المؤلفون: Leonhard Geist, Paola Martinelli, Shereena Mohideen-Ali, Patrick Werni, Gerhard Fischer, Julian E. Fuchs, Klaus Rumpel, Moriz Mayer

المصدر: Journal of Magnetic Resonance Open, Vol 12, Iss , Pp 100075- (2022)

مصطلحات موضوعية: 19F NMR screening, STD NMR, 13C precursor protein labeling, 19F reporter molecule, Medical physics. Medical radiology. Nuclear medicine, R895-920, Physics, QC1-999

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666441022000450; https://doaj.org/toc/2666-4410

URL الوصول: https://doaj.org/article/89944a6f4a7c4c1e9a8c96a64ec685de

المؤلفون: Andreas Beier (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna), Gerald Platzer (MAG-LAB), Theresa Höfurthner (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna), Aleksandra L. Ptaszek (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna), Roman J. Lichtenecker (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Leonhard Geist (Boehringer Ingelheim RCV GmbH & Co. KG), Julian E. Fuchs (Boehringer Ingelheim RCV GmbH & Co. KG), Darryl B. McConnell (Curie Bio), Moriz Mayer (Boehringer Ingelheim RCV GmbH & Co. KG), Robert Konrat (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna)

المصدر: Journal of Medicinal Chemistry ; issn:0022-2623

مصطلحات موضوعية: Alkyls, Aromatic compounds, Chemical structure, Ligands, Mathematical methods

وصف الملف: application/pdf

Relation: hdl:11353/10.2114145; https://phaidra.univie.ac.at/o:2114145

الاتاحة: https://doi.org/10.1021/acs.jmedchem.4c01128
https://phaidra.univie.ac.at/o:2114145

المؤلفون: Giorgia Toscano (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Theresa Höfurthner (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna), Benjamin Nagl (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Andreas Beier (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna), Moriz Mayer (Boehringer Ingelheim RCV GmbH & Co. KG), Leonhard Geist (Boehringer Ingelheim RCV GmbH & Co. KG), Darryl B. McConnell (Boehringer Ingelheim RCV GmbH & Co. KG), Harald Weinstabl (Boehringer Ingelheim RCV GmbH & Co. KG), Robert Konrat (Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna), Roman J. Lichtenecker (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)

المصدر: ChemBioChem ; issn:1439-4227

مصطلحات موضوعية: CH−Pi interaction, methine isotope labeling, NMR spectroscopy, protein ligand interaction, protein modifications

وصف الملف: application/pdf

Relation: hdl:11353/10.2082927; https://phaidra.univie.ac.at/o:2082927

الاتاحة: https://doi.org/10.1002/cbic.202300762
https://phaidra.univie.ac.at/o:2082927

المؤلفون: Theresa Höfurthner (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Giorgia Toscano (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Georg Kontaxis (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Andreas Beier (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Moriz Mayer (Boehringer Ingelheim RCV GmbH & Co, Austria), Leonhard Geist (Boehringer Ingelheim RCV GmbH & Co, Austria), Darryl B. McConnell (Boehringer Ingelheim RCV GmbH & Co, Austria), Harald Weinstabl (Boehringer Ingelheim RCV GmbH & Co, Austria), Roman Lichtenecker (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Robert Konrat (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna)

المصدر: Journal of Biomolecular NMR ; issn:0925-2738

مصطلحات موضوعية: Precursor labeling, Transversal relaxation studies, CH-π interaction, Ligand binding

وصف الملف: application/pdf

Relation: hdl:11353/10.2003332; https://phaidra.univie.ac.at/o:2003332

الاتاحة: https://doi.org/10.1007/s10858-023-00427-2
https://phaidra.univie.ac.at/o:2003332

المؤلفون: Gerald Platzer (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Moriz Mayer (Boehringer Ingelheim RCV GmbH & Co. KG), Andreas Beier (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Sven Brüschweiler (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Julian E. Fuchs (Boehringer Ingelheim RCV GmbH & Co. KG), Harald Engelhardt (Boehringer Ingelheim RCV GmbH & Co. KG), Leonhard Geist (Boehringer Ingelheim RCV GmbH & Co. KG), Gerd Bader (Boehringer Ingelheim RCV GmbH & Co. KG), Julia Schörghuber (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Roman Lichtenecker (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Bernhard Wolkerstorfer (Boehringer Ingelheim RCV GmbH & Co. KG), Dirk Kessler (Boehringer Ingelheim RCV GmbH & Co. KG), Darryl B. McConnell (Boehringer Ingelheim RCV GmbH & Co. KG), Robert Konrat (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna)

المصدر: Angewandte Chemie International Edition ; issn:1433-7851

مصطلحات موضوعية: CH–π interactions, medicinal chemistry, NMR spectroscopy, protein–ligand interactions, structure-based drug design

وصف الملف: application/pdf

Relation: isPartOf:https://phaidra.univie.ac.at/o:243553[u:scholar collection]; hdl:11353/10.1218692; https://phaidra.univie.ac.at/o:1218692

الاتاحة: https://doi.org/10.1002/anie.202003732
https://phaidra.univie.ac.at/o:1218692

المؤلفون: Julia Schörghuber (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Leonhard Geist (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Gerald Platzer (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Michael Feichtinger (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Marilena Bisaccia (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Lukas Scheibelberger (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Frederik Weber (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Robert Konrat (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Roman J. Lichtenecker (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)

المصدر: Journal of Biomolecular NMR

مصطلحات موضوعية: Protein labeling, Aromatic residues, Protein overexpression, Chemical shift mapping, Ligand induced cross-correlation, Intrinsically disordered proteins

وصف الملف: application/pdf

Relation: isPartOf:https://phaidra.univie.ac.at/o:243553[u:scholar collection]; hdl:11353/10.937294; https://phaidra.univie.ac.at/o:937294

الاتاحة: https://doi.org/10.1007/s10858-018-0188-z
https://phaidra.univie.ac.at/o:937294

المؤلفون: Julia Schörghuber (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Leonhard Geist (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Marilena Bisaccia (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Frederik Weber (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna), Robert Konrat (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Roman J. Lichtenecker (Department of Organic Chemistry, Faculty of Chemistry, University of Vienna)

المصدر: Journal of Biomolecular NMR

مصطلحات موضوعية: Isotope labeling, Protein NMR, Tryptophan, Anthranilic acid

وصف الملف: application/pdf

Relation: isPartOf:https://phaidra.univie.ac.at/o:243553[u:scholar collection]; hdl:11353/10.688041; https://phaidra.univie.ac.at/o:688041

الاتاحة: https://doi.org/10.1007/s10858-017-0129-2
https://phaidra.univie.ac.at/o:688041

المؤلفون: Roland Kousek, Dirk Kessler, Stephan Karl Zahn, Jens Bruchhaus, Darryl B. McConnell, Mark Pearson, Franziska Moser, Bernhard Wolkerstorfer, Dennis Breitsprecher, Maximilian Scharnweber, Teresa Puchner, Georg Dahmann, Philipp Baaske, Julian E. Fuchs, Sandra Döbel, Wolfgang Hela, Christiane Kofink, Klaus Rumpel, Leonhard Geist, Simon Wöhrle, Andreas Bergner, Moriz Mayer, Jark Böttcher, Patrick Werni, Markus Zeeb, Maike Dettling, Tuncay Ciftci

المصدر: Chemmedchem

مصطلحات موضوعية: Tumor suppressor gene, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Small Molecule Libraries, PROTAC, Structure-Activity Relationship, BCL9, Very Important Paper, Drug Discovery, Humans, fragment-based screening, Protein Interaction Maps, General Pharmacology, Toxicology and Pharmaceutics, Binding site, beta Catenin, Pharmacology, Binding Sites, 010405 organic chemistry, Chemistry, Communication, WaterLOGSY, Organic Chemistry, Wnt signaling pathway, TCF4, β-catenin, microscale thermophoresis, Small molecule, Communications, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Catenin, Armadillo repeats, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bddd2c4cb79fde7e745f2b35f2c8e2
https://doi.org/10.1002/cmdc.202000839

المؤلفون: Moriz Mayer, Julian E. Fuchs, Darryl B. McConnell, Leonhard Geist, Robert Konrat, Gerald Platzer, Jark Boettcher

مصطلحات موضوعية: Crystallography, Proton, Drug discovery, Chemistry, Chemical shift, Bound state, Intermolecular force, Solvation, Crystal structure, Ligand (biochemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5d50da44ac9f1d89c7ecf7eb5a1af145
https://doi.org/10.1101/2021.11.30.470546

المؤلفون: Ariadna Rodriguez Chamorro, Andrea Ghisleni, Pierantonio Doto, Eneda Hollerl, Borja Mateos, Wiktor Kozminski, Robert Konrat, Kristina Djinović-Carugo, Miriam Pedron, Dmitri I. Svergun, Friedel Drepper, Anna Zawadzka-Kazimierczuk, Julius Kostan, Bettina Warscheid, Bojan Zagrovic, Georgine Faulkner, Claudia Schreiner, Joan L. Arolas, G. Mlynek, Euripedes de Almeida Ribeiro, Thomas Peterbauer, Cy M. Jeffries, Antonio Sponga, Leonhard Geist, Anton A. Polyansky, Mathias Gautel, Thomas C. Schwarz

المصدر: Science Advances
Science advances 7(22), eabg7653-(2021). doi:10.1126/sciadv.abg7653
'Science Advances ', vol: 7, pages: eabg7653-1-eabg7653-20 (2021)

مصطلحات موضوعية: 0303 health sciences, Myofibril assembly, Multidisciplinary, Chemistry, 030302 biochemistry & molecular biology, SciAdv r-articles, macromolecular substances, Compartmentalization (psychology), Filamin, musculoskeletal system, Sarcomere, 03 medical and health sciences, Molecular recognition, Structural Biology, Biophysics, ddc:500, Binding site, Actin, Function (biology), Research Articles, 030304 developmental biology, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6df15fcff097138a51c1137346fd138
http://europepmc.org/articles/PMC8163081

المؤلفون: Ravichandran Mc, Mark Petronczki, Matthias Samwer, Jark Böttcher, Klaus Rumpel, Opher Gileadi, Leonhard Geist, J.A. Newman, Engen, Katja Hauer, Patrick Werni, Angeline E Gavard, Simone Lieb

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, education.field_of_study, congenital, hereditary, and neonatal diseases and abnormalities, biology, Chemistry, DNA repair, Helicase, nutritional and metabolic diseases, Werner Syndrome Helicase, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cancer cell, biology.protein, Microsatellite, Nucleotide, education, 030217 neurology & neurosurgery, DNA, 030304 developmental biology, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76606eaeba86ec1aeabbf3224a87a361

المؤلفون: Sven Brüschweiler, Robert Konrat, Julia Schörghuber, Darryl B. McConnell, Gerd Bader, Andreas Beier, Bernhard Wolkerstorfer, Leonhard Geist, Dirk Kessler, Harald Engelhardt, Moriz Mayer, Gerald Platzer, Julian E. Fuchs, Roman J. Lichtenecker

المصدر: Angewandte Chemie (International Ed. in English)

مصطلحات موضوعية: Specific protein, Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Chemistry, NMR Spectroscopy | Hot Paper, Chemical shift, Proteins, General Chemistry, Nuclear magnetic resonance spectroscopy, General Medicine, Carbon-13 NMR, Drug molecule, Catalysis, NMR spectroscopy, medicinal chemistry, Pi, structure-based drug design, Humans, CH–π interactions, protein–ligand interactions, Research Articles, Protein ligand, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f4c4ecbf6441f842757fe25e95d829
https://pubmed.ncbi.nlm.nih.gov/32421895

المؤلفون: Harald Engelhardt, Xiao-Ling Cockcroft, Leonhard Geist, Bernhard Wolkerstorfer, Darryl B. McConnell, Dirk Kessler, Robert Konrat, Moriz Mayer

المصدر: Journal of Medicinal Chemistry. 60:8708-8715

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Drug, Stereochemistry, media_common.quotation_subject, Cell Cycle Proteins, Plasma protein binding, Ligands, 01 natural sciences, 03 medical and health sciences, Low affinity, Drug Discovery, Humans, Binding site, Cell Cycle Protein, Nuclear Magnetic Resonance, Biomolecular, media_common, Binding Sites, 010405 organic chemistry, Chemistry, Ligand, Titrimetry, Nuclear Proteins, Proteins, Water, Combinatorial chemistry, 0104 chemical sciences, Bromodomain, 030104 developmental biology, Drug Design, Molecular Medicine, Protein Binding, Transcription Factors, Protein ligand

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bb2b2299cd1e3e722c6fdf9517ce2a
https://doi.org/10.1021/acs.jmedchem.7b00845

المؤلفون: Antonio Sponga, Joan L. Arolas, Thomas C. Schwarz, Cy M. Jeffries, Ariadna Rodriguez Chamorro, Julius Kostan, Andrea Ghisleni, Friedel Drepper, Anton Polyansky, Euripedes De Almeida Ribeiro, Miriam Pedron, Anna Zawadzka-Kazimierczuk, Georg Mlynek, Thomas Peterbauer, Pierantonio Doto, Claudia Schreiner, Eneda Hollerl, Borja Mateos, Leonhard Geist, Georgine Faulkner, Wiktor Kozminski, Dmitri I. Svergun, Bettina Warscheid, Bojan Zagrovic, Mathias Gautel, Robert Konrat, Kristina Djinović-Carugo

المصدر: Acta Crystallographica Section A Foundations and Advances. 77:C288-C288

مصطلحات موضوعية: Inorganic Chemistry, Structural Biology, General Materials Science, Physical and Theoretical Chemistry, Condensed Matter Physics, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::320786f5e7fb43ee3967039bc5265f25
https://doi.org/10.1107/s0108767321093946

المؤلفون: J.A. Newman, Katja Hauer, Klaus Rumpel, Opher Gileadi, Patrick Werni, Madhwesh C Ravichandran, Angeline E Gavard, John R. Engen, Jark Böttcher, Simone Lieb, Leonhard Geist, Mark Petronczki, Matthias Samwer

المصدر: Life Science Alliance

مصطلحات موضوعية: Models, Molecular, Protein Conformation, alpha-Helical, 0301 basic medicine, Magnetic Resonance Spectroscopy, Health, Toxicology and Mutagenesis, Cell Cycle Proteins, Plant Science, Winged Helix, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Catalytic Domain, A-DNA, Nucleotide, Research Articles, chemistry.chemical_classification, Ecology, biology, Hydrolysis, Cell biology, Adenosine Diphosphate, Zinc, 030220 oncology & carcinogenesis, Microsatellite Instability, Colorectal Neoplasms, Crystallization, Research Article, Binding domain, congenital, hereditary, and neonatal diseases and abnormalities, Werner Syndrome Helicase, Cell Survival, Protein Serine-Threonine Kinases, Transfection, Biochemistry, Genetics and Molecular Biology (miscellaneous), 03 medical and health sciences, Proto-Oncogene Proteins, medicine, Humans, Gene Silencing, Nuclease, nutritional and metabolic diseases, Helicase, Microsatellite instability, DNA, HCT116 Cells, medicine.disease, 030104 developmental biology, chemistry, biology.protein, Protein Conformation, beta-Strand, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8537331a31ae7f2dac10e861eafb5cae
https://doi.org/10.26508/lsa.202000795

المؤلفون: Moriz Mayer, Roman J. Lichtenecker, Bernhard Wolkerstorfer, Sven Brüschweiler, Robert Konrat, Gerald Platzer, Julian E. Fuchs, Harald Engelhardt, Darryl B. McConnell, Julia Schörghuber, Gerd Bader, Leonhard Geist, Andreas Beier, Dirk Kessler

المصدر: Angewandte Chemie. 132:14805-14805

مصطلحات موضوعية: Stereochemistry, Chemistry, Pi, General Medicine, Nuclear magnetic resonance spectroscopy, Protein ligand

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa463c2ddf917cac66c36356be582a6
https://doi.org/10.1002/ange.202009454

المؤلفون: Dirk Kessler, Robert Konrat, Bernhard Wolkerstorfer, Moriz Mayer, Harald Engelhardt, Roman J. Lichtenecker, Gerald Platzer, Julian E. Fuchs, Leonhard Geist, Julia Schörghuber, Sven Brüschweiler, Gerd Bader, Andreas Beier, Darryl B. McConnell

المصدر: Angewandte Chemie International Edition. 59:14697-14697

مصطلحات موضوعية: Crystallography, Chemistry, INT, Pi, Cover (algebra), General Chemistry, Nuclear magnetic resonance spectroscopy, Catalysis, Protein ligand

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5c68349f279ea8cb5df3e583149f6fec
https://doi.org/10.1002/anie.202009454

المؤلفون: Julia Schörghuber, Gerald Platzer, Leonhard Geist, Robert Konrat, Roman J. Lichtenecker

المصدر: Chembiochem : a European journal of chemical biology. 18(15)

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Residue (chemistry), chemistry.chemical_compound, Side chain, Escherichia coli, Imidazole, Humans, Histidine, Carbon Radioisotopes, Pyruvates, Molecular Biology, Transaminases, chemistry.chemical_classification, 010405 organic chemistry, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Organic Chemistry, Imidazoles, Nuclear magnetic resonance spectroscopy, Deuterium, 0104 chemical sciences, Amino acid, NMR spectra database, Metabolic pathway, chemistry, Isotope Labeling, alpha-Synuclein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a107041fe14154af327f895cd79795
https://pubmed.ncbi.nlm.nih.gov/28489326

المؤلفون: Robert Konrat, Antonio Sponga, Leonhard Geist, Euripedes de Almeida Ribeiro, Friedel Drepper, Georg Mlynek, Bettina Warscheid, Kristina Djinović-Carugo, Ariadna Rodriguez-Chamorro, Joan L. Arolas, Thomas Peterbauer

المصدر: Acta Crystallographica Section A Foundations and Advances. 75:e143-e143

مصطلحات موضوعية: Inorganic Chemistry, Physics, Crystallography, Structural Biology, Structure (category theory), Fuzzy complex, α actinin, General Materials Science, Physical and Theoretical Chemistry, Condensed Matter Physics, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1d423ac6a7f74422428f56229198443a
https://doi.org/10.1107/s2053273319094130

المؤلفون: Julia Schörghuber, Marilena Bisaccia, Leonhard Geist, Robert Konrat, Roman J. Lichtenecker, Frederik Weber

المصدر: Journal of Biomolecular Nmr

مصطلحات موضوعية: Indole test, 010405 organic chemistry, Stereochemistry, Relaxation (NMR), Tryptophan, Proteins, Context (language use), 010402 general chemistry, Ring (chemistry), 01 natural sciences, Biochemistry, Article, 0104 chemical sciences, Residue (chemistry), chemistry.chemical_compound, chemistry, Anthranilic acid, Side chain, ortho-Aminobenzoates, Protein NMR, Nuclear Magnetic Resonance, Biomolecular, Spectroscopy, Isotope labeling

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3f2829d979f085de3a6bbe7ec4ff17
https://phaidra.univie.ac.at/o:688041