المؤلفون: Song, Tongkun¹ (AUTHOR), Xu, Kai¹ (AUTHOR), Xing, JiaDi¹ (AUTHOR), Liu, Maoxing¹ (AUTHOR), Tan, Fei¹ (AUTHOR), Su, Xiangqian¹ (AUTHOR) suxiangqian@bjmu.edu.cn

المصدر: Clinical Case Reports. Dec2024, Vol. 12 Issue 12, p1-5. 5p.

مصطلحات موضوعية: *PULMONARY nodules, *LEIOMYOSARCOMA, *LUNG cancer, *LUNGS, *METASTASIS

المؤلفون: Jadhav, Shraddha Vikas¹ shraddhavjadhav14@gmail.com, Kumbhare, Manoj Ramesh¹, Kshatriya, Vaibhavi Vijay¹, Thorat, Prajakata Jaywant¹, Bhambarge, Rushikesh Gajanan¹

المصدر: Intelligent Pharmacy. Oct2024, Vol. 2 Issue 5, p737-741. 5p.

مصطلحات موضوعية: *LEIOMYOSARCOMA, *BIOMATERIALS, *NANOMEDICINE, *ANTINEOPLASTIC agents, *CANCER cell growth

المؤلفون: Pautier, P.¹ patricia.pautier@gustaveroussy.fr, Italiano, A.², Piperno-Neumann, S.³, Chevreau, C.⁴, Penel, N.⁵, Firmin, N.⁶, Boudou-Rouquette, P.⁷, Bertucci, F.^8,9, Lebrun-Ly, V.¹⁰, Ray-Coquard, I.¹¹, Kaibacher, E.¹², Bompas, E.¹³, Collard, O.¹⁴, Isambert, N.¹⁵, Guillemet, C.¹⁶, Rios, M.¹⁷, Le Cesne, A.¹, Balleyguier, C.¹⁸, Archambaud, B.¹⁹, Duffaud, F.^9,20

المصدر: New England Journal of Medicine. 9/5/2024, Vol. 391 Issue 9, p789-799. 11p.

مصطلحات موضوعية: *TRABECTEDIN, *LEIOMYOSARCOMA, *PROGRESSION-free survival, *CLINICAL trials, *OVERALL survival

Alternate Title: Uterin Leiomyosarkomda Klinik Özelliklerin ve İnflamasyon Bazlı Belirteçlerin Prognostik Değerinin Karşılaştırılması.

المؤلفون: Sekmek, Serhat¹ serhatsekmek@gmail.com, Kos, Fahriye Tugba¹, Ucar, Gokhan¹, Bayram, Dogan¹, Civelek, Burak¹

المصدر: Dicle Medical Journal / Dicle Tip Dergisi. Sep2024, Vol. 51 Issue 3, p325-332. 8p.

مصطلحات موضوعية: *LEIOMYOSARCOMA, *PROGNOSIS

المؤلفون: Canadian Cancer Trials Group, ECOG-ACRIN Cancer Research Group, Anticancer Fund, Belgium, Australia and New Zealand Sarcoma Association, Japan Clinical Oncology Group

المصدر: A Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Patients With High Risk RetroPeritoneal Sarcoma (RPS)

المصدر: ADI-PEG 20 or Placebo Plus Gemcitabine and Docetaxel in Previously Treated Subjects with Leiomyosarcoma (ARGSARC): a Randomized, Double Blind, Multi-Center Phase 3 Trial

المصدر: Phase I/II Study to Evaluate the Feasibility and Efficacy of Sequential Abemaciclib and Gemcitabine Treatment in Patients With Retinoblastoma (Rb)+ Sarcomas

Other URLs: https://grants.nih.gov/policy/sharing.htm

المصدر: Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754)
Avutu V, Weiss AR, Reed DR, Ahmed SK, Allen-Rhoades WA, Chen YE, Davis LE, Eaton BR, Hawkins DS, Indelicato DJ, Patel SR, Randall RL, Reinke DK, Riedel RF, Scharschmidt TJ, Thornton KA, Wang D, Janeway KA, Kopp LM. Identified Enrollment Challenges of Adolescent and Young Adult Patients on the Nonchemotherapy Arm of Children's Oncology Group Study ARST1321. J Adolesc Young Adult Oncol. 2022 Jun;11(3):328-332. doi: 10.1089/jayao.2021.0103. Epub 2021 Sep 9.
Vatner R, James CD, Sathiaseelan V, Bondra KM, Kalapurakal JA, Houghton PJ. Radiation therapy and molecular-targeted agents in preclinical testing for immunotherapy, brain tumors, and sarcomas: Opportunities and challenges. Pediatr Blood Cancer. 2021 May;68 Suppl 2:e28439. doi: 10.1002/pbc.28439. Epub 2020 Aug 22.
Weiss AR, Chen YL, Scharschmidt TJ, Chi YY, Tian J, Black JO, Davis JL, Fanburg-Smith JC, Zambrano E, Anderson J, Arens R, Binitie O, Choy E, Davis JW, Hayes-Jordan A, Kao SC, Kayton ML, Kessel S, Lim R, Meyer WH, Million L, Okuno SH, Ostrenga A, Parisi MT, Pryma DA, Randall RL, Rosen MA, Schlapkohl M, Shulkin BL, Smith EA, Sorger JI, Terezakis S, Hawkins DS, Spunt SL, Wang D. Pathological response in children and adults with large unresected intermediate-grade or high-grade soft tissue sarcoma receiving preoperative chemoradiotherapy with or without pazopanib (ARST1321): a multicentre, randomised, open-label, phase 2 trial. Lancet Oncol. 2020 Aug;21(8):1110-1122. doi: 10.1016/S1470-2045(20)30325-9. Epub 2020 Jul 20.

المصدر: Randomized, Controlled, Open-label, Phase IIb/III Study of Lurbinectedin in Combination with Doxorubicin Versus Doxorubicin Alone As First-line Treatment in Patients with Metastatic Leiomyosarcoma

المؤلفون: Recordati UK

المصدر: Combined Treatment With Dinutuximab Beta, Zoledronic Acid and Low-dose Interleukin (IL-2) in Patients With Metastatic or Inoperable Leiomyosarcoma - DiTuSarc Study

المصدر: A Randomized Phase 2/3 Study of Olaparib Plus Temozolomide Versus Investigator's Choice for the Treatment of Patients With Advanced Uterine Leiomyosarcoma After Progression on Prior Chemotherapy

Other URLs: https://grants.nih.gov/policy/sharing.htm

المصدر: Clinical Management and Outcomes of Primary Ovarian Leiomyosarcoma
Mandato VD, Torricelli F, Mastrofilippo V, Palicelli A, Costagliola L, Aguzzoli L. Primary Ovarian Leiomyosarcoma Is a Very Rare Entity: A Narrative Review of the Literature. Cancers (Basel). 2023 May 28;15(11):2953. doi: 10.3390/cancers15112953.
Pu T, Fan L, Wang L, Li L, Zeng H. Recurrent primary ovarian leiomyosarcoma preconception, pregnancy, delivery, and puerperal management: A case report and literature review. J Obstet Gynaecol Res. 2022 Jun;48(6):1489-1494. doi: 10.1111/jog.15244. Epub 2022 Mar 30.
Yuksel D, Cakir C, Kilic C, Karalok A, Kimyon G, Coteli S, Boyraz G, Tekin OM, Turan T. Primary leiomyosarcoma of the ovary: a report of three cases and a systematic review of literature. J Gynecol Obstet Hum Reprod. 2021 Jun;50(6):101825. doi: 10.1016/j.jogoh.2020.101825. Epub 2020 Jun 1.
Pongsuvareeyakul T, Sukpan K, Chaicharoen S, Khunamornpong S. Leiomyosarcoma and Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary. Case Rep Pathol. 2017;2017:7907359. doi: 10.1155/2017/7907359. Epub 2017 Jul 2.
He M, Deng YJ, Zhao DY, Zhang Y, Wu T. Synchronous leiomyosarcoma and fibroma in a single ovary: A case report and review of the literature. Oncol Lett. 2016 Apr;11(4):2510-2514. doi: 10.3892/ol.2016.4241. Epub 2016 Feb 17.
Zygouris D, Androutsopoulos G, Grigoriadis C, Arnogiannaki N, Terzakis E. Primary ovarian leiomyosarcoma. Eur J Gynaecol Oncol. 2012;33(3):331-3.
Chang A, Schuetze SM, Conrad EU 3rd, Swisshelm KL, Norwood TH, Rubin BP. So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. Int J Surg Pathol. 2005 Apr;13(2):185-95. doi: 10.1177/106689690501300210.
Nicotina PA, Antico F, Caruso C, Triolo O. Primary ovarian leiomyosarcoma. Proliferation rate and survival. Eur J Gynaecol Oncol. 2004;25(4):515-6.
Mayerhofer K, Lozanov P, Bodner K, Bodner-Adler B, Mayerhofer-Gallenbacher N, Hudelist G, Czerwenka K. Immunohistochemical analysis of a primary ovarian leiomyosarcoma. Case report. Anticancer Res. 2003 Jul-Aug;23(4):3433-6.
Seracchioli R, Colombo FM, Bagnoli A, Trengia V, Venturoli S. Primary ovarian leiomyosarcoma as a new component in the nevoid basal cell carcinoma syndrome: a case report. Am J Obstet Gynecol. 2003 Apr;188(4):1093-5. doi: 10.1067/mob.2003.86.
Balaton A, Vaury P, Imbert MC, Mussy MA. Primary leiomyosarcoma of the ovary: a histological and immunocytochemical study. Gynecol Oncol. 1987 Sep;28(1):116-20. doi: 10.1016/s0090-8258(87)80016-1.
Nogales FF, Ayala A, Ruiz-Avila I, Sirvent JJ. Myxoid leiomyosarcoma of the ovary: analysis of three cases. Hum Pathol. 1991 Dec;22(12):1268-73. doi: 10.1016/0046-8177(91)90110-b.
Anderson B, Turner DA, Benda J. Ovarian sarcoma. Gynecol Oncol. 1987 Feb;26(2):183-92. doi: 10.1016/0090-8258(87)90272-1.
Shakfeh SM, Woodruff JD. Primary ovarian sarcomas: report of 46 cases and review of the literature. Obstet Gynecol Surv. 1987 Jun;42(6):331-49. No abstract available.
Azoury RS, Woodruff JD. Primary ovarian sarcomas. Report of 43 cases from the Emil Novak Ovarian Tumor Registry. Obstet Gynecol. 1971 Jun;37(6):920-41. No abstract available.
Nieminen U, Numers CV, Purola E. Primary sarcoma of the ovary. Acta Obstet Gynecol Scand. 1969;48(3):423-32. doi: 10.3109/00016346909156657. No abstract available.
KELLEY RR, SCULLY RE. Cancer developing in dermoid cysts of the ovary. A report of 8 cases, including a carcinoid and a leiomyosarcoma. Cancer. 1961 Sep-Oct;14:989-1000. doi: 10.1002/1097-0142(196109/10)14:53.0.co;2-u. No abstract available.
Shafiee MN, Kah Teik C, Md Zain RR, Kampan N. Ovarian and uterine leiomyosarcoma: which one is the primary? Horm Mol Biol Clin Investig. 2019 Aug 9;41(2). doi: 10.1515/hmbci-2019-0037.
Rampaul RS, Barrow S, Naraynsingh V. A primary ovarian leiomyosarcoma with micro-invasive features (stage I): is surgical excision enough? Gynecol Oncol. 1999 Jun;73(3):464; author reply 465-7. doi: 10.1006/gyno.1999.5384. No abstract available.
Dixit S, Singhal S, Baboo HA, Vyas RK, Neema JP, Murthy R, Sooryanaraya U. Leiomyosarcoma of the ovary. J Postgrad Med. 1993 Jul-Sep;39(3):151-3.
Inoue J, Gomibuchi H, Minoura S. A case of a primary ovarian leiomyosarcoma. J Obstet Gynaecol Res. 2000 Dec;26(6):401-7. doi: 10.1111/j.1447-0756.2000.tb01349.x.
Walts AE, Lichtenstein I. Primary leiomyosarcoma associated with serous cystadenocarcinoma of the ovary. Gynecol Oncol. 1977 Mar;5(1):81-6. doi: 10.1016/0090-8258(77)90010-5. No abstract available.
Taskin S, Taskin EA, Uzum N, Ataoglu O, Ortac F. Primary ovarian leiomyosarcoma: a review of the clinical and immunohistochemical features of the rare tumor. Obstet Gynecol Surv. 2007 Jul;62(7):480-6. doi: 10.1097/01.ogx.0000268629.16151.71.
Lastarria D, Sachdev RK, Babury RA, Yu HM, Nuovo GJ. Immunohistochemical analysis for desmin in normal and neoplastic ovarian stromal tissue. Arch Pathol Lab Med. 1990 May;114(5):502-5.
Lerwill MF, Sung R, Oliva E, Prat J, Young RH. Smooth muscle tumors of the ovary: a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants, and differential diagnosis. Am J Surg Pathol. 2004 Nov;28(11):1436-51. doi: 10.1097/01.pas.0000141393.99300.d0.
Bouie SM, Cracchiolo B, Heller D. Epithelioid leiomyosarcoma of the ovary. Gynecol Oncol. 2005 May;97(2):697-9. doi: 10.1016/j.ygyno.2005.02.008.
Vijaya Kumar J, Khurana A, Kaur P, Chuahan AK, Singh S. A rare presentation of primary leiomyosarcoma of ovary in a young woman. Ecancermedicalscience. 2015 Apr 21;9:524. doi: 10.3332/ecancer.2015.524. eCollection 2015.
Furutake Y, Fukagawa T, Suga Y, Nagasawa T, Sato S, Omi H, Kagabu M, Chiba A, Shoji T, Takeuchi S, Sugai T, Itamochi H, Sugiyama T. Gemcitabine and docetaxel in a patient with primary ovarian leiomyosarcoma: a case report and review of literature. Int Cancer Conf J. 2017 Sep 11;7(1):11-15. doi: 10.1007/s13691-017-0309-7. eCollection 2018 Jan.
Rasmussen CC, Skilling JS, Sorosky JI, Lager DJ, Buller RE. Stage IIIC ovarian leiomyosarcoma in a premenopausal woman with multiple recurrences: prolonged survival with surgical therapy. Gynecol Oncol. 1997 Sep;66(3):519-25. doi: 10.1006/gyno.1997.4824.
Friedman HD, Mazur MT. Primary ovarian leiomyosarcoma. An immunohistochemical and ultrastructural study. Arch Pathol Lab Med. 1991 Sep;115(9):941-5.
Cojocaru E, Palahepitiva Gamage G, Butler J, Barton DP, Thway K, Fisher C, Messiou C, Miah AB, Zaidi S, Gennatas S, Benson C, Huang P, Jones RL. Clinical management and outcomes of primary ovarian leiomyosarcoma - Experience from a sarcoma specialist unit. Gynecol Oncol Rep. 2021 Mar 2;36:100737. doi: 10.1016/j.gore.2021.100737. eCollection 2021 May.
Monk BJ, Nieberg R, Berek JS. Primary leiomyosarcoma of the ovary in a perimenarchal female. Gynecol Oncol. 1993 Mar;48(3):389-93. doi: 10.1006/gyno.1993.1067.
Arslan OS, Sumer C, Cihangiroglu G, Kanat-Pektas M, Gungor T. A rare tumor of the female genital tract: primary ovarian leiomyosarcoma. Arch Gynecol Obstet. 2011 Mar;283 Suppl 1:83-5. doi: 10.1007/s00404-010-1735-3.
Goodall EJ, Madhuri T, Manuel SB. The Management Dilemma of Leiomyosarcoma of the Ovary. World J Oncol. 2011 Oct;2(5):265-266. doi: 10.4021/wjon362w. Epub 2011 Oct 28.
Pankaj, S., Choudhary, V., Singh, R. K., & Harsvardhan, R. (2013). High grade pleomorphic leiomyosarcoma of ovary in a young female: a case report. World Journal of Surgical Research, 2(3).

المصدر: An Open-Label, Multicenter Phase 1b/2 Study of Nanatinostat and Valganciclovir in Patients With Advanced Epstein-Barr Virus-Positive (EBV+) Solid Tumors and in Combination With Pembrolizumab in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma

المصدر: A Phase 1 Study of Peposertib (M3814) and Low-Dose Liposomal Doxorubicin in Patients With Metastatic Leiomyosarcoma and Other Soft Tissue Sarcomas

Other URLs: https://grants.nih.gov/policy/sharing.htm

المصدر: An Open-label, Single-arm, Multicohort, Phase 2 Study to Assess the Efficacy and Safety of Tabelecleucel in Subjects with Epstein-Barr Virus-associated Diseases (EBVision)

المساهمون: Gabriel Tinoco, Principal Investigator

المصدر: A Phase II Study of All-Trans Retinoic Acid (ATRA) and Cemiplimab in Patients with Advanced Leiomyosarcoma

المؤلفون: National Cancer Institute (NCI)

المصدر: A Phase II Study of Cabozantinib and Temozolomide in Patients With Unresectable or Metastatic Leiomyosarcoma and Other Soft Tissue Sarcomas

المؤلفون: PharmaMar

المصدر: A Randomized Phase II Trial Comparing the Activity of trabectedIn vs Gemcitabine in Patients With Metastatic or Locally Advanced Leiomyosarcoma Pretreated With Conventional Chemotherapy
Hensley ML, Miller A, O'Malley DM, Mannel RS, Behbakht K, Bakkum-Gamez JN, Michael H. Randomized phase III trial of gemcitabine plus docetaxel plus bevacizumab or placebo as first-line treatment for metastatic uterine leiomyosarcoma: an NRG Oncology/Gynecologic Oncology Group study. J Clin Oncol. 2015 Apr 1;33(10):1180-5. doi: 10.1200/JCO.2014.58.3781. Epub 2015 Feb 23.
Pautier P, Floquet A, Chevreau C, Penel N, Guillemet C, Delcambre C, Cupissol D, Selle F, Isambert N, Piperno-Neumann S, Thyss A, Bertucci F, Bompas E, Alexandre J, Collard O, Lavau-Denes S, Soulie P, Toulmonde M, Le Cesne A, Lacas B, Duffaud F; French Sarcoma Group. Trabectedin in combination with doxorubicin for first-line treatment of advanced uterine or soft-tissue leiomyosarcoma (LMS-02): a non-randomised, multicentre, phase 2 trial. Lancet Oncol. 2015 Apr;16(4):457-64. doi: 10.1016/S1470-2045(15)70070-7. Epub 2015 Mar 18.
Demetri GD, Chawla SP, von Mehren M, Ritch P, Baker LH, Blay JY, Hande KR, Keohan ML, Samuels BL, Schuetze S, Lebedinsky C, Elsayed YA, Izquierdo MA, Gomez J, Park YC, Le Cesne A. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. J Clin Oncol. 2009 Sep 1;27(25):4188-96. doi: 10.1200/JCO.2008.21.0088. Epub 2009 Aug 3.
Patel SR, Gandhi V, Jenkins J, Papadopolous N, Burgess MA, Plager C, Plunkett W, Benjamin RS. Phase II clinical investigation of gemcitabine in advanced soft tissue sarcomas and window evaluation of dose rate on gemcitabine triphosphate accumulation. J Clin Oncol. 2001 Aug 1;19(15):3483-9. doi: 10.1200/JCO.2001.19.15.3483.
Pautier P, Floquet A, Penel N, Piperno-Neumann S, Isambert N, Rey A, Bompas E, Cioffi A, Delcambre C, Cupissol D, Collin F, Blay JY, Jimenez M, Duffaud F. Randomized multicenter and stratified phase II study of gemcitabine alone versus gemcitabine and docetaxel in patients with metastatic or relapsed leiomyosarcomas: a Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) French Sarcoma Group Study (TAXOGEM study). Oncologist. 2012;17(9):1213-20. doi: 10.1634/theoncologist.2011-0467. Epub 2012 Aug 20.
Seddon B, Strauss SJ, Whelan J, Leahy M, Woll PJ, Cowie F, Rothermundt C, Wood Z, Benson C, Ali N, Marples M, Veal GJ, Jamieson D, Kuver K, Tirabosco R, Forsyth S, Nash S, Dehbi HM, Beare S. Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial. Lancet Oncol. 2017 Oct;18(10):1397-1410. doi: 10.1016/S1470-2045(17)30622-8. Epub 2017 Sep 4.

المساهمون: Catherine Bollard, Director- Program for Cell Enhancement and Technologies for Immunotherapy (CETI)

المصدر: ADMINISTRATION of LMP-SPECIFIC CYTOTOXIC T-LYMPHOCYTES to PATIENTS with RELAPSED EBV-POSITIVE LYMPHOMA
McLaughlin LP, Rouce R, Gottschalk S, Torrano V, Carrum G, Wu MF, Hoq F, Grilley B, Marcogliese AM, Hanley PJ, Gee AP, Brenner MK, Rooney CM, Heslop HE, Bollard CM. EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation. Blood. 2018 Nov 29;132(22):2351-2361. doi: 10.1182/blood-2018-07-863654. Epub 2018 Sep 27.

المصدر: A Randomized Phase II Study of Letrozole Versus Observation in Patients with Newly Diagnosed Uterine Leiomyosarcoma