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1
المؤلفون: Jelle Reinen, Daan Noort, A. Fidder, Leyla Nematollahi, Nico P. E. Vermeulen, Jan N. M. Commandeur
المساهمون: Molecular and Computational Toxicology, AIMMS
المصدر: Reinen, J, Nematollahi, L, Fidder, A, Vermeulen, N P E, Noort, D & Commandeur, J N M 2015, ' Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP) ', Chemical Research in Toxicology, vol. 28, no. 4, pp. 711-721 . https://doi.org/10.1021/tx500490v
Chemical Research in Toxicology, 4 (20 April), 28, 711-721
Chemical Research in Toxicology, 28(4), 711-721. American Chemical Societyمصطلحات موضوعية: Cholinesterase inhibition, Unclassified drug, Metabolite, IC50, Pharmacology, Toxicology, Cytochrome P450 3A4, 329736-03-0, Activation, Metabolic, chemistry.chemical_compound, Aerotoxic syndrome, Cytochrome P-450 Enzyme System, Biotransformation, Butyrylcholinesterase, TS - Technical Sciences, Hydrolysis, Enzyme inactivation, Acetylcholinesterase, 9000-81-1, General Medicine, Observation, Weapon & Protection Systems, Acetylcholinesterase, Tritolyl Phosphates, cytochrome P450, 9035-51-2, Biochemistry, Tri ortho cresyl phosphate, 78-30-8, Microsomes, Liver, Liver microsome, Animal cell, Liver microsome metabolism, Cytochrome P450 3A5, 336874-97-6, Cytochrome P450 1A2, Biology, Gas Chromatography-Mass Spectrometry, SDG 3 - Good Health and Well-being, Cytochrome P450 3A4, Cytochrome P450 3A5, Cytochrome P450 2C18, Neurotoxicity, medicine, Animals, Humans, Cholinesterase, 9001-08-5, CYP3A4, human cell, CBRN - CBRN Protection, CYP1A2, In vitro study, Cytochrome P450 2D6, Nonhuman, medicine.disease, Rats, chemistry, Organophosphorus compound, Microsome, Controlled study
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2
المؤلفون: Dirk K. F. Meijer, Hans Lennernäs
المساهمون: Nanomedicine & Drug Targeting
المصدر: European Journal of Pharmaceutical Sciences, 26(1), 130-143
مصطلحات موضوعية: verapamil, intestine cell, talinolol, positron emission tomography, brain blood vessel, Pharmaceutical Science, blood brain barrier, Pharmacology, rifampicin, medical research, Protein expression, hydroxymethylglutaryl coenzyme A reductase inhibitor, drug binding, dose response, kidney cell, cell interaction, Sociology, cerivastatin, liver metabolism, conference paper, ADME, media_common, drug bile level, liver microsome metabolism, pravastatin, intestine mucosa permeability, beta adrenergic receptor blocking agent, methodology, digoxin, cell line, cardiac glycoside, Kidney cell, Drug metabolizing enzymes, probenecid, Liver metabolism, priority journal, erythromycin, gemfibrozil, temocaprilat, elacridar, Drug, drug transport, rifamycin, hyperbilirubinemia, membrane transport, media_common.quotation_subject, ketoconazole, Computational biology, doxorubicin, cerebrospinal fluid, drug metabolizing enzyme, estradiol, drug disposition, unindexed drug, bromsulfophthalein, drug screening, human, fexofenadine, protein expression, Drug transport, structure activity relation, nonhuman, bosentan, tramazoline, concentration (parameters), Drug disposition, drug half life, antidiabetic agent, prediction, central nervous system, drug metabolism, cyclosporin, intestine absorption, carrier protein, molecular interaction, physiology, chemical structure, rosuvastatin, azasetron, quinidine
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3
المؤلفون: Boris Mildner, F. Schrander, Katarina Orešković, M.W. Schut, J.J.P. Bogaards, Michael J. Parnham
المساهمون: TNO Kwaliteit van Leven
المصدر: Biopharmaceutics and Drug Disposition, 1, 26, 27-33
مصطلحات موضوعية: cytochrome P450 2B6, enzyme assay, Antifungal Agents, CYP2B6, CYP3A, Chemistry, Pharmaceutical, Drug Evaluation, Preclinical, Antifungal drug, Administration, Oral, Pharmaceutical Science, Cytochrome P450, bufuralol, coumarin, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, PLD-118, metabolism, cytochrome P450, derivatization, antifungal agent, rat, Pharmacology (medical), enzyme inhibition, liver microsome metabolism, analytic method, cytochrome P450 2C9, biology, Ribosomal Protein S9, article, General Medicine, CYP2E1, structure analysis, unclassified drug, mephenytoin, Biochemistry, dog, liver homogenate, Microsomes, Liver, lipids (amino acids, peptides, and proteins), cytochrome P450 1A2, amino acid, Ribosomal Proteins, in vitro study, high performance liquid chromatography, Health Pharmacology, ketoconazole, resorufin, Physiological Sciences, 2 amino 4 methylenecyclopentanecarboxylic acid, cytochrome P450 3A, sulfaphenazole, animal tissue, alpha naphthoflavone, umbelliferone, fluorescence analysis, Dogs, reduced nicotinamide adenine dinucleotide phosphate, unindexed drug, Animals, Humans, controlled study, Cycloleucine, human, enzyme stability, cytochrome P450 2D6, enzyme substrate, Pharmacology, nonhuman, cytochrome P450 2A6, diethyldithiocarbamic acid, monoclonal antibody 2B6, Bufuralol, CYP1A2, candidiasis, human tissue, Rats, diclofenac, chlorzoxazone, drug structure, enzymes and coenzymes (carbohydrates), Metabolism, chemistry, monoclonal antibody, concentration response, ethoxyresorufin, testosterone, Microsome, biology.protein, cytochrome P450 2E1, cytochrome P450 2C19, quinidine
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4Academic Journal
المؤلفون: Reinen, J., Nematollahi, L., Fidder, A., Vermeulen, N.P.E., Noort, D., Commandeur, J.N.M.
المصدر: Chemical Research in Toxicology, 4 (20 April), 28, 711-721
مصطلحات موضوعية: Toxicology, Cytochrome P450 1A2, Cytochrome P450 2C18, Cytochrome P450 2D6, Cytochrome P450 3A4, Cytochrome P450 3A5, Organophosphorus compound, Unclassified drug, Animal cell, Biotransformation, Cholinesterase inhibition, Controlled study, Enzyme inactivation, Humans, human cell, Hydrolysis, IC50, In vitro study, Liver microsome, Liver microsome metabolism, Neurotoxicity, Nonhuman, Rats, Acetylcholinesterase, 9000-81-1, Cholinesterase, 9001-08-5, cytochrome P450, 9035-51-2, 329736-03-0
Relation: uuid:0e4751a3-f3d8-4055-807f-eeefbb818fa6; 528077; http://resolver.tudelft.nl/uuid:0e4751a3-f3d8-4055-807f-eeefbb818fa6
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5
مصطلحات موضوعية: Cholinesterase inhibition, Unclassified drug, cytochrome P450, 329736-03-0, Cytochrome P450 1A2, Observation, IC50, Toxicology, 336874-97-6, Cytochrome P450 3A4, Cytochrome P450 3A5, Cytochrome P450 2C18, Neurotoxicity, Humans, 9001-08-5, Biotransformation, 78-30-8, TS - Technical Sciences, human cell, Hydrolysis, 9035-51-2, CBRN - CBRN Protection, Enzyme inactivation, In vitro study, Cytochrome P450 2D6, Cholinesterase, Nonhuman, Rats, Weapon & Protection Systems, Tri ortho cresyl phosphate, Organophosphorus compound, Acetylcholinesterase, 9000-81-1, Liver microsome, Animal cell, Controlled study, Liver microsome metabolism
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6
المؤلفون: Piloto Ferrer, J., Cozzi, R., Cornetta, T., Fiore, M., Degrassi, F., De Salvia, R., Remigio, A., Francisco, M., Quiñones, O., Valdivia, D., González, M. L., Sánchez Lamar, A., Pérez, C., STANO, Pasquale
المساهمون: Piloto Ferrer, J, Cozzi, Renata, Cornetta, T, Stano, P, Fiore, M, Degrassi, F, De Salvia, R, Remigio, A, Francisco, M, Quiñones, O, Valdivia, D, González, M. L., Sánchez Lamar, A, Pérez, C., Piloto Ferrer, J., Cozzi, R., Cornetta, T., Stano, Pasquale, Fiore, M., Degrassi, F., De Salvia, R., Remigio, A., Francisco, M., Quiñones, O., Valdivia, D., Sánchez Lamar, A.
المصدر: BioMed Research International
BioMed Research International, Vol 2014 (2014)مصطلحات موضوعية: Salmonella typhimurium, CHO cell line, Xanthium strumarium, lcsh:Medicine, plant extract, animal cell, Pharmacology, Gene mutation, medicine.disease_cause, Mice, animal, rat, gene mutation, Xanthium, Animal, Genetics, liver microsome metabolism, DNA strand breakage, MTT assay, aneugen, drug cytotoxicity, drug effect, article, General Medicine, cytotoxicity assay, unclassified drug, micronucleus test, female, Micronucleus test, sister chromatid exchange, plant extract, metabolic activation, Cricetulu, Research Article, antiproliferative activity, bone marrow, in vitro study, Article Subject, animal experiment, Sister chromatid exchange, CHO Cells, Biology, chemistry, Chromosome aberration, General Biochemistry, Genetics and Molecular Biology, in vivo study, Cricetulus, Xanthium strumarium plant extract, comet assay, Salmonella enterica subsp. enterica serovar Typhimurium, mitosis index, medicine, Animals, controlled study, Viability assay, cell viability, mouse, Micronuclei, Chromosome-Defective, micronucleu, nonhuman, General Immunology and Microbiology, Plant Extracts, animal model, lcsh:R, genotoxicity, clastogen, mutagenicity, IC 50, animal cell culture, Xanthium, Rats, Comet assay, CHO Cell, concentration response, gene expression, chromosome damage, DNA damage, chromosome aberration, Micronucleus, Genotoxicity, bone marrow cell, DNA Damage
وصف الملف: text/xhtml; ELETTRONICO
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7
المصدر: Pharmaceutisch Weekblad. 132(28):948-963
مصطلحات موضوعية: tramadol, cytochrome P450, phenotype, amphetamine, zuclopenthixol, antiarrhythmic agent, nortriptyline, haloperidol, mianserin, unindexed drug, genetic polymorphism, antidepressant agent, propafenone, propranolol, human, tropisetron, enzyme specificity, clomipramine, proguanil, liver microsome metabolism, drug interaction, risperidone, fluoxetine, article, beta adrenergic receptor blocking agent, analgesic agent, encainide, perphenazine, timolol, metoprolol, xenobiotic metabolism, brofaromine, drug metabolism, flecainide, unclassified drug, imipramine, tolbutamide, cytochrome P450 isoenzyme, antihypertensive agent, desipramine, maprotiline, mexiletine, paroxetine
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8
المصدر: Acta Neuropsychiatrica. 11(2):77-79
مصطلحات موضوعية: isoniazid, treatment planning, cytochrome P450, paracetamol, dose liver function relation, genotype, review, nefazodone, thiopurine methyltransferase, rifampicin, omeprazole, serotonin 2A receptor, cisapride, acyltransferase, unindexed drug, antidepressant agent, human, proguanil, apolipoprotein E, codeine, diazepam, triazolam, pharmacogenetics, liver microsome metabolism, clozapine, sertraline, fluoxetine, beta adrenergic receptor blocking agent, theophylline, drug metabolism, psychiatry, cyclosporin, itraconazole, enzyme activity, catechol methyltransferase, midazolam, erythromycin, calcium antagonist, diagnostic value, fluvoxamine
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9
مصطلحات موضوعية: cytochrome P450 2B6, enzyme assay, Antifungal Agents, Cytochrome P450, bufuralol, coumarin, Cytochrome P-450 Enzyme System, derivatization, antifungal agent, rat, enzyme inhibition, liver microsome metabolism, analytic method, cytochrome P450 2C9, article, structure analysis, Preclinical, unclassified drug, Chemistry, mephenytoin, Liver, dog, liver homogenate, Administration, lipids (amino acids, peptides, and proteins), cytochrome P450 1A2, amino acid, Oral, Ribosomal Proteins, in vitro study, high performance liquid chromatography, Health Pharmacology, ketoconazole, resorufin, Physiological Sciences, 2 amino 4 methylenecyclopentanecarboxylic acid, cytochrome P450 3A, sulfaphenazole, animal tissue, alpha naphthoflavone, umbelliferone, fluorescence analysis, Dogs, Microsomes, reduced nicotinamide adenine dinucleotide phosphate, unindexed drug, Animals, Humans, controlled study, Cycloleucine, human, enzyme stability, cytochrome P450 2D6, enzyme substrate, PLD-118, nonhuman, cytochrome P450 2A6, diethyldithiocarbamic acid, monoclonal antibody 2B6, candidiasis, human tissue, Rats, diclofenac, enzymes and coenzymes (carbohydrates), chlorzoxazone, drug structure, Metabolism, monoclonal antibody, concentration response, ethoxyresorufin, testosterone, Pharmaceutical, cytochrome P450 2E1, Drug Evaluation, cytochrome P450 2C19, quinidine
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10
المؤلفون: Price, R.J., Scott, M.P., Walters, D.G., Stierum, R.H., Groten, J.P., Meredith, C., Lake, B.G.
المساهمون: TNO Voeding
المصدر: Food and Chemical Toxicology, 6, 42, 899-908
مصطلحات موضوعية: Male, drug megadose, enzyme induction, Administration, Oral, Cytochrome P450, animal cell, cytochrome P450 1A, Antioxidants, Rats, Sprague-Dawley, liver mitochondrion, Cumene hydroperoxide, Cytochrome P-450 Enzyme System, CYP, Thiabendazole, dose response, glutathione transferase, rat, apoprotein, cytochrome P450 2B2, cytochrome P450 2B1, liver microsome metabolism, messenger RNA, Antinematodal Agents, article, 1-chloro-2,4-dinitrobenzene, CH, xenobiotic metabolism, tiabendazole, CDNB, butylcresol, enzyme activity, Liver, cytochrome P450 1A2, cytochrome P450 1A1, Rat liver, BHT, animal experiment, Physiological Sciences, DCNB, liver weight, Animals, controlled study, RNA, Messenger, Nutrition, enzyme substrate, nonhuman, Dose-Response Relationship, Drug, nucleotide sequence, enzyme activation, Butylated Hydroxytoluene, cytochrome P450 2B, Rats, enzyme metabolism, protein blood level, GSH S-transferase, Acyltransferases
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11
مصطلحات موضوعية: Male, drug megadose, enzyme induction, Messenger, Cytochrome P450, animal cell, cytochrome P450 1A, Antioxidants, liver mitochondrion, Cumene hydroperoxide, Cytochrome P-450 Enzyme System, CYP, Thiabendazole, dose response, glutathione transferase, rat, apoprotein, cytochrome P450 2B2, cytochrome P450 2B1, liver microsome metabolism, messenger RNA, Antinematodal Agents, article, CH, xenobiotic metabolism, tiabendazole, CDNB, butylcresol, enzyme activity, Liver, Administration, Drug, cytochrome P450 1A2, cytochrome P450 1A1, Rat liver, Oral, BHT, animal experiment, Physiological Sciences, DCNB, Dose-Response Relationship, liver weight, Animals, controlled study, Nutrition, enzyme substrate, nonhuman, 1-chloro-2, nucleotide sequence, enzyme activation, Butylated Hydroxytoluene, 4-dinitrobenzene, cytochrome P450 2B, Rats, enzyme metabolism, protein blood level, RNA, Sprague-Dawley, GSH S-transferase, Acyltransferases
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12Academic Journal
المؤلفون: Dahl, M.L., Voortman, G., Alm, C., Elwin, C.E., Delbressine, L., Vos, R., Bogaards, J.J.P., Bertilsson, L.
المصدر: Clinical Drug Investigation, 1, 13, 37-46
مصطلحات موضوعية: Antidepressant agent, Bufuralol, Cytochrome p450 isoenzyme, Ebrisoquine, Drug metabolizing enzyme, Ethoxyresorufin, Mirtazapine, Testosterone, Adult, Clinical trial, Drug blood level, Drug clearance, Drug disposition, Drug half life, Drug metabolism, Drug structure, Enantiomer, Female, Human, Human experiment, Human tissue, Liver microsome metabolism, Male, Normal human, Oral drug administration, Plasma clearance, Racemic mixture
Relation: uuid:3c31de02-3f2b-43eb-9f3e-85034afd8dc7; 55584; http://resolver.tudelft.nl/uuid:3c31de02-3f2b-43eb-9f3e-85034afd8dc7
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13Academic JournalComparison of five incubation systems for rat liver slices using functional and viability parameters
المؤلفون: Olinga, P., Groen, K., Hof, I.H., Kanter, R. de, Koster, H.J., Leeman, W.R., Rutten, A.A.J.J.L., Twillert, K. van, Groothuis, G.M.M.
المصدر: Journal of Pharmacological and Toxicological Methods, 2, 38, 59-69
مصطلحات موضوعية: Incubation system, Rat liver slices, Vaibility, Lidocaine, Phenazone, Testosterone, Animal tissue, Cell viability, Controlled study, Culture medium, Drug metabolism, Incubation time, Liver microsome metabolism, Liver slice, Nonhuman, Preservation, Animals, Energy Metabolism, L-Lactate Dehydrogenase, Liver, Male, Organ Culture Techniques, Potassium, Rats, Wistar, Xenobiotics, Animalia
Relation: uuid:f6794b84-6a11-4b01-a6c0-e932d2d5367e; 234070; http://resolver.tudelft.nl/uuid:f6794b84-6a11-4b01-a6c0-e932d2d5367e
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14Academic Journal
المصدر: Chemical Research in Toxicology, 8, 9, 1249-1256
مصطلحات موضوعية: 1,2 dichlorobenzene, ascorbic acid, cytochrome p450, epoxide hydrolase, glutathione, glutathione transferase, isoniazid, phenobarbital, animal cell, animal experiment, article, biotransformation, conjugation, controlled study, covalent bond, human, human cell, hydrolysis, liver microsome metabolism, liver toxicity, male, nonhuman, rat, Animals, Chlorobenzenes, Chromatography, High Pressure Liquid, Cytochrome P-450 Enzyme System, Humans, Insecticides
Relation: uuid:8188ec52-3acb-464e-99e2-73ad6ea807d8; 233715; http://resolver.tudelft.nl/uuid:8188ec52-3acb-464e-99e2-73ad6ea807d8
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15Academic Journal
المؤلفون: Bogaards, J.J.P., Venekamp, J.C., Bladeren, P.J. van
المصدر: Chemico-Biological Interactions, 3, 102, 169-182
مصطلحات موضوعية: Cytochrome P-450, Isoprene, Metabolism, cyclohexane oxide, cytochrome p450, cytochrome p450 isoenzyme, epoxide hydrolase, animal experiment, article, controlled study, enzyme activity, enzyme specificity, epoxidation, human, human tissue, liver microsome metabolism, mouse, nonhuman, rat, species difference, xenobiotic metabolism, Animals, Biotransformation, Butadienes, Cyclohexanes, Cyclohexenes, Cytochrome P-450 CYP2E1, Cytochrome P-450 Enzyme System, Enzyme Inhibitors, Epoxide Hydrolases
Relation: uuid:e8f8a9ab-e983-4729-b405-8be12bdd4ecc; 233718; http://resolver.tudelft.nl/uuid:e8f8a9ab-e983-4729-b405-8be12bdd4ecc
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16
المؤلفون: Touw, D.J., Breimer, D.D.
المساهمون: Nanomedicine & Drug Targeting, Biopharmaceuticals, Discovery, Design and Delivery, Groningen Research Institute for Asthma and COPD, Critical care, Anesthesiology, Peri-operative and Emergency medicine, Synthesis and Analysis
المصدر: Pharmaceutisch Weekblad, 132(28), 948-963. Kon. Ned. Mij. ter Bevordering der Pharmacie (KNMP)
مصطلحات موضوعية: tramadol, cytochrome P450, phenotype, amphetamine, zuclopenthixol, antiarrhythmic agent, nortriptyline, haloperidol, mianserin, unindexed drug, genetic polymorphism, antidepressant agent, propafenone, propranolol, human, tropisetron, enzyme specificity, clomipramine, proguanil, liver microsome metabolism, drug interaction, risperidone, fluoxetine, article, beta adrenergic receptor blocking agent, analgesic agent, encainide, perphenazine, timolol, metoprolol, xenobiotic metabolism, brofaromine, drug metabolism, flecainide, unclassified drug, imipramine, tolbutamide, cytochrome P450 isoenzyme, antihypertensive agent, desipramine, maprotiline, mexiletine, paroxetine
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17Comparison of five incubation systems for rat liver slices using functional and viability parameters
المؤلفون: K. Groen, Henk J. Koster, Ingrid H. Hof, A.A.J.J.L. Rutten, K. van Twillert, G.M.M. (Geny) Groothuis, R. de Kanter, Peter Olinga, W.R. Leeman
المساهمون: Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding, Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Groningen Institute for Organ Transplantation (GIOT)
المصدر: Journal of Pharmacological and Toxicological Methods, 2, 38, 59-69
Journal of Pharmacological and Toxicological Methods, 38(2), 59-69مصطلحات موضوعية: Male, Cell viability, HEPATOCYTES, Animal tissue, law.invention, law, DYNAMIC ORGAN-CULTURE, Testosterone, Energy charge, Incubation, INDUCTION, Culture medium, Liver slice, Preservation, Biochemistry, Liver, Liver microsome metabolism, HEPATOTOXICITY, TOXICOLOGY, Biology, METABOLISM, Organ culture, Incubation period, Xenobiotics, Incubation time, Erlenmeyer flask, Incubation system, Organ Culture Techniques, Animals, Animalia, MTT assay, Viability assay, ENZYME-ACTIVITIES, Rats, Wistar, CUT TISSUE-SLICES, Pharmacology, Drug metabolism, Chromatography, L-Lactate Dehydrogenase, viability, Rat liver slices, CYTOCHROME-P450, Lidocaine, Phenazone, Nonhuman, Rats, ANTIPYRINE, Potassium, Vaibility, Energy Metabolism, Controlled study
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18
مصطلحات موضوعية: Adult, Male, Cytochrome p450 isoenzyme, Plasma clearance, Drug structure, Mirtazapine, Drug half life, Ebrisoquine, Drug blood level, Oral drug administration, Bufuralol, Racemic mixture, Testosterone, Human tissue, Drug metabolizing enzyme, Drug metabolism, Enantiomer, Antidepressant agent, Normal human, Clinical trial, Human experiment, Drug clearance, Drug disposition, Female, Ethoxyresorufin, Liver microsome metabolism, Human
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19
المؤلفون: Christina Alm, R. Vos, C.-E. Elwin, G. Voortman, Marja-Liisa Dahl, L. Delbressine, Leif Bertilsson, J. J. P. Bogaards
المساهمون: Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding
المصدر: Clinical Drug Investigation, 1, 13, 37-46
مصطلحات موضوعية: Adult, Male, CYP2D6, medicine.medical_specialty, Metabolite, Cytochrome p450 isoenzyme, Mirtazapine, Plasma clearance, Drug structure, Drug half life, Pharmacology, chemistry.chemical_compound, Ebrisoquine, Drug blood level, Oral drug administration, Internal medicine, medicine, Bufuralol, Racemic mixture, Pharmacology (medical), Testosterone, Human tissue, Drug metabolizing enzyme, Drug metabolism, Enantiomer, business.industry, Antidepressant agent, CYP1A2, General Medicine, Normal human, Clinical trial, Endocrinology, chemistry, Debrisoquine, Human experiment, Drug clearance, Drug disposition, Female, Ethoxyresorufin, business, Liver microsome metabolism, medicine.drug, Human
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20Comparison of five incubation systems for rat liver slices using functional and viability parameters
مصطلحات موضوعية: Male, Cell viability, Wistar, Animal tissue, Xenobiotics, Incubation time, Incubation system, Organ Culture Techniques, Animals, Animalia, Testosterone, Drug metabolism, L-Lactate Dehydrogenase, Rat liver slices, Lidocaine, Phenazone, Culture medium, Liver slice, Nonhuman, Preservation, Rats, Liver, Potassium, Vaibility, Energy Metabolism, Controlled study, Liver microsome metabolism