المؤلفون: Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Farmer, Pierre, DuMouchel, William, Shoichet, Brian K, Urban, Laszlo

مصطلحات موضوعية: 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Adverse Drug Reaction Reporting Systems, Humans, Pharmacological Phenomena, Product Surveillance, Postmarketing, United States, United States Food and Drug Administration, FAERS, adverse drug reactions, big data, data analysis, human, human biology, medicine, Biochemistry and Cell Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4jq232kd
https://escholarship.org/content/qt4jq232kd/qt4jq232kd.pdf

المؤلفون: Gregori-Puigjané, Elisabet, Setola, Vincent, Hert, Jérôme, Crews, Brenda A, Irwin, John J, Lounkine, Eugen, Marnett, Lawrence, Roth, Bryan L, Shoichet, Brian K

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 109(28)

مصطلحات موضوعية: Theory Of Computation, Information and Computing Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Computational Biology, Databases, Factual, Dose-Response Relationship, Drug, Drug Approval, Drug Delivery Systems, Humans, Kinetics, Ligands, Molecular Probes, Pharmaceutical Preparations, Software, Technology, Pharmaceutical, United States, United States Food and Drug Administration, ortho-Aminobenzoates, chemical tools, drug target identification, polypharmacology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/19v6b4h0

المؤلفون: Whitebread, Steven, Mikhailov, Dmitri, Hamon, Jacques, Jenkins, Jeremy, Lavan, Paul, Weber, Eckhard, Doak, Allison, Côté, Serge, Lounkine, Eugen, Urban, Laszlo, Keiser, Michael, Shoichet, Brian

المصدر: Nature. 486(7403)

مصطلحات موضوعية: Blood Platelets, Chlorotrianisene, Cyclooxygenase 1, Cyclooxygenase Inhibitors, Databases, Factual, Drug Evaluation, Preclinical, Drug-Related Side Effects and Adverse Reactions, Estrogens, Non-Steroidal, Forecasting, Humans, Models, Biological, Molecular Targeted Therapy, Platelet Aggregation, Reproducibility of Results, Substrate Specificity, Toxicity Tests

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8br0q6n2

المؤلفون: Renner, Steffen, Bergsdorf, Christian, Bouhelal, Rochdi, Koziczak-Holbro, Magdalena, Amati, Andrea Marco, Techer-Etienne, Valerie, Flotte, Ludivine, Reymann, Nicole, Kapur, Karen, Hoersch, Sebastian, Oakeley, Edward James, Schuffenhauer, Ansgar, Gubler, Hanspeter, Lounkine, Eugen, Farmer, Pierre

المصدر: Scientific Reports ; volume 10, issue 1 ; ISSN 2045-2322

الاتاحة: http://dx.doi.org/10.1038/s41598-020-66533-5
https://www.nature.com/articles/s41598-020-66533-5.pdf
https://www.nature.com/articles/s41598-020-66533-5

المؤلفون: Moret, Nienke, Clark, Nicholas A., Hafner, Marc, Wang, Yuan, Lounkine, Eugen, Medvedovic, Mario, Wang, Jinhua, Gray, Nathanael, Jenkins, Jeremy, Sorger, Peter K.

المساهمون: NIH, Novartis Institutes for BioMedical Research

المصدر: Cell Chemical Biology ; volume 26, issue 5, page 765-777.e3 ; ISSN 2451-9456

الاتاحة: http://dx.doi.org/10.1016/j.chembiol.2019.02.018
https://api.elsevier.com/content/article/PII:S245194561930073X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S245194561930073X?httpAccept=text/plain

المؤلفون: Papillon, Julien P. N., Nakajima, Katsumasa, Adair, Christopher D., Hempel, Jonathan, Jouk, Andriana O., Karki, Rajeshri G., Mathieu, Simon, Möbitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Susan E., Hurtado, Felipe Kellermann, Chenail, Gregg, Bhang, Hyo-Eun C., Bric, Anka, Xiang, Kay, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily A., Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Q. Kimberley, Xie, Xiaoling, Zhu, Xiaoping, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine, Jagani, Zainab

المصدر: Journal of Medicinal Chemistry ; volume 61, issue 22, page 10155-10172 ; ISSN 0022-2623 1520-4804

الاتاحة: https://doi.org/10.1021/acs.jmedchem.8b01318
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01318

المؤلفون: Lounkine, Eugen

الاتاحة: http://data.europeana.eu/aggregation/europeana/2048441/item_JLILLW2VY5HZNF4EZFLIAM6XKW2HD4I7

المؤلفون: Lounkine, Eugen.

الاتاحة: http://nbn-resolving.de/urn:nbn:de:hbz:5N-19725
http://hss.ulb.uni-bonn.de/2009/1972/1972.pdf
http://hss.ulb.uni-bonn.de/2009/1972/1972.htm
http://d-nb.info/1000659178/34

المؤلفون: Urban, Laszlo, Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Jenkins, Jeremy L., Hamon, Jacques, Fekete, Alexander, Muller, Patrick Y.

المصدر: Toxicol. Res. ; volume 3, issue 6, page 433-444 ; ISSN 2045-452X 2045-4538

الاتاحة: https://doi.org/10.1039/c4tx00077c
http://pubs.rsc.org/en/content/articlepdf/2014/TX/C4TX00077C

المؤلفون: Lounkine, Eugen, Bajorath, Jürgen

المصدر: Journal of Cheminformatics ; volume 2, issue S1 ; ISSN 1758-2946

الاتاحة: http://dx.doi.org/10.1186/1758-2946-2-s1-p21
https://link.springer.com/content/pdf/10.1186/1758-2946-2-S1-P21.pdf
https://link.springer.com/article/10.1186/1758-2946-2-S1-P21/fulltext.html

المؤلفون: Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Hanneke, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren, Pelliccioli, Anna, Schwarze, Manuel, Shultz, Michael, Stiefl, Nikolaus, Baeschlin, Daniel

Relation: Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Hanneke, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren, Pelliccioli, Anna, Schwarze, Manuel, Shultz, Michael, Stiefl, Nikolaus and Baeschlin, Daniel (2020) Evolution of Novartis' Small Molecule Screening Deck Design. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الاتاحة: https://oak.novartis.com/43061/
https://doi.org/10.1021/acs.jmedchem.0c01332

المؤلفون: Santa Maria, John, Gleim, Scott, Lounkine, Eugen, Jenkins, Jeremy

الاتاحة: http://dx.doi.org/10.26434/chemrxiv.13151303.v1
https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c751bd0f50dbbbbb397810/original/document-embedding-centroids-new-and-versatile-semantic-descriptors-for-compounds.pdf

المؤلفون: Papillon, Julien, Nakajima, Katsumasa, Hempel, Jonathan, Karki, Rajeshri, Moebitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Sue, Kellermann Hurtado, Felipe, Chenail, Gregg, Bhang, Hyo-Eun, Xiang, Xiaoqin, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily, Adair, Chris, Jouk, Andriana, Li, Jingzhou, Bric, Anka, Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Qing, Xie, Xiaoling, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine, Jagani, Zainab

Relation: Papillon, Julien, Nakajima, Katsumasa, Hempel, Jonathan, Karki, Rajeshri, Moebitz, Henrik, Ntaganda, Rukundo, Smith, Troy, Visser, Michael, Hill, Sue, Kellermann Hurtado, Felipe, Chenail, Gregg, Bhang, Hyo-Eun, Xiang, Xiaoqin, Bushold, Geoffrey, Gilbert, Tamara, Vattay, Anthony, Dooley, Julie, Costa, Emily, Adair, Chris, Jouk, Andriana, Li, Jingzhou, Bric, Anka, Park, Isabel, Li, Ailing, Farley, David, Lounkine, Eugen, Yue, Qing, Xie, Xiaoling, Kulathila, Raviraj, King, Daniel, Hu, Tiancen, Vulic, Katarina, Cantwell, John, Luu, Catherine and Jagani, Zainab (2018) Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. Journal of Medicinal Chemistry, 61 (22). pp. 10155-10172. ISSN 15204804

الاتاحة: https://oak.novartis.com/37141/
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.8b01318?mi=aayia761&af=R&AllFiel
https://doi.org/10.1021/acs.jmedchem.8b01318

المؤلفون: Moret, Nienke, Clark, Nicholas A., Hafner, Marc, Wang, Yuan, Lounkine, Eugen, Medvedovic, Mario, Wang, Jinhua, Gray, Nathanael, Jenkins, Jeremy, Sorger, Peter

المصدر: SSRN Electronic Journal ; ISSN 1556-5068

الاتاحة: http://dx.doi.org/10.2139/ssrn.3219258

المؤلفون: Lounkine, Eugen, Camargo, Miguel L.

المصدر: ACS Symposium Series ; Frontiers in Molecular Design and Chemical Information Science - Herman Skolnik Award Symposium 2015: Jürgen Bajorath ; page 331-343 ; ISSN 0097-6156 1947-5918 ; ISBN 9780841231412 9780841231405

الاتاحة: http://dx.doi.org/10.1021/bk-2016-1222.ch015
https://pubs.acs.org/doi/pdf/10.1021/bk-2016-1222.ch015

المؤلفون: Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Chen, Shanni, Shoichet, Brian, Urban, Laszlo, DuMouchel, William

مصطلحات موضوعية: psy, info

Relation: https://oak.novartis.com/33803/

الاتاحة: https://oak.novartis.com/33803/

المؤلفون: Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Farmer, Pierre, DuMouchel, William, Shoichet, Brian K, Urban, Laszlo

الاتاحة: http://dx.doi.org/10.7554/elife.25818.018

المؤلفون: Stumpfe, Dagmar, Lounkine, Eugen, Bajorath, Jürgen

المصدر: Methods in Molecular Biology ; Chemoinformatics and Computational Chemical Biology ; page 503-515 ; ISSN 1064-3745 1940-6029 ; ISBN 9781607618386 9781607618393

الاتاحة: http://dx.doi.org/10.1007/978-1-60761-839-3_20
http://link.springer.com/content/pdf/10.1007/978-1-60761-839-3_20

المؤلفون: Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Shoichet, Brian, Urban, Laszlo, Chen, Shanni

مصطلحات موضوعية: manag, demo

Relation: https://oak.novartis.com/23178/

الاتاحة: https://oak.novartis.com/23178/

المؤلفون: Maciejewski, Mateusz, Wassermann, Anne, Glick, Meir, Lounkine, Eugen

Relation: Maciejewski, Mateusz, Wassermann, Anne, Glick, Meir and Lounkine, Eugen (2015) Experimental Design Strategy: Weak Reinforcement Leads to Increased Hit Rates and Enhanced Chemical Diversity. Journal of Chemical Information and Modelling, 55 (5). pp. 956-962. ISSN 1549-95961549-960X

الاتاحة: https://oak.novartis.com/24901/
https://doi.org/10.1021/acs.jcim.5b00054