يعرض 1 - 20 نتائج من 108 نتيجة بحث عن '"Lieven, Meerpoel"', وقت الاستعلام: 0.71s تنقيح النتائج
  1. 1
    Academic Journal
    Stereodivergent Synthesis of Biologically Active Spironucleoside Scaffolds via Catalytic Cyclopropanation of 4- exo -Methylene Furanosides

    المؤلفون: Zeina Neouchy (4967218), Jonas Verhoeven (9646827), Hanchu Kong (11642099), Yongbin Zhao (4907128), Wenbin Wang (404991), Marta Brambilla (4169134), Kristof Van Hecke (7196306), Lieven Meerpoel (1457320), Jan Willem Thuring (2198326), Guido Verniest (1599958), Johan Winne (3812020)

    مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Chemical Sciences not elsewhere classified, protein methyltransferase prmt5, powerful design strategy, one analogue inhibiting, four possible configurations, conformationally constrained analogues, spirocyclopropane furanoses, mep50 complex, furanosyl nucleosides, exo <

    Relation: https://figshare.com/articles/journal_contribution/Stereodivergent_Synthesis_of_Biologically_Active_Spironucleoside_Scaffolds_via_Catalytic_Cyclopropanation_of_4-_i_exo_i_-Methylene_Furanosides/16958404

    الاتاحة: https://doi.org/10.1021/acs.joc.1c01611.s001

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  2. 2
    Academic Journal
    Regio- and Stereoselective Synthesis of C‑4′ Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues

    المؤلفون: Lucile Jouffroy (11642096), Jonas Verhoeven (9646827), Marta Brambilla (4169134), Guido Verniest (1599958), Hanchu Kong (11642099), Yongbin Zhao (4907128), Wenbin Wang (404991), Lieven Meerpoel (1457320), Jan Willem Thuring (2198326), Johan M. Winne (2524540)

    مصطلحات موضوعية: Biochemistry, Molecular Biology, Physiology, Pharmacology, Biotechnology, Infectious Diseases, Virology, Computational Biology, Chemical Sciences not elsewhere classified, protein methyltransferase prmt5, carbonyl transposition sequence, 5 ′ cyclobutane, 4 ′, unusual stereoselective ionic, required constrained ribofuranoses, stereoselective synthesis, methylaluminoxane gave, mep50 complex, first entry, exo <, direct approach, dependent inhibition

    Relation: https://figshare.com/articles/journal_contribution/Regio-_and_Stereoselective_Synthesis_of_C_4_Spirocyclobutyl_Ribofuranose_Scaffolds_and_Their_Use_as_Biologically_Active_Nucleoside_Analogues/16923911

    الاتاحة: https://doi.org/10.1021/acs.orglett.1c03334.s001

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  3. 3
    Academic Journal
    FEP+ calculations predict a stereochemical SAR switch for first-in-class indoline NIK inhibitors for multiple myeloma

    المؤلفون: Edgar Jacoby, Herman Van Vlijmen, Olivier Querolle, Ian Stansfield, Lieven Meerpoel, Matthias Versele, George Hynd, Ricardo Attar

    المصدر: Future Drug Discovery, Vol 2, Iss 3 (2020)

    مصطلحات موضوعية: free energy perturbation, JNJ64290694, lead optimization, multiple myeloma, NIK, Pharmacy and materia medica, RS1-441

    Relation: https://doaj.org/toc/2631-3316; https://doaj.org/article/a72afa18a5434f74909b12876dc83999

    الاتاحة: https://doi.org/10.4155/fdd-2020-0004
    https://doaj.org/article/a72afa18a5434f74909b12876dc83999

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  4. 4
    Supplementary Data 4 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b412d4d52e0d535f1c8c6d13401b4a02
    https://doi.org/10.1158/1535-7163.22522974.v1

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  5. 5
    Supplementary Data 8 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34804cb0125a81473c7d210b57a8ac51
    https://doi.org/10.1158/1535-7163.22522962.v1

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  6. 6
    Data from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb756fdc24c04d7164e04381faf2716
    https://doi.org/10.1158/1535-7163.c.6543534

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  7. 7
    Supplementary Data 2 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f427283d55abb76e964cda4ea0a4f9
    https://doi.org/10.1158/1535-7163.22522980

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  8. 8
    Supplementary Data 6 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa35053fc761b250e3b1e58cb6ddca8
    https://doi.org/10.1158/1535-7163.22522968.v1

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  9. 9
    Supplementary Data 5 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c60f9d4ec5dd81e09281d56be0371c
    https://doi.org/10.1158/1535-7163.22522971

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  10. 10
    Supplementary Data 1 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a67e34f3b97f6a1cb6d6d88a89a877f
    https://doi.org/10.1158/1535-7163.22522983

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  11. 11
    Supplementary Data 3 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9357ac4b74d0a19b1138db2c193e9a97
    https://doi.org/10.1158/1535-7163.22522977.v1

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  12. 12
    Supplementary Data 7 from Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer

    المؤلفون: Gilles Bignan, Marco M. Gottardis, Yolanda T. Chong, Christopher J. Parrett, Kathryn Packman, Lieven Meerpoel, Geert Van Hecke, Georges Habineza, James R. Bischoff, Steffen Jaensch, Janine Ondrus, Ian Hickson, Zhuming Zhang, Peter J. Connolly, Vineet Pande, Tammy L. Bush, Jonathan R. Branch

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217aba4d9eeb9f12924f124c1bf8b96f
    https://doi.org/10.1158/1535-7163.22522965.v1

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  13. 13
    Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer

    المؤلفون: Zhuming Zhang, Heng-Keang Lim, Jonathan Branch, Vineet Pande, Janine Ondrus, James R. Bischoff, Peter J. Connolly, Bush Tammy, Lieven Meerpoel, Ian Hickson, Christian Rocaboy, Luis B. Trabalón Escolar, Gilles Bignan

    المصدر: ACS Med Chem Lett

    مصطلحات موضوعية: Chemistry, Antiandrogens, Point mutation, Organic Chemistry, Apalutamide, Mutant, Wild type, urologic and male genital diseases, medicine.disease, Biochemistry, Androgen receptor, Prostate cancer, chemistry.chemical_compound, Drug Discovery, medicine, Cancer research, Enzalutamide

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2583de003d65667131bf1b1caba4e
    https://doi.org/10.1021/acsmedchemlett.1c00032

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  14. 14
    Preparation of Novel 4′-Spirocyclopropyl Nucleoside Analogues

    المؤلفون: Jan Willem Thuring, Hanchu Kong, Guido Verniest, Wenbin Wang, Kristof Van Hecke, Lieven Meerpoel, Yongbin Zhao, Vineet Pande, Marta Brambilla, Jonas Verhoeven

    المصدر: Synlett. 32:892-896

    مصطلحات موضوعية: Glycosylation, Nucleoside analogue, 010405 organic chemistry, Organic Chemistry, 010402 general chemistry, Favorskii rearrangement, 01 natural sciences, Combinatorial chemistry, Cycloaddition, 0104 chemical sciences, Nucleobase, chemistry.chemical_compound, Stereospecificity, chemistry, medicine, Stereoselectivity, Nucleoside, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d3279e95162d84baaee38defe91b1c22
    https://doi.org/10.1055/a-1386-7194

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  15. 15
    Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)

    المؤلفون: Zhuming Zhang, Yolanda T. Chong, James R. Bischoff, Jonathan Branch, Christopher J. Parrett, Janine Ondrus, Gilles Bignan, Lieven Meerpoel, Kathryn Packman, Leopoldo Luistro, Marco Gottardis, Bush Tammy, Salam H. Ibrahim, Christopher A. Teleha, Vineet Pande, Peter J. Connolly, Heng-Keang Lim, Ian Hickson

    المصدر: Journal of Medicinal Chemistry. 64:909-924

    مصطلحات موضوعية: Male, Models, Molecular, Pyridines, medicine.disease_cause, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Prostate cancer, chemistry.chemical_compound, Dogs, Piperidines, Cell Line, Tumor, Nitriles, Drug Discovery, Androgen Receptor Antagonists, medicine, Animals, Humans, Enzalutamide, Spiro Compounds, Biotransformation, 030304 developmental biology, 0303 health sciences, Mutation, Point mutation, Apalutamide, Antagonist, Wild type, Prostatic Neoplasms, medicine.disease, Rats, 0104 chemical sciences, Androgen receptor, Prostatic Neoplasms, Castration-Resistant, 010404 medicinal & biomolecular chemistry, chemistry, Drug Resistance, Neoplasm, Picolines, Hepatocytes, Cancer research, Molecular Medicine

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a913df6dcf096e8ad0ea7030d6423e6f
    https://doi.org/10.1021/acs.jmedchem.0c01563

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  16. 16
    A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode

    المؤلفون: Lijs Beke, Didier Berthelot, David Brown, Colin Robinson, Lieven Meerpoel, Weimei Sun, Dirk Brehmer, Tongfei Wu, Viellevoye Marcel, Thomas Nys, Cois Sommen, Jordi Corbera, Vineet Pande, Marc Parade, Steve Irving, Jan Willem Thuring

    المصدر: ACS Med Chem Lett

    مصطلحات موضوعية: chemistry.chemical_classification, Methyltransferase, Methionine, Arginine, biology, 010405 organic chemistry, Stereochemistry, Protein arginine methyltransferase 5, Organic Chemistry, 01 natural sciences, Biochemistry, Cofactor, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Enzyme, Non-histone protein, chemistry, Drug Discovery, biology.protein, Binding site

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a16efef12f0eabe456aa4f7875dd313
    https://doi.org/10.1021/acsmedchemlett.0c00355

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  17. 17
    Synthesis of Cyclopropyl Pinacol Boronic Esters from Dibromo-cyclopropanes

    المؤلفون: Zeina Neouchy, Jan Hullaert, Jonas Verhoeven, Lieven Meerpoel, Jan-Willem Thuring, Guido Verniest, Johan Winne

    المساهمون: Faculty of Physical Education and Physical Therapy, Department of Bio-engineering Sciences, Chemistry

    مصطلحات موضوعية: Matteson-Pasto rearrangement, borylcyclopropanes, pinacolborane, Organic Chemistry, olefins, dibromocyclopropanes

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdc3adf115e0176c7967ec1d75f8435
    https://biblio.vub.ac.be/vubir/synthesis-of-cyclopropyl-pinacol-boronic-esters-from-dibromocyclopropanes(41234753-b831-4e2e-9931-f543901fa654).html

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  18. 18
    Academic Journal
    Conazoles

    المؤلفون: Jan Heeres, Lieven Meerpoel, Paul Lewi

    المصدر: Molecules, Vol 15, Iss 6, Pp 4129-4188 (2010)

    مصطلحات موضوعية: miconazole, ketoconazole, itraconazole, posaconazole, fluconazole, voriconazole, antifungal, Organic chemistry, QD241-441

    وصف الملف: electronic resource

    Relation: http://www.mdpi.com/1420-3049/15/6/4129/; https://doaj.org/toc/1420-3049

    URL الوصول: https://doaj.org/article/14698487fee44c7aa0a8daeea34f790b

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  19. 19
    Stereodivergent Synthesis of Biologically Active Spironucleoside Scaffolds via Catalytic Cyclopropanation of 4

    المؤلفون: Zeina, Neouchy, Jonas, Verhoeven, Hanchu, Kong, Yongbin, Zhao, Wenbin, Wang, Marta, Brambilla, Kristof, Van Hecke, Lieven, Meerpoel, Jan Willem, Thuring, Guido, Verniest, Johan, Winne

    المصدر: The Journal of organic chemistry. 86(23)

    مصطلحات موضوعية: Adenosine, Nucleosides, Catalysis

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e5d09aa24eae66e648c46513b08eb948
    https://pubmed.ncbi.nlm.nih.gov/34748342

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  20. 20
    Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues

    المؤلفون: Guido Verniest, Yongbin Zhao, Lucile Marguerite Jouffroy, Jan Willem Thuring, Hanchu Kong, Jonas Verhoeven, Marta Brambilla, Wenbin Wang, Lieven Meerpoel, Johan M. Winne

    المساهمون: Faculty of Physical Education and Physical Therapy, Department of Bio-engineering Sciences, Chemistry

    المصدر: Organic letters. 23(22)

    مصطلحات موضوعية: Adenosine, Chemistry, Stereochemistry, Organic Chemistry, Methylaluminoxane, Ionic bonding, Biological activity, Ribonucleoside, Biochemistry, Cycloaddition, chemistry.chemical_compound, medicine, Stereoselectivity, Physical and Theoretical Chemistry, Nucleoside, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c016ec9e92c62fef46ad8db24971640b
    https://pubmed.ncbi.nlm.nih.gov/34978448

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