المؤلفون: Jack A. Terrett, Justin Q. Ly, Paula Katavolos, Catrin Hasselgren, Steven Laing, Fiona Zhong, Elisia Villemure, Martin Déry, Robin Larouche-Gauthier, Huifen Chen, Daniel G. Shore, Wyne P. Lee, Eric Suto, Kevin Johnson, Marjory Brooks, Alyssa Stablein, Francis Beaumier, Léa Constantineau-Forget, Chantal Grand-Maître, Luce Lépissier, Stéphane Ciblat, Claudio Sturino, Yong Chen, Baihua Hu, Justin Elstrott, Vineela Gandham, Victory Joseph, Helen Booler, Gary Cain, Carolina Chou, Aaron Fullerton, Michelle Lepherd, Shannon Stainton, Elizabeth Torres, Konnie Urban, Lanlan Yu, Yu Zhong, Linda Bao, Kang-Jye Chou, Jessica Lin, Wei Zhang, Hank La, Liling Liu, Teresa Mulder, Jun Chen, Tania Chernov-Rogan, Adam R. Johnson, David H. Hackos, Rebecca Leahey, Shannon D. Shields, Alessia Balestrini, Lorena Riol-Blanco, Brian S. Safina, Matthew Volgraf, Steven Magnuson, Satoko Kakiuchi-Kiyota

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Neuroscience, Pharmacology, Cancer, Mental Health, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, thorough investigative toxicology, several lead molecules, primary sensory neurons, metabolite  generated, e ., coumarins, clinical pathology analysis, ao ) possessing, ameliorated coagulation effects, aldehyde oxidase metabolism, aldehyde oxidase, coagulation parameters, clinical candidate, block ao, anticoagulation effects, vivo <, term repeat, target engagement, similar pharmacophore

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_TRPA1_Antagonist_b_GDC-6599_b_Derisking_Preclinical_Toxicity_and_Aldehyde_Oxidase_Metabolism_with_a_Potential_First-in-Class_Therapy_for_Respiratory_Disease/25331537

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02121.s001
https://figshare.com/articles/journal_contribution/Discovery_of_TRPA1_Antagonist_b_GDC-6599_b_Derisking_Preclinical_Toxicity_and_Aldehyde_Oxidase_Metabolism_with_a_Potential_First-in-Class_Therapy_for_Respiratory_Disease/25331537

المؤلفون: Yingqing Ran, Le An, Linda Bao

المصدر: Journal of Pharmaceutical Sciences. 107:327-333

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, 0301 basic medicine, Drug, Chemistry, Pharmaceutical, Fibrosarcoma, media_common.quotation_subject, Pharmaceutical Science, Permeability, 03 medical and health sciences, medicine, Humans, Solubility, Protein Kinase Inhibitors, Dissolution, media_common, Aqueous solution, Chromatography, Chemistry, Metabolism, Hydrogen-Ion Concentration, medicine.disease, Bioavailability, 030104 developmental biology, Solubilization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfb3be0c2fc847902111285ced5e8d1
https://doi.org/10.1016/j.xphs.2017.09.023

المؤلفون: Daniel P Sutherlin, Linda Bao, Megan Berry, Georgette Castanedo, Irina Chuckowree, Jenna Dotson, Adrian Folks, Lori Friedman, Richard Goldsmith, Janet Gunzner, Timothy Heffron, John Lesnick, Cristina Lewis, Simon Mathieu, Jeremy Murray, Jim Nonomiya, Jodie Pang, Niel Pegg, Wei Wei Prior, Lionel Rouge, Laurent Salphati, Deepak Sampath, Qingping Tian, Vickie Tsui, Nan Chi Wan, Shumei Wang, BinQing Wei, Christian Wiesmann, Ping Wu, Bing-Yan Zhu, Alan Olivero

مصطلحات موضوعية: Uncategorised value

Relation: 10779/uos.23419241.v1; https://figshare.com/articles/journal_contribution/Discovery_of_a_potent_selective_and_orally_available_class_I_phosphatidylinositol_3-kinase_PI3K_mammalian_target_of_rapamycin_mTOR_kinase_inhibitor_GDC-0980_for_the_treatment_of_cancer/23419241

الاتاحة: https://figshare.com/articles/journal_contribution/Discovery_of_a_potent_selective_and_orally_available_class_I_phosphatidylinositol_3-kinase_PI3K_mammalian_target_of_rapamycin_mTOR_kinase_inhibitor_GDC-0980_for_the_treatment_of_cancer/23419241

المؤلفون: Yuzhong Deng, Po-Chang Chiang, Amy Sambrone, Linda Bao, Wei Jia, Hank La, Harvey Wong, Yong Cui, Ann Qin, Yingqing Ran, Joe Lubach, Jonathan Hau, Kang-Jye Chou

المصدر: The AAPS journal. 15(2)

مصطلحات موضوعية: Male, Materials science, Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Drug Compounding, Evaporation, Pharmaceutical Science, Administration, Oral, Biological Availability, Methylcellulose, Crystallography, X-Ray, Griseofulvin, Matrix (chemical analysis), Rats, Sprague-Dawley, Freeze-drying, Drug Stability, In vivo, Organic chemistry, Animals, Technology, Pharmaceutical, Solubility, chemistry.chemical_classification, Calorimetry, Differential Scanning, Polymer, Amorphous solid, Bioavailability, Rats, Freeze Drying, Chemical engineering, chemistry, Thermogravimetry, Powder Diffraction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b56fb4fc30fabcfe00c11cf747bb869
https://pubmed.ncbi.nlm.nih.gov/23456436

المؤلفون: Elizabeth Blackwood, Yung-Hsiang Chen, Frederick Cohen, Jim Nonomiya, Gauri Deshmukh, Suzanne Tay, Ulka Vijapurkar, Joseph P. Lyssikatos, Marcia Belvin, Jennifer Epler, Xianrui Zhao, Sophie Mukadam, Lan Trinh, Huifen Chen, Linda Bao, Philippe Bergeron, Xiao Ding, Michael F. T. Koehler, Shiva Malek, Jane R. Kenny, Steve Sideris, Tom Truong, Daniel F. Ortwine, Anthony A. Estrada, John Lesnick, Zhonghua Pei, Cuong Ly, Kevin Lau, Lichuan Liu, Lori Friedman

المصدر: ACS medicinal chemistry letters. 4(1)

مصطلحات موضوعية: business.industry, Kinase, Organic Chemistry, Tumor cells, Pharmacology, Discovery and development of mTOR inhibitors, Biochemistry, Mouse xenograft, Drug Discovery, Cancer research, Medicine, Signal transduction, business, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c1a6eae96f72cb1732590416447611
https://pubmed.ncbi.nlm.nih.gov/24900569

المؤلفون: Vickie Tsui, Laurent Salphati, Binqing Wei, Linda Bao, Richard Goldsmith, Niel Pegg, Megan Berry, Wei Wei Prior, Bing-Yan Zhu, Jim Nonomiya, Shumei Wang, Ping Wu, Jeremy Murray, Timothy P. Heffron, Adrian Folks, Irina Chuckowree, Qingping Tian, Alan G. Olivero, Janet L. Gunzner, Cristina Lewis, Jodie Pang, Lionel Rouge, Nan Chi Wan, Simon Mathieu, Georgette Castanedo, Christian Wiesmann, Lori Friedman, John Lesnick, Daniel P. Sutherlin, Jenna Dotson, Deepak Sampath

المصدر: Journal of medicinal chemistry. 54(21)

مصطلحات موضوعية: Gene isoform, Models, Molecular, Class I Phosphatidylinositol 3-Kinases, Protein Conformation, Transplantation, Heterologous, Administration, Oral, Mice, Nude, Antineoplastic Agents, Pharmacology, In Vitro Techniques, Crystallography, X-Ray, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Animals, Humans, Phosphatidylinositol, Cell potency, PI3K/AKT/mTOR pathway, Indazole, Kinase, TOR Serine-Threonine Kinases, Stereoisomerism, Bridged Bicyclo Compounds, Heterocyclic, Rats, Isoenzymes, Pyrimidines, Biochemistry, chemistry, Free fraction, Microsome, Microsomes, Liver, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ddde0beea93ee1938d2e986322ae16
https://pubmed.ncbi.nlm.nih.gov/21981714

المؤلفون: Binqing Wei, Tim Heffron, Georgette Castanedo, Leanne Berry, Laurent Salphati, Jim Nonomiya, Cristina Lewis, Jeff Wallin, Wei Wei Prior, James C. Marsters, Deepak Sampath, Kyle A. Edgar, Megan Berry, Adrian Folkes, Sonal Patel, Marcia Belvin, Alan G. Olivero, Vickie Tsui, Linda Bao, Daniel P. Sutherlin, John Lesnick, Lori Friedman, Jodie Pang, Bing-Yan Zhu, Christian Weismann

المصدر: Cancer Research. 71:2787-2787

مصطلحات موضوعية: Cancer Research, Oncology, In vivo, Cell growth, Kinase, Cancer cell, Potency, Plasma protein binding, Biology, Signal transduction, Pharmacology, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::00ce6d28e3741ec52e1230abee092263
https://doi.org/10.1158/1538-7445.am2011-2787

المؤلفون: Po-Chang Chiang, Yong Cui, Yingqing Ran, Joe Lubach, Kang-Jye Chou, Linda Bao, Wei Jia, Hank La, Jonathan Hau, Amy Sambrone, Ann Qin, Yuzhong Deng, Harvey Wong

المصدر: AAPS Journal; Apr2013, Vol. 15 Issue 2, p608-617, 10p

المؤلفون: Daniel P. Sutherlin¹, Linda Bao¹, Megan Berry¹, Georgette Castanedo¹, Irina Chuckowree¹, Jenna Dotson¹, Adrian Folks¹, Lori Friedman¹, Richard Goldsmith¹, Janet Gunzner¹, Timothy Heffron¹, John Lesnick¹, Cristina Lewis¹, Simon Mathieu¹, Jeremy Murray¹, Jim Nonomiya¹, Jodie Pang¹, Niel Pegg¹, Wei Wei Prior¹, Lionel Rouge¹

المصدر: Journal of Medicinal Chemistry. Nov2011, Vol. 54 Issue 21, p7579-7587. 9p.

مصطلحات موضوعية: *DRUG development, *ORAL medicine, *PHOSPHOINOSITIDES, *RAPAMYCIN, *CANCER treatment, *ONCOLOGY, *AZOLES, *CLINICAL trials