المؤلفون: Sergi Chumillas, Saurabh Loharch, Manuela Beltrán, Mateusz P. Szewczyk, Silvia Bernal, Maria C. Puertas, Javier Martinez-Picado, José Alcamí, Luis M. Bedoya, Vicente Marchán, José Gallego

المصدر: Molecules, Vol 28, Iss 20, p 7031 (2023)

مصطلحات موضوعية: antiviral drug discovery, benfluron, benzo[c]fluorenone, human immunodeficiency virus type 1, Rev, RNA, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/20/7031; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/d18d42978e3647e197f011f1c2e7ef62

المؤلفون: Luis M. Bedoya, Manuela Beltrán, Javier García-Pérez, Patricia Obregón-Calderón, Oliver Callies, Ignacio A. Jímenez, Isabel L. Bazzocchi, José Alcamí

المصدر: Frontiers in Pharmacology, Vol 9 (2018)

مصطلحات موضوعية: HIV-1, antiretrovirals, maturation, triterpenoids, lupanes, promiscuous compounds, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fphar.2018.00358/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/6d2e36e7b57e4efd8a160bf22fc16676

المؤلفون: José Alcamí, Mahabir P. Gupta, Eduardo Muñoz, Esther del Olmo, José L. López-Pérez, Luis M. Bedoya, Rocío Sancho, Dionisio Olmedo, Arturo San Feliciano

المصدر: Molecules, Vol 17, Iss 8, Pp 9245-9257 (2012)

مصطلحات موضوعية: 3-phenylcoumarins, AIDS, Tat protein, NF-κB inhibition, anti-HIV activity, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/17/8/9245; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/2697945e31af44308a3e9241ab97e3b4

المؤلفون: Dionisio A. Olmedo, José Luis López-Pérez, Esther del Olmo, Luis M. Bedoya, Rocío Sancho, José Alcamí, Eduardo Muñoz, Arturo San Feliciano, Mahabir P. Gupta

المصدر: Molecules, Vol 22, Iss 2, p 321 (2017)

مصطلحات موضوعية: neoflavonoids, 4-phenyl-chromen-one, AIDS, Tat protein, NF-κB inhibition, anti-HIV activity, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/22/2/321; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/3cf9aff5d6cd4e8bb0dec164ac0cf7e3

المؤلفون: Lorna Leal, Alberto C. Guardo, Luis M. Bedoya, Cristina Rodríguez de Miguel, Núria Climent, Cristina Rovira, Manuela Beltrán, Josep Llach, Jose Alcamí, Angela D.M. Kashuba, Jose M. Gatell, Montserrat Plana, Felipe García

المصدر: AIDS Research and Human Retroviruses. 39:211-221

مصطلحات موضوعية: Infectious Diseases, Virology, Immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::beb21d00b2fa02a880b909864142f2ad
https://doi.org/10.1089/aid.2021.0232

المؤلفون: Vito A. Taddeo (11466755), Marvin J. Núñez (3225402), Manuela Beltrán (1673608), Ulises G. Castillo (11466758), Jenny Menjívar (11466761), Ignacio A. Jiménez (1673614), José Alcamí (1618549), Luis M. Bedoya (1673611), Isabel L. Bazzocchi (1421170)

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, unusual side chain, uncommon cycloperoxide functionality, physalis nicandroides <, extensive spectroscopic analysis, exocyclic double bond, 2d nmr techniques, distinct structural motifs, whereas nicansteroidins c, four new withanolide, 7 , 50 , inhibit hiv transcription, hiv replication cycle, viral transcription, structural elucidation, 1 replication, values lower, type steroids, provides insight, preclinical studies, named nicansteroidins, main target, lactone system

Relation: https://figshare.com/articles/journal_contribution/Withanolide-Type_Steroids_from_i_Physalis_nicandroides_i_Inhibit_HIV_Transcription/16661075

الاتاحة: https://doi.org/10.1021/acs.jnatprod.1c00637.s001

المؤلفون: Cristina Medina-Trillo, Daniel M. Sedgwick, Lidia Herrera, Manuela Beltrán, Ángela Moreno, Pablo Barrio, Luis. M. Bedoya, José Alcamí, Santos Fustero, José Gallego

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

مصطلحات موضوعية: Medicine, Science

Relation: https://doi.org/10.1038/s41598-020-64120-2; https://doaj.org/toc/2045-2322; https://doaj.org/article/bc755e05db704dcfa42be8ed46552b46

الاتاحة: https://doi.org/10.1038/s41598-020-64120-2
https://doaj.org/article/bc755e05db704dcfa42be8ed46552b46

المؤلفون: Luis M. Bedoya, Ignacio A. Jiménez, Marvin J. Núñez, Ulises G. Castillo, Vito Alessandro Taddeo, José Alcamí, Jenny Menjívar, Manuela Beltrán, Isabel L. Bazzocchi

المصدر: Journal of Natural Products. 84:2717-2726

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Double bond, Organic Chemistry, Human immunodeficiency virus (HIV), Pharmaceutical Science, medicine.disease_cause, Analytical Chemistry, Cellular mechanism, chemistry.chemical_compound, Complementary and alternative medicine, Withanolide, chemistry, Physalis nicandroides, Biochemistry, Transcription (biology), Drug Discovery, medicine, Molecular Medicine, Structural motif, Two-dimensional nuclear magnetic resonance spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::de7f0c27c7b8cc0fd254607b6a79df55
https://doi.org/10.1021/acs.jnatprod.1c00637

المؤلفون: Elena González Burgos, María S. Fernández-Alfonso, Luis M. Bedoya, Aránzazu Bocanegra, Luis García-García, Alba Garcimartín, José A. Guerra, Francisca Gómez-Oliver, Marina Hernández-Martín, Javier Manzano, José J. Merino, Isabel Ureña-Vacas, Ana García-Aguilar

المصدر: INTED2022 Proceedings.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::17cf1c321a6cfc4e78fc6156d136d18e
https://doi.org/10.21125/inted.2022.0110

المؤلفون: Vito A, Taddeo, Marvin J, Núñez, Manuela, Beltrán, Ulises G, Castillo, Jenny, Menjívar, Ignacio A, Jiménez, José, Alcamí, Luis M, Bedoya, Isabel L, Bazzocchi

المصدر: Journal of natural products. 84(10)

مصطلحات موضوعية: Molecular Structure, Physalis, Anti-HIV Agents, El Salvador, HIV-1, Humans, Plant Components, Aerial, Virus Replication, Withanolides, Cell Line

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::209200ec5b419fb677f7f51b13dedd36
https://pubmed.ncbi.nlm.nih.gov/34549952

المؤلفون: R. Jiménez, Luis M. Bedoya, J.L. Fernández-García, Julien Paolini, Manuela Beltrán, Louis-Félix Nothias, José Alcamí, H.E. De la Torre-Tarazona, L. Román, S. Camarero, Marc Litaudon, P. Bueno, Xavier Cachet

المساهمون: Complutense University of Madrid (España), Instituto de Salud Carlos III, Red de Investigación Cooperativa en Investigación en Sida (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Agence Nationale de la Recherche (Francia), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Sciences pour l'environnement (SPE), Centre National de la Recherche Scientifique (CNRS)-Université Pascal Paoli (UPP), Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)

المصدر: Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2020, 177, pp.113937. ⟨10.1016/j.bcp.2020.113937⟩

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, 0301 basic medicine, Anti-HIV Agents, Cell Survival, [SDV]Life Sciences [q-bio], HIV Infections, CCR5 receptor antagonist, Pharmacology, Phorbol esters, Biochemistry, Jurkat Cells, 03 medical and health sciences, Transactivation, chemistry.chemical_compound, 0302 clinical medicine, Protein kinase C, Phorbol Esters, medicine, Humans, Bryostatin, Prostratin, Vorinostat, Latency reversing agents, Protein Kinase C, Mitogen-Activated Protein Kinase Kinases, Chemistry, Drug Synergism, Bryostatins, Virus Latency, 3. Good health, 030104 developmental biology, Mechanism of action, 030220 oncology & carcinogenesis, Phorbol, HIV-1, Virus Activation, medicine.symptom, Viral reactivation, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a5cdca517c017a4c08675b4942afa5
https://hdl.handle.net/20.500.12105/11339

المؤلفون: Raúl Cazorla-Luna, Araceli Martín-Illana, Roberto Ruiz-Caro, María Dolores Veiga, Luis M. Bedoya, Fernando Notario-Pérez

المصدر: European Journal of Pharmaceutical Sciences. 127:38-51

مصطلحات موضوعية: Drug, Sexual transmission, Bioadhesive, media_common.quotation_subject, Population, Polysorbates, Pharmaceutical Science, HIV Infections, 02 engineering and technology, Antiviral Agents, Galactans, 030226 pharmacology & pharmacy, Cell Line, Mannans, 03 medical and health sciences, 0302 clinical medicine, Plant Gums, medicine, Humans, Food science, Tenofovir, education, Hexoses, media_common, education.field_of_study, Mucous Membrane, Guar gum, Chemistry, Adhesiveness, Hydrogels, 021001 nanoscience & nanotechnology, Controlled release, Drug Liberation, Delayed-Action Preparations, Vagina, Toxicity, Female, Swelling, medicine.symptom, 0210 nano-technology, Sesame Oil

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd4d4f158ba184f040371b75a36e790
https://doi.org/10.1016/j.ejps.2018.10.013

المؤلفون: Mar Iacute A-Dolores Veiga, Fernando Notario-Pérez, Raúl Cazorla-Luna, Luis M. Bedoya, Araceli Martín-Illana, Roberto Ruiz-Caro, Aitana Tamayo, Juan Rubio

المساهمون: Ministerio de Economía y Competitividad (España)

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Sexual transmission, Polymers and Plastics, Tenofovir, Bioengineering, In Vitro/Ex Vivo Characterization, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Virus, Biomaterials, Biopolymers, parasitic diseases, Materials Chemistry, Medicine, Vaginal Mucoadhesive, Women, Vaginal Sustained Release, Human Immunodeficiency Virus (HIV), business.industry, Bilayer, Prevention, 021001 nanoscience & nanotechnology, Virology, Controlled release, In vitro, 0104 chemical sciences, Ethylcellulose, 0210 nano-technology, business, Sexual contact, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df391da7e7368b16bc6c1ad74bcc0b4
http://hdl.handle.net/10261/235474

المؤلفون: Dionisio Olmedo, Rocío Sancho, Luis M. Bedoya, José L. López-pérez, Esther Del Olmo, Eduardo Muñoz, José Alcamí, Mahabir P. Gupta, Arturo San Feliciano

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://www.mdpi.com/1420-3049/17/8/9245/pdf/.

مصطلحات موضوعية: 3-phenylcoumarins, AIDS, Tat protein, NF-κB inhibition, anti-HIV activity OPEN ACCESS

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.670.4391; http://www.mdpi.com/1420-3049/17/8/9245/pdf/

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.670.4391
http://www.mdpi.com/1420-3049/17/8/9245/pdf/

المؤلفون: José M. Gallego, Luis M. Bedoya, Ángela Moreno, Manuela Beltrán, Silvia Prado, José Alcamí

المصدر: Biochemical Pharmacology. 156:68-77

مصطلحات موضوعية: 0301 basic medicine, viruses, 030106 microbiology, Drug Evaluation, Preclinical, Response Elements, Antiviral Agents, Biochemistry, Virus, Cell Line, Structure-Activity Relationship, 03 medical and health sciences, Transcription (biology), Humans, Binding site, Nuclear export signal, Ribonucleoprotein, Pharmacology, Molecular Structure, Chemistry, RNA, rev Gene Products, Human Immunodeficiency Virus, Small molecule, Cell biology, 030104 developmental biology, HIV-1, RNA, Viral, Biogenesis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9e4b2c02d13c238931824f59fd2d6a
https://doi.org/10.1016/j.bcp.2018.07.040

المؤلفون: Santos Fustero, Ángela Moreno, Daniel M. Sedgwick, Manuela Beltrán, Pablo Barrio, Lidia Herrera, Cristina Medina-Trillo, Luis M. Bedoya, José M. Gallego, José Alcamí

المساهمون: Ministerio de Economía y Competitividad (España), Generalitat Valenciana, Red Temática Cooperativa de Investigación en Sida (España)

المصدر: Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, alpha-Helical, Anti-HIV Agents, viruses, Science, Mechanism of action, 010402 general chemistry, 01 natural sciences, Virus, Article, Cell Line, 03 medical and health sciences, Protein structure, Transcription (biology), Target identification, Terphenyl Compounds, Humans, Regulation of gene expression, Multidisciplinary, Retrovirus, Chemistry, Drug discovery, Small molecules, RNA, rev Gene Products, Human Immunodeficiency Virus, Antivirals, 0104 chemical sciences, 030104 developmental biology, Viral replication, Biochemistry, Cell culture, Nucleic acid, HIV-1, Nucleic Acid Conformation, RNA, Viral, Medicine, HIV infections

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383dc9676023845ea35a9bb7829f1031
http://hdl.handle.net/20.500.12105/9917

المؤلفون: Luis M. Bedoya, Roberto Ruiz-Caro, Raúl Cazorla-Luna, Araceli Martín-Illana, Aitana Tamayo, María-Dolores Veiga, Fernando Notario-Pérez, Juan Rubio

المساهمون: Ministerio de Economía y Competitividad (España), Bedoya, Luis-Miguel, Tamayo Hernando, Aitana, Bedoya, Luis-Miguel [0000-0001-6249-6847], Tamayo Hernando, Aitana [0000-0002-9828-3461]

المصدر: Marine Drugs
Volume 18
Issue 1
Marine Drugs, Vol 18, Iss 1, p 44 (2020)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Digital.CSIC. Repositorio Institucional del CSIC

مصطلحات موضوعية: mucoadhesive film, Scanning electron microscope, Pharmaceutical Science, HIV Infections, 02 engineering and technology, Tartrate, 030226 pharmacology & pharmacy, layer-by-layer film, Chitosan, chemistry.chemical_compound, 0302 clinical medicine, Drug Delivery Systems, Drug Discovery, Texture (crystalline), Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, Biología molecular, chitosan tartrate, Mucoadhesive film, vaginal preexposure prophylaxis, Chitosan lactate, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, Polyelectrolyte, Chitosan citrate, Vagina, Female, Swelling, medicine.symptom, 0210 nano-technology, Eudragit® S100, Tenofovir controlled release, Anti-HIV Agents, Farmacología, macromolecular substances, Enfermedades infecciosas, PH responsive release, Chitosan tartrate, Article, pH responsive release, 03 medical and health sciences, chitosan citrate, Polymethacrylic Acids, medicine, Mucoadhesion, Animals, Humans, Layer-by-layer film, chitosan lactate, Tenofovir, Mucous Membrane, Layer by layer, technology, industry, and agriculture, Vaginal preexposure prophylaxis, equipment and supplies, carbohydrates (lipids), HIV sexual transmission, Administration, Intravaginal, chemistry, lcsh:Biology (General), Cattle, Nuclear chemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b504a581b811af20ad6ccf27b844a52b
http://europepmc.org/articles/PMC7024361

المؤلفون: Roberto Ruiz-Caro, Juan Rubio, Raúl Cazorla-Luna, Araceli Martín-Illana, Aitana Tamayo, Luis M. Bedoya, Fernando Notario-Pérez, María Dolores Veiga-Ochoa

المساهمون: Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), European Commission

المصدر: Digital.CSIC. Repositorio Institucional del CSIC
instname
Materials
Volume 13
Issue 16
Materials, Vol 13, Iss 3494, p 3494 (2020)

مصطلحات موضوعية: Sexual transmission, Tenofovir, Kinetics, Sol-gel chemistry, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, lcsh:Technology, Article, chemistry.chemical_compound, Smart material, Monolayer, medicine, Molecule, General Materials Science, lcsh:Microscopy, drug release, lcsh:QC120-168.85, chemistry.chemical_classification, lcsh:QH201-278.5, hybrid, lcsh:T, HIV, Polymer, smart material, sol-gel chemistry, Drug release, 021001 nanoscience & nanotechnology, Silane, Hybrid, 0104 chemical sciences, chemistry, Chemical engineering, lcsh:TA1-2040, lcsh:Descriptive and experimental mechanics, lcsh:Electrical engineering. Electronics. Nuclear engineering, 0210 nano-technology, Mesoporous material, lcsh:Engineering (General). Civil engineering (General), lcsh:TK1-9971, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44042bc2fadd0865ec0fd3d2fa5b2f80
http://hdl.handle.net/10261/218474

المؤلفون: Fernando Notario-Pérez, Roberto Ruiz-Caro, Raúl Cazorla-Luna, Juan Rubio, Araceli Martín-Illana, Luis M. Bedoya, María Dolores Veiga, Aitana Tamayo

المصدر: International Journal of Pharmaceutics. 602:120665

مصطلحات موضوعية: Sexual transmission, food.ingredient, Polymers, Pharmaceutical Science, HIV Infections, 02 engineering and technology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, food, Polymethacrylic Acids, Mucoadhesion, medicine, Humans, Karaya Gum, Food science, Tenofovir, Chemistry, Vaginal microbicide, Tragacanth, 021001 nanoscience & nanotechnology, Controlled release, Administration, Intravaginal, Gum arabic, Female, Swelling, medicine.symptom, 0210 nano-technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc74bfe4afba8c51686ffb195f389c35
https://doi.org/10.1016/j.ijpharm.2021.120665

المؤلفون: Laura Capa, José Alcamí, David Auñón, Nuria González, Mayte Pérez-Olmeda, Javier García-Pérez, Patricia Obregón-Calderón, Manuela Beltrán, Humberto E. de la Torre, Luis M. Bedoya, Eduardo Gómez-Acebo

المساهمون: Unión Europea. Comisión Europea. 7 Programa Marco, Instituto de Salud Carlos III

المصدر: AIDS (London, England)
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, HIV prevention, Immunology, Integrase inhibitor, Microbial Sensitivity Tests, Emtricitabine, Nucleoside Reverse Transcriptase Inhibitor, 03 medical and health sciences, 0302 clinical medicine, Basic Science, Anti-Infective Agents, Microbicide, medicine, Animals, Humans, Immunology and Allergy, Human Activities, 030212 general & internal medicine, antiretrovirals, Cells, Cultured, Protease, Chemistry, HIV, virus diseases, Lamivudine, Drug Synergism, Phenylethyl Alcohol, Virology, Reverse transcriptase, 3. Good health, 030104 developmental biology, Infectious Diseases, microbicides, Toxicity, HIV-1, Leukocytes, Mononuclear, Female, Rabbits, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2269fb7275606f43c12e0ba5fa7abd7
https://doi.org/10.1097/qad.0000000000001283