المؤلفون: Baodong Zeng, Tao Ma, Yongqiang Wang, Jie Zhang, Liangren Zhang, Xi’en Chang

المصدر: Heritage Science, Vol 11, Iss 1, Pp 1-19 (2023)

مصطلحات موضوعية: Xinjiang, Bronze age, Pottery analysis, Technological exchange, Population migration, Fine Arts, Analytical chemistry, QD71-142

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2050-7445

URL الوصول: https://doaj.org/article/c34822ebb71e40fdad47b11ef283e8a2

المؤلفون: Zhongtang Li, Fan Fang, Yiyan Li, Xuehui Lv, Ruqiu Zheng, Peili Jiao, Yuxi Wang, Guiwang Zhu, Zefang Jin, Xiangqing Xu, Yinli Qiu, Guisen Zhang, Zhongjun Li, Zhenming Liu, Liangren Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4553-4577 (2023)

مصطلحات موضوعية: Dopamine D3 receptor, Carbazole derivatives, Tetrahydro-carboline, Bitopic ligand, Antipsychotic, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523002861; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/08553c6ed9fd4efaa867b3079b9ecb63

المؤلفون: Dongxue Chang, Zhiqing Zhang, Xiaoshuang Li, Liangren Zhang

المصدر: Heritage Science, Vol 11, Iss 1, Pp 1-13 (2023)

مصطلحات موضوعية: Yuan dynasty, Taicang Port, Koryŏ inlay celadon, Sino-Korean interaction, Scanning electron microscopy, Fine Arts, Analytical chemistry, QD71-142

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2050-7445

URL الوصول: https://doaj.org/article/5110387ee12c4c0db42071fc5f04b3f7

المؤلفون: Chenxia Yang, Ying Meng, Xintong Wang, Xin Li, Tong Yu, Weiming Liao, Wenjun Xie, Qianchen Jiang, Han Wang, Cheng Shi, Wenxuan Jiao, Xiling Bian, Fang Hu, Xiaowei Wang, Yani Liu, Liangren Zhang, KeWei Wang, Qi Sun

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Physiology, Pharmacology, Biotechnology, Mental Health, Chemical Sciences not elsewhere classified, exhibits potent activation, representative atypical type, positive allosteric modulators, methyl group results, 100 μm ), 9 , 7b , 6p , maximum activation effect, 50 , allosteric activation, xenopus <, typical type, max effect, amino group, 3 μm, α7 currents, therapeutic strategy, mouse schizophrenia, like model, cognitive disorders, cognitive deficits

Relation: https://figshare.com/articles/journal_contribution/Allosteric_Activation_of_7_Nicotinic_Acetylcholine_Receptors_by_Novel_2_Arylamino-thiazole-5-carboxylic_Acid_Amide_Derivatives_for_the_Improvement_of_Cognitive_Deficits_in_Mice/25276604

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c02323.s001
https://figshare.com/articles/journal_contribution/Allosteric_Activation_of_7_Nicotinic_Acetylcholine_Receptors_by_Novel_2_Arylamino-thiazole-5-carboxylic_Acid_Amide_Derivatives_for_the_Improvement_of_Cognitive_Deficits_in_Mice/25276604

المؤلفون: Burglind Jungmann, Liangren Zhang

المساهمون: École française d'Extrême-Orient

المصدر: Arts asiatiques 65(1):75-94

URL الوصول: http://www.persee.fr/doc/arasi_0004-3958_2010_num_65_1_1702

المؤلفون: Ningfeng Liu, Hongwei Jin, Liangren Zhang, Zhenming Liu

المصدر: Health Data Science, Vol 3 (2023)

مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2765-8783

URL الوصول: https://doaj.org/article/b3ee9f10e15f4d8fa5eb8ad1d52f05b3

المؤلفون: Wenyu Zhu, Yanxing Wang, Yan Niu, Liangren Zhang, Zhenming Liu

المصدر: Health Data Science, Vol 3 (2023)

مصطلحات موضوعية: Computer applications to medicine. Medical informatics, R858-859.7

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2765-8783

URL الوصول: https://doaj.org/article/24e3ab913acd464ab1bb9c5b090ca34b

المؤلفون: Changbiao Chi (6527651), Run Xu (1977841), Qianqian Chen (172349), Xiaohui Zhang (81778), Xiaomeng Shi (839260), Hongwei Jin (391981), Fuling Yin (10757693), Hongli Jia (9574449), Liangren Zhang (114208), Donghui Yang (289640), Jianhua Ju (773073), Qinglian Li (1438771), Ming Ma (43147)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Evolutionary Biology, Ecology, Cancer, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, shows poor tertiary, sequence alignment shows, important building blocks, covalently mediated interconversion, common catalytic paradigm, dependent mutase revealing, dependent mutase mtdl, dependent mutases, structure similarity, structural insight, secondary metabolites, molecular dynamics, known enzymes, key residues, directed mutagenesis, crystal structure, containing molecules, based pyranose, arginine residue

Relation: https://figshare.com/articles/journal_contribution/Structural_Insight_into_a_Metal-Dependent_Mutase_Revealing_an_Arginine_Residue-Covalently_Mediated_Interconversion_between_Nucleotide-Based_Pyranose_and_Furanose/21872459

الاتاحة: https://doi.org/10.1021/acscatal.2c04907.s001

المؤلفون: Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1947-1964 (2021)

مصطلحات موضوعية: ANO1 (anoctamin 1, TMEM16A), Inhibitor, Synthesis, Structure–activity relationship, Analgesia, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383520307929; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/65a6ec1bc8c447e5ae90d1f9ab335c92

المؤلفون: Liang Peng, Liting Zeng, Hongwei Jin, Lixin Yang, Yi Xiao, Ziquan Lan, Zhanpeng Yu, Shi Ouyang, Liangren Zhang, Ning Sun

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1224-1232 (2020)

مصطلحات موضوعية: antibacterial, uropathogenic e. coli, ppk1, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

URL الوصول: https://doaj.org/article/072ddb39e5924fdb91de9471710fd0c4

المؤلفون: Zhi Ying Zhao, Xu Jie Xie, Wan Hua Li, Jun Liu, Zhe Chen, Ben Zhang, Ting Li, Song Lu Li, Jun Gang Lu, Liangren Zhang, Li-he Zhang, Zhengshuang Xu, Hon Cheung Lee, Yong Juan Zhao

المصدر: iScience, Vol 15, Iss , Pp 452-466 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004219301373; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/5d45c6daf8bc4ce292b8a265b924f321

المؤلفون: Xintong Wang (336550), Haoran Xiao (11255668), Jing Wang (6206297), Zongze Huang (5074178), Geng Peng (416757), Wenjun Xie (482792), Xiling Bian (5074190), Huijie Liu (717840), Cheng Shi (3950261), Taoyi Yang (5074199), Xin Li (51274), Jian Gao (307118), Ying Meng (327793), Qianchen Jiang (11255671), Wei Chen (23863), Fang Hu (476414), Ningning Wei (8208558), Xiaowei Wang (27921), Liangren Zhang (114208), KeWei Wang (5074196), Qi Sun (127)

مصطلحات موضوعية: Biochemistry, Neuroscience, Pharmacology, Biotechnology, Mental Health, Chemical Sciences not elsewhere classified, representative compound 10 e functions, homopentameric α7 nAChR, 3.0 μ M, α7 Nicotinic Acetylcholine Receptor., PAM, EC, auditory gating deficit, Positive Allosteric Modulators, 10 e, Compound 10 e, novel α7 nAChR, Novel Triazine Derivatives

Relation: https://figshare.com/articles/journal_contribution/Synthesis_and_Biological_Evaluation_of_Novel_Triazine_Derivatives_as_Positive_Allosteric_Modulators_of_7_Nicotinic_Acetylcholine_Receptors/15142330

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01058.s001

المؤلفون: Jiahui Yu (4184329), Juan Song (162907), Changbiao Chi (6527651), Tan Liu (5735786), Tongtong Geng (6527642), Zonghui Cai (8163516), Weidong Dong (11402789), Cheng Shi (3950261), Xueyang Ma (3604004), Zhongyi Zhang (219440), Xiaojie Ma (285722), Baiying Xing (6527648), Hongwei Jin (391981), Liangren Zhang (114208), Suwei Dong (2017039), Donghui Yang (289640), Ming Ma (43147)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Biotechnology, Cancer, Computational Biology, hallmark building blocks, facilitates chemoenzymatic synthesis, amino acid residues, amino acid residue, bifunctional thioesterase domain, versatile te domains, te specifically catalyzes, te domain, terminal l, study expands, skyllamycin biosynthesis, nonribosomal peptides, linear substrate, functional characterization, directed mutagenesis, crystal structure, combinatorial biosynthesis, 25 å

Relation: https://figshare.com/articles/journal_contribution/Functional_Characterization_and_Crystal_Structure_of_the_Bifunctional_Thioesterase_Catalyzing_Epimerization_and_Cyclization_in_Skyllamycin_Biosynthesis/16583495

الاتاحة: https://doi.org/10.1021/acscatal.1c03064.s001

المؤلفون: Ningfeng Liu (11009093), Junyong Lai (8904569), Chuanyu Lyu (11009096), Bo Qiang (5444252), Heyu Wang (8354757), Hongwei Jin (391981), Liangren Zhang (114208), Zhenming Liu (448850)

مصطلحات موضوعية: Biophysics, Pharmacology, Biotechnology, Ecology, Science Policy, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, chemoinformatic analysis methods, Comprehensive Chemoinformatic Analysis, MNP, CMNPD, TNP, drug discovery, 30 000 marine

Relation: https://figshare.com/articles/journal_contribution/Chemical_Space_Scaffolds_and_Halogenated_Compounds_of_CMNPD_A_Comprehensive_Chemoinformatic_Analysis/14824910

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00162.s001

المؤلفون: Han Zhang (110653), Peilin Yu (114197), Hongwei Lin (6169187), Zefang Jin (10499985), Siqi Zhao (3164940), Yi Zhang (9093), Qingxia Xu (10160397), Hongwei Jin (391981), Zhenming Liu (448850), Wei Yang (109917), Liangren Zhang (114208)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Pharmacology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, TRPM 8, artery occlusion model, calcium imaging, Novel ACA Derivatives, compound, pharmacokinetic studies, TRPV 1 channels, Specific TRPM 2 Inhibitors, sub-micromolar half-maximal, concentration values, TRPM 2 selectivity, TRPM 2 inhibitors, ischemic injury, TRPM 2-targeted, electrophysiology approaches, neurodegenerative diseases, anthranilic acid, neuroprotective activity, TRPM 2-related research, TRPM 2 channel

Relation: https://figshare.com/articles/journal_contribution/The_Discovery_of_Novel_ACA_Derivatives_as_Specific_TRPM2_Inhibitors_that_Reduce_Ischemic_Injury_Both_In_Vitro_and_In_Vivo/14342547

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02129.s002

المؤلفون: Bo Qiang, Junyong Lai, Hongwei Jin, Liangren Zhang, Zhenming Liu

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 9; Pages: 4632

مصطلحات موضوعية: target prediction, deep learning, transfer learning, natural product

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Informatics; https://dx.doi.org/10.3390/ijms22094632

الاتاحة: https://doi.org/10.3390/ijms22094632

المؤلفون: Han Huang, Jiansong Fang, Xiude Fan, Tatsunori Miyata, Xiaoyue Hu, Lihe Zhang, Liangren Zhang, Yimin Cui, Zhenming Liu, Xiaoqin Wu

المصدر: Frontiers in Pharmacology, Vol 11 (2020)

مصطلحات موضوعية: Traditional Chinese medicine (TCM), cancer cells, tumor immunosuppressive microenvironment (TIM), immune response, synergistic effect, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.01009/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/6528554f7b1549d7b069c6d68824be4e

المؤلفون: Yibo Li, Liangren Zhang, Zhenming Liu

المصدر: Journal of Cheminformatics, Vol 10, Iss 1, Pp 1-24 (2018)

مصطلحات موضوعية: Deep learning, De novo drug design, Graph generative model, Information technology, T58.5-58.64, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13321-018-0287-6; https://doaj.org/toc/1758-2946

URL الوصول: https://doaj.org/article/3a2a376d4efc4d63be521adaab98451c

المؤلفون: Changbiao Chi, Run Xu, Qianqian Chen, Xiaohui Zhang, Xiaomeng Shi, Hongwei Jin, Fuling Yin, Hongli Jia, Liangren Zhang, Donghui Yang, Jianhua Ju, Qinglian Li, Ming Ma

المصدر: ACS Catalysis. 13:1597-1603

مصطلحات موضوعية: General Chemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0fd98750876160920b248137b53cb9bb
https://doi.org/10.1021/acscatal.2c04907

المؤلفون: Chao Wang, Han Wang, Cangxin Zheng, Bingru Li, Zhenming Liu, Liangren Zhang, Lan Yuan, Ping Xu

المصدر: ACS Medicinal Chemistry Letters. 14:92-102

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::22561880bd72a8d73f2d4a1263781d25
https://doi.org/10.1021/acsmedchemlett.2c00446