryn Rudd, Thomas Verron, Tanvir Walele, Edgar Trelles Sticken, Liam Simms
المصدر: Current Research in Toxicology
Current Research in Toxicology, Vol 2, Iss, Pp 99-115 (2021)مصطلحات موضوعية: THR, Tobacco Harm Reduction, MIE, Molecular Initiating Event, Health, Toxicology and Mutagenesis, DPBS, Dulbecco's phosphate-buffered saline containing Ca2+ and Mg2+, EVP, Electronic Vapor Product, AOP, Adverse Outcome Pathway, Pharmacology, Toxicology, Applied Microbiology and Biotechnology, MWP, Multi-Well Plate, TNF-α, Tumor Necrosis Factor Alpha, RA1190-1270, Cigarette smoke, 3D, Three Dimensional, Respiratory system, Cigarette, Tobacco harm reduction, ANOVA, Analysis of Variance, FOX-J1, Forkhead Box J1 protein, H&E, Hematoxylin and Eosin, Immunohistochemistry, NKT, Natural Killer T Cells, medicine.anatomical_structure, CAA, Cilia Active Area, IIVS, Institute for In Vitro Sciences, TEER, Transepithelial Electrical Resistance, IL-8, Interleukin-8, PBS, Phosphate Buffered Saline, Organotypic tissue model, CBF, Cilia Beat Frequency, ALI, Air-Liquid Interface, PMN, polymorphonuclear, KERs, Key Event Relationships, Article, MMP-1, Matrix Metalloproteinase-1, MMP-3, Matrix Metalloproteinase-3, medicine, IL-13, Interleukin 13, Cilia, IL-6, Interleukin-6, MUC5AC, Mucin 5AC Protein, ComputingMethodologies_COMPUTERGRAPHICS, Smoke, Lung, LDH, Lactate Dehydrogenase, business.industry, COPD, Chronic Obstructive Pulmonary Disease, CYP450, Cytochrome P450, TPM, Total Particulate Matter, Human airway, 3R4F, Scientific Reference Tobacco Cigarette (University of Kentucky), Aerosol, SAEIVS, Smoke Aerosol Exposure In Vitro System, Pro-inflammatory markers, Electronic vapor product, Toxicology. Poisons, Respiratory epithelium, ISO, International Organization for Standardization, EGFR, Epidermal Growth Factor Receptor, business, 2D, Two Dimensional, KEs, Key Events, MMP-9, Matrix Metalloproteinase-9, IL-1β, Interleukin 1 Beta
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المؤلفون: M.E. (Bette) Meek, Anna Bal-Price
المصدر: Pharmacology & Therapeutics
مصطلحات موضوعية: 0301 basic medicine, KE, key event, OECD, Organisation for Economic Co-operation and Development, Disease, PD, Parkinson's disease, Toxicology, DNT, developmental neurotoxicity, AOP, adverse outcome pathway, Adverse Outcome Pathway, MPTP, 1-methyl-4-phenyl-3104 1,2,3,6-tetrahydropyridine, Pharmacology (medical), Mechanistic understanding, B/H, Bradford-Hill, HTT, high-throughput toxicity testing, CNS, Central nervous system, TFHA, Task Force for Hazard Assessment, Late stage, Neurodegenerative Diseases, Weight of evidence, ADME, absorption, distribution, metabolism and excretion, CI, complex I of mitochondrial chain, Mechanism (philosophy), Environmental Pollutants, Neurotoxicity Syndromes, WNT, Working Group of the National Coordinators for the Test Guidelines Programme, KER, key event relationship, Neurotoxicity Syndrome, Adverse outcomes, AO, adverse outcome, BDNF, brain derived neurotrophic factor, Receptors, N-Methyl-D-Aspartate, MIE, molecular initiating event, Article, Quantitation, Economic cooperation, 03 medical and health sciences, NT, neurotoxicity, Key event relationship, Toxicity Tests, medicine, Neurotoxicity, Animals, Humans, PBPK, physiologically based pharmacokinetic, WOE, weight of evidence, Key event, QSAR, quantitative structure activity relationship, Pharmacology, Adverse Outcome Pathways, AD, Alzheimer disease, business.industry, MOA, mode of action, AOP-KB, adverse outcome pathway knowledge base, medicine.disease, IATA, integrated approaches to testing and assessment, 030104 developmental biology, business, Neuroscience