المؤلفون: Marjolein Soethoudt, Uwe Grether, Jürgen Fingerle, Travis W. Grim, Filomena Fezza, Luciano de Petrocellis, Christoph Ullmer, Benno Rothenhäusler, Camille Perret, Noortje van Gils, David Finlay, Christa MacDonald, Andrea Chicca, Marianela Dalghi Gens, Jordyn Stuart, Henk de Vries, Nicolina Mastrangelo, Lizi Xia, Georgios Alachouzos, Marc P. Baggelaar, Andrea Martella, Elliot D. Mock, Hui Deng, Laura H. Heitman, Mark Connor, Vincenzo Di Marzo, Jürg Gertsch, Aron H. Lichtman, Mauro Maccarrone, Pal Pacher, Michelle Glass, Mario van der Stelt

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/d8fb448abc4444e3a10089f8b36e11e6

المؤلفون: Jara, Bouma, Marjolein, Soethoudt, Noortje, van Gils, Lizi, Xia, Mario, van der Stelt, Laura H, Heitman

المصدر: Methods in molecular biology (Clifton, N.J.). 2576:189-199

مصطلحات موضوعية: beta-Arrestin 1, GTP-Binding Proteins, Humans, Ligands, Receptors, Cannabinoid, beta-Galactosidase, beta-Arrestins, Receptors, G-Protein-Coupled

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4dfdeb7859c910a4d16bcd2d5daf9df7
https://doi.org/10.1007/978-1-0716-2728-0_15

المؤلفون: Stephen J. Hill, Lizi Xia, Monica Bouzo-Lorenzo, Adriaan P. IJzerman, Laura H. Heitman, Leigh A. Stoddart, Stephen J. Briddon

المصدر: Purinergic Signalling
Purinergic Signalling, 15(2), 139-153

مصطلحات موضوعية: 0301 basic medicine, Kinetics, Adenosine A3 Receptor Antagonists, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Fluorescence Resonance Energy Transfer, Humans, Adenosine A3 receptor, Receptor, Molecular Biology, Chemistry, Residence time, NanoBRET, Ligand binding assay, Receptor, Adenosine A3, Antagonist, Cell Biology, Fluorescence, Receptor–ligand kinetics, 3. Good health, HEK293 Cells, 030104 developmental biology, Binding kinetics, Luminescent Measurements, Biophysics, Original Article, Adenosine A(3) receptor, Lead compound, 030217 neurology & neurosurgery

وصف الملف: application/pdf; PDF

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731cd68b611f897a31af58900a44ab61
https://doi.org/10.1007/s11302-019-09650-9

المؤلفون: Robert J. Sheppard, Peter Schell, Eelke B. Lenselink, Leifeng Cheng, Laura H. Heitman, Adriaan P. IJzerman, Henk de Vries, Maria J. Petersson, Roine I. Olsson, Sara Pahlén, Michael J. Waring, Lizi Xia, Julien Louvel

المصدر: Journal of Medicinal Chemistry
JOURNAL OF MEDICINAL CHEMISTRY, 60(23), 9545-9564
JOURNAL OF MEDICINAL CHEMISTRY

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Stereochemistry, medicine.drug_class, medicine.medical_treatment, Carboxamide, CHO Cells, Article, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Cricetulus, Receptor, Cannabinoid, CB1, Drug Discovery, Radioligand, medicine, Structure–activity relationship, Animals, Humans, Receptor, Chemistry, Drug discovery, Ligand binding assay, Imidazoles, Receptor–ligand kinetics, Molecular Docking Simulation, Kinetics, 030104 developmental biology, HEK293 Cells, Molecular Medicine, Cannabinoid, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff212f527a82b848d9f47dfc77c4462a
https://hdl.handle.net/1887/58213

المؤلفون: Eelke B. Lenselink, Jacobus P. D. van Veldhoven, Tirsa T. van Duijl, Laura H. Heitman, Adriaan P. IJzerman, Boaz J. Kuiper, Ellen Paasman, Lizi Xia, Wessel A.C. Burger

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 60(17), 7555-7568
Journal of Medicinal Chemistry, 60(17), 7555-7568. AMER CHEMICAL SOC

مصطلحات موضوعية: 0301 basic medicine, Purine, Stereochemistry, Kinetics, Adenosine A3 Receptor Antagonists, CHO Cells, Article, 03 medical and health sciences, chemistry.chemical_compound, Cricetulus, Drug Discovery, Animals, Humans, Receptor, Drug discovery, Chemistry, Receptor, Adenosine A3, Adenosine A3 receptor, Affinities, Receptor–ligand kinetics, Molecular Docking Simulation, 030104 developmental biology, Biochemistry, Purines, Molecular Medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ecab5d892365671aa9093720b68b2e
https://hdl.handle.net/1887/135658

المؤلفون: Natalia V. Ortiz Zacarías, Lizi Xia, Raymond C. Stevens, Eelke B. Lenselink, Adriaan P. IJzerman, Laura H. Heitman, Vsevolod Katritch, Hugo Gutiérrez-de-Terán, Arnault Massink

المصدر: Mol Pharmacol

مصطلحات موضوعية: Receptor, Adenosine A2A, Sodium, Allosteric regulation, Adenosine A2A receptor, chemistry.chemical_element, Crystallography, X-Ray, Protein Structure, Secondary, Allosteric Regulation, medicine, Humans, Binding site, Receptor, Pharmacology, Binding Sites, Dose-Response Relationship, Drug, Ligand (biochemistry), Amiloride, HEK293 Cells, chemistry, Biochemistry, Mutation, Biophysics, Molecular Medicine, Erratum, Sodium ion binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cc98860c91f30e850dfb065675ade7
https://doi.org/10.1124/mol.114.095737

المؤلفون: Dong Guo, Tamara A. M. Mocking, Marta Agliardi, Julien Louvel, Laura H. Heitman, Adriaan P. IJzerman, Roland Kars, Lizi Xia, Henk de Vries, Johannes Brussee, Tan Phát Pham

المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 57(8), 3213-3222

مصطلحات موضوعية: Drug, Stereochemistry, Drug discovery, media_common.quotation_subject, Aryl, CHO Cells, Receptor–ligand kinetics, Adenosine A1 Receptor Agonists, Radioligand Assay, Structure-Activity Relationship, Adenosine A1 receptor, chemistry.chemical_compound, Cricetulus, HEK293 Cells, Pyrimidines, chemistry, Drug Discovery, Animals, Humans, Molecular Medicine, Receptor, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe20828dd16ce6081861182f289cea72
https://doi.org/10.1021/jm401643m

المؤلفون: Fangyuan Bao, Junzhi Yi, Yixiao Liu, Yuliang Zhong, Hui Zhang, Zhonglin Wu, Boon Chin Heng, Ying Wang, Ziyang Wang, Lizi Xiao, Hua Liu, Hongwei Ouyang, Jing Zhou

المصدر: Bioactive Materials, Vol 18, Iss , Pp 539-551 (2022)

مصطلحات موضوعية: Applied forms, nHAP, Osteogenesis, ITGA7, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X22001323; https://doaj.org/toc/2452-199X

URL الوصول: https://doaj.org/article/0314e24314fe49fea54dedf4d5cb03a8

المؤلفون: Lizi Xia, Laura H. Heitman, Ad P. IJzerman, Henk de Vries

المصدر: Purinergic Signalling
Purinergic signalling

مصطلحات موضوعية: 0301 basic medicine, Kinetics, CHO Cells, Adenosine A1 Receptor Antagonists, Kinetic energy, Ligands, Binding, Competitive, Receptors, G-Protein-Coupled, 03 medical and health sciences, Cellular and Molecular Neuroscience, Adenosine A1 receptor, Radioligand Assay, Cricetulus, Drug Delivery Systems, G protein-coupled receptors, Cricetinae, Animals, Humans, Molecular Biology, G protein-coupled receptor, Chemistry, Receptor, Adenosine A1, Residence time, Cell Membrane, Cell Biology, Ligand (biochemistry), Receptor–ligand kinetics, 030104 developmental biology, Scintillation proximity assay, Biochemistry, Binding kinetics, Xanthines, Original Article, Biological system, Filtration

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a3d785bb407690eb5386c4c5c88029
https://pubmed.ncbi.nlm.nih.gov/26647040

المؤلفون: Marc Hazeu, Laura H. Heitman, Dong Guo, Lizi Xia, Johannes Brussee, Jacobus P. D. van Veldhoven, Tamara A. M. Mocking, Adriaan P. IJzerman

المصدر: ChemMedChem, 9(4), 752-761
ChemMedChem

مصطلحات موضوعية: Receptor, Adenosine A2A, Stereochemistry, Adenosine A2A receptor, Biochemistry, Structure-Activity Relationship, Drug Discovery, Humans, General Pharmacology, Toxicology and Pharmaceutics, Receptor, G protein-coupled receptor, Pharmacology, Binding Sites, Dose-Response Relationship, Drug, Molecular Structure, Triazines, Chemistry, Organic Chemistry, Antagonist, SUPERFAMILY, Triazoles, Receptor–ligand kinetics, Adenosine A2 Receptor Antagonists, Kinetics, Molecular Medicine, Antagonism

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348d076deea1fea2155e27955b55f3f3
http://hdl.handle.net/1887/3209420

المؤلفون: Adriaan P. IJzerman, Laura H. Heitman, Gye Won Han, Jeremiah S. Joseph, David Rodríguez, Vsevolod Katritch, Hugo Gutiérrez-de-Terán, Arnault Massink, Ilia Katritch, Wei Liu, Lizi Xia, Vadim Cherezov, Raymond C. Stevens

المصدر: Structure (London, England : 1993). 21(12)

مصطلحات موضوعية: Hot Temperature, Adenosine A2 Receptor Agonists, Receptor, Adenosine A2A, Protein Conformation, Sodium, Allosteric regulation, Molecular Sequence Data, chemistry.chemical_element, Molecular Dynamics Simulation, Article, Amiloride, 03 medical and health sciences, Radioligand Assay, 0302 clinical medicine, Allosteric Regulation, Structural Biology, medicine, Humans, Amino Acid Sequence, Molecular Biology, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, biology, Chemistry, Protein Stability, Cations, Monovalent, Adenosine receptor, Adenosine A2 Receptor Antagonists, HEK293 Cells, Allosteric enzyme, Biochemistry, biology.protein, Sodium ion binding, 030217 neurology & neurosurgery, Allosteric Site, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1930b3889c00b2e93097b8c6cf69c3a7
https://pubmed.ncbi.nlm.nih.gov/24210756

المؤلفون: Lizi Xia¹, de Vries, Henk¹, Lenselink, Eelke B.¹, Louvel, Julien¹, Waring, Michael J., Leifeng Cheng, Pahlén, Sara², Petersson, Maria J.², Schell, Peter, Olsson, Roine I., Heitman, Laura H.¹, Sheppard, Robert J.³ Robert.Sheppard@astrazeneca.com, IJzerman, Adriaan P.¹ ijzerman@lacdr.leidenuniv.nl

المصدر: Journal of Medicinal Chemistry. 12/14/2017, Vol. 60 Issue 23, p9545-9564. 20p.

مصطلحات موضوعية: *CARBOXAMIDES, *CANNABINOID receptors, *RADIOLIGAND assay, *STRUCTURE-activity relationship in pharmacology, *CHEMICAL kinetics, *DRUG design

المؤلفون: Lizi Xia¹, Burger, Wessel A. C.¹, van Veldhoven, Jacobus P. D.¹, Kuiper, Boaz J.¹, van Duijl, Tirsa T.¹, B. Lenselink, Eelke¹, Paasman, Ellen¹, Heitman, Laura H.¹, IJzerman, Adriaan P.¹ ijzerman@lacdr.leidenuniv.nl

المصدر: Journal of Medicinal Chemistry. Sep2017, Vol. 60 Issue 17, p7555-7568. 14p.

مصطلحات موضوعية: *ADENOSINES, *STRUCTURE-activity relationships, *BIOGEOCHEMICAL residence time, *DRUG antagonism, *DRUG receptors

المؤلفون: HuaFang Wu, WenBin Lin, LiZi Xia, YingGang Luo, XiaoZhen Chen, GuoYou Li, GuoLin Zhang, XinFu Pan

المصدر: Helvetica Chimica Acta; Apr2009, Vol. 92 Issue 4, p677-688, 12p