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1Academic Journal
المؤلفون: Christophe Glorieux, Peng Huang
المصدر: Cancer Communications, Vol 39, Iss 1, Pp 1-11 (2019)
مصطلحات موضوعية: CD137, K-Ras, IL-1α (interleukin-1 alpha), MAPK (mitogen-activated protein kinases), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), Pancreatic cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
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المؤلفون: Prafulla K. Mohanty, Swati Sucharita Mohanty
المصدر: Genes and Diseases, Vol 8, Iss 2, Pp 117-123 (2021)
Genes & Diseasesمصطلحات موضوعية: IRS-1, insulin receptor substrate-1, 0301 basic medicine, Medicine (General), ER, estrogen receptor, medicine.drug_class, BMI, body mass index, TNFα, tumor necrosis factor-α, Estrogen receptor, Physiology, Review Article, E2, estradiol, QH426-470, Overweight, Biochemistry, 03 medical and health sciences, Aromatase, Breast cancer, R5-920, 0302 clinical medicine, Breast Cancer Risk Factor, GPER1, G protein-coupled estrogen receptor 1, GPR30, G protein-coupled receptor 30, Genetics, Medicine, Obesity, IL-6, interleukin-6, Molecular Biology, Genetics (clinical), Adipocyte, biology, business.industry, Cancer, Cell Biology, medicine.disease, Estrogen, Menopause, 030104 developmental biology, MAPK, mitogen-activated protein kinases, 030220 oncology & carcinogenesis, biology.protein, medicine.symptom, business
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المؤلفون: Bulbuli Khanikor, Kamal Adhikari
المصدر: Toxicology Reports, Vol 8, Iss, Pp 1883-1891 (2021)
Toxicology Reportsمصطلحات موضوعية: NADPH, nicotinamide adenine dinucleotide phosphate hydrogen, GSH, reduced glutathione, Health, Toxicology and Mutagenesis, DMSO, dimethyl sulfoxide, Toxicology, chemistry.chemical_compound, RA1190-1270, GST, glutathione-s-transferase, Bioassay, PBO, piperonyl butoxide, ANOVA, analysis of variance, chemistry.chemical_classification, education.field_of_study, Dengue vector, biology, Organophosphate, Regular Article, PPM, parts per million, Organophosphates, CDNB, 1-chloro-2,4-dinitrobenzene, DEM, diethyl maleate, Toxicity, OP, organophosphate, Larvicide, Population, Pesticide resistance, Aedes aegypti, ºC, degree celsius, WHO, World Health Organization, CPCSEA, committee for the purpose of control and supervision of experiments on animals, Microbiology, DEET, NN-diethyl-meta-toluamide, Detoxification, TMBZ, 3, 3, 5, 5-tetramethyl benzidine, TPP, triphenyl phosphate, SPSS, statistical package for the social sciences, education, ComputingMethodologies_COMPUTERGRAPHICS, SE, standard error, Temephos, LC50, lethal concentration 50, biology.organism_classification, Enzyme assay, OD, optical density, Enzyme, chemistry, MAPK, mitogen-activated protein kinases, Toxicology. Poisons, biology.protein, BSA, bovine serum albumin, IAEC, institutional animal ethical committee
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المؤلفون: Anuar Salazar-Gómez, Saudy Saret Pablo-Pérez, M. Elena Vargas-Dı́az, Julio C. Ontiveros-Rodríguez, Leticia Garduño-Siciliano
المصدر: South African Journal of Botany
مصطلحات موضوعية: IL-1β, interleukin 1 beta, 0106 biological sciences, GSH, reduced glutathione, Structural diversity, Review, Plant Science, 01 natural sciences, G6Pase, glucose-6-phosphatase, Hypolipidemic, chemistry.chemical_compound, Broad spectrum, IR, insulin resistance, TBARS, thiobarbituric acid reactive substances, FFA, free fatty acids, TNF-α, tumor necrosis factor alpha, AMPK, activated protein kinase, Medicinal plants, STAT1, signal transducer and activator of transcription 1, NF-κB, nuclear factor kappa B, GPx, glutathione peroxidase, SLns, sesquiterpene lactones, JNK, c-Jun N-terminal kinases, Biological activity, TG, triglycerides, Metabolic syndrome, IL-6, interleukin 6, iNOS, inducible nitric oxide synthase, LPS, lipopolysaccharide, MetS, metabolic syndrome, Sesquiterpene lactones, COX-2, cyclooxygenase 2, GK, glucokinase, MCP-1, monocyte chemoattractant protein 1, Computational biology, CVD, cardiovascular disease, Biology, Sesquiterpene, STZ, streptozotocin, Tc total cholesterol, ROS, reactive oxygen species, SOD, superoxide dismutase, AT, adipose tissue, medicine, LDL-C, low-density lipoprotein-cholesterol, Beneficial effects, FN, fibronectin, TLRs, Toll-like receptor, NO, nitric oxide, IFN-γ, interferon gamma, HDL-C, high-density lipoproteins-cholesterol, VLDL, very-low-density lipoprotein, T2DM, type 2 diabetes mellitus, Hypoglycemic, medicine.disease, ACE, angiotensin I-converting enzyme, 0104 chemical sciences, APOC3, apolipoprotein C3, TC, total cholesterol, TGF-β1, transforming growth factor beta, 010404 medicinal & biomolecular chemistry, Antidiabetic, chemistry, MAPK, mitogen-activated protein kinases, CAT, catalase, 010606 plant biology & botany
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المؤلفون: Alexandre Gries, Michael A. Grotzer, Anuja Neve, Marc Thomas Schönholzer, Min Ma, Karthiga Santhana Kumar, Martin Baumgartner, Jessica Migliavacca, Elena Alvarez
المساهمون: University of Zurich, Baumgartner, Martin
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 470-483 (2020)مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, ERK, Extracellular regulated kinase, Basic fibroblast growth factor, Dasatinib, Apoptosis, Cerebellum slice culture, SHH, sonic hedgehog, c-Met, cellular mesenchymal epithelial transition factor, chemistry.chemical_compound, 0302 clinical medicine, bFGF, basic fibroblast growth factor, Epidermal growth factor, Cell Movement, hemic and lymphatic diseases, Tumor Cells, Cultured, 1306 Cancer Research, Kinase, Cell migration, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Hepatocyte growth factor, Mitogen-Activated Protein Kinases, medicine.drug, Nuclear ERK1/2 activation sensor, Original article, FGFR, fibroblast growth factor receptor, MAP Kinase Signaling System, 610 Medicine & health, Antineoplastic Agents, lcsh:RC254-282, 03 medical and health sciences, medicine, Humans, Neoplasm Invasiveness, Protein kinase A, Fluorescent biosensor, Live cell imaging, Cerebellar Neoplasms, Cell Proliferation, EGF, epidermal growth factor, MB, medulloblastoma, SKARS, Synthetic Kinase Activation Relocation Sensor, 030104 developmental biology, WST, water soluble tetrazolium salt, chemistry, FDA, food and drug administration, 10036 Medical Clinic, MAPK, mitogen-activated protein kinases, Cancer research, JNK, c-jun N-terminal kinase, HGF, hepatocyte growth factor, Medulloblastoma
وصف الملف: 1-s2.0-S1476558620301378-main.pdf - application/pdf
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المؤلفون: Emma Rose McGlone, Alejandra Tomas, Sunil Kumar, Zijian Fang, Ben Jones, Paul M. W. French, Stephen R. Bloom, Phil Pickford, Christopher Dunsby, Asuka Inoue, Tricia Tan, Ivan R. Corrêa, Frederik Görlitz, Ralf Jockers, Guy A. Rutter, Atsuro Oishi
المساهمون: Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes, British Society for Neuroendocrinology, Wellcome Trust
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Ligands, Biochemistry, Mice, Glucagon-Like Peptide 1, Insulin Secretion, DPP-4, dipeptidyl dipeptidase-4, Functional selectivity, Cyclic AMP, Receptor, beta-Arrestins, 11 Medical and Health Sciences, GIP, diabetes, Chemistry, membrane trafficking, GIP, glucose-dependent insulinotropic polypeptide, GLP-1, glucagon-like peptide-1, incretin, GCGR, glucagon receptor, biased agonism, receptor endocytosis, 03 Chemical Sciences, Signal Transduction, Research Article, Agonist, medicine.medical_specialty, Biochemistry & Molecular Biology, GIPR, glucose-dependent insulinotropic polypeptide receptor, medicine.drug_class, GPCR, G protein–coupled receptors, Incretin, T2D, type 2 diabetes, Gastric Inhibitory Polypeptide, Incretins, Glucagon-Like Peptide-1 Receptor, Receptors, Gastrointestinal Hormone, 03 medical and health sciences, Downregulation and upregulation, DERET, diffusion-enhanced resonance energy transfer, trafficking, Internal medicine, medicine, Arrestin, Animals, Humans, Molecular Biology, GCG, glucagon, G protein-coupled receptor, 030102 biochemistry & molecular biology, β-arrestin, molecular pharmacology, Cell Biology, 06 Biological Sciences, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, HEK293 Cells, glucagon, MAPK, mitogen-activated protein kinases, PKA, protein kinase A, GLP-1, Glucagon receptor, GLP-1R, glucagon-like peptide-1 receptor
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المؤلفون: Daniel W.S. Tan, Fred W.S. Wong, Dorothy H.J. Cheong, Thai Tran
المصدر: Pharmacological Research
مصطلحات موضوعية: CTX, cyclophosphamide, STAT, signal transducers and activators of transcription, Artesunate (PubChem CID:156252), HDAC2, histone deacetylase 2, Pharmacology, Nrf2, nuclear factor erythroid 2-related factor 2, TNF, tumour necrosis factor, SLE, systemic lupus erythematosus, VCAM-1, vascular cell adhesion molecule 1, 0302 clinical medicine, eos, eosinophil, GSH, glutathione, 3-NT, 3-nitrotyrosine, Medicine, IκBα, inhibitor of NF-κB alpha, Th17, T helper 17, HO-1, heme oxygenase-1, ICAM-1, intercellular adhesion molecule 1, chemistry.chemical_classification, XIAP, X-linked inhibitor of apoptosis protein, YKL-40, chitinase-like glycoprotein, Chemical compounds studied in this article Artemisinin (PubChem CID: 68827), MCP-1, monocyte chemoattractant protein-1, HIF-1α, hypoxia-inducible factor 1-alpha, Artemisinins, DHA, dihydroartemisinin, GLUT, glucose transporter, HELF, human embryonic lung fibroblasts, RNAi, RNA interference, VDAC2, voltage-dependent anion channel 2, 030220 oncology & carcinogenesis, COX-2, cyclooxygenase-2, LADPI, liposomal artesunate dry powder inhalers, behavior and behavior mechanisms, iNOS, inducible nitric oxide synthase, IP-10, IFNγ-induced protein 10, 8-iso, 8-isoprostane, psychological phenomena and processes, Foxo1, forkhead box O1, KDR/flk-1, kinase insert domain receptor /fetal liver kinase-1, education, H2AX, H2A histone family member X, PCNA, proliferating cell nuclear antigen, Pneumonia, Viral, MIP-2, macrophage inflammatory protein 2, mTOR, mammalian target of rapamycin, ACE2, angiotensin-converting enzyme 2, Antiviral Agents, Article, 4EBP1, eukaryotic translation initiation factor 4E-binding protein 1, 03 medical and health sciences, LD50, lethal dose, Betacoronavirus, ARTD, artemisinin-daumone hybrid 15, BDHA, biotinylated dihydroartesunate, PGE2, prostaglandin E2, TGF, tumour growth factor, Humans, DHA-NLC, dihydroartemisinin-nanostructured lipid carriers, u-PA, urokinase-type plasminogen activator, TSLP, thymic stromal lymphopoietin, E2F1, E2F transcription factor 1, LLC, lewis lung carcinoma, PEG, polyethylene glycol, MDA, malondialdehyde, NO, nitric oxide, hsp47, heat shock protein 47, Arteether (PubChem CID: 3000469), medicine.disease, IL, interleukin, 030104 developmental biology, Mcl-1, myeloid cell leukemia-1, cell proliferation, chemistry, COPD, chronic obstructive pulmonary disease, Smac, second mitochondrial activator of caspases, Treg, regulatory T, artemisinin, Apoptosis, NQO1, NAD(P)H quinone dehydrogenase 1, CSE, cigarette smoke extract, Malaria, 0301 basic medicine, Lung Diseases, Lymp, lymphocyte, Respiratory diseases, ALI, acute lung injury, DLAedried, leaf artemisia extract, MPO, myeloperoxidase, 8-OHdG, 8-hydroxy-2’-deoxyguanosine, AP-1, activator protein 1, LMVD, lymphatic microvessel density, TLR4, toll-like receptor 4, 2DG, 2-Deoxy-D-glucose, chemistry.chemical_compound, Artemether (PubChem CID: 68911), DNA, deoxyribonucleic acid, SCLC, small cell lung cancer, KC, keratinocyte chemoattractant, BALF, bronchoalveolar lavage fluid, Artemisinin, Rb, retinoblastoma, ABCG2, ATP-binding cassette subfamily member 2, NF-κB, nuclear factor-kappa B, CDK, cyclin-dependent kinase, ATF3, activating transcription factor 3, GPx, glutathione peroxidase, INF, interferon, CDDP, cisplatin, RA, FLS rheumatoid arthritis fibroblast-like synoviocytes, [Ca2+]i, intracellular calcium ion, NOX, NADPH oxidase, RIR, renal ischemia reperfusion, VEGF, vascular endothelial growth factor, Vascular endothelial growth factor, MMP, matrix metalloproteinase, AHR, airway hyperresponsiveness, JNK, c-Jun N-terminal kinase, shRNA, short hairpin RNA, LPS, lipopolysaccharide, medicine.symptom, EMT, epithelial-mesenchymal transition, Coronavirus Infections, NKD2, naked cuticle homolog 2, PI3K, phosphoinositide 3-kinase, Artemisitene (PubChem CID: 11000442), medicine.drug, AEC, alveolar epithelial cells, GSK3β, glycogen synthase kinase 3 beta, NPC, nasopharyngeal carcinoma, ATP, adenosine triphosphate, Dihydroartemisinin (PubChem CID: 139073990), Inflammation, neu, neutrophil, lung, ER, endoplasmic reticulum, OVA, ovalbumin, ROS, reactive oxygen species, RANKL, receptor activator of nuclear factor kappa-B ligand, NSCLC, non-small cell lung cancer, SOD, superoxide dismutase, parasitic diseases, TIMP, tissue inhibitor of metalloproteinases, Ym2, chitinase 3-like protein 4, HNF4A, hepatocyte nuclear factor 4 alpha, Pandemics, Mac, macrophage, Reactive oxygen species, HCMV, human cytomegalovirus, NLRP3, NLR family pyrin domain containing 3, business.industry, Cell growth, SARS-CoV-2, COVID-19, ASC, apoptosis-associated speck-like protein containing CARD, EGFR, epidermal growth factor receptor, AIF, apoptosis-inducing factor, MAPK, mitogen-activated protein kinases, inflammation, Keap1, kelch-like ECH-associated protein 1, Axin2, axis inhibition protein 2, business, sm-α, actin smooth muscle-α actin
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المؤلفون: Shengbing Yang, Hanjun Li, Jingtian Mei, Han Qiao, Feng Zhou, Minqi Wang, Linyang Chu, Tingting Tang, Xiuguo Han
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)مصطلحات موضوعية: MAPK/ERK pathway, C/EBP β, CCAAT/enhancer-binding protein β, RA, rheumatoid arthritis, OARSI, Osteoarthritis Research Society International, TNF-α, tumor necrosis factor-α, chemistry.chemical_compound, 0302 clinical medicine, GA, gouty arthritis, Polarization, BV, bone volume, IFN-γ, interferon-γ, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, medicine.diagnostic_test, Chemistry, Kinase, S&F, safranin O-fast green, NSAIDs, non-steroidal anti-inflammatory drugs, Cell biology, Tb.Sp, trabecular separation, medicine.anatomical_structure, 030220 oncology & carcinogenesis, behavior and behavior mechanisms, iNOS, inducible nitric oxide synthase, Phosphorylation, OA, osteoarthritis, TLRs, toll-like receptors, AP-1, activator protein-1, Cell signaling, Original article, HUVECs, human umbilical vein endothelial cells, NF-κB, nuclear factor-κB, MSU, monosodium urate, Chondrocyte, 03 medical and health sciences, DMEM, Dulbecco׳s minimum essential medium, CM, conditioned medium, ROS, reactive oxygen species, Chondrocytes, Western blot, Osteoarthritis, medicine, otorhinolaryngologic diseases, IRF4, interferon regulatory factor 4, BV/TV, bone volume/total tissue volume, 030304 developmental biology, Macrophages, lcsh:RM1-950, Tb.N, trabecular number, Kin, kinsenoside, NF-κB, Tb.Th, trabecular thickness, H&E, hematoxylin & eosin, PPARγ, peroxisome proliferator-activated receptor γ, Kinsenoside, IκBα, lcsh:Therapeutics. Pharmacology, Arg-1, arginase-1, MAPK, mitogen-activated protein kinases, LPS, lipopolysaccharides
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المؤلفون: Kinga Gawlińska, Edmund Przegaliński, Michal Korostynski, Marcin Piechota, Małgorzata Filip, Dawid Gawliński, Małgorzata Frankowska, Malgorzata Borczyk
المصدر: Developmental Cognitive Neuroscience
Developmental Cognitive Neuroscience, Vol 47, Iss, Pp 100879-(2021)مصطلحات موضوعية: Male, DOHaD, developmental origins of health and disease, HFD, high-fat diet, PND, postnatal day, 0302 clinical medicine, Pregnancy, Lactation, Fetal programming, PV, parvalbumin, Depressive-like behavior, Original Research, EXT, excitatory neurons, FST, forced swimming test, lcsh:QP351-495, 05 social sciences, Phenotype, EZM, elevated zero maze, HCD, high-carbohydrate diet, medicine.anatomical_structure, High-fat diet, Prenatal Exposure Delayed Effects, Female, medicine.symptom, Psychology, NGS, Next Generation Sequencing, medicine.medical_specialty, ASD, autism spectrum disorder, Offspring, Cognitive Neuroscience, SD, standard diet, mPFCx, medial prefrontal cortex, Diet, High-Fat, 050105 experimental psychology, MD, mixed diet, 03 medical and health sciences, Internal medicine, medicine, Animals, 0501 psychology and cognitive sciences, Maternal diet, Epigenetics, Rats, Wistar, ADHD, attention-deficit hyperactivity disorder, NOR, novel object recognition, ComputingMethodologies_COMPUTERGRAPHICS, Fetus, Offspring frontal cortex, VIP, vasoactive intestinal polypeptide, Anhedonia, Maternal Nutritional Physiological Phenomena, medicine.disease, Obesity, Rats, lcsh:Neurophysiology and neuropsychology, Endocrinology, MAPK, mitogen-activated protein kinases, GABA, gamma-aminobutyric acid, RNA-seq, SST, somatostatin, 030217 neurology & neurosurgery
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المؤلفون: Puja Ohri, Ajaz Ahmad, Renu Bhardwaj, Sukhmeen Kaur Kohli, Abhay Bhardwaj, Anket Sharma, Kanika Khanna, Parvaiz Ahmad, Ravdeep Kaur, Vinay Bhardwaj
المصدر: Phytomedicine
مصطلحات موضوعية: ACTH, adrenocorticotrophic hormones, Battle, viruses, Tfh, follicular helper T-cells, Pharmaceutical Science, Review, MT, metalloprotease, APC, antigen presenting cell, Natural therapeutics, 0302 clinical medicine, GCSF, granulocyte-colony stimulating factor, Drug Discovery, Pandemic, CHM, Chinese herbal medicine, NF, neuro fibromatosis, Medicine, Chinese Traditional, NLRP3, NOD-like receptor proteins, PDB, protein data bank, media_common, 0303 health sciences, TNF, tumor necrosis factor, ARC, artepillin C, Social distance, RBD, receptor-binding domain, R0, basic reproduction number, 030220 oncology & carcinogenesis, Molecular Medicine, MIP1, macrophage inflammatory protein 1, WHO, World Health Organisation, NK, natural killer, SARS-CoV, severe acute respiratory syndrome, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, AYUSH, ayurvedic, yoga and naturopathy, unani, siddha and homeopathy, NLR, neutrophil-to-lymphocyte ratio, IgG, immunoglobulin G, ACE2, angiotensin-converting enzyme, MVD, molegro virtual docker, 03 medical and health sciences, Globalization, Adjuvants, Immunologic, Political science, Immune-System Rebooting, Development economics, MAPK, mitogen activated protein kinases, MCP1, monocytechemoattractant protein 1, medicine, TCM, traditional Chinese medicines, Humans, PAK-1 Blockers, C-1, Caspase-1, MERS-CoV, middle east respiratory syndrome, Pandemics, ARDS, acute respiratory distress syndrome, 030304 developmental biology, Pharmacology, ICTV, international committee on taxonomy of viruses, Plants, Medicinal, SARS-CoV-2, Public health, fungi, COVID-19, Traditional medicine, IL, interleukin, Medicine, Ayurvedic, COVID-19 Drug Treatment, Herbal plants, IgM, immunoglobulin M, Complementary and alternative medicine, ASCs, antibody-secreting cells, Immune System, Dietary Supplements, RNA, ribonucleic acid, CAPE, caffeic acid phenyl ester, Plant Preparations, SARS-CoV-2, severe acute respiratory syndrome coronavirus-2, Phytotherapy
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المؤلفون: Ling Shao, Zhang-Xu Liu, Janet Kwok, Katherine Donovan, Brian T. Lee, Andrea Iorga, Layla Shojaie, Heather S. Johnson, Lily Dara, Mariam Aghajan, Jo Suda
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, MAP Kinase Kinase 4, RHIM, RIP homotypic interaction motif, receptor interacting protein, Apoptosis, Pharmacology, ASK1, apoptosis signal-regulating kinase 1, Biochemistry, Severity of Illness Index, necrosis, Mice, GSH, glutathione, AAC, asparagine, TBP, TATA box binding protein, ASK1, GAC, aspartic acid, drug action, TNFAIP3, RIPK1/3, receptor interacting protein kinase-1/3, TNF, tumor necrosis factor, Chemistry, Kinase, Co-IP, Coimmunoprecipitation, digestive, oral, and skin physiology, A20HepCKO, targeted hepatocyte A20 knockout, PHB1, prohibitin-1, cell death, TNFAIP3, TNF-induced protein 3, also known as A20, Liver, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Receptor-Interacting Protein Serine-Threonine Kinases, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, Chemical and Drug Induced Liver Injury, Protein Binding, Research Article, Programmed cell death, hepatotoxicity, RIPK1, RCD, regulated cell death, MAP Kinase Signaling System, Necroptosis, necroptosis, APAP, acetaminophen, Mice, Transgenic, ASO, antisense oligonucleotide, MKK4, MAP2 kinase mitogen-activated protein kinase 4, MAP Kinase Kinase Kinase 5, RIPK3, drug induced liver injury, 03 medical and health sciences, ROS, reactive oxygen species, Downregulation and upregulation, RIPK1HepCKO, targeted hepatocyte RIPK1 knockout, ALT, alanine aminotransferase, Animals, Molecular Biology, Tumor Necrosis Factor alpha-Induced Protein 3, Acetaminophen, DYKDDDK Tag, Flag Tag, MLKL, mixed lineage kinase domain like pseudokinase, 030102 biochemistry & molecular biology, RIPK1D138N, kinase dead RIPK1 knock-in, Nec-1, necrostatin-1, DMSO, Dimethyl sulfoxide, Cell Biology, 030104 developmental biology, Gene Expression Regulation, MAPK, mitogen-activated protein kinases, siRNA, small interfering RNA, Hepatocytes, NFkB, nuclear factor kB, NAPQI, N-acetyl-p-benzoquinone imine, PMH, primary mouse hepatocyte
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المؤلفون: Jian Huang, Jinwei Wang, Jianyun Lu, Jinhua Huang, Zhaoqi Yin, Radean T. Anvari, Yaping Xiang, Jing Chen, Shiyao Pei, Wenbin Tan, J. Stuart Nelson
المصدر: JAAD case reports, vol 4, iss 4
JAAD Case Reports, Vol 4, Iss 4, Pp 355-358 (2018)
JAAD Case Reports
Lu, J; Anvari, R; Wang, J; Huang, J; Pei, S; Xiang, Y; et al.(2018). Propranolol as a potentially novel treatment of arteriovenous malformations.. JAAD case reports, 4(4), 355-358. doi: 10.1016/j.jdcr.2017.11.005. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7343x3mkمصطلحات موضوعية: MAPK/ERK pathway, arteriovenous malformation, p-AKT, phosphorylated extracellular signal-regulated kinases, Dermatology, Propranolol, 030204 cardiovascular system & hematology, Pharmacology, phosphorylated protein kinase B, p-S6K, Article, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, phosphorylated ribosomal s6 kinase, p-ERK, lcsh:Dermatology, Medicine, phosphorylated c-Jun N-terminal protein kinases, propranolol, AVM, arteriovenous malformation, p-PI3K, p-JNK, phosphorylated c-Jun N-terminal protein kinases, business.industry, lcsh:RL1-803, AVM, MAPK, p-JNK, p-S6K, phosphorylated ribosomal s6 kinase, p-PI3K, phosphorylated phosphatidylinositol 3-kinases, p-ERK, phosphorylated extracellular signal-regulated kinases, MAPK, mitogen-activated protein kinases, mitogen-activated protein kinases, phosphorylated phosphatidylinositol 3-kinases, business, p-AKT, phosphorylated protein kinase B, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Natalia Dovlatova, Vera Ralevic, William R. Dunn, Zainab Abbas, Stan Heptinstall, M. Liaque Latif, Susan C. Fox
المصدر: Vascular Pharmacology
مصطلحات موضوعية: 0301 basic medicine, Male, DABCO, 1,4-diazabicyclo[2.2.2]octane, P2Y14 receptor, RCF, relative centrifugal force, Physiology, Swine, ERK, extracellular signal-regulated kinases, TBST, Tris-buffered saline and Tween 20, Pharmacology, chemistry.chemical_compound, Isothiocyanates, Vasoconstrictor Agents, Sugar nucleotides, SDS, sodium dodecyl sulphate, Receptor, Forskolin, Thiourea, UDP sugars, L-NAME, Nω-nitro-L-arginine methyl ester, Receptor antagonist, Coronary Vessels, OCT, optimal temperature cutting compound, PPTN, 4-((piperidin-4-yl)-phenyl)-7-(4-(trifluoromethyl)-phenyl)-2-naphthoic acid, SNP, sodium nitroprusside, Molecular Medicine, Female, FITC, fluorescein isothiocyanate, Signal transduction, medicine.drug, Signal Transduction, Agonist, Adult, Uridine Diphosphate Glucose, NTPDase1, nucleotide triphosphate diphosphohydrolase-1, medicine.drug_class, Suramin, P2 receptor, P2Y6 receptor, Coronary artery, Article, 03 medical and health sciences, PBS, phosphate buffered saline, medicine, Animals, Humans, PPADS, PAGE, polyacrylamide gel electrophoresis, MRS2690, diphosphoric acid 1-α-d-glucopyranosyl ester 2-[(4′-methylthio)uridin-5″-yl] ester disodium salt, NO, nitric oxide, Receptors, Purinergic P2, Colforsin, MRS2690, Uridine Diphosphate Sugars, 030104 developmental biology, UDP-glucose, chemistry, MAPK, mitogen-activated protein kinases, Vasoconstriction, BSA, bovine serum albumin,
MRS2578, N,N"-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)thiourea, VASP, vasodilator-stimulated phosphoprotein, KCl, potassium chloride, DAPI, 4′,6-diamidino-2-phenylindole -
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المؤلفون: Si-Chi Xu, Qi-Zhu Tang, Sha-Sha Wang, Zhen-Guo Ma, Yu-Pei Yuan, Xin Zhang
المصدر: EBioMedicine
EBioMedicine, Vol 18, Iss C, Pp 179-187 (2017)مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, β-MHC, (β-myosin heavy chain), PI3K, (phosphatidylinositol-3-kinase), Cardiac fibrosis, lcsh:Medicine, BW, (body weight), chemistry.chemical_compound, Mice, 0302 clinical medicine, Piperidines, GSK-3, Transforming Growth Factor beta, Cytochrome P-450 Enzyme Inhibitors, AKT, (protein kinase B), Anilides, LVIDd, (left ventricle end-diastolic internal diameter), PPAR-γ, (peroxisome proliferator activated receptor-γ), RNA, Small Interfering, ISO, (isoprenaline), Myofibroblasts, Cells, Cultured, lcsh:R5-920, Angiotensin II, MAPK, (mitogen-activated protein kinases), Cell Differentiation, Heart, General Medicine, α-SMA, (α-smooth muscle actin), 030220 oncology & carcinogenesis, Piperine, TL, (tibial length), AMPKα, (AMPactivated protein kinase α), HW, (heart weight), RNA Interference, lcsh:Medicine (General), Research Paper, Signal Transduction, medicine.medical_specialty, PPAR-γ, Polyunsaturated Alkamides, GSK3β, (glycogen synthase kinase 3β), Biology, Cardiac fibroblast, General Biochemistry, Genetics and Molecular Biology, BNP, (brain natriuretic peptide), FS, (fractional shortening), 03 medical and health sciences, Alkaloids, Internal medicine, medicine, Animals, ERK, (extracellular signal-regulated kinase), Benzodioxoles, Protein kinase A, Protein kinase B, PI3K/AKT/mTOR pathway, Glycogen Synthase Kinase 3 beta, AKT, Myocardium, lcsh:R, Isoproterenol, Fibroblasts, medicine.disease, Fibrosis, GAPDH, (glyceraldehyde 3-phosphate dehydrogenase), AB, (aortic banding), ANP, (atrial natriuretic peptide), Mice, Inbred C57BL, PPAR gamma, 030104 developmental biology, Endocrinology, chemistry, PE, (phenylephrine), CF, (cardiac fibroblast), TGF-β, (transforming growth factor-β), Proto-Oncogene Proteins c-akt
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المؤلفون: Shih-Hsiang Chen, Chih-Ching Wu, Arnold Stern, Wei-Chen Yen, Hsin-Ru Lin, Daniel Tsun-Yee Chiu, Yi-Hsuan Wu, Jwu-Ching Shu
المصدر: Redox Biology
Redox Biology, Vol 28, Iss, Pp-(2020)مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Lipopolysaccharide, THP-1 Cells, Clinical Biochemistry, Interleukin-1beta, AP-1, activator protein 1, G6PD, glucose-6-phosphate dehydrogenase, p38 Mitogen-Activated Protein Kinases, Biochemistry, Inflammasome, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Bactericidal response, NOS, nitric oxide synthase, lcsh:QH301-705.5, chemistry.chemical_classification, Gene knockdown, lcsh:R5-920, NADPH oxidase, biology, Chemistry, NADPH, reduced form of nicotinamide adenine dinucleotide phosphate, NOX, NADPH oxidase, Cell biology, G6PD-kd, G6PD knockdown, PBMC, peripheral blood mononuclear cells, IL-1β, H2O2, hydrogen peroxide, Gene Knockdown Techniques, Phosphorylation, Female, lcsh:Medicine (General), Redox homeostasis, medicine.drug, Research Paper, PMA, phorbol 12-myristate 13-acetate, Adult, congenital, hereditary, and neonatal diseases and abnormalities, ATP, adenosine triphosphate, Down-Regulation, 03 medical and health sciences, Young Adult, ROS, reactive oxygen species, parasitic diseases, medicine, Humans, Aged, Reactive oxygen species, NO, nitric oxide, Innate immune system, Organic Chemistry, UP-LPS, ultrapure lipopolysaccharide, nutritional and metabolic diseases, NADPH Oxidases, Transcription Factor AP-1, 030104 developmental biology, Glucosephosphate Dehydrogenase Deficiency, HEK293 Cells, lcsh:Biology (General), MAPK, mitogen-activated protein kinases, Case-Control Studies, biology.protein, THP-1, human monocytic cells, Leukocytes, Mononuclear, Adenosine triphosphate, 030217 neurology & neurosurgery, G6PD
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المؤلفون: Peng Huang, Christophe Glorieux
المصدر: Cancer Communications
Cancer Communications, Vol 39, Iss 1, Pp 1-11 (2019)مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, medicine.medical_treatment, Cell, Biology, Models, Biological, lcsh:RC254-282, Proto-Oncogene Proteins p21(ras), MAPK (mitogen-activated protein kinases), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), 03 medical and health sciences, Tumor Necrosis Factor Receptor Superfamily, Member 9, 0302 clinical medicine, Cancer immunotherapy, Cell Line, Tumor, Interleukin-1alpha, Pancreatic cancer, CD137, medicine, Gene silencing, Humans, Kinase, NF-kappa B, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Research Highlight, Gene Expression Regulation, Neoplastic, IL-1α (interleukin-1 alpha), Pancreatic Neoplasms, 030104 developmental biology, medicine.anatomical_structure, Oncology, Oxidative stress, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Original Article, Mitogen-Activated Protein Kinases, K-Ras, Soluble CD137, Signal Transduction
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المؤلفون: Reto Rufener, Dominic Ritler, Raphael Peter Zurbriggen, Britta Lundström-Stadelmann, Andrew Hemphill
المصدر: Lundström-Stadelmann, Britta; Rufener, Reto; Ritler, Dominic; Zurbriggen, Raphael Peter; Hemphill, Andrew (2019). The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis. Food and waterborne parasitology, 15, e00040. Elsevier 10.1016/j.fawpar.2019.e00040 <http://dx.doi.org/10.1016/j.fawpar.2019.e00040>
Food and Waterborne Parasitology, Vol 15, Iss, Pp-(2019)
Food and Waterborne Parasitologyمصطلحات موضوعية: 0301 basic medicine, Drug, Epidemiology, media_common.quotation_subject, 030231 tropical medicine, PGI, phosphoglucose isomerase, Pharmacology, MMV, Medicines for Malaria Venture, Albendazole, Echinococcus multilocularis, Article, lcsh:Infectious and parasitic diseases, MBZ, mebendazole, Drug treatment, 03 medical and health sciences, 0302 clinical medicine, AE, alveolar echinococcosis, In vivo, MAPK, mitogen activated protein kinases, medicine, Chemotherapy, lcsh:RC109-216, Artemisinin, media_common, biology, 630 Agriculture, business.industry, Mefloquine, Nitazoxanide, 2-ME, 2-methoxyestradiol, 030108 mycology & parasitology, SPEMs, small particles of Echinococcus multilocularis, biology.organism_classification, Malate dismutation, 3. Good health, Drug development, ABZ, albendazole, 570 Life sciences, Parasitology, business, Buparvaquone, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Ola D. A. Shammout, Zainab M. Al Shareef, Sarra B. Shakartalla, Sameh S. M. Soliman, Razan B. Alhumaidi, Naglaa S. Ashmawy
المصدر: Infection, Genetics and Evolution
مصطلحات موضوعية: 0301 basic medicine, lysoPC, Lyso-phosphatidylcholine, viruses, ERK, Extracellular signal-regulated kinases, Disease, Review, HETEs, Hydroxyeicosatetraenoic acids, Gastroenterology, Lipid-lowering agents, chemistry.chemical_compound, Breast cancer, Th, T helper cells, EETs, Epoxyeicosatrienoic acids, SR-BI, Scavenger receptor class B type I, LOX, Lipoxygenases, PE, Phosphatidylethanolamine, Respiratory system, Cause of death, Hypolipidemic Agents, lysoPE, Lyso-phosphatidylethanolamine, VLDL, Very-low-density lipoproteins, CT, CTP-choline cytidylyltransferase, Incidence (epidemiology), COVID-19, Corona virus disease-19, HDL, High- density lipoproteins, S1PR1, Sphingosine kinase 1 receptor 1, Infectious Diseases, mPGES-1, Microsomal prostaglandin E synthase-1, ChoK, Choline kinases, ATP, Adenosine triphosphate, Female, Microbiology (medical), medicine.medical_specialty, COX, Cyclooxygenases, PC, Phosphatidylcholine, 030106 microbiology, CHPT, CDP-choline diacylglycerol phosphocholinetransferase, PG, Prostaglandins, Breast Neoplasms, Biology, TX, Thromboxanes, Microbiology, HMGCR, Hydroxymethylglutaryl-coenzyme A reductase, LDL, Low-density lipoproteins, SARS-CoV, Severe acute respiratory syndrome coronavirus, 03 medical and health sciences, Internal medicine, Genetics, medicine, Humans, MAPK, Mitogen-activated protein kinases, PLA2G2D, Phospholipase A2 group IID, Molecular Biology, C1P, Ceramide-1-phophate, LT, Leukotrienes, Ecology, Evolution, Behavior and Systematics, Dyslipidemias, DMVs, Double membrane vesicles, cPLA2α, Cytosolic phospholipase A2α enzyme, S1P, Sphingosine-1-phophate, Cholesterol, SARS-CoV-2, PCho, Phosphocholine, TNF, Tumor necrosis factor, Cancer, COVID-19, IL-1β, Interleukin-1β, PI3K, Phosphatidylinositol-3-kinase, medicine.disease, SK1, Sphingosine kinase 1, 030104 developmental biology, chemistry, Dyslipidemia, ACE-2, Angiotensin converting enzyme-2, IDL, Intermediate-density lipoproteins, HPETEs, Hydroperoxyeicosatetraenoic acids
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المؤلفون: Chang Hyun Byon, Jack M. Heath, Yabing Chen
المصدر: Redox Biology, Vol 9, Iss C, Pp 244-253 (2016)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, CREB, cyclic AMP response element–binding protein, Vascular smooth muscle, Clinical Biochemistry, AGEs, advanced glycation end products, Review Article, 030204 cardiovascular system & hematology, medicine.disease_cause, Nrf2, nuclear factor erythroid 2-related factor 2, Biochemistry, PDGF, platelet-derived growth factor, Antioxidants, Muscle, Smooth, Vascular, Pathogenesis, 0302 clinical medicine, Runx2, lcsh:QH301-705.5, chemistry.chemical_classification, lcsh:R5-920, GPx, glutathione peroxidase, TRAP, tartrate-resistant acid phosphatase, eNOS, endothelial NO synthase, JNK, c-Jun N-terminal kinases, O-GlcNAcylation, O-linked β-N-acetylglucosamine modification, MCP-1, monocyte chemoattractant protein-1, NOX, NADPH oxidases, VEGF, vascular endothelial growth factor, Cell biology, VSMC, vascular smooth muscle cells, Cardiovascular Diseases, medicine.symptom, Signal transduction, lcsh:Medicine (General), Oxidation-Reduction, Intracellular, Signal Transduction, medicine.medical_specialty, Myocytes, Smooth Muscle, ERK, extracellular-regulated kinase, Inflammation, Biology, AKT, protein kinase B, Calcification, 03 medical and health sciences, ROS, reactive oxygen species, RANKL, receptor activator of nuclear factor kappa-B ligand, AAA, abdominal aortic aneurysms, Internal medicine, PKC, protein kinase C, Vascular smooth muscle cells, medicine, Animals, Humans, PI3K/AKT/mTOR pathway, Ang II, angiotensin II, NO, nitric oxide, Reactive oxygen species, SOD, superoxide dismutases, TNF-α, tumor necrosis factor-alpha, Organic Chemistry, Hydrogen peroxide, PTEN, phosphatase and tensin homolog, Mitochondria, Muscle, 030104 developmental biology, Endocrinology, oxLDL, oxidized low-density lipoprotein, lcsh:Biology (General), chemistry, MAPK, mitogen-activated protein kinases, Oxidative stress, mmLDL, minimally oxidized low-density lipoprotein, PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase, Prx, peroxiredoxin, PASMC, pulmonary arterial smooth muscle cells, Reactive Oxygen Species
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المؤلفون: Xavier Roucou, Maxime Gagnon, Martin Savard, Jean-François Jacques, Ghassan Bkaily, Sameh Geha, Fernand Gobeil
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Proteomics, 0301 basic medicine, MAPK/ERK pathway, AltORFs, alternative open reading frames, Receptor, Bradykinin B2, BiFC, bimolecular fluorescence complementation, CDC, coding DNA sequence, Biochemistry, alternative open reading frames (AltORFs), WB, western blot, Bimolecular fluorescence complementation, Protein Isoforms, Receptor, Internalization, media_common, DMEM, Dulbecco's modified Eagle's medium, Chemistry, Endocytosis, 3. Good health, Cell biology, bradykinin (BK), Proteome, Phosphorylation, Signal transduction, BK, bradykinin, signal transduction, IHC, immunohistochemistry, Research Article, G-protein-coupled receptors (GPCRs), MAP Kinase Signaling System, media_common.quotation_subject, PBS, phosphate-buffered saline, Endosomes, Bradykinin, B2 receptor (B2R), DAB, diaminobenzidine, IP3, 1,4,5-inositol trisphosphate, Open Reading Frames, 03 medical and health sciences, FBS, fetal bovine serum, Humans, IF, immunofluorescence, coding DNA sequence (CDS), Molecular Biology, GPCR, G-protein-coupled receptor, G protein-coupled receptor, 030102 biochemistry & molecular biology, Cell Biology, EGFR, epidermal growth factor receptor, Alternative Splicing, HEK293 Cells, 030104 developmental biology, MAPK, mitogen-activated protein kinases, mitogen-activated protein kinases (MAPK), HeLa Cells, KD, kallidin
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