المؤلفون: Md Toufiqur Rahman (9655855), Ann M. Decker (1322412), Lucas Laudermilk (9655858), Rangan Maitra (1893976), Weiya Ma (1330083), Sami Ben Hamida (11335270), Emmanuel Darcq (741574), Brigitte L. Kieffer (9655861), Chunyang Jin (1327155)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Amide Bioisosteres, striatal-associated disorders, amide bioisosteric replacement, brain-penetrant GPR 88 agonist 53, cAMP EC 50, receptor GPR 88, amine functionality, chemistry efforts, GPR 88 Agonists, 2- AMPP-derived GPR 88 agonists, study GPR 88 functions

Relation: https://figshare.com/articles/journal_contribution/Evaluation_of_Amide_Bioisosteres_Leading_to_1_2_3-Triazole_Containing_Compounds_as_GPR88_Agonists_Design_Synthesis_and_Structure_Activity_Relationship_Studies/16444072

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01075.s002

المؤلفون: Nayaab Khan (10275497), Lucas Laudermilk (9655858), Jalen Ware (10275500), Taylor Rosa (3864517), Kelly Mathews (3864520), Elaine Gay (3864511), George Amato (257188), Rangan Maitra (1893976)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Neuroscience, Physiology, Pharmacology, Chemical Sciences not elsewhere classified, β- cell function, CB 1R antagonist SR 141716A, type 1 cannabinoid receptor, Hepatic triglyceride content, RTI, MetS, CB 1 antagonists, Mice Metabolic syndrome, NASH, CB 1 Receptor Antagonist, brain exposure, NAFLD, CNS-sparing CB 1R antagonists

Relation: https://figshare.com/articles/journal_contribution/Peripherally_Selective_CB1_Receptor_Antagonist_Improves_Symptoms_of_Metabolic_Syndrome_in_Mice/14185649

الاتاحة: https://doi.org/10.1021/acsptsci.0c00213.s001

المؤلفون: Sanju Narayanan (2449750), Shaobin Wang (1554541), Vineetha Vasukuttan (5202884), Ravi Kumar Vyas Devambatla (10291090), Donghua Dai (10291093), Chunyang Jin (1327155), Rodney Snyder (1331475), Lucas Laudermilk (9655858), Scott P. Runyon (1315095), Rangan Maitra (1893976)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Compound 13, weight loss, apelinergic system, liver microsome stability, compound, liver steatosis, novel pyrazole-based agonist scaffold, pharmacokinetic profile, agonist potency, ADME properties, glucose utilization, apelin receptor, Metabolic Syndrome, disease-associated biomarkers, vivo investigation, cAMPi EC 50, apelin peptides, diet-induced obesity, mouse model, DIO, syndrome, small-molecule agonist, Systematic modification

Relation: https://figshare.com/articles/journal_contribution/Pyrazole_Agonist_of_the_Apelin_Receptor_Improves_Symptoms_of_Metabolic_Syndrome_in_Mice/14200009

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01448.s001

المؤلفون: Md Toufiqur Rahman (9655855), Ann M. Decker (1322412), Lucas Laudermilk (9655858), Rangan Maitra (1893976), Weiya Ma (1330083), Sami Ben Hamida (11335270), Emmanuel Darcq (741574), Brigitte L. Kieffer (9655861), Chunyang Jin (1327155)

مصطلحات موضوعية: Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Amide Bioisosteres, striatal-associated disorders, amide bioisosteric replacement, brain-penetrant GPR 88 agonist 53, cAMP EC 50, receptor GPR 88, amine functionality, chemistry efforts, GPR 88 Agonists, 2- AMPP-derived GPR 88 agonists, study GPR 88 functions

Relation: https://figshare.com/articles/dataset/Evaluation_of_Amide_Bioisosteres_Leading_to_1_2_3-Triazole_Containing_Compounds_as_GPR88_Agonists_Design_Synthesis_and_Structure_Activity_Relationship_Studies/16444069

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01075.s001