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المؤلفون: Jia Yin, Joanne Wang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 363-373 (2016)مصطلحات موضوعية: 0301 basic medicine, SLC, solute carrier, CL, plasma clearance, TMD, transmembrane domain, IC50, half maximal inhibitory concentration, Review, Pharmacology, MW, molecular weight, P-gp, P-glycoprotein, GSH, glutathione, OATP or Oatp, organic anion-transporting peptide, Organic cations, OAT or Oat, organic anion transporters, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, Nephrotoxicity, media_common, Kidney, biology, Chemistry, Reabsorption, ABC, ATP-binding cassette, NSAID, non-steroidal anti-inflammatory drugs, Organic anions, MPP+, 1-methyl-4-phenylpyridimium, 3. Good health, medicine.anatomical_structure, Biochemistry, Toxicity, Renal drug transporters, SNP, single-nucleotide polymorphism, MATE, multidrug and toxin extrusion protein, Organic anion, Drug–drug interactions, Drug, ATP, adenosine triphosphate, media_common.quotation_subject, Ki, inhibitory constant, OC, organic cation, NME, new molecular entity, CHO, Chinese hamster ovary, TEA, tetraethylammonium, Cmax, maximum plasma concentration, HEK, human embryonic kidney, 03 medical and health sciences, MSD, membrane-spanning domain, medicine, OCTN, Organic zwitterions/cation transporters, CLR, renal clearance, NBD, nucleotide-binding domain, OA, organic anion, lcsh:RM1-950, ITC, International Transporter Consortium, HEK 293 cells, MRP, multidrug resistance-associated protein, Transporter, AUC, area under the plasma concentration curve, DDIs, drug–drug interactions, fe, fraction of the absorbed dose excreted unchanged in urine, PAH, p-aminohippurate, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, URAT, urate transporter, biology.protein, OCT or Oct, organic cation transporter
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المؤلفون: Nathan J. Cherrington, Michael Goedken, Joseph L. Jilek, Kevyn A. Jacobus, Wenxi He, Kayla Frost, Erica Toth
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3869-3878 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Nonalcoholic steatohepatitis, ATPase, DT, drug transporter, Pharmacology, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, LC–MS/MS, liquid chromatography–tandem mass spectrometry, General Pharmacology, Toxicology and Pharmaceutics, Nephrotoxicity, OCT, organic cation transporter, 0303 health sciences, biology, Chemistry, CDDP, cisplatin, NASH, DDTC, diethyldithiocarbamate, CTR, copper transporter, 030220 oncology & carcinogenesis, Toxicity, MCD, methionine- and choline-deficient diet, Original Article, NASH, nonalcoholic steatohepatitis, MATE, multidrug and toxin extrusion protein, Biotechnology, medicine.drug, inorganic chemicals, Drug transporter, RM1-950, 03 medical and health sciences, Pharmacokinetics, Genetics, medicine, neoplasms, Molecular Biology, 030304 developmental biology, Cisplatin, Methionine, business.industry, GFR, glomerular filtration rate, ATP7, ATPase copper transporting protein, Transporter, P-gp, p-glycoprotein, Renal physiology, biology.protein, PK, pharmacokinetics, NAFLD, nonalcoholic fatty liver disease, Therapeutics. Pharmacology, business
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3
المصدر: European Journal of Pharmaceutical Sciences
مصطلحات موضوعية: Tubular reabsorption, BCRP, breast cancer resistance protein, Metabolic Clearance Rate, TSA, tubular surface area, Freab, fraction of the drug reabsorbed in the renal tubule, CD, collecting duct, PT, proximal tubule, RMSE, root mean squared error, Models, Biological, Article, IVIVE, in vitro–in vivo extrapolation, TFR, tubular flow rate, Renal excretion clearance, P-gp, P-glycoprotein, Humans, AUC, area under the plasma concentration-time profile, fu,p, fraction of drug unbound in plasma, DT, distal tubule, OCT, organic cation transporter, Clinical Trials as Topic, LoH, loop of Henle, GFR, glomerular filtration rate, CLR, renal excretion clearance, Cp, plasma concentration, CLR, filt, renal filtration clearance, OATP, organic anion-transporting peptides, gmfe, geometric mean fold error, OCTN, organic cation/l-carnitine transporter, Renal Elimination, Kidney Tubules, CLR, int,reab, intrinsic permeability clearance in renal tubule, Papp, apparent permeability, Pharmaceutical Preparations, PBPK, physiologically-based pharmacokinetic, CLR,sec, renal secretion clearance, In vitro–in vivo extrapolation, OAT, organic anion transporter, Freab’, intermediate model parameter, representing the fraction of the equilibrium reached between unbound drug concentration in the plasma and urine, MRP, multidrug resistance protein, LogD, octanol-buffer distribution coefficient, Glomerular Filtration Rate, MATE, multidrug and toxin extrusion protein