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    المصدر: Rheumatology Science and Practice; Vol 62, No 3 (2024); 319-324 ; Научно-практическая ревматология; Vol 62, No 3 (2024); 319-324 ; 1995-4492 ; 1995-4484

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    Relation: https://rsp.mediar-press.net/rsp/article/view/3580/2380; Minnig MCC, Golightly YM, Nelson AE. Epidemiology of osteoarthritis: Literature update 2022–2023. Curr Opin Rheum. 2024;36(2):108-112. doi:10.1097/BOR.0000000000000985; Fazli F, Farsi A, Ebrahimi Takamjani I, Mansour Sohani S, Yousefi N, Azadinia F. Effect of knee orthosis and kinesio taping on clinical and neuromuscular outcomes in patients with knee osteoarthritis: A randomized clinical trial. Arch Bone Jt Surg. 2023;11(10):625-634. doi:10.22038/ABJS.2023.72208.3362; El Zahraa Wehbi F, Huo W, Amirat Y, Rafei ME, Khalil M, Mohammed S. Active impedance control of a knee-joint orthosis during swing phase. IEEE Int Conf Rehabil Robot. 2017;2017:435- 440. doi:10.1109/ICORR.2017.8009286; Zhang B, Qian H, Wu H, Yang X. Unicompartmental knee arthroplasty versus high tibial osteotomy for medial knee osteoarthritis: A systematic review and meta-analysis. J Orthop Surg (Hong Kong). 2023;31(1):10225536231162829. doi:10.1177/10225536231162829; Sukerkar PA, Doyle Z. Imaging of osteoarthritis of the knee. Radiol Clin North Am. 2022;60(4):605-616. doi:10.1016/j.rcl.2022.03.004; Brophy RH, Fillingham YA. AAOS clinical practice guideline summary: Management of osteoarthritis of the knee (Nonarthroplasty), third edition. J Am Acad Orthop Surg. 2022;30(9):721-729. doi:10.5435/JAAOS-D-21-01233; Fesharaki SA, Farahmand F, Saeedi H, Raeissadat SA, Abdollahy E, Ahmadi A, et al. The effects of knee orthosis with two degrees of freedom joint design on gait and sit-to-stand task in patients with medial knee osteoarthritis. Sultan Qaboos Univ Med J. 2020;20(4):e324-e331. doi:10.18295/squmj.2020.20.04.008; Cudejko T, van der Esch M, van den Noort JC, Rijnhart JJM, van der Leeden M, Roorda LD, et al. Decreased pain and improved dynamic knee instability mediate the beneficial effect of wearing a soft knee brace on activity limitations in patients with knee osteoarthritis. Arthritis Care Res (Hoboken). 2019;71(8):1036-1043. doi:10.1002/acr.23722; Hall M, Starkey S, Hinman RS, Diamond LE, Lenton GK, Knox G, et al. Effect of a valgus brace on medial tibiofemoral joint contact force in knee osteoarthritis with varus malalignment: A within-participant cross-over randomised study with an uncontrolled observational longitudinal follow-up. PLoS One. 2022;17(6):e0257171. doi:10.1371/journal.pone.0257171; Barati K, Kamyab M, Ebrahimi Takamjani I, Parnianpour M, Hosseini N, Bidari S. Evaluating the effect of equipping an unloading knee orthosis with local muscle vibrators on clinical parameters, muscular activation level, and medial contact force in patients with medial knee osteoarthritis: A randomized trial. Prosthet Orthot Int. 2024;48(1):46-54. doi:10.1097/PXR.0000000000000243; Pfeiffer SJ, Valentine JA, Goodwin JS, Nissman DB, Blackburn T, Pietrosimone B. Effects of a knee valgus unloader brace on medial femoral articular cartilage deformation following walking in varusaligned individuals. Knee. 2019;26(5):1067-1072. doi:10.1016/j.knee.2019.06.014; Brand A, Klöpfer-Krämer I, Morgenstern M, Kröger I, Michel B, Thannheimer A, et al. Effects of knee orthosis adjustment on biomechanical performance and clinical outcome in patients with medial knee osteoarthritis. Prosthet Orthot Int. 2017;41(6): 587-594. doi:10.1177/0309364617691623; Konopka J, Finlay A, Eckstein F, Dragoo J. Effects of unloader bracing on clinical outcomes and articular cartilage regeneration following microfracture of isolated chondral defects: A randomized trial. Knee Surg Sports Traumatol Arthrosc. 2021;29(9):2889-2898. doi:10.1007/s00167-020-06228-6; Robert-Lachaine X, Dessery Y, Belzile É, Turmel S, Corbeil P. Three-month efficacy of three knee braces in the treatment of medial knee osteoarthritis in a randomized crossover trial. J Orthop Res. 2020;38(10):2262-2271. doi:10.1002/jor.24634; Hart H, Crossley K, Ackland D, Cowan S, Collins N. Effects of an unloader knee brace on knee-related symptoms and function in people with post-traumatic knee osteoarthritis after anterior cruciate ligament reconstruction. Knee. 2016;23(1):85-90. doi:10.1016/j.knee.2015.05.006; Petersen W, Ellermann A, Henning J, Nehrer S, Rembitzki IV, Fritz J, et al. Non-operative treatment of unicompartmental osteoarthritis of the knee: A prospective randomized trial with two different braces-ankle-foot orthosis versus knee unloader brace. Arch Orthop Trauma Surg. 2019;139(2):155-166. doi:10.1007/s00402-018-3040-8; Beaudreuil J, Bendaya S, Faucher M, Coudeyre E, Ribinik P, Revel M, et al. Clinical practice guidelines for rest orthosis, knee sleeves, and unloading knee braces in knee osteoarthritis. Joint Bone Spine. 2009;76(6):629-636. doi:10.1016/j.jbspin.2009.02.002; https://rsp.mediar-press.net/rsp/article/view/3580

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    المصدر: Rheumatology Science and Practice; Vol 61, No 6 (2023); 758-762 ; Научно-практическая ревматология; Vol 61, No 6 (2023); 758-762 ; 1995-4492 ; 1995-4484

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    Relation: https://rsp.mediar-press.net/rsp/article/view/3477/2337; Offierski CM, MacNab I. Hip-spine syndrome. Spine (Phila Pa 1976). 1983;8(3):316-321. doi:10.1097/00007632-198304000-00014; Iidaka T, Muraki S, Oka H, Kodama R, Tanaka S, Kawaguchi H, et al. Radiographic measurements of the hip joint and their associations with hip pain in Japanese men and women: The Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. Osteoarthritis Cartilage. 2017;25(12):2072-2079. doi:10.1016/j.joca.2017.08.008; Splettstößer A, Khan MF, Zimmermann B, Vogl TJ, Ackermann H, Middendorp M, et al. Correlation of lumbar lateral recess stenosis in magnetic resonance imaging and clinical symptoms. World J Radiol. 2017;9(5):223-229. doi:10.4329/wjr.v9.i5.223; Zhang H, Yu H, Zhang M, Huang Z, Xiang L, Liu X, et al. Selection of spinal surgery and hip replacement sequence in patients with both degenerative scoliosis and hip disease. J Int Med Res. 2020;48(12):300060520959224. doi:10.1177/0300060520959224; Yin TC, Wegner AM, Lu ML, Yang YH, Wang YC, Kung WM, et al. Do orthopedic surgeons or neurosurgeons detect more hip disorders in patients with hip-spine syndrome? A nationwide database study. Brain Sci. 2021;11(4):485. doi:10.3390/brainsci11040485; Кирпичев ИВ, Кирпикова МН. Внесуставной болевой синдром после первичного протезирования тазобедренного сустава. Клиницист. 2016;10(1):17-21 doi:10.17650/1818-8338-2016-10-1-17-21; Hicks GE, Sions JM, Velasco TO. Hip symptoms, physical performance, and health status in older adults with chronic low back pain: A preliminary investigation. Arch Phys Med Rehabil. 2018;99(7):1273-1278. doi:10.1016/j.apmr.2017.10.006; Kuittinen P, Sipola P, Aalto TJ, Määttä S, Parviainen A, Saari T, et al. Correlation of lateral stenosis in MRI with symptoms, walking capacity and EMG findings in patients with surgically confirmed lateral lumbar spinal canal stenosis. BMC Musculoskelet Disord. 2014;15:247. doi:10.1186/1471-2474-15-247; Patel EA, Perloff MD. Radicular pain syndromes: Cervical, lumbar, and spinal stenosis. Semin Neurol. 2018;38(6):634-639. doi:10.1055/s-0038-1673680; Devin CJ, McCullough KA, Morris BJ, Yates AJ, Kang JD. Hip-spine syndrome. J Am Acad Orthop Surg. 2012;20(7): 434-442.; Devin CJ, McCullough KA, Morris BJ, Yates AJ, Kang JD. Hipspine syndrome. J Am Acad Orthop Surg. 2012;20(7):434-442.; Eneqvist T, Bülow E, Nemes S, Brisby H, Garellick G, Fritzell P, et al. Patients with a previous total hip replacement experience less reduction of back pain following lumbar back surgery. J Orthop Res. 2018;36(9):2484-2490. doi:10.1002/jor.24018; Rodkey DL, Lundy AE, Tracey RW, Helgeson MD. Hip-spine syndrome: Which surgery first? Clin Spine Surg. 2022;35(1):1-3. doi:10.1097/BSD.0000000000001028; Лычагин А, Кавалерский Г, Рукин Я, Петров П, Демин С, Черепанов В. Эндопротезирование тазобедренного сустава при сопутствующей патологии позвоночника. Врач. 2017;(5):16-19.; https://rsp.mediar-press.net/rsp/article/view/3477

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    المساهمون: Работа выполнена при финансовой поддержке Министерства науки и высшего образования России (Project № 1021062512064-0).

    المصدر: Modern Rheumatology Journal; Том 18, № 1 (2024); 21-27 ; Современная ревматология; Том 18, № 1 (2024); 21-27 ; 2310-158X ; 1996-7012

    وصف الملف: application/pdf

    Relation: https://mrj.ima-press.net/mrj/article/view/1527/1434; Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006 Mar 18;332(7542):639-42. doi:10.1136/bmj.332.7542.639.; Abramson SB, Attur M. Developments in the scientific understanding of osteoarthritis. Arthritis Res Ther. 2009;11(3):227. doi:10.1186/ar2655. Epub 2009 May 19.; Wylde V, Hewlett S, Learmonth ID, et al. Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants. Pain. 2011 Mar;152(3): 566-572. doi:10.1016/j.pain.2010.11.023. Epub 2011 Jan 15.; Orita S, Ishikawa T, Miyagi M, et al. Painrelated sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain. BMC Musculoskelet Disord. 2011 Jun 16;12:134. doi:10.1186/1471-2474-12-134.; Ordeberg G. Characterization of joint pain in human OA. Novartis Found Symp. 2004: 260:105-15.; Attur MI, Belitskaya-Levy C, Krasnokutsky S, et al. Increased interleukin-1 gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum. 2011 Jul;63(7): 1908-17. doi:10.1002/art.30360.; Vardeh D, Wang D, Costigan M, et al. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest. 2009 Feb;119(2):287-94. doi:10.1172/JCI37098 Epub 2009 Jan 5.; Leichsenring A, Bäcker I, Wendt W, et al. Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. BMC Neurosci. 2008 Aug 12;9:80. doi:10.1186/1471-2202-9-80.; Kawasaki Y, Xu ZZ, Wang X, et al. Distinct roles of matrix metalloproteases in the earlyand late-phase development of neuropathic pain. Nat Med. 2008 Mar;14(3):331-6. doi:10.1038/nm1723. Epub 2008 Feb 10.; Ohtori S, Takahashi K, Moriya H, Myers RR. TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord. Spine (Phila Pa 1976). 2004 May 15;29(10):1082-8. doi:10.1097/00007632-200405150-00006.; Четина ЕВ, Глемба КЕ, Маркова ГА и др. Прогнозирование развития послеоперационной боли у пациентов с поздней стадией остеоартрита коленного сустава по экспрессии генов деградации внеклеточного матрикса, воспаления и апоптоза в крови. Современная ревматология. 2022;16(3):42-49. doi:10.14412/1996-7012-2022-3-42-49; Четина ЕВ, Маркова ГА, Шарапова ЕП. Сахарный диабет 2 типа при остеоартрите: существует ли связь метаболических нарушений с деструкцией суставов и болевым синдромом? Биомедицинская химия. 2019;65(6):441-456.; Sellam J, Berenbaum F. Is osteoarthritis a metabolic disease? Joint Bone Spine. 2013 Dec;80(6):568-73. doi:10.1016/j.jbspin.2013.09.007.; O'Neill LA, Hardie DG. Metabolism of inflammation limited by AMPK and pseudostarvation. Nature. 2013 Jan 17;493(7432): 346-55. doi:10.1038/nature11862.; Yang X, Chen W, Zhao X, et al. Pyruvate Kinase M2 Modulates the Glycolysis of Chondrocyte and Extracellular Matrix in Osteoarthritis. DNA Cell Biol. 2018 Mar;37(3): 271-277. doi:10.1089/dna.2017.4048.; Johnson K, Jung A, Murphy A, et al. Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization. Arthritis Rheum. 2000 Jul;43(7): 1560-70. doi:10.1002/1529-0131(200007)43:73.0.CO;2-S.; Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015 Jan;11(1): 35-44. doi:10.1038/nrrheum.2014.162.; Hosler JP, Ferguson-Miller S, Mills DA. Energy transduction: proton transfer through the respiratory complexes. Annu Rev Biochem. 2006:75:165-87. doi:10.1146/annurev.biochem.75.062003.101730.; Azzu V, Jastroch M, Divakaruni AS, Brand MD. The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):785-91. doi:10.1016/j.bbabio.2010.02.035.; Altman R, Asch E, Bloch D. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Arthritis Rheum. 1986 Aug;29(8):1039-49. doi:10.1002/art.1780290816.; Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis. 1957 Dec;16(4):494-502. doi:10.1136/ard.16.4.494.; Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singap. 1994 Mar;23(2):129-38.; Bellamy N. WOMAC Osteoarthritis Index: A User’s Guide. London: University of Western Ontario; 1995.; Freynhagen R, Baron R, Gockel U, Tolle TR. PainDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin. 2006 Oct;22(10):1911-20. doi:10.1185/030079906X132488.; Bouhassira D, Attal N, Alchaar H, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain. 2005 Mar;114 (1-2):29-36. doi:10.1016/j.pain.2004.12.010. Epub 2005 Jan 26.; Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983 Jun;67(6):361-70. doi:10.1111/j.1600-0447.1983.tb09716.x.; Liu TF, Brown CM, El Gazzar M, et al. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012 Sep;92(3):499-507. doi:10.1189/jlb.0212078.; Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012 Apr;11(2):230-41. doi:10.1016/j.arr.2011.12.005.; Williams NC, O'Neill LAJ. A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation. Front Immunol. 2018 Feb 5; 9:141. doi:10.3389/fimmu.2018.00141.; Galvan-Pena S, O’Neill LAJ. Metabolic reprograming in macrophage polarization. Front Immunol. 2014 Sep 2:5:420. doi:10.3389/fimmu.2014.00420. eCollection 2014.; O’Neill LAJ. Glycolytic reprogramming by TLRs in dendritic cells. Nat Immunol. 2014 Apr;15(4):314-5. doi:10.1038/ni.2852.; McGettrick AF, O’Neill LAJ. How metabolism generates signals during innate immunity and inflammation. J Biol Chem. 2013 Aug 9;288(32):22893-8. doi:10.1074/jbc.R113.486464. Epub 2013 Jun 24.; Mills E, O’Neill LAJ. Succinate: a metabolic signal in inflammation. Trends Cell Biol. 2014 May;24(5):313-20. doi:10.1016/j.tcb. 2013.11.008. Epub 2013 Dec 19.; Altman FP. A metabolic dysfunction in early murine osteoarthritis. Ann Rheum Dis. 1981 Jun;40(3):303-6. doi:10.1136/ard.40.3.303.; Mills EL, Kelly B, Logan A, et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell. 2016 Oct 6;167(2): 457-470.e13. doi:10.1016/j.cell.2016.08.064. Epub 2016 Sep 22.; Moukdar F, Robidoux J, Lyght O, et al. Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein2-deficient mice. J Lipid Res. 2009 Jan; 50(1):59-70. doi:10.1194/jlr.M800273-JLR200.; Nahir AM, Vitis N, Silbermann M. Cellular enzymatic activities in the articular cartilage of osteoarthritic and osteoporotic hip joints of humans: a quantitative cytochemical study. Aging (Milano). 1990 Dec;2(4):363-9. doi:10.1007/BF03323952.; Van Pevenage PM, Birchmier JT, June RK. Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: A systematic review. Semin Arthritis Rheum. 2023 Apr;59:152163. doi:10.1016/j.semarthrit.2023.152163; Lungu E, Vendittoli PA, Desmeules F. Preoperative Determinants of Patient-reported Pain and Physical Function Levels Following Total Knee Arthroplasty: A Systematic Review. Open Orthop J. 2016 Jun 23:10: 213-31. doi:10.2174/1874325001610010213. eCollection 2016.; Li J, Zhang B, Liu WX, et al. Metformin limits osteoarthritis development and progression through activation of AMPK signalling. Ann Rheum Dis. 2020 May;79(5):635-645. doi:10.1136/annrheumdis-2019-216713. Epub 2020 Mar 10.; https://mrj.ima-press.net/mrj/article/view/1527

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    المساهمون: The work was carried out with the financial support of the Ministry of Science and Higher Education of Russia (project № 1021062512064-0). The investigation has not been sponsored, Работа выполнена при финансовой поддержке Министерства науки и высшего образования России (Project № 1021062512064-0). Исследование не имело спонсорской поддержки

    المصدر: Modern Rheumatology Journal; Том 18, № 3 (2024); 63-70 ; Современная ревматология; Том 18, № 3 (2024); 63-70 ; 2310-158X ; 1996-7012

    وصف الملف: application/pdf

    Relation: https://mrj.ima-press.net/mrj/article/view/1590/1473; Sharma L. Osteoarthritis of the Knee. N Engl J Med. 2021 Jan 7;384(1):51-59. doi:10.1056/NEJMcp1903768.; Hunter DJ, March L, Chew M. Osteoarthritis in 2020 and beyond: a lancet commission. Lancet. 2020 Nov 28;396(10264):1711-1712. doi:10.1016/S0140-6736(20)32230-3. Epub 2020 Nov 4.; Turkiewicz A, Petersson IF, Bjork J, et al. Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032. Osteoarthritis Cartilage. 2014 Nov;22(11):1826-32. doi:10.1016/j.joca.2014.07.015. Epub 2014 Jul 30.; Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019 Apr 27;393(10182): 1745-1759. doi:10.1016/S0140-6736(19)30417-9.; Jang S, Lee K, Ju JH. Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. Int J Mol Sci. 2021 Mar 5;22(5):2619. doi:10.3390/ijms22052619.; Kurtz S, Ong K, Lau E, et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007 Apr;89(4):780-5. doi:10.2106/JBJS.F.00222.; Wylde V, Hewlett S, Learmonth ID, Dieppe P. Persistent pain after joint replacement: prevalence, sensory qualities, and post-operative determinants. Pain. 2011 Mar; 152(3):566-572. doi:10.1016/j.pain.2010.11.023. Epub 2011 Jan 15.; Santaguida PL, Hawker GA, Hudak PL, et al. Patient characteristics affecting the prognosis of total hip and knee joint arthroplasty : a systematic review. Can J Surg. 2008 Dec; 51(6):428-36.; Четина ЕВ, Глемба КЕ, Маркова ГА и др. Прогнозирование развития послеоперационной боли у пациентов с поздней стадией остеоартрита коленного сустава по экспрессии генов деградации внеклеточного матрикса, воспаления и апоптоза в крови. Современная ревматология. 2022;16(3):42-49. doi:10.14412/1996-7012-2022-3-42-49; Четина ЕВ, Маркова ГА. Сахарный диабет 2 типа при остеоартрите: существует ли связь метаболических нарушений с деструкцией суставов и болевым синдромом? Биомедицинская химия, 2019;65(6): 441-456.; Четина EB, Маркова ГА, Глемба КЕ, Макаров МА. Ассоциация высокой скорости гликолиза и активности разобщения окисления и фосфорилирования в клетках крови больных на поздней стадии остеоартрита коленного сустава с развитием послеоперационной боли. Современная ревматология. 2024;18(1):21-27. doi:10.14412/1996-7012-2024-1-21-27; Jansen NEJ, Molendijk E, Schiphof D, et al. Metabolic syndrome and the progression of knee osteoarthritis on MRI. Osteoarthritis Cartilage. 2023 May;31(5):647-655. doi:10.1016/j.joca.2023.02.003. Epub 2023 Feb 16.; Niu J, Clancy M, Aliabadi P, et al. Metabolic Syndrome, Its Components, and Knee Osteoarthritis: The Framingham Osteoarthritis Study. Arthritis Rheumatol. 2017 Jun;69(6): 1194-1203. doi:10.1002/art.40087. Epub 2017 May 8.; Chen L, Zheng JJY, Li G, et al. Pathogenesis and clinical management of obesity-related knee osteoarthritis: Impact of mechanical loading. J Orthop Translat. 2020 May 15: 24:66-75. doi:10.1016/j.jot.2020.05.001. eCollection 2020 Sep.; Raud B, Gay C, Guiguet-Auclair C, et al. Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis. Sci Rep. 2020 Feb 27;10(1): 3601. doi:10.1038/s41598-020-60587-1.; Stryer L. Fatty acid metabolism. In: Biochemistry. 4th ed. New York: W.H. Freeman and Company; 1995. P. 603–628.; Zechner R, Strauss JG, Haemmerle G, et al. Lipolysis: pathway under construction. Curr Opin Lipidol. 2005 Jun;16(3):333-40. doi:10.1097/01.mol.0000169354.20395.1c.; Anderson CM. Stahl A. SLC27 fatty acid transport proteins. Mol Aspects Med. 2013 Apr-Jun;34(2-3):516-28. doi:10.1016/j.mam.2012.07.010.; Zaidi N, Swinnen JV, Smans K. ATP-citrate lyase: a key player in cancer metabolism. 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