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1Academic Journal
المؤلفون: Gross, Catharina, Meyer, Céline, Bhatia, Urvashi, Yshii, Lidia, Kleffner, Ilka, Bauer, Jan, Tröscher, Anna, Schulte-Mecklenbeck, Andreas, Herich, Sebastian, Schneider-Hohendorf, Tilman, Plate, Henrike, Kuhlmann, Tanja, Schwaninger, Markus, Bruck, Wolfgang, Pawlitzki, Marc, Laplaud, David-Axel, Loussouarn, Delphine, Parratt, John, Barnett, Michael, Buckland, Michael, Hardy, Todd, Reddel, Stephen, Ringelstein, Marius, Dörr, Jan, Wildemann, Brigitte, Kraemer, Markus, Lassmann, Hans, P, Höftberger, Romana, Beltrán, Eduardo, Dornmair, Klaus, Schwab, Nicholas, Klotz, Luisa, Meuth, Sven, G, Martin-Blondel, Guillaume, Wiendl, Heinz, Liblau, Roland
المساهمون: University Hospital Münster - Universitaetsklinikum Muenster Germany (UKM), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ruhr University Bochum = Ruhr-Universität Bochum (RUB), Universitätsklinikum Knappschaftskrankenhaus = University Hospital Knappschaftskrankenhaus Bochum, Medizinische Universität Wien = Medical University of Vienna, Universität zu Lübeck = University of Lübeck Lübeck, University Medical Center Göttingen (UMG), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de neurologie Nantes, Université de Nantes (UN)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Hôpital Guillaume-et-René-Laennec Saint-Herblain, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Royal North Shore Hospital (RNSH), The University of Sydney, Royal Prince Alfred Hospital Sydney, Australia, Heinrich Heine Universität Düsseldorf = Heinrich Heine University Düsseldorf, Charité - UniversitätsMedizin = Berlin University Medicine, University of Heidelberg, Medical Faculty, Institute of Clinical Neuroimmunology Munich, Germany, Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU), Munich Cluster for systems neurology Munich (SyNergy), Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM)-Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU), Service Maladies infectieuses et tropicales CHU Toulouse, Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), ANR-10-MIDI-0013,MigreFlame,Infiltration tissulaire des macrophages et inflammation : identification d'inhibiteurs de la migration cellulaire en trois dimensions.(2010), ANR-13-BSV3-0003,T cell Mig,Migration des lymp^hocytes T CD8 T dans le système nerveux central(2013)
المصدر: ISSN: 2041-1723.
مصطلحات موضوعية: Neuroimmunology, Autoimmunity, MESH: Adult, MESH: Animals, MESH: Endothelium, Vascular / drug effects, Vascular / immunology, Vascular / pathology, MESH: Female, MESH: Humans, MESH: Integrin alpha4 / antagonists & inhibitors, MESH: Integrin alpha4 / metabolism, MESH: Male, MESH: Mice, Transgenic, MESH: Microvessels / drug effects, MESH: Microvessels / immunology, MESH: Microvessels / pathology, MESH: Cell Adhesion / drug effects, MESH: Cell Adhesion / immunology, MESH: Central Nervous System / blood suppl, MESH: Central Nervous System / immunology, MESH: Central Nervous System / pathology, MESH: Disease Models, Animal, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology
Relation: info:eu-repo/semantics/altIdentifier/pmid/31852955; PUBMED: 31852955; PUBMEDCENTRAL: PMC6920411
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2Academic Journal
المؤلفون: Khamessi, Oussema, Ben Mabrouk, Hazem, Othman, Houcemeddine, Elfessi-Magouri, Rym, de Waard, Michel, Hafedh, Mejdoub, Marrakchi, Naziha, Srairi-Abid, Najet, Kharrat, Riadh
المساهمون: Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur), ITX - unité de recherche de l'institut du thorax (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Smartox Biotechnology, USCR Séquenceur de Protéines, Faculté des Sciences de Sfax (FSS), Université de Sfax - University of Sfax-Université de Sfax - University of Sfax, This work was supported by grants from the Tunisian Ministry of Higher Education and Scientific Research (LR11IPT08) and Institut Pasteur of Tunisia (approval number: LNFP/Pro 152012)., We thank Pr Hechmi Louzir, head of Institut Pasteur de Tunis for his continued interest in this study and for his support.
المصدر: ISSN: 0141-8130 ; International Journal of Biological Macromolecules ; https://riip.hal.science/pasteur-02003807 ; International Journal of Biological Macromolecules, 2018, 120 (B), pp.1777-1788. ⟨10.1016/j.ijbiomac.2018.09.180⟩.
مصطلحات موضوعية: Molecular modeling, Adhesion, RK peptide, MESH: Amino Acid Sequence, MESH: Animals, MESH: Disintegrins/chemistry, MESH: Disintegrins/metabolism, MESH: Disintegrins/pharmacology, MESH: Humans, MESH: Integrin alpha1beta1/metabolism, MESH: Integrin alphaVbeta3/metabolism, MESH: Male, MESH: Mice, MESH: Molecular Docking Simulation, MESH: Molecular Dynamics Simulation, MESH: Protein Conformation, MESH: Scorpion Venoms/chemistry, MESH: Cell Adhesion/drug effects, MESH: Cell Line, Tumor, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
Relation: info:eu-repo/semantics/altIdentifier/pmid/30287364; PUBMED: 30287364
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3Academic Journal
المؤلفون: Touihri-Barakati, Imen, Kallech-Ziri, Olfa, Boulila, Abdennacer, Khwaldia, Khaoula, Marrakchi, Naziha, Hanchi, Belgacem, Hosni, Karim, Luis, José
المساهمون: Laboratoire des Substances Naturelles (LR02INRAP10), Institut National de Recherche et d'Analyse Physico-chimique Ariana, Tunisie (INRAP), Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Faculté des Sciences Mathématiques, Physiques et Naturelles de Tunis (FST), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)-Hôpital de la Timone CHU - APHM (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), This research was supported by Ministry of High Education and Scientific Research of Tunisia (MERST) and the Institut National de la Santé et de la Recherche Médicale (INSERM) and by grants from INCa (Institut National du Cancer) and ARCUS (Action en Région de Coopération Universitaire et Scientifique).
المصدر: ISSN: 0753-3322.
مصطلحات موضوعية: Seed oil, αvβ3 and α5β1 integrins, Ecballium elaterium, Glioma cell line, Angiogenesis, Adhesion, MESH: Brain Neoplasms/blood supply, MESH: Brain Neoplasms/drug therapy, MESH: Glioma/drug therapy, MESH: Glioma/pathology, MESH: Humans, MESH: Integrin alpha5beta1/metabolism, MESH: Integrin beta3/metabolism, MESH: Neovascularization, Pathologic/drug therapy, MESH: Plant Oils/pharmacology, MESH: Plant Oils/therapeutic use, MESH: Seeds/chemistry, MESH: Time-Lapse Imaging, MESH: Brain Neoplasms/pathology, MESH: Cell Adhesion/drug effects, MESH: Cell Line, Tumor, MESH: Cell Movement/drug effects, MESH: Cell Proliferation/drug effects, MESH: Cucurbitaceae/chemistry, MESH: Glioma/blood supply, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV]Life Sciences [q-bio]
Relation: info:eu-repo/semantics/altIdentifier/pmid/27810778; hal-01474971; https://amu.hal.science/hal-01474971; https://amu.hal.science/hal-01474971/document; https://amu.hal.science/hal-01474971/file/16.95-Huile%20E.%20elaterium%20gliome-BP.pdf; PUBMED: 27810778
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المؤلفون: Zaineb Abdelkafi-Koubaa, Mohamed El Ayeb, Erij Messadi, Najet Srairi Abid, Maram Morjen, Jed Jebali, Houcemeddine Othman, José Luis, Naziha Marrakchi
المساهمون: Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut de neurophysiopathologie (INP), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), This work was supported in part by MERST (Ministère de l'Enseignement Supérieur de la Recherche et de la Technologie) (Laboratoire des venins et biomolécules thérapeutiques: LR11IPT08), INSERM UMR911 (Institut National de la Santé et de la Recherche Médicale) and by grants ARCUS (Action en Région de Coopération Universitaire et Scientifique (2008–2012)) and PHC Utique (17G0811: 2017–2019)., We thank Pr Hechmi Louzir, head of Institut Pasteur de Tunis for his continuous interest in this study and for his support. Dr. Benlasfar Zakaria (Institut Pasteur de Tunis) is acknowledged for providing viper venom., Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
المصدر: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International Journal of Biological Macromolecules, Elsevier, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩مصطلحات موضوعية: 0301 basic medicine, Snake venom, MESH: Neovascularization, Pathologic/drug therapy, MESH: Viper Venoms/therapeutic use, Carcinogenesis, Angiogenesis, Integrin, Angiogenesis Inhibitors, Peptide, Venom, MESH: Amino Acid Sequence, medicine.disease_cause, PC12 Cells, Biochemistry, MESH: Carcinogenesis/drug effects, MESH: Cell Movement/drug effects, MESH: Cell Proliferation/drug effects, MESH: Cricetulus, Cell Movement, Structural Biology, MESH: Animals, MESH: Angiogenesis Inhibitors/pharmacology, Migration, chemistry.chemical_classification, MESH: Integrin alpha1beta1/chemistry, Neovascularization, Pathologic, biology, Chinese hamster ovary cell, General Medicine, 3. Good health, Cell biology, Adhesion, MESH: Protein Domains, MESH: Rats, CHO Cells, Viper Venoms, Integrin alpha1beta1, 03 medical and health sciences, Cricetulus, MESH: Cell Adhesion/drug effects, Protein Domains, MESH: Viper Venoms/pharmacology, MESH: CHO Cells, MESH: Integrin alpha1beta1/metabolism, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Cell Adhesion, medicine, MESH: PC12 Cells, Animals, Amino Acid Sequence, Molecular Biology, Cell Proliferation, In vitro, Rats, 030104 developmental biology, MESH: Viper Venoms/chemistry, chemistry, MESH: Angiogenesis Inhibitors/therapeutic use, biology.protein, MESH: Viper Venoms/metabolism, MESH: Angiogenesis Inhibitors/metabolism, Ex vivo
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المؤلفون: Marius Ringelstein, L. M. Yshii, Ilka Kleffner, Stephen W. Reddel, Brigitte Wildemann, Todd A. Hardy, Markus Schwaninger, Guillaume Martin-Blondel, Nicholas Schwab, Delphine Loussouarn, John Parratt, Marc Pawlitzki, Henrike Plate, Eduardo Beltrán, Catharina C. Gross, Anna R. Tröscher, Tanja Kuhlmann, Tilman Schneider-Hohendorf, Klaus Dornmair, Jan Dörr, Roland S. Liblau, Urvashi Bhatia, Hans Lassmann, Sven G. Meuth, Luisa Klotz, Sebastian Herich, Markus Kraemer, Jan Bauer, Céline Meyer, David-Axel Laplaud, Wolfgang Brück, Romana Höftberger, Michael Barnett, Michael E. Buckland, Andreas Schulte-Mecklenbeck, Heinz Wiendl
المساهمون: University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Medizinische Universität Wien = Medical University of Vienna, Institute for Experimental and Clinical Pharmacology and Toxicology [Lübeck, Germany], University of Lübeck [Germany], Institute of Neuropathology [Göttingen, Germany], University Medical Center Göttingen (UMG), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service d’Anatomopathologie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Royal North Shore Hospital [Sydney, Australia], Microsoft Research [Redmond], Microsoft Corporation [Redmond, Wash.], The University of Sydney, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Heidelberg, Medical Faculty, University of Vienna [Vienna], Institute of Clinical Neuroimmunology [Munich, Germany], Ludwig-Maximilians University [Munich] (LMU), Service des maladies infectieuses et tropicales [Toulouse], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Le Bihan, Sylvie, MECANISMES INTEGRES DE L'INFLAMMATION - Infiltration tissulaire des macrophages et inflammation : identification d'inhibiteurs de la migration cellulaire en trois dimensions. - - MigreFlame2010 - ANR-10-MIDI-0013 - MI2 - VALID, Blanc 2013 - Migration des lymp^hocytes T CD8 T dans le système nerveux central - - T cell Mig2013 - ANR-13-BSV3-0003 - Blanc 2013 - VALID, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Ruhr University Bochum (RUB), Universitätsklinikum Knappschaftskrankenhaus = University Hospital Knappschaftskrankenhaus [Bochum], Universität zu Lübeck = University of Lübeck [Lübeck], Service de neurologie [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Royal North Shore Hospital (RNSH), Royal Prince Alfred Hospital [Sydney, Australia], Ludwig-Maximilians-Universität München (LMU), Munich Cluster for systems neurology [Munich] (SyNergy), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU), Service Maladies infectieuses et tropicales [CHU Toulouse], Pôle Inflammation, infection, immunologie et loco-moteur [CHU Toulouse] (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), ANR-10-MIDI-0013,MigreFlame,Infiltration tissulaire des macrophages et inflammation : identification d'inhibiteurs de la migration cellulaire en trois dimensions.(2010), ANR-13-BSV3-0003,T cell Mig,Migration des lymp^hocytes T CD8 T dans le système nerveux central(2013), Centre de Physiopathologie Toulouse Purpan (CPTP - U1043 INSERM - UMR5282 CNRS - UT3), University Medical Center Göttingen [Germany], Heinrich-Heine-Universität Düsseldorf [Düsseldorf], Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Service des maladies infectieuses et tropicales[Toulouse]
المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5779. ⟨10.1038/s41467-019-13593-5⟩
Nature Communications, 2019, 10, pp.5779. ⟨10.1038/s41467-019-13593-5⟩
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)مصطلحات موضوعية: 0301 basic medicine, MESH: Integrin alpha4 / metabolism, [SDV]Life Sciences [q-bio], Neuroimmunology, General Physics and Astronomy, Autoimmunity, 0302 clinical medicine, Natalizumab, Cytotoxic T cell, MESH: Animals, lcsh:Science, MESH: Endothelium, Vascular / drug effects, Multidisciplinary, MESH: Central Nervous System / immunology, MESH: Endothelium, Vascular / pathology, MESH: Microvessels / pathology, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, MESH: Cell Adhesion / drug effects, [SDV.IMM]Life Sciences [q-bio]/Immunology, Function and Dysfunction of the Nervous System, MESH: Central Nervous System / pathology, medicine.drug, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH: Mice, Transgenic, Science, Central nervous system, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immune system, MESH: Microvessels / immunology, medicine, MESH: Cell Adhesion / immunology, Neuroinflammation, Susac Syndrome, MESH: Central Nervous System / blood suppl, MESH: Humans, business.industry, MESH: Adult, General Chemistry, MESH: Integrin alpha4 / antagonists & inhibitors, MESH: Male, Granzyme B, Susac syndrome, neuro-inflammation, endotheliopathy, 030104 developmental biology, Immunology, lcsh:Q, MESH: Endothelium, Vascular / immunology, MESH: Microvessels / drug effects, MESH: Disease Models, Animal, business, MESH: Female, 030217 neurology & neurosurgery, CD8
وصف الملف: application/pdf
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المؤلفون: Lamia Borchani, Ivana Catacchio, Antonio Giovanni Solimando, Hafed Majdoub, Imen Jridi, Maria Antonia Frassanito, Delavar Shahbazzadeh, Angelo Vacca, Mohamed El Ayeb, Domenico Ribatti
المساهمون: Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage, Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Tunis El Manar (UTM), University of Bari Aldo Moro (UNIBA), Faculté des Sciences de Sfax, Université de Sfax - University of Sfax, Institut Pasteur d'Iran, Réseau International des Instituts Pasteur (RIIP), This work has been financially supported by the Tunisian Ministry of Research and Technology (MERST), and by the Associazione Italiana per la Ricerca sul Cancro (AIRC), Investigator Grant (no. 14095 to AV), Special Program Molecular Clinical Oncology 5 per 1000 (no. 9965 to AV), Milan, IT, and the European Commission's Seventh Framework Programme (EU FPT7) OVER-MyR (no. 278706 to AV)., We gratefully thank Professor Hechmi Louzir, Head of Pateur Institute of Tunis and Professor Mohamed Samir Boubaker Head of the Laboratoire d' Anathomopathologie, Pasteur Institute of Tunis for their continuous interest and their support during this work. We also thank Daniel Lafitte and Claude Villard (INSERM UMR 911-CRO2 Faculty of Pharmacy Marseille, France) for their technical assistance in mass spectrometry.
المصدر: Toxicon
Toxicon, Elsevier, 2017, 126, pp.38-46. ⟨10.1016/j.toxicon.2016.12.001⟩مصطلحات موضوعية: 0301 basic medicine, Hemiscorpius lepturus sPLA2 group III, MESH: Phospholipases A2/chemistry, Angiogenesis, MESH: Angiogenesis Inhibitors/isolation & purification, Angiogenesis Inhibitors, Chick Embryo, Toxicology, Chorioallantoic Membrane, HUVEC, Small subunit, MESH: Animals, MESH: Angiogenesis Inhibitors/pharmacology, MESH: Human Umbilical Vein Endothelial Cells, Tube formation, biology, HPAEC, MESH: Protein Subunits/pharmacology, MESH: Chick Embryo, MESH: Protein Subunits/physiology, Chorioallantoic membrane, Biochemistry, [SDV.TOX]Life Sciences [q-bio]/Toxicology, MESH: Scorpion Venoms/chemistry, MESH: Phospholipases A2/isolation & purification, Protein subunit, Scorpion Venoms, Cell Line, 03 medical and health sciences, Phospholipase A2, MESH: Cell Adhesion/drug effects, In vivo, MESH: Angiogenesis Inhibitors/chemistry, Cell Adhesion, Human Umbilical Vein Endothelial Cells, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Acetophenones/chemistry, MESH: Humans, 030102 biochemistry & molecular biology, Edman degradation, Acetophenones, MESH: Phospholipases A2/pharmacology, Molecular biology, In vitro, MESH: Cell Line, Phospholipases A2, Protein Subunits, 030104 developmental biology, MESH: Protein Subunits/chemistry, biology.protein, MESH: Chorioallantoic Membrane/drug effects
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المؤلفون: Hazem Ben Mabrouk, Oussema Khamessi, Michel De Waard, Mejdoub Hafedh, Houcemeddine Othman, R. Kharrat, Najet Srairi-Abid, Naziha Marrakchi, Rym ElFessi-Magouri
المساهمون: Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Smartox Biotechnology, USCR Séquenceur de Protéines, Faculté des Sciences de Sfax, Université de Sfax - University of Sfax-Université de Sfax - University of Sfax, This work was supported by grants from the Tunisian Ministry of Higher Education and Scientific Research (LR11IPT08) and Institut Pasteur of Tunisia (approval number: LNFP/Pro 152012)., We thank Pr Hechmi Louzir, head of Institut Pasteur de Tunis for his continued interest in this study and for his support.
المصدر: International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, Elsevier, 2018, 120 (B), pp.1777-1788. ⟨10.1016/j.ijbiomac.2018.09.180⟩مصطلحات موضوعية: 0301 basic medicine, MESH: Cell Line, Tumor, Integrin, Molecular modeling, Venom, Peptide, MESH: Amino Acid Sequence, MESH: Disintegrins/metabolism, Biochemistry, MESH: Integrin alphaVbeta3/metabolism, 03 medical and health sciences, 0302 clinical medicine, MESH: Protein Conformation, MESH: Cell Adhesion/drug effects, Structural Biology, RK peptide, Disintegrin, MESH: Integrin alpha1beta1/metabolism, MESH: Molecular Docking Simulation, MESH: Animals, MESH: Molecular Dynamics Simulation, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cell adhesion, Receptor, Molecular Biology, MESH: Mice, chemistry.chemical_classification, MESH: Humans, biology, Chemistry, MESH: Disintegrins/chemistry, General Medicine, biology.organism_classification, MESH: Male, Cell biology, 030104 developmental biology, Snake venom, biology.protein, Adhesion, MESH: Disintegrins/pharmacology, MESH: Scorpion Venoms/chemistry, Buthus occitanus, 030217 neurology & neurosurgery
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المؤلفون: Erwann P. Loret, Olfa Kallech-Ziri, Naziha Marrakchi, Amine Bazaa, Sofiane Bezzine, Najet Srairi-Abid, Aida Karray, José Luis, Raoudha Zouari-Kessentini, Mohamed El Ayeb
المساهمون: Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Supérieur de Biotechnologie de Sfax (ISBS), Université de Sfax - University of Sfax, Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), This work was supported in part by grants from the CMCU (Comité Mixte de Coopération Universitaire France-Tunisie), the ARC (Association pour la Recherche sur le Cancer) and the Cancéropôle Provence-Alpes-Côte d'Azur., We thank Pr. Hechmi Louzir, head of Institut Pasteur de Tunis for his continuous interest in this study and for his support. Dr Benlasfar Zakaria (Laboratoire Vétérinaire, Institut Pasteur de Tunis) is acknowledged for providing viper venom. We thank Ms Dorra Abdelmalek for her help during the preparation of this work. Authors thank Pr. Youssef Gargouri (Laboratoire de Biochimie et de Génie Enzymatique des Lipases, Sfax, Tunisia) for his fruitful interest to this work. We thank Pr Juan. J. Calvete for mass spectrometry experiment (Instituto de Biomedicina de Valencia, C.S.I.C., Jaume Roig 11, 46010 Valencia, Spain).
المصدر: Toxicon
Toxicon, Elsevier, 2009, 53 (4), pp.444-53. ⟨10.1016/j.toxicon.2009.01.003⟩مصطلحات موضوعية: Blood Platelets, MESH: Cell Line, Tumor, MESH: Phospholipases A2/chemistry, [SDV]Life Sciences [q-bio], Molecular Sequence Data, MESH: Rabbits, Venom, Viper Venoms, MESH: Amino Acid Sequence, Toxicology, 03 medical and health sciences, MESH: Phospholipases A2/pharmacology, MESH: Blood Platelets/drug effects, Phospholipase A2, Cell Movement, Cell Line, Tumor, Cell Adhesion, Viperidae, Animals, Humans, MESH: Blood Coagulation/drug effects, MESH: Animals, Amino Acid Sequence, Blood Coagulation, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, MESH: Humans, MESH: Molecular Sequence Data, biology, 030302 biochemistry & molecular biology, Cerastes cerastes, biology.organism_classification, MESH: Viper Venoms/chemistry, Fibronectin, Phospholipases A2, Enzyme, MESH: Viperidae/physiology, Biochemistry, chemistry, Snake venom, Sephadex, MESH: Cell Movement/drug effects, MESH: Viper Venoms/enzymology, biology.protein, lipids (amino acids, peptides, and proteins), HT1080, Rabbits, MESH: Cell Adhesion/drug effects
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9Academic Journal
المؤلفون: Marrakchi, N, Sarray, S, Marvaldi, J, El Ayeb, M, Luis, J
المساهمون: Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Aix-Marseille Université - Faculté de pharmacie (AMU PHARM), Aix Marseille Université (AMU)
المصدر: ISSN: 0020-2509 ; Archives de l'Institut Pasteur de Tunis ; https://hal.science/hal-01975005 ; Archives de l'Institut Pasteur de Tunis, 2002, 79 (1-4), pp.3--9.
مصطلحات موضوعية: cellular adhesion, cancerous cells, extra cellular matrix proteins, Snake venom, venin de serpents, adhérence cellulaire, protéines de la matrice extracellulaire, cellules cancéreuses, MESH: Animals, MESH: Antineoplastic Agents/pharmacology, MESH: Dose-Response Relationship, Drug, MESH: Drug Evaluation, Preclinical, MESH: Extracellular Matrix Proteins/drug effects, MESH: HT29 Cells/drug effects, MESH: Humans, MESH: Integrins/drug effects, MESH: Melanoma, MESH: Oligopeptides/pharmacology, MESH: Polylysine/drug effects, MESH: Tunisia, MESH: Viper Venoms/administration & dosage, MESH: Viper Venoms/pharmacology, MESH: Cell Adhesion/drug effects, MESH: Cell Line, Tumor/drug effects, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Relation: info:eu-repo/semantics/altIdentifier/pmid/15072239; hal-01975005; https://hal.science/hal-01975005; PUBMED: 15072239
الاتاحة: https://hal.science/hal-01975005
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10Academic Journal
المؤلفون: Sarray, Sameh, Srairi, Najet, Luis, José, Marvaldi, Jacques, El Ayeb, Mohamed, Marrakchi, Naziha, N.
المساهمون: Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale (ISPDCT), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), The autors recognize the friendly efforts of Dr. Cassian Bon from I.P.P. They also thank Prof. K. Dellagi for his support during this study
المصدر: ISSN: 1424-8832.
مصطلحات موضوعية: Snake venom, C-letin protein, Anti-platelet aggregation, Anti-agglutination protein, MESH: Animals, MESH: Cell Adhesion/drug effects, MESH: Platelet Aggregation/drug effects, MESH: Platelet Aggregation Inhibitors/chemistry, MESH: Platelet Aggregation Inhibitors/isolation & purification, MESH: Platelet Aggregation Inhibitors/pharmacology, MESH: Protein Binding/drug effects, MESH: Rabbits, MESH: Tumor Cells, Cultured/drug effects, MESH: Viper Venoms/chemistry, MESH: Viper Venoms/isolation & purification, MESH: Viper Venoms/pharmacology, MESH: Extracellular Matrix Proteins/metabolism, MESH: Fibrinogen/metabolism, MESH: Humans, MESH: Laminin/metabolism, MESH: Lectins, C-Type*/chemistry, C-Type*/isolation & purification, C-Type*/metabolism, MESH: Neoplasms/pathology, [SDV]Life Sciences [q-bio]
Relation: info:eu-repo/semantics/altIdentifier/pmid/11910182; pasteur-02049503; https://riip.hal.science/pasteur-02049503; PUBMED: 11910182
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11
المؤلفون: Sarray, Sameh, Srairi, Najet, Luis, José, Marvaldi, Jacques, El Ayeb, Mohamed, Marrakchi, Naziha
المساهمون: Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Interaction entre Systèmes Protéiques et Différenciation dans la Cellule Tumorale (ISPDCT), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), The autors recognize the friendly efforts of Dr. Cassian Bon from I.P.P. They also thank Prof. K. Dellagi for his support during this study
المصدر: Pathophysiology of Haemostasis and Thrombosis
Pathophysiology of Haemostasis and Thrombosis, Karger, 2001, 31 (3-6), pp.173-176. ⟨10.1159/000048060⟩
Pathophysiology of Haemostasis and Thrombosis, 2001, 31 (3-6), pp.173-176. ⟨10.1159/000048060⟩مصطلحات موضوعية: Snake venom, Platelet Aggregation, [SDV]Life Sciences [q-bio], MESH: Rabbits, Viper Venoms, MESH: Cell Adhesion/drug effects, MESH: Tumor Cells, Cultured/drug effects, MESH: Extracellular Matrix Proteins/metabolism, MESH: Fibrinogen/metabolism, MESH: Laminin/metabolism, Neoplasms, Cell Adhesion, Tumor Cells, Cultured, MESH: Platelet Aggregation Inhibitors/chemistry, Animals, Humans, MESH: Animals, Lectins, C-Type, MESH: Neoplasms/pathology, MESH: Lectins, C-Type*/isolation & purification, MESH: Viper Venoms/pharmacology, Extracellular Matrix Proteins, MESH: Humans, MESH: Lectins, C-Type*/chemistry, Anti-platelet aggregation, MESH: Platelet Aggregation Inhibitors/pharmacology, C-letin protein, Fibrinogen, MESH: Platelet Aggregation Inhibitors/isolation & purification, MESH: Viper Venoms/chemistry, MESH: Protein Binding/drug effects, MESH: Viper Venoms/isolation & purification, MESH: Platelet Aggregation/drug effects, Anti-agglutination protein, Laminin, Rabbits, MESH: Lectins, C-Type*/metabolism, Platelet Aggregation Inhibitors, Protein Binding
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12
المؤلفون: Marrakchi, N, Sarray, S, Marvaldi, J, EL Ayeb, M, Luis, J
المساهمون: Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Aix-Marseille Université - Faculté de pharmacie (AMU PHARM), Aix Marseille Université (AMU), Ben Hassine, AbdelHakim
المصدر: Archives de l'Institut Pasteur de Tunis
Archives de l'Institut Pasteur de Tunis, 2002, 79 (1-4), pp.3--9مصطلحات موضوعية: Integrins, Snake venom, Tunisia, cellules cancéreuses, MESH: Melanoma, MESH: Polylysine/drug effects, Drug Evaluation, Preclinical, Antineoplastic Agents, Viper Venoms, MESH: Dose-Response Relationship, Drug, Cell Line, Tumor, adhérence cellulaire, Cell Adhesion, cancerous cells, Animals, Humans, Polylysine, MESH: Animals, MESH: Extracellular Matrix Proteins/drug effects, Melanoma, Extracellular Matrix Proteins, MESH: Viper Venoms/pharmacology, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Humans, Dose-Response Relationship, Drug, MESH: Antineoplastic Agents/pharmacology, MESH: HT29 Cells/drug effects, cellular adhesion, MESH: Integrins/drug effects, protéines de la matrice extracellulaire, MESH: Viper Venoms/administration & dosage, MESH: Cell Line, Tumor/drug effects, extra cellular matrix proteins, venin de serpents, MESH: Drug Evaluation, Preclinical, MESH: Tunisia, HT29 Cells, Oligopeptides, MESH: Oligopeptides/pharmacology, MESH: Cell Adhesion/drug effects, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology