المؤلفون: Roy D Schwarz, Michael J Callahan, Linda L Coughenour, Melvin R Dickerson, Jack J Kinsora, William J Lipinski, Charlotte A Raby, Carolyn J Spencer, Haile Tecle

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/291/2/812.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1044.6446; http://jpet.aspetjournals.org/content/jpet/291/2/812.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1044.6446
http://jpet.aspetjournals.org/content/jpet/291/2/812.full.pdf

المؤلفون: Linda L Coughenour, John J Cordon

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/280/2/584.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1046.1302; http://jpet.aspetjournals.org/content/jpet/280/2/584.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1046.1302
http://jpet.aspetjournals.org/content/jpet/280/2/584.full.pdf

المؤلفون: Linda L. Coughenour, Bridget M. Barr, Sham S. Nikam, David L. Rock, James Michael Graham

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:489-493

مصطلحات موضوعية: ERG1 Potassium Channel, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Indane, Pharmaceutical Science, Atypical antipsychotic, Pharmacology, Biochemistry, chemistry.chemical_compound, Dopamine, Drug Discovery, medicine, Humans, Receptor, Serotonin, 5-HT2A, Ziprasidone, Oxindole, Molecular Biology, Molecular Structure, Receptors, Dopamine D2, Organic Chemistry, medicine.disease, Ether-A-Go-Go Potassium Channels, Chemical space, chemistry, Schizophrenia, Indans, Receptor, Serotonin, 5-HT1A, Molecular Medicine, Serotonin, Antipsychotic Agents, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c49d0cefb5e90a818f338bf9527c1a1
https://doi.org/10.1016/j.bmcl.2007.11.106

المؤلفون: Linda L. Coughenour, Jamie Singer, Walters Michael, Tracy Fay Gregory, Bridget M. Barr

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:4560-4563

مصطلحات موضوعية: medicine.drug_class, Chemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Atypical antipsychotic, Carboxamide, Quinolones, Biochemistry, Chemical synthesis, In vitro, Dopamine, Drug Discovery, Schizophrenia, medicine, Humans, Molecular Medicine, Potency, Serotonin, Antipsychotic, Molecular Biology, Antipsychotic Agents, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4c179a3db18ce9f9148dd8c518318a
https://doi.org/10.1016/j.bmcl.2005.06.097

المؤلفون: Edward R. Whittemore, Minhtam Tran, David Rock, Richard M. Woodward, Zhang-Lin Zhou, Sui Xiong Cai, Christopher S. Konkoy, Stephen A. Espitia, Lawrence D. Wise, Christopher F. Bigge, John F. W. Keana, Jon E. Hawkinson, Eckard Weber, Peter A. Boxer, Linda L. Coughenour

المصدر: Journal of Medicinal Chemistry. 42:2993-3000

مصطلحات موضوعية: Patch-Clamp Techniques, Potassium Channels, Stereochemistry, medicine.drug_class, Substituent, Superior Cervical Ganglion, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Xenopus laevis, chemistry.chemical_compound, Piperidines, Receptors, Adrenergic, alpha-1, Drug Discovery, Potassium Channel Blockers, medicine, Animals, Potency, Receptor, Cerebral Cortex, Neurons, Antagonist, Receptor antagonist, Rats, chemistry, Oocytes, Molecular Medicine, NMDA receptor, Piperidine, Excitatory Amino Acid Antagonists, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f0076ffe71bb601601d1cf2ac46fcd
https://doi.org/10.1021/jm990246i

المؤلفون: Albert W. Probert, Peter A. Boxer, SA Borosky, Kevin K.W. Wang, Linda L. Coughenour, Iradj Hajimohammadreza, Frank W. Marcoux

المصدر: The Journal of Neuroscience. 15:4093-4101

مصطلحات موضوعية: N-Methylaspartate, Cell Survival, Carbazoles, chemistry.chemical_element, Kainate receptor, AMPA receptor, Naphthalenes, Biology, Calcium, Pharmacology, Hypoglycemia, Neuroprotection, Piperazines, Indole Alkaloids, Rats, Sprague-Dawley, Fetus, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, medicine, Animals, Polycyclic Compounds, Enzyme Inhibitors, Protein Kinase Inhibitors, Cells, Cultured, Protein Kinase C, Cerebral Cortex, Neurons, Cell Death, Dose-Response Relationship, Drug, General Neuroscience, Imidazoles, Glutamate receptor, Spectrin, Long-term potentiation, Articles, Isoquinolines, medicine.disease, Genistein, Isoflavones, Cell Hypoxia, Rats, Kinetics, chemistry, Biochemistry, Calcium-Calmodulin-Dependent Protein Kinases, NMDA receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e06f3297048e6b5ef7b9987ba74a7eb
https://doi.org/10.1523/jneurosci.15-05-04093.1995

المؤلفون: Thomas Charles Malone, Gregory W. Campbell, Elsebet Ø. Nielsen, Peter A. Boxer, Jorgen Drejer, Christopher F. Bigge, Frank Wätjen, Frank W. Marcoux, David M. Rock, Leif Helth Jensen, Leonard Joseph Lescosky, Linda L. Coughenour

المصدر: Bioorganic & Medicinal Chemistry Letters. 4:371-376

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, medicine.medical_treatment, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Biological activity, AMPA receptor, Biochemistry, Chemical synthesis, Sulfonamide, chemistry.chemical_compound, Anticonvulsant, chemistry, Drug Discovery, Lactam, medicine, Molecular Medicine, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d8c346721d74ca36cf753dffe53bc279
https://doi.org/10.1016/s0960-894x(01)80147-5

المؤلفون: Walter H. Moos, Stephen Joseph Johnson, Sharie L. Myers, Michael R. Pavia, Suzanne R. Kesten, Roy D. Schwarz, Robert E. Davis, Sheila H. Hobbs, Linda L. Coughenour, David T. Dudley

المصدر: ChemInform. 22

مصطلحات موضوعية: Biochemistry, Pilocarpine, Chemistry, medicine, Cholinergic, General Medicine, Pharmacology, Muscarinic agonist, medicine.drug, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c5c72bac365091fa5c5c42af714f78de
https://doi.org/10.1002/chin.199142186

المؤلفون: Leonard Joseph Lescosky, Peter A. Boxer, Christopher F. Bigge, E. Oe. Nielen, Thomas Charles Malone, David M. Rock, Gregory W. Campbell, Frank W. Marcoux, F. Waetjen, L. H. Jensen, J. Drejer, Linda L. Coughenour

المصدر: ChemInform. 25

مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Stereochemistry, Antagonist, General Medicine, AMPA receptor, Sulfonamide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8c38063053e43445d1cf35f12d1ae9f8
https://doi.org/10.1002/chin.199427105

المؤلفون: Susan Fisher, Anthony Jerome Thomas, Sharie L. Myers, Michael R. Pavia, Walter H. Moos, Kathryn B. Sanders, Robert E. Davis, Linda L. Coughenour

المصدر: Bioorganic & Medicinal Chemistry Letters. 2:803-808

مصطلحات موضوعية: chemistry.chemical_classification, Ketone, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Muscarinic acetylcholine receptor M1, Oxime, Biochemistry, Muscarinic agonist, In vitro, chemistry.chemical_compound, Drug Discovery, Muscarinic acetylcholine receptor, Oxotremorine, medicine, Molecular Medicine, Cholinergic, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0756b300258b502df83d79675763c24d
https://doi.org/10.1016/s0960-894x(00)80535-1

المؤلفون: Laura J. Brahce, Daniel F. Ortwine, Christopher F. Bigge, Daniel Martin Retz, Linda L. Coughenour, Frank W. Marcoux, Graham Johnson, Albert W. Probert, James T. Drummond

المصدر: Journal of Medicinal Chemistry. 35:1371-1384

مصطلحات موضوعية: Models, Molecular, N-Methylaspartate, Stereochemistry, Molecular Conformation, Organophosphonates, N-Methyl-D-aspartic acid, Binding, Competitive, Receptors, N-Methyl-D-Aspartate, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Structure–activity relationship, Amino Acids, IC50, Cells, Cultured, chemistry.chemical_classification, Antagonist, Brain, Rats, Inbred Strains, Phosphonate, Rats, Amino acid, chemistry, Molecular Medicine, NMDA receptor, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c927f723ddcc8ca7e03127ecbe94d
https://doi.org/10.1021/jm00086a005

المؤلفون: Linda L. Coughenour, Christopher F. Bigge, Cynthia M. Hanchin, James T. Drummond, Jiang-Ping Wu

المصدر: Bioorganic & Medicinal Chemistry Letters. 2:207-212

مصطلحات موضوعية: biology, Excitatory amino-acid transporter, Hydrogen bond, Stereochemistry, Ligand binding assay, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, N-Methyl-D-aspartic acid, Biochemistry, chemistry.chemical_compound, Equivalent, chemistry, Drug Discovery, biology.protein, Free fatty acid receptor, Molecular Medicine, NMDA receptor, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a0d302c38f2e631aa5be9e81476561
https://doi.org/10.1016/s0960-894x(01)81066-0

المؤلفون: Michael R. Pavia, Roy D. Schwarz, Robert E. Davis, Linda L. Coughenour, Stephen Joseph Johnson, Sharie L. Myers, David T. Dudley, Walter H. Moss, Sheila H. Hobbs, Suzanne R. Kesten

المصدر: Bioorganic & Medicinal Chemistry Letters. 1:147-150

مصطلحات موضوعية: Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Alpha (ethology), Pharmacology, Biochemistry, Muscarinic agonist, In vitro, Pilocarpine, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Molecular Medicine, Cholinergic, Molecular Biology, medicine.drug, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1986ad776c0f5bc246f691c5030b5ee2
https://doi.org/10.1016/s0960-894x(01)80787-3

المؤلفون: Leonard T. Meltzer, Sham S. Nikam, Jon L. Wright, Julie McCormick, Kevin A. Serpa, Brian Edward Kornberg, Bridget M. Barr, Suzanne Ross Kesten, Linda L. Coughenour

المصدر: ChemInform. 35

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, Receptors, N-Methyl-D-Aspartate, Drug Discovery, Animals, Structure–activity relationship, Receptor, Structural motif, Molecular Biology, IC50, Bicyclic molecule, Chemistry, Organic Chemistry, Antagonist, Brain, General Medicine, Subtype selective, In vitro, Rats, Alkynes, Molecular Medicine, NMDA receptor, Excitatory Amino Acid Antagonists, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaa78f4f3421e20dd86be49c38a65b0
https://doi.org/10.1002/chin.200423162

المؤلفون: Michael R. Pavia, Haile Tecle, Roy D. Schwarz, Robert E. Davis, Linda L. Coughenour, Walter H. Moos, David T. Dudley

المصدر: Cholinergic Basis for Alzheimer Therapy ISBN: 9781489967404

مصطلحات موضوعية: education.field_of_study, business.industry, Population, Cognition, Disease, medicine.disease, Visuospatial ability, Muscarinic agonist, chemistry.chemical_compound, chemistry, Muscarinic acetylcholine receptor, Medicine, Alzheimer's disease, business, education, Neuroscience, Ibotenic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::274ea6824437ad2289153b24259fc62c
https://doi.org/10.1007/978-1-4899-6738-1_37

المؤلفون: Christopher F. Bigge, Perry M. Novak, Sheryl J. Hays, James T. Drummond, Laura J. Brahce, Thomas P. Bobovski, Michael J. Rice, Graham Johnson, Linda L. Coughenour

المصدر: Journal of medicinal chemistry. 33(10)

مصطلحات موضوعية: N-Methylaspartate, Chemical Phenomena, Stereochemistry, Synaptic Membranes, Alkylation, Phosphinate, In Vitro Techniques, Binding, Competitive, Receptors, N-Methyl-D-Aspartate, Piperazines, chemistry.chemical_compound, Structure-Activity Relationship, Piperidines, Drug Discovery, Phenyl group, Structure–activity relationship, Moiety, Animals, Cerebral Cortex, Chemistry, Physical, Aryl, Phosphonate, Rats, chemistry, Molecular Medicine, Piperidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc2693378cea2cc2e47f87554eda469
https://pubmed.ncbi.nlm.nih.gov/2145436

المؤلفون: Haile Tecle, Stephen C. Bergmeier, Linda L. Coughenour, Lawrence D. Wise, Fred M. Hershenson, Thomas G. Heffner

المصدر: ChemInform. 21

مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Phenol, Organic chemistry, General Medicine, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7b1031fe887039b3871ccd832a677dce
https://doi.org/10.1002/chin.199001196

المؤلفون: Walter H. Moos, Linda L. Coughenour

المصدر: The Quarterly Review of Biology. 65:381-381

مصطلحات موضوعية: Muscarinic acetylcholine receptor, General Agricultural and Biological Sciences, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9b78cf80223f1f8dc30dcaf44eb02cdc
https://doi.org/10.1086/416914

المؤلفون: David A. Downs, Lawrence D. Wise, Ian C. Pattison, Horace A. DeWald, Dieter N. Schweiss, Donald E. Butler, Thomas A. Pugsley, David M. Lustgarten, Linda L. Coughenour, Thomas G. Heffner

المصدر: Journal of Medicinal Chemistry. 30:1807-1812

مصطلحات موضوعية: Ketone, Stereochemistry, Imine, Substituent, Motor Activity, Pyrazole, Receptors, Dopamine, Mice, chemistry.chemical_compound, Self Stimulation, Drug Discovery, Avoidance Learning, Animals, Moiety, Saimiri, chemistry.chemical_classification, Membranes, Behavior, Animal, Biological activity, Corpus Striatum, Rats, chemistry, Dopamine receptor, Molecular Medicine, Acetamide, Antipsychotic Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4a575ec39abe88818b0cc7464803e
https://doi.org/10.1021/jm00393a021

المؤلفون: Christopher F. Bigge, Albert W. Probert, Laura J. Brahce, Thomas Charles Malone, Frank W. Marcoux, James T. Drummond, Graham Johnson, Linda L. Coughenour

المصدر: Journal of Medicinal Chemistry. 32:1580-1590

مصطلحات موضوعية: Male, N-Methylaspartate, Chemical Phenomena, Stereochemistry, N-Methyl-D-aspartic acid, Phenylalanine, Receptors, N-Methyl-D-Aspartate, Phenylalanine derivatives, Mice, chemistry.chemical_compound, Organophosphorus Compounds, In vivo, Drug Discovery, Animals, Amino Acids, Alkyl, chemistry.chemical_classification, Aspartic Acid, Antagonist, Rats, Inbred Strains, Rats, Receptors, Neurotransmitter, Chemistry, chemistry, Molecular Medicine, NMDA receptor, Acid group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717cbbed1646195628b56aaaa995cd09
https://doi.org/10.1021/jm00127a030