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المؤلفون: Silvia, Maruelli, Roberta, Besio, Julie, Rousseau, Nadia, Garibaldi, Jérôme, Amiaud, Bénédicte, Brulin, Pierre, Layrolle, Virginie, Escriou, Antonio, Rossi, Valerie, Trichet, Antonella, Forlino
المصدر: Matrix Biology Plus
مصطلحات موضوعية: musculoskeletal diseases, EDS, Ehlers Danlos syndrome, congenital, hereditary, and neonatal diseases and abnormalities, NMD, nonsense mediated RNA decay, MSC, mesenchymal stem cell, macromolecular substances, BCP, biphasic calcium phosphate, MEF, murine embryonic fibroblast, Article, Gene therapy, FBS, fetal bovine serum, PBS, phosphate buffered saline, SDS, sodium dodecyl sulphate, skin and connective tissue diseases, D-MEM, Dulbecco-modified Eagle's medium, integumentary system, TRAP, tartrate-resistant acid phosphatase, Silencing, EGFP, enhanced green fluorescent protein, OI, osteogenesis imperfecta, RNAi, RNA interference, siRNA, small interfering RNA, siRNA, shRNA, short hairpin RNA, Osteogenesis imperfecta, Collagen
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المؤلفون: Katharina Knittler, Stefan Schreiber, Simone Lipinski, Kareen Bartsch, Athena Chalaris, Witigo von Schoenfels, Christoph Kaleta, Daniela Esser, Go Ito, Joseph Dahl, Konrad Aden, Felix Wottawa, Christine Boeger, Martin A M Reijns, Clemens Schafmayer, Stefan Rose-John, Thomas A. Kunkel, Philip Rosenstiel, Adam B. Burkholder, Lennart Lenk, Lina Welz, Johan H. van Es, Björn Rabe, Neha Mishra, Ralph Lucius, Florian Tran, Christoph Röcken, Nassim Kakavand, Anupam Sinha, Raheleh Sheibani-Tezerji, Hans Clevers
المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research
المصدر: Aden, K, Bartsch, K, Dahl, J, Reijns, M A M, Esser, D, Sheibani-Tezerji, R, Sinha, A, Wottawa, F, Ito, G, Mishra, N, Knittler, K, Burkholder, A, Welz, L, van Es, J, Tran, F, Lipinski, S, Kakavand, N, Boeger, C, Lucius, R, von Schoenfels, W, Schafmayer, C, Lenk, L, Chalaris, A, Clevers, H, Röcken, C, Kaleta, C, Rose-John, S, Schreiber, S, Kunkel, T, Rabe, B & Rosenstiel, P 2019, ' Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice ', Gastroenterology . https://doi.org/10.1053/j.gastro.2018.09.047
Gastroenterology, 156(1), 145. W.B. Saunders Ltd
Gastroenterology
Gastroenterology, 156(1), 145-159.e19. W.B. Saunders Ltdمصطلحات موضوعية: Male, 0301 basic medicine, DNA Repair, Ribonucleotide excision repair, medicine.disease_cause, IEC, intestinal epithelial cell, p53, tumor-suppressor protein p53, 0302 clinical medicine, Intestine, Small, DSS, dextran sodium sulfate, Mice, Knockout, Mutation, biology, Colon Cancer, RER, ribonucleotide excision repair, Dextran Sulfate, Gastroenterology, Colitis, COSMIC, Catalogue of Somatic Mutations in Cancer, Cell Transformation, Neoplastic, Phenotype, CRC, colorectal cancer, Female, 030211 gastroenterology & hepatology, InDel, insertion and deletion, DNA damage, DNA repair, RNase P, Ribonuclease H, MEF, murine embryonic fibroblast, KEGG, Kyoto Encyclopedia of Genes and Genomes, Article, Genomic Instability, 03 medical and health sciences, Intestinal Neoplasms, medicine, Animals, Humans, Genetic Predisposition to Disease, Ribonuclease, Gene, COADREAD, RNA sequencing data of 467 patients with colorectal adenocarcinoma, Cell Proliferation, Mouse Model, Hepatology, SNV, single nucleotide variant, Epithelial Cells, STRING, Search Tool for the Retrieval of Interacting Genes/Proteins, Molecular biology, Disease Models, Animal, 030104 developmental biology, Ribonucleotide Excision Repair, biology.protein, TCGA, The Cancer Genome Atlas, HR, homologous recombination, Tumor Suppressor Protein p53, Carcinogenesis, DNA Damage
وصف الملف: application/pdf; image/pdf
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المؤلفون: Ivan Hong Wee Ng, David A. Jans, Dominic C.H. Ng, Marie A. Bogoyevitch
المصدر: Biochemical Journal
مصطلحات موضوعية: STAT3, signal transducer and activator of transcription 3, Gene Expression, Biochemistry, Gene Knockout Techniques, Mice, 0302 clinical medicine, transcriptome analysis, ERt, substrate-binding portion of the oestrogen receptor, nucleocytoplasmic trafficking, Gene expression, Transcriptional regulation, cytokine, signal transducer and activator of transcription 3 (STAT3), Phosphorylation, 10. No inequality, STAT3, transcription factor, gp130, glycoprotein 130, Cells, Cultured, iSTAT3, inducible specific STAT3 spliceform, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, Hsp90, heat-shock protein of 90 kDa, Fc, cytoplasmic fluorescence, 030220 oncology & carcinogenesis, CLSM, confocal laser-scanning microscopy, Cytokines, JAK, Janus kinase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Research Article, STAT3 Transcription Factor, Biology, interleukin-6 (IL-6), MEF, murine embryonic fibroblast, VP16, viral protein 16, src Homology Domains, 03 medical and health sciences, HEK, human embryonic kidney, FBS, fetal bovine serum, 4-HT, 4-hydroxytamoxifen, Animals, Humans, Molecular Biology, Gene knockout, 030304 developmental biology, GO, gene ontology, DNA Primers, Cell Nucleus, Base Sequence, Fn, nuclear fluorescence, Cell Biology, Molecular biology, WT, wild-type, IL, interleukin, Alternative Splicing, Kinetics, HEK293 Cells, OSM, oncostatin M, Amino Acid Substitution, Fn/Fc, ratio of nuclear to cytoplasmic fluorescence, SHP, SH2 domain-containing protein tyrosine phosphatase, STAT protein, biology.protein, Mutagenesis, Site-Directed, Tyrosine, Nuclear transport, MAPK, mitogen-activated protein kinase, DAPI, 4′,6-diamidino-2-phenylindole
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المؤلفون: Joanna Wesoly, Adam Olejnik, Balint L. Balint, Yi-Ling Chen, Chien-Kuo Lee, Katarzyna Blaszczyk, Hans A.R. Bluyssen, Lilla Ozgyin, Hanna Nowicka, Kaja Kostyrko, Stefan Chmielewski
المصدر: Biochemical Journal
مصطلحات موضوعية: mSTAT2-MS1KO, MS1KO stably overexpressing mouse STAT2, ISGF3, interferon-stimulated gene factor 3, SOCS1, suppressor of cytokine signalling 1, Biochemistry, IRF9-U3C, U3C stably overexpressing human IRF9, MEF, murine embryonic fibroblast cells, Transactivation, Mice, Ddx60, DEAD (Asp-Glu-Ala-Asp) box polypeptide 60, Migr1-MS1KO, MS1KO stably overexpressing Migr1, Transcriptional regulation, CCL8, chemokine (C–C motif) ligand 8, STAT1, STAT2, HDACi, histone deacetylase inhibitor, MOI, multiplicity of infection, Mice, Knockout, HA, haemagglutinin, qRT-PCR, quantitative reverse transcription–PCR, U3C, TNFα, tumour necrosis factor α, qPCR, quantitative real-time PCR, VSV, vesicular stomatitis Indiana virus, MS1KO, STAT1-deficient murine embryonic fibroblast cells, STAT, signal transducer and activator of transcription, STAT1 Transcription Factor, RIG-G, retinoic acid-induced gene G, cytokines/interferon, hST2-U3C, U3C stably overexpressing human STAT2, microarray, signal transduction, Research Article, host–pathogen interactions, Transcriptional Activation, Ifit1, interferon-induced protein with tetratricopeptide repeats 1, alternative interferon response pathway, Alpha interferon, Biology, Antiviral Agents, Cell Line, MX1, myxovirus (influenza virus) resistance 1, interferon-inducible protein, CX3CL1, chemokine (C–X3–C motif) ligand 1, Cell Line, Tumor, Animals, Humans, ISG, interferon-stimulated gene, IFN, interferon, ΔmSTAT2-MS1KO, MS1KO stably overexpressing mouse ΔmSTAT2, Molecular Biology, DUOX2, dual oxidase 2, RSAD2, radical S-adenosylmethionine domain-containing 2, STAT transcription factor, HEK 293 cells, STAT2 Transcription Factor, EMCV, encephalomyocarditis virus, Cell Biology, ISRE, IFN-stimulated response element, Molecular biology, IFI27, interferon alpha-inducible protein, WT, wild-type, Interferon-Stimulated Gene Factor 3, gamma Subunit, Migr1-U3C, U3C stably overexpressing Migr1, HEK293 Cells, HERC5, HECT and RLD domain-containing E3 ubiquitin protein ligase 5, NLS, nuclear localization signal, STAT protein, biology.protein, PKR, protein kinase, interferon-inducible double-stranded RNA-dependent activator, OAS2, 2′-5′-oligoadenylate synthase 2, Interferon regulatory factors, IRF, interferon regulatory factor