-
1Academic Journal
المؤلفون: Shuangding Wu, Mathieu Coureuil, Xavier Nassif, Lutz Tautz
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
-
2Academic Journal
المؤلفون: Marek Baranowski, Jiaqian Wu, Ye Na Han, Lester Lambert, Nicholas Cosford, Lutz Tautz
المصدر: Bio-Protocol, Vol 12, Iss 18 (2022)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
-
3Academic Journal
المؤلفون: Jian Xu, Manavi Chatterjee, Tyler D Baguley, Jonathan Brouillette, Pradeep Kurup, Debolina Ghosh, Jean Kanyo, Yang Zhang, Kathleen Seyb, Chimezie Ononenyi, Ethan Foscue, George M Anderson, Jodi Gresack, Gregory D Cuny, Marcie A Glicksman, Paul Greengard, TuKiet T Lam, Lutz Tautz, Angus C Nairn, Jonathan A Ellman, Paul J Lombroso
المصدر: PLoS Biology, Vol 12, Iss 8, p e1001923 (2014)
مصطلحات موضوعية: Biology (General), QH301-705.5
وصف الملف: electronic resource
-
4Academic Journal
المؤلفون: Dongmei Wu, Yuhong Pang, Yuehai Ke, Jianxiu Yu, Zhao He, Lutz Tautz, Tomas Mustelin, Sheng Ding, Ziwei Huang, Gen-Sheng Feng
المصدر: PLoS ONE, Vol 4, Iss 3, p e4914 (2009)
وصف الملف: electronic resource
-
5Academic Journal
المؤلفون: Lester J Lambert, Stefan Grotegut, Maria Celeridad, Palak Gosalia, Laurent JS De Backer, Andrey A Bobkov, Sumeet Salaniwal, Thomas DY Chung, Fu-Yue Zeng, Ian Pass, Paul J Lombroso, Nicholas DP Cosford, Lutz Tautz
المصدر: International Journal of Molecular Sciences; Volume 22; Issue 9; Pages: 4417
مصطلحات موضوعية: protein tyrosine phosphatase, PTPN5, small-molecule screening, neurodegenerative disorders, Alzheimer’s disease
جغرافية الموضوع: agris
وصف الملف: application/pdf
Relation: Biochemistry; https://dx.doi.org/10.3390/ijms22094417
الاتاحة: https://doi.org/10.3390/ijms22094417
-
6
المؤلفون: Dhanya Raveendra-Panickar, Darren Finlay, Fabiana Izidro Layng, Lester J. Lambert, Maria Celeridad, Ming Zhao, Karina Barbosa, Laurent J.S. De Backer, Elizabeth Kwong, Palak Gosalia, Socorro Rodiles, John Holleran, Robert Ardecky, Stefan Grotegut, Steven Olson, John H. Hutchinson, Elena B. Pasquale, Kristiina Vuori, Aniruddha J. Deshpande, Nicholas D.P. Cosford, Lutz Tautz
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: PTS, protein thermal shift, Carcinogenesis, Protein Tyrosine Phosphatase, Non-Receptor Type 11, PTPN11, DMF, N,N-dimethylformamide, DMSO, dimethyl sulfoxide, protein tyrosine phosphatase, ERK, extracellular signal–regulated kinase, Biochemistry, AML, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, EtOAc, ethyl acetate, TBS-T, Tris-buffered saline–Tween-20, anticancer drug, Enzyme Inhibitors, AML, acute myeloid leukemia, STEP, striatal-enriched tyrosine phosphatase, AIC, Akaike's Information Criterion, ESI, electrospray ionization, SH2, Src-homology 2, leukemia, IRS-1, insulin receptor substrate 1, SHP2cat, SHP2 catalytic domain, inhibitor, Leukemia, Myeloid, Acute, Benzamides, RT, room temperature, RTK, receptor tyrosine kinase, PTP, protein tyrosine phosphatase, THF, tetrahydrofuran, Research Article, N-SH2, N-terminal SH2 domain, FGFR, fibroblast growth factor receptor, sgRNA, single-guide RNA, OMFP, 3-O-methylfluorescein phosphate, small molecule, chemical biology, TNBC, triple-negative breast cancer, breast cancer, FBS, fetal bovine serum, SAR, structure–activity relationship, SHP2, Src-homology 2 domain–containing phosphatase 2, Humans, EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, Molecular Biology, RFU, relative fluorescence unit, pTyr, phosphotyrosine, SHP2-WT, full-length SHP2 WT, Cell Biology, Oncogenes, AICc, second-order corrected Akaike’s Information Criterion, SHP2, DIEA, N,N-diisopropylethylamine, p-ERK1/2, phospho-ERK1/2, HOBt, hydroxybenzotriazole
-
7
المؤلفون: Nicole A Bakas, Lester J. Lambert, Nicholas D. P. Cosford, Mitchell Vamos, Huiyu Ren, Apirat Chaikuad, Reuben J. Shaw, Carina Wimer, Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Sonja N. Brun, Allison S. Limpert, Stefan Knapp
المصدر: J Med Chem
مصطلحات موضوعية: Cell Survival, Poly ADP ribose polymerase, Antineoplastic Agents, Apoptosis, Triple Negative Breast Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Protein Serine-Threonine Kinases, Article, Piperazines, Olaparib, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Autophagy, Animals, Autophagy-Related Protein-1 Homolog, Humans, Protein Kinase Inhibitors, Triple-negative breast cancer, Cell Proliferation, Kinase, HEK 293 cells, Intracellular Signaling Peptides and Proteins, Drug Synergism, Mice, Inbred C57BL, HEK293 Cells, Pyrimidines, chemistry, Cell culture, PARP inhibitor, Cancer research, Molecular Medicine, Phthalazines, Female, Drug Screening Assays, Antitumor
-
8
المؤلفون: Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Nicholas D. P. Cosford, Lester J. Lambert, Celeste Romero
المصدر: J Vis Exp
مصطلحات موضوعية: MAPK/ERK pathway, Cell signaling, biology, General Immunology and Microbiology, Drug discovery, T cell, General Chemical Engineering, General Neuroscience, Phosphatase, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Proto-Oncogene Mas, Article, Receptor tyrosine kinase, General Biochemistry, Genetics and Molecular Biology, medicine.anatomical_structure, Cancer research, biology.protein, medicine, Humans, Enzyme Inhibitors, Receptor, Signal Transduction
-
9Academic Journal
المؤلفون: Rachel Henkens, Mohammad Arafa, Michel Moutschen, Mustapha Zeddou, Lutz Tautz, Jacques Boniver, Tomas Mustelin, Souad Rahmouni
المساهمون: The Pennsylvania State University CiteSeerX Archives
المصدر: ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/83/82/BMC_Cancer_2008_May_27_8_147.tar.gz
وصف الملف: application/zip
-
10Academic Journal
المؤلفون: Protein Tyrosine Phosphatase, Ivan Mijakovic, Lucia Musumeci, Lutz Tautz, Robert A. Edwards, Peter Ruhdal Jensen, Tomas Mustelin, Josef Deutscher, Nunzio Bottini, Phosphatase Ywqe, Dina Petranovic
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.7215; http://jb.asm.org/content/187/10/3384.full.pdf
-
11Academic Journal
المؤلفون: Lucia Musumeci, Cristina Bongiorni, Lutz Tautz, Robert A, Andrei Osterman, Marta Perego, Tomas Mustelin, Nunzio Bottini, Robert A. Edwards
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.4208; http://jb.asm.org/content/187/14/4945.full.pdf
-
12
المؤلفون: Eduard Sergienko, Lester J. Lambert, Celeste Romero, Socorro Rodiles, Laurent J.S. De Backer, Douglas J. Sheffler, Elena B. Pasquale, Lutz Tautz, Stefan Grotegut, Nicholas D. P. Cosford, Dhanya Raveendra-Panickar, John Holleran, Maria Celeridad
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cell signaling, Carcinogenesis, Allosteric regulation, Regulator, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Biochemistry, Proto-Oncogene Mas, Cell Line, 03 medical and health sciences, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, 030102 biochemistry & molecular biology, Drug discovery, Chemistry, Methods and Resources, Cell Biology, Immune checkpoint, 030104 developmental biology, Gain of Function Mutation, Cancer research, Protein Binding
-
13
المؤلفون: Stefan Vasile, Torkel Vang, Laurence Delacroix, Rebecca Page, Robert C. Rickert, Benedicte A. Lie, Souad Rahmouni, Tomas Mustelin, Johannes Landskron, Wallace Liu, Kjetil Taskén, Li-Li Yang, Michel L. Tremblay, Lucia Musumeci, Shuangding Wu, Dana M. Francis, Russell Dahl, Lutz Tautz
المصدر: Nature chemical biology
مصطلحات موضوعية: T-Lymphocytes, T cell, Phosphatase, Receptors, Antigen, T-Cell, Down-Regulation, Plasma protein binding, Biology, Lymphocyte Activation, Article, CSK Tyrosine-Protein Kinase, Cell membrane, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, medicine, Humans, Molecular Biology, 030304 developmental biology, 0303 health sciences, Tyrosine-protein kinase CSK, Kinase, Cell Membrane, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Cell Biology, Protein-Tyrosine Kinases, 3. Good health, Cell biology, src-Family Kinases, medicine.anatomical_structure, Biochemistry, Signal transduction, Protein Binding, Signal Transduction, 030215 immunology
-
14
المؤلفون: Xochella Chan, Eduard Sergienko, David A Critton, Ekaterina V. Bobkova, Nicholas D. P. Cosford, Li Yang, Rebecca Page, Paul J. Lombroso, Brock Brown, Shyama Sidique, Justin Rascon, Stefan Vasile, Ying Su, Thomas D.Y. Chung, Russell Dahl, Tomas Mustelin, Hongbin Yuan, Sharon Colayco, Wallace Liu, Lutz Tautz, Jian Xu
المصدر: ACS Chemical Biology. 7:367-377
مصطلحات موضوعية: Models, Molecular, Cell signaling, Cell cycle checkpoint, T-Lymphocytes, p38 mitogen-activated protein kinases, T cell, Phosphatase, Protein tyrosine phosphatase, Biology, p38 Mitogen-Activated Protein Kinases, Biochemistry, Article, Cell Line, Mice, Structure-Activity Relationship, Genetics, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Chemistry, Kinase, Hematopoietic Protein Tyrosine Phosphatase, General Medicine, Molecular biology, Cell biology, Enzyme Activation, Mice, Inbred C57BL, medicine.anatomical_structure, Cancer cell, Molecular Medicine, Protein Tyrosine Phosphatases, Biotechnology
-
15
المؤلفون: Dusica Vidovic, Donald W. Landry, Stephan C. Schürer, Deborah H. Smith, Yuli Xie, Caty Chung, Lutz Tautz, Alison Rinderspacher, Shi Xian Deng
المصدر: J Comput Aided Mol Des
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Phosphatase, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Protein tyrosine phosphatase, Biology, Small molecule, Article, Computer Science Applications, Small Molecule Libraries, Dephosphorylation, Protein structure, Biochemistry, Docking (molecular), Catalytic Domain, Drug Discovery, Humans, Homology modeling, Enzyme Inhibitors, Physical and Theoretical Chemistry, Binding site, Protein Binding
-
16
المؤلفون: Rebecca Page, David A Critton, Lutz Tautz
المصدر: Journal of Molecular Biology. 405:619-629
مصطلحات موضوعية: Anions, Models, Molecular, Stereochemistry, Molecular Sequence Data, Protein Data Bank (RCSB PDB), Protein tyrosine phosphatase, Crystallography, X-Ray, Protein Structure, Secondary, Article, Substrate Specificity, Conserved sequence, Structural Biology, Catalytic Domain, Hydrolase, Coordinated movement, Humans, Amino Acid Sequence, Enzyme Inhibitors, Molecular Biology, Peptide sequence, Conserved Sequence, biology, Chemistry, Active site, Protein Tyrosine Phosphatases, Non-Receptor, Protein Structure, Tertiary, Oxygen, Crystallography, Catalytic cycle, biology.protein
-
17
المؤلفون: Ekaterina V. Bobkova, Wallace Liu, Lutz Tautz, Xochella Chan, David A Critton, Stefan Vasile, Rebecca Page, Tomas Mustelin, Sharon Colayco, Thomas D.Y. Chung, Carlton Gasior, Ying Su, Justin Rascon, Russell Dahl, Eduard Sergienko
المصدر: ACS Medicinal Chemistry Letters. 2:113-118
مصطلحات موضوعية: MAPK/ERK pathway, Kinase, business.industry, p38 mitogen-activated protein kinases, Organic Chemistry, Cell, Protein tyrosine phosphatase, medicine.disease, Biochemistry, Haematopoiesis, Myelogenous, Leukemia, medicine.anatomical_structure, Drug Discovery, Immunology, Cancer research, medicine, business
-
18
المؤلفون: Lutz Tautz, János Rétey
المصدر: European Journal of Organic Chemistry. 2010:1728-1735
مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, Organic Chemistry, Rational design, Convergent synthesis, Article, Virus, Residue (chemistry), Membrane, Enzyme, Biochemistry, In vivo, Physical and Theoretical Chemistry, Myristoylation
-
19
المؤلفون: Massimo Bottini, Robert C. Rickert, Tomas Mustelin, Shuangding Wu, Lutz Tautz
المصدر: ChemMedChem. 4:440-444
مصطلحات موضوعية: Protein Conformation, Stereochemistry, In silico, Mutant, Phosphatase, Tryptophan, Autoimmune Diseases, Fluorescence, Recombinant Proteins, Humans, Algorithms, Catalytic Domain, Benzamides, Drug Design, Protein Binding, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Small Molecule Libraries, Escherichia coli, Crystallography, X-Ray, Ligands, Biochemistry, Article, law.invention, PTPN22, law, Drug Discovery, Settore BIO/10, General Pharmacology, Toxicology and Pharmaceutics, Lymphoid Phosphatase, Pharmacology, Virtual screening, Crystallography, Chemistry, Organic Chemistry, Non-Receptor Type 22, Docking (molecular), X-Ray, Recombinant DNA, Molecular Medicine, Protein Tyrosine Phosphatase
-
20
المؤلفون: Tomas Mustelin, Yutaka Arimura, Lutz Tautz, Scott Williams, Torkel Vang
المصدر: Molecular Immunology. 45:3074-3084
مصطلحات موضوعية: Transcriptional Activation, T-Lymphocytes, T cell, Protein Tyrosine Phosphatase, Non-Receptor Type 12, Immunology, Receptors, Antigen, T-Cell, Down-Regulation, chemical and pharmacologic phenomena, Biology, Lymphocyte Activation, environment and public health, Jurkat cells, Gene Expression Regulation, Enzymologic, Article, CSK Tyrosine-Protein Kinase, Jurkat Cells, Mice, Interleukin 21, Membrane Microdomains, Proto-Oncogene Proteins, medicine, Animals, Humans, Cytotoxic T cell, RNA, Messenger, IL-2 receptor, Phosphorylation, Phosphotyrosine, Molecular Biology, Interleukin 3, Leukemia, ZAP70, CD28, hemic and immune systems, Protein-Tyrosine Kinases, Cell biology, Mice, Inbred C57BL, enzymes and coenzymes (carbohydrates), src-Family Kinases, medicine.anatomical_structure, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Cancer research, Immunologic Memory, Signal Transduction
Full Text Finder