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1Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor☆
المؤلفون: Kendra K. Bence, Derek J. Zimmer, Kimberly Rak, Ryan C. Tsou
المصدر: Molecular Metabolism
مصطلحات موضوعية: Leptin, WAT, White adipose tissue, White adipose tissue, SHP2, Src homology 2 domain-containing protein tyrosine phosphatase, GTT, Glucose tolerance test, 0302 clinical medicine, Prdm16, PR domain containing 16, PTP1B, Protein tyrosine phosphatase 1B, Glucose homeostasis, JAK2, Janus kinase 2, PRDM16, 0303 health sciences, Glucose tolerance test, medicine.diagnostic_test, digestive, oral, and skin physiology, POMC, Proopiomelanocortin, UCP1, Uncoupling protein 1, Hypothalamus, Original Article, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, HFD, High-fat diet, Biology, PI3K, Phosphatidylinositol 3-kinase, 03 medical and health sciences, Proopiomelanocortin, Internal medicine, BAT, Brown adipose tissue, LepRb, Leptin receptor long form, Phosphatase, medicine, Obesity, IL-6, Interleukin-6, Molecular Biology, 030304 developmental biology, Leptin receptor, Nkx2.1, NK2 homeobox 1 protein or thyroid transcription factor-1, ob/ob, leptin-deficient mice, Cell Biology, HPA, hypothalamus–pituitary–adrenal, STAT3, Signal transducer and activator of transcription 3, Endocrinology, ITT, Insulin tolerance test, biology.protein, CNTF, Ciliary neurotrophic factor, db/db, Leptin receptor-deficient mice, 030217 neurology & neurosurgery, Cre, Cre recombinase, PTPs, Protein tyrosine phosphatases