المؤلفون: Joelle M. Onorato, Ching-Hsuen Chu, Zhengping Ma, Lisa M. Kopcho, Hannguang J. Chao, R.Michael Lawrence, Dong Cheng

المصدر: Journal of Lipid Research, Vol 56, Iss 3, Pp 747-753 (2015)

مصطلحات موضوعية: monoacylglycerol acyltransferase, diacylglycerol acyltransferase, triglycerides, liquid chromatography/mass spectrometry, cell-based assay, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520356029; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/d164256204b843b0ad2be9f52d8848a8

المؤلفون: Shu Chang, Anthony V. Azzara, Yi-Xin Li, Marta Dabros, James Kempson, Reshma Panemangelor, Huji Turdi, Kimberly A. Foster, William J. Keim, Jean M. Whaley, Jeffrey A. Robl, Fang Moore, Luping Chen, Mary Jane Cullen, Xiaoping Hou, Atsu Apedo, R. Michael Lawrence, Arvind Mathur, David G. Harden, Wei Meng, Kevin O'Malley, Mary Ann Pelleymounter, Hannguang Chao, Pratik Devasthale, Jon J. Hangeland, Zhengping Ma, Dauh-Rurng Wu, Robert Paul Brigance, Guohua Zhao, Lynn M. Abell, Qi Gao, Susan Harvey, Lisa M. Kopcho, Dong Cheng, Elizabeth A. Dierks, Ching-Hsuen Chu, Suzanne Rooney, Xiang-Yang Ye, Saleem Ahmad, Wei Wang

المصدر: Journal of Medicinal Chemistry. 64:14773-14792

مصطلحات موضوعية: Metabolism, Metabolic stability, Pharmacology, Crystallography, X-Ray, N-Acetylglucosaminyltransferases, High-Throughput Screening Assays, Structure-Activity Relationship, chemistry.chemical_compound, Metabolic Diseases, chemistry, Pharmacokinetics, Tolerability, In vivo, Drug Discovery, Animals, Humans, Molecular Medicine, Potency, Tetrazole, Enzyme Inhibitors, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e90999a2854f1a395c0459b5cd876d
https://doi.org/10.1021/acs.jmedchem.1c01356

المؤلفون: Mark Fereshteh, Xiao Zhu, Tai-An Lin, Prabhakar Rajanna, Cherney Emily Charlotte, Aravind Anandam, Xin Li, Derrick Maley, Liping Zhang, Gopal Dhar, Aaron Balog, Robert M. Borzilleri, Johnni Gullo-Brown, T. Thanga Mariappan, Kathy Johnston-Allegretto, Christine Huang, Venkata Murali, John T. Hunt, Sandeep Mahankali, Gregory D. Vite, Lisa M. Kopcho, Shweta Padmanabhan, Sarah C. Traeger

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Metastatic melanoma, 010405 organic chemistry, business.industry, medicine.medical_treatment, Organic Chemistry, Phases of clinical research, Immunotherapy, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cancer immunotherapy, Renal cell carcinoma, Drug Discovery, medicine, Cancer research, business, Indoleamine 2,3-dioxygenase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69bf6be584624b416a38e3f63d582b0
https://doi.org/10.1021/acsmedchemlett.1c00014

المؤلفون: Mian Gao, David J. Shuster, Hai-Yun Xiao, Christine B. Goldstine, Jing Chen, Zhonghui Lu, Victor R. Guarino, Khehyong Ngu, Lisa M. Kopcho, Deepa Calambur, Kurt R. Gregor, Andrew J. Tebben, Jingwu Duan, Luisa Salter-Cid, Hao Lu, Joseph A. Tino, Ning Li, John Hynes, James R. Burke, Joseph Yanchunas, John E. Macor, Steven Sheriff, Dauh-Rurng Wu, Bin Jiang, Patrick J. Shaw, ChiehYing Y. Chang, Jenny Xie, Vojkan Susulic, T. G. Murali Dhar

المصدر: Journal of Medicinal Chemistry. 63:15050-15071

مصطلحات موضوعية: Arthritis, Trimer, Proof of Concept Study, 01 natural sciences, Arthritis, Rheumatoid, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Naphthyridines, 030304 developmental biology, 0303 health sciences, Molecular Structure, Tumor Necrosis Factor-alpha, Chemistry, medicine.disease, Arthritis, Experimental, Small molecule, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Drug Design, Microsomes, Liver, Quinolines, Biophysics, Molecular Medicine, Female, Tumor necrosis factor alpha

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4023f6e8b3a6052dbeee946d81173312
https://doi.org/10.1021/acs.jmedchem.0c01732

المؤلفون: Dong Cheng, Bradley A. Zinker, Yi Luo, Petia Shipkova, Claudia H. De Oliveira, Gopal Krishna, Elizabeth A. Brown, Stephanie L. Boehm, Giridhar S. Tirucherai, Huidong Gu, Zhengping Ma, Ching-Hsuen Chu, Joelle M. Onorato, Lisa M. Kopcho, Ron Ammar, Julia Smith, Pratik Devasthale, R. Michael Lawrence, Steven A. Stryker, Elizabeth A. Dierks, Anthony V. Azzara, Leon Carayannopoulos, Edgar D. Charles, Kimberley A. Lentz, David A. Gordon

المصدر: Cell metabolism. 34(11)

مصطلحات موضوعية: Inflammation, Liver Cirrhosis, Adult, Mice, Clinical Trials, Phase I as Topic, Physiology, Non-alcoholic Fatty Liver Disease, Body Weight, Animals, Humans, Cell Biology, Obesity, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394387e9e73eae85eafb5bf7ab1908f8
https://pubmed.ncbi.nlm.nih.gov/36323235

المؤلفون: Lisa M. Kopcho, Johnni Gullo-Brown, Shweta Padmanabhan, Pattasseri Shabeerali, Arvind Mathur, Prabhakar Rajanna, Lorell Discenza, Liping Zhang, Zhenqiu Hong, Sarah C. Traeger, Zheng Yang, Cherney Emily Charlotte, Richard Rampulla, David K. Williams, Gopal Dhar, Kimberly A. Foster, James Kempson, Derrick Maley, Mary F. Grubb, Xiao Zhu, Xin Li, Weifang Shan, Robert M. Borzilleri, Diane Delpy, Kevin Stefanski, T. Thanga Mariappan, Gregory D. Vite, Kathy A. Johnston, Audris Huang, Asoka Ranasinghe, Mark Fereshteh, Aravind Anandam, Steven P. Seitz, John T. Hunt, Aaron Balog, Celia D’Arienzo, Anuradha Gupta, Tai-An Lin, Roshan Y. Nimje, Weiwei Guo, Christine Huang, Venkata Murali, Sandeep Mahankali

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: chemistry.chemical_compound, Oxidative metabolism, chemistry, Metastatic melanoma, Mouse xenograft, Organic Chemistry, Drug Discovery, Pyridine, Quinoline, Biochemistry, Combinatorial chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f0d7f8a891846e7ad07844b139d549
https://europepmc.org/articles/PMC8274105/

المؤلفون: Steven P. Seitz, Gregory D. Vite, John T. Hunt, Mark Fereshteh, Cherney Emily Charlotte, Joseph Fargnoli, Lorell Discenza, Liping Zhang, Jennifer Brown, Xin Li, Kevin Stefanski, Christine Huang, Asoka Ranasinghe, Lisa M. Kopcho, Xiao Zhu, Aaron Balog, Diane Delpy, Sarah C. Traeger, Jesse Swanson, Mary F. Grubb, Zheng Yang, Theresa Ziemba, Kathy A. Johnston, Kimberly A. Foster, Johnni Gullo-Brown, Celia D’Arienzo, Susheel Jethanand Nara, Robert M. Borzilleri, Derrick Maley, Tai-An Lin

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: 010405 organic chemistry, business.industry, medicine.medical_treatment, Organic Chemistry, Cancer, medicine.disease, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Immune system, Cancer immunotherapy, In vivo, Renal cell carcinoma, Dioxygenase, Drug Discovery, medicine, Cancer research, Indoleamine 2,3-dioxygenase, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01df4e45b608d7e7f9d0a0d2c59445e
https://pubmed.ncbi.nlm.nih.gov/33603977

المؤلفون: Arathi Krishnakumar, Lisa M. Kopcho, Michael Basso, Benjamin P. Vokits, Glenn H. Cantor, Sutjano Jusuf, Lei Zhao, Lynn M. Abell, Ashok Dongre, Javed Khan, Steven A. Spronk, Gregory A. Locke, Gerald J. Duke, Andrew Quoc Viet, Scott A. Shaw, Franck Duclos, Ellen K. Kick, Joelle M. Onorato, Charles G. Clark, Ruth R. Wexler, Dilger Andrew K, Ji Gao

المصدر: Bioorganicmedicinal chemistry. 28(22)

مصطلحات موضوعية: Hypochlorous acid, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Endogeny, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Thyroid peroxidase, In vivo, DNA Repair Protein, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, Peroxidase, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Triazoles, Antimicrobial, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Myeloperoxidase, biology.protein, Molecular Medicine, Triazolopyridine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30388866645cc723c34668c20055fd32
https://pubmed.ncbi.nlm.nih.gov/33007547

المؤلفون: Leonard P. Adam, Wei Meng, Ruth R. Wexler, Lisa M. Kopcho, Heather Finlay, Richard Yang, Xiaohong Yin, Kamelia Behnia, David S. Taylor, Gregory A. Locke, Lei Zhao

المصدر: Bioorganicmedicinal chemistry letters. 29(20)

مصطلحات موضوعية: Endothelial lipase, Models, Molecular, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Distribution (pharmacology), Structure–activity relationship, Animals, Humans, Benzothiazoles, Enzyme Inhibitors, Molecular Biology, ADME, Mice, Knockout, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Metabolism, Lipase, 0104 chemical sciences, Lipoproteins, LDL, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Benzothiazole, chemistry, Gene Expression Regulation, Cardiovascular Diseases, Molecular Medicine, Hepatic lipase, Lipoproteins, HDL

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d066a528718e06e53e431b6fbfee1443
https://pubmed.ncbi.nlm.nih.gov/31519373

المؤلفون: Matt Soars, Lisa M. Kopcho, Carolyn A. Weigelt, Shilpa Demes, Gregory D. Vite, Mary J. Harner, Rohit Malik, Guo Li, David G. Harden, Charles F. Voliva, Kevin O’Malley, Zheming Ruan, Lan-Ying Qin, Brian J. Arey, Peter K. Park, Jennifer Price, Steven Sheriff, Gerald J. Duke, Ashvinikumar V. Gavai, JIngjing Deng, Brian E. Fink, Christopher M. Barbieri, Max Ruzanov, Muge Celiktas, Mark R. Witmer, Yuval Blat, William D. Schmitz, Joseph G. Naglich, Iyoncy Rodrigo

المصدر: Cancer Research. 81:1140-1140

مصطلحات موضوعية: Cancer Research, Gene knockdown, Chemistry, Protein arginine methyltransferase 5, Cancer, medicine.disease, Molecular biology, In vitro, law.invention, Oncology, CDKN2A, In vivo, law, Cancer cell, medicine, Suppressor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::769a298e5dedd6469a5cf85008a3a619
https://doi.org/10.1158/1538-7445.am2021-1140

المؤلفون: Liping Zhang, Andrew J. Tebben, Chunhong Yan, Mian Gao, Maxim Ruzanov, Dianlin Xie, Hao Lu, Susan E. Kiefer, Lisa M. Kopcho, Kyoung S. Kim, John A. Newitt, Steven Sheriff

المصدر: Acta Crystallographica Section D Structural Biology. 72:658-674

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Gene isoform, Receptor, Transforming Growth Factor-beta Type I, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Ligands, Serine, 03 medical and health sciences, Adenosine Triphosphate, 0302 clinical medicine, Structural Biology, Humans, Protein Isoforms, Threonine, Protein Kinase Inhibitors, Binding Sites, Kinase, Chemistry, Receptor, Transforming Growth Factor-beta Type II, Ligand (biochemistry), Fusion protein, Transmembrane protein, Cell biology, 030104 developmental biology, Protein kinase domain, 030220 oncology & carcinogenesis, Receptors, Transforming Growth Factor beta, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f388f61583d0e9d9e91e4a8d326d83c
https://doi.org/10.1107/s2059798316003624

المؤلفون: Lei Zhao, Scott A. Shaw, Lynn M. Abell, Fred Lo, Gregory A. Locke, Meriah Neissel Valente, Xiaoqin Liu, Paul G. Sleph, Lisa M. Kopcho, Michael Basso, Andrew Quoc Viet, Rangaraj Narayanan, Nicholas R. Wurtz, Franck Duclos, Sutjano Jusuf, Ellen K. Kick, Dilger Andrew K, Ruth R. Wexler, Gayani Fernando, Javed Khan

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Reactive oxygen species, biology, Organic Chemistry, Rational design, Active site, Inflammation, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Thioether, 030220 oncology & carcinogenesis, Myeloperoxidase, Drug Discovery, biology.protein, medicine, Triazolopyridine, medicine.symptom, Peroxidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d146ac6bd8e0ed839899be07882101e6
https://europepmc.org/articles/PMC6295853/

المؤلفون: Dong Cheng, R. Michael Lawrence, Ching-Hsuen Chu, Lisa M. Kopcho, Chao Hannguang J, Joelle M. Onorato, Zhengping Ma

المصدر: Journal of Lipid Research, Vol 56, Iss 3, Pp 747-753 (2015)

مصطلحات موضوعية: liquid chromatography/mass spectrometry, Cell, Drug Evaluation, Preclinical, Palmitic Acid, cell-based assay, Enteroendocrine cell, QD415-436, monoacylglycerol acyltransferase, N-Acetylglucosaminyltransferases, Biochemistry, Cell Line, law.invention, Diglycerides, Mice, Endocrinology, Liquid chromatography–mass spectrometry, law, Methods, medicine, Animals, Humans, Bioassay, Obesity, Enzyme Inhibitors, triglycerides, Diacylglycerol kinase, biology, Cell Biology, Enzyme assay, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Cell culture, biology.protein, Recombinant DNA, Biological Assay, diacylglycerol acyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bf4dd5ec328a0c3dd49b8390a04f42
http://www.sciencedirect.com/science/article/pii/S0022227520356029

المؤلفون: Huji Turdi, Jon J. Hangeland, Lisa M. Kopcho, Todd J. Friends, Dong Cheng, Zhengping Ma, R. Michael Lawrence, Chao Hannguang J

المصدر: Analytical biochemistry. 501

مصطلحات موضوعية: 0301 basic medicine, Biophysics, Drug Evaluation, Preclinical, Biology, Ligands, Biochemistry, 03 medical and health sciences, Mice, Radioligand Assay, 0302 clinical medicine, Radioligand, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Diacylglycerol kinase, Enzyme Assays, chemistry.chemical_classification, Intestinal lipid absorption, Ligand binding assay, Cell Biology, Recombinant Proteins, Rats, Monoacylglycerol lipase, 030104 developmental biology, Enzyme, chemistry, Acyltransferases, 030220 oncology & carcinogenesis, Acyltransferase, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662789ded6d85c306fe9cd27d7f8a9f5
https://pubmed.ncbi.nlm.nih.gov/26925857

المؤلفون: Dianlin Xie, Litao Zhang, Basanth Laksmaiah, Prasad Krishnamurthy, Mark R. Witmer, Marilyn Paul, Kaushik Ghosh, Sumit Gupta, Lisa M. Kopcho, Michael F. Parker, Jeffrey Tredup, Lynn M. Abell, Hao Lu

المصدر: Analytical biochemistry. 501

مصطلحات موضوعية: 0301 basic medicine, Central nervous system, Biophysics, Drug Evaluation, Preclinical, Mass spectrometry, Kynurenic Acid, Biochemistry, Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, Central Nervous System Diseases, High-Throughput Screening Assays, medicine, Humans, Enzyme Inhibitors, Molecular Biology, Transaminases, Enzyme Assays, chemistry.chemical_classification, biology, Brain, Kynurenine aminotransferase II, Cell Biology, Enzyme assay, 030104 developmental biology, medicine.anatomical_structure, Enzyme, Spectrometry, Fluorescence, chemistry, biology.protein, biology.gene, 030217 neurology & neurosurgery, Kynurenine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4761c9461b729a9eb73ac9429e8a4e9e
https://pubmed.ncbi.nlm.nih.gov/26874021

المؤلفون: Young B. Kim, Mark S. Kirby, Lawrence G. Hamann, William J. Metzler, Carolyn A. Weigelt, Jovita Marcinkeviciene, Lisa M. Kopcho

المصدر: Archives of Biochemistry and Biophysics. 445:9-18

مصطلحات موضوعية: Serine protease, biology, Hydrogen bond, Chemistry, Stereochemistry, Dipeptidyl Peptidase 4, Biophysics, Leaving group, Active site, Adamantane, Dipeptides, Hydrogen-Ion Concentration, Biochemistry, Catalysis, Dipeptidyl peptidase, Kinetics, Tetrahedral carbonyl addition compound, Covalent bond, Solvents, biology.protein, Proton NMR, Humans, Enzyme Inhibitors, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f0180925bb94ca7a2bf78b5a877ae1
https://doi.org/10.1016/j.abb.2005.11.010

المؤلفون: Young B. Kim, Jovita Marcinkeviciene, Aiying Wang, Lisa M. Kopcho, Margaret A. Liu, Mark S. Kirby

المصدر: Archives of Biochemistry and Biophysics. 436:367-376

مصطلحات موضوعية: Time Factors, Stereochemistry, Dipeptidyl Peptidase 4, Biophysics, Binding, Competitive, Biochemistry, Dipeptidyl peptidase, Substrate Specificity, Scissile bond, Protein structure, Glucagon-Like Peptide 1, Humans, Glucose homeostasis, Enzyme kinetics, Cloning, Molecular, Protein Precursors, Binding site, Molecular Biology, Chromatography, High Pressure Liquid, Binding Sites, Chymotrypsin, biology, Chemistry, Hydrolysis, Temperature, Active site, Glucagon, Peptide Fragments, Recombinant Proteins, Protein Structure, Tertiary, Kinetics, Models, Chemical, biology.protein, Thermodynamics, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ada872cb148aca523e9654585fc3a5
https://doi.org/10.1016/j.abb.2005.02.015

المؤلفون: Martin J. Corbett, Daniel M. Camac, Lisa M. Kopcho, Randine Dowling, Paul E. Morin, Vidhyashankar Ramamurthy, Grace Lee, Jeffrey Tredup, Deepa Calambur, Amy L Lasut, Henry George, Subinay Ganguly, Zhihong Lai, Robert A. Copeland, Dharti Kothari, O Harold Ross, Michael Wittekind, Young B. Kim, Barbara Fish, Jovita Marcinkeviciene, Milton C Hillman, Dale Collins, Janet D. Cheng, Manjula Paruchuri, Andrew P. Combs, Mark R. Witmer, Keqiang Shen, Rob King, Joseph Yanchunas, Lorin A. Thompson, Nilsa R. Graciani, Jianhong Ma

المصدر: Archives of Biochemistry and Biophysics. 410:307-316

مصطلحات موضوعية: Glycosylation, Time Factors, Light, Lipid Bilayers, Biophysics, Peptide, CHO Cells, Ligands, Biochemistry, Catalysis, Cell Line, Inhibitory Concentration 50, chemistry.chemical_compound, Alzheimer Disease, Catalytic Domain, Cricetinae, Endopeptidases, Escherichia coli, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Scattering, Radiation, Lipid bilayer, Molecular Biology, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Binding Sites, Dose-Response Relationship, Drug, biology, Cell Membrane, Active site, Ligand (biochemistry), Recombinant Proteins, Protein Structure, Tertiary, Kinetics, Transmembrane domain, Enzyme, chemistry, biology.protein, Drosophila, Amyloid Precursor Protein Secretases, Peptides, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea05a173414a33c249027d3b4e45708e
https://doi.org/10.1016/s0003-9861(02)00690-2

المؤلفون: George L. Trainor, Andrew P. Combs, Karen Amsler, Dong Liang Zhan, Andrew M. Stern, Robert A. Copeland, Tasir Shamsul Haque, Christine F. Sizemore, Lisa D. Ecret, Lisa M. Kopcho, Seifu Tadesse, Andrew M. Slee, Frank W. Hobbs, M. John Rogers, Jovita Marcinkeviciene

المصدر: Journal of Medicinal Chemistry. 45:4669-4678

مصطلحات موضوعية: chemistry.chemical_classification, Helicobacter pylori, biology, medicine.drug_class, Carboxamide, Pyrazole, Chemical synthesis, In vitro, Structure-Activity Relationship, chemistry.chemical_compound, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Dihydroorotate dehydrogenase, Combinatorial Chemistry Techniques, Humans, Pyrazoles, Molecular Medicine, Enzyme Inhibitors, Oxidoreductases, Antibacterial agent

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039f4c4515594fb0da094487fc62ca17
https://doi.org/10.1021/jm020112w

المؤلفون: Andrew P. Combs, Lisa M. Kopcho, Tao Yang, Jovita Marcinkeviciene, Nikoo Falahatpisheh, Robert A. Copeland, Brian M. Glass, Lorin A. Thompson

المصدر: Journal of Biological Chemistry. 277:28677-28682

مصطلحات موضوعية: chemistry.chemical_classification, Conformational change, biology, Stereochemistry, Substrate (chemistry), Active site, Cell Biology, Biochemistry, chemistry.chemical_compound, Enzyme, chemistry, Statine, biology.protein, Piperidine, Molecular Biology, Conformational isomerism, Pepstatin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e0ca36fc454af1efdbd0af152f0e96d7
https://doi.org/10.1074/jbc.m203120200