المؤلفون: Bentum, Sabine van, Lei, Zhiyong (Thesis Advisor)

مصطلحات الفهرس: Trying to perform targeted protein degradation of the Phospholamban protein with the use of a fusion protein (VHL fused to B4) in PLN and PLN_R14del HEK-cells and iPSC-CMs, Master Thesis, Student Thesis

URL: https://studenttheses.uu.nl/handle/20.500.12932/45162

المؤلفون: Kalaitsidou, Elisavet, Lei, Zhiyong (Thesis Advisor)

مصطلحات الفهرس: The phosphorylation of proteins on tyrosine residues is a critical modification, that can be rapidly reversed by protein tyrosine phosphatases (PTPs). Dysregulation of the PTP leads to abnormal levels of phosphorylation and subsequently contributes to a plethora of diseases, including metabolic diseases, and cancers. Our antibody and MS-based methods successfully identify PTP in human-derived material, making optimal further explorations., Master Thesis, Student Thesis

URL: https://studenttheses.uu.nl/handle/20.500.12932/43485

المؤلفون: Manjikian, Herak, Lei, Zhiyong (Thesis Advisor)

مصطلحات الفهرس: This thesis discusses the role of mechanical load during development, health, and disease. Moreover, the role of left ventricular assist device in inducing mechanical unloading and reverse remodeling is presented. Subsequently, a detailed summary of the various in vivo and in vitro techniques used to simulate mechanical load are discussed. Finally, the current gaps in our knowledge of mechanical load in regards to the presented topics are discussed., Master Thesis, Student Thesis

URL: https://studenttheses.uu.nl/handle/20.500.12932/42934