المؤلفون: Chen, Xiaowen, Tober, Joanna, Dominguez, Martin, Tang, Alan T., Bockman, Jenna, Yang, Jisheng, Mani, Sneha, Lee, Chin Nien, Chen, Mei, Thillaikumaran, Triloshan, Mericko-Ishizuka, Patricia, Mainigi, Monica, Speck, Nancy A., Kahn, Mark L.

المصدر: PLoS Biology; 1/28/2025, Vol. 23 Issue 1, p1-24, 24p

مصطلحات موضوعية: HEMATOPOIETIC stem cells, YOLK sac, UMBILICAL cord, TRANSCRIPTION factors, PLACENTA, TROPHOBLAST

المؤلفون: Guan, Lei, Wu, Bin, Li, Ting, Beer, Lynn A., Sharma, Gaurav, Li, Mingyue, Lee, Chin Nien, Liu, Shujing, Yang, Changsong, Huang, Lili, Frederick, Dennie T., Boland, Genevieve M., Shao, Guangcan, Svitkina, Tatyana M., Cai, Kathy Q., Chen, Fangping, Dong, Meng-Qiu, Mills, Gordon B., Schuchter, Lynn M., Karakousis, Giorgos C., Mitchell, Tara C., Flaherty, Keith T., Speicher, David W., Chen, Youhai H., Herlyn, Meenhard, Amaravadi, Ravi K., Xu, Xiaowei, Guo, Wei

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences, U.S. Department of Health & Human Services | NIH | National Cancer Institute

المصدر: Nature Communications ; volume 13, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-022-31713-6
https://www.nature.com/articles/s41467-022-31713-6.pdf
https://www.nature.com/articles/s41467-022-31713-6

المؤلفون: Bressy, Christian, Zemani, Ali, Goyal, Shreya, Jishkariani, Davit, Lee, Chin Nien, Chen, Youhai H.

المساهمون: Montazeri Aliabadi, Hamidreza, National Institutes of Health

المصدر: PLOS ONE ; volume 17, issue 12, page e0276905 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0276905
https://dx.plos.org/10.1371/journal.pone.0276905

المؤلفون: Yu, Jiyeon, Zamani, Ali, Goldsmith, Jason R, Etwebi, Zienab, Lee, Chin Nien, Chen, Youhai H, Sun, Honghong

المصدر: Journal of Leukocyte Biology; Mar2024, Vol. 115 Issue 3, p511-524, 14p

مصطلحات موضوعية: T cells, IMMIGRATION enforcement, G protein coupled receptors, TUMOR necrosis factors, MEMBRANE proteins

المؤلفون: Wang, Kai, Lin, Ruei-Zeng, Hong, Xuechong, Ng, Alex H., Lee, Chin Nien, Neumeyer, Joseph, Wang, Gang, Wang, Xi, Ma, Minglin, Pu, William T., Church, George M., Melero-Martin, Juan M.

المساهمون: National Institutes of Health, Juvenile Diabetes Research Foundation

المصدر: Science Advances ; volume 6, issue 30 ; ISSN 2375-2548

الاتاحة: http://dx.doi.org/10.1126/sciadv.aba7606
https://syndication.highwire.org/content/doi/10.1126/sciadv.aba7606
https://www.science.org/doi/pdf/10.1126/sciadv.aba7606

المؤلفون: Yu, Jiyeon, Zamani, Ali, Goldsmith, Jason R, Etwebi, Zienab, Lee, Chin Nien, Chen, Youhai H, Sun, Honghong

المساهمون: National Institutes of Health

المصدر: Journal of Leukocyte Biology ; volume 115, issue 3, page 511-524 ; ISSN 1938-3673

مصطلحات موضوعية: Cell Biology, Immunology, Immunology and Allergy

الاتاحة: http://dx.doi.org/10.1093/jleuko/qiad141
https://academic.oup.com/jleukbio/advance-article-pdf/doi/10.1093/jleuko/qiad141/54082299/qiad141.pdf
https://academic.oup.com/jleukbio/article-pdf/115/3/511/56750370/qiad141.pdf

المؤلفون: Lahoud, Mireille H., Ahmet, Fatma, Zhang, Jian-Guo, Meuter, Simone, Policheni, Antonia N., Kitsoulis, Susie, Lee, Chin-Nien, O'Keeffe, Meredith, Sullivan, Lucy C., Brooks, Andrew G., Berry, Richard, Rossjohn, Jamie, Mintern, Justine D., Vega-Ramos, Javier, Villadangos, Jose A., Nicola, Nicos A., Nussenzweig, Michel C., Stacey, Katryn J., Shortman, Ken, Heath, William R., Caminschi, Irina

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2012 Oct 01. 109(40), 16270-16275.

URL الوصول: https://www.jstor.org/stable/41763238

المؤلفون: Hong, Xuechong, Oh, Nicholas, Wang, Kai, Neumeyer, Joseph, Lee, Chin Nien, Lin, Ruei-Zeng, Piekarski, Breanna, Emani, Sitaram, Greene, Arin K., Friehs, Ingeborg, del Nido, Pedro J., Melero-Martin, Juan M.

المساهمون: National Institutes of Health

المصدر: Angiogenesis ; volume 24, issue 2, page 327-344 ; ISSN 0969-6970 1573-7209

الاتاحة: http://dx.doi.org/10.1007/s10456-020-09765-3
https://link.springer.com/content/pdf/10.1007/s10456-020-09765-3.pdf
https://link.springer.com/article/10.1007/s10456-020-09765-3/fulltext.html

المؤلفون: Guan, Lei, Wu, Bin, Li, Ting, Beer, Lynn A., Sharma, Gaurav, Li, Mingyue, Lee, Chin Nien, Liu, Shujing, Yang, Changsong, Huang, Lili, Frederick, Dennie T., Boland, Genevieve M., Shao, Guangcan, Svitkina, Tatyana M., Cai, Kathy Q., Chen, Fangping, Dong, Meng-Qiu, Mills, Gordon B., Schuchter, Lynn M., Karakousis, Giorgos C.

المصدر: Nature Communications; 7/14/2022, Vol. 13 Issue 1, p1-12, 12p

مصطلحات موضوعية: EXOSOMES, CYTOTOXIC T cells, T cells, PHOSPHORYLATION, CELL migration, SECRETION, IMMUNE checkpoint proteins, PROGRAMMED cell death 1 receptors

المؤلفون: Li, Ting, Li, Xinyuan, Zamani, Ali, Wang, Wei, Lee, Chin-Nien, Li, Mingyue, Luo, George, Eiler, Emily, Sun, Honghong, Ghosh, Sankar, Jin, Jian, Murali, Ramachandran, Ruan, Qingguo, Shi, Weiyun, Chen, Youhai H.

المساهمون: National Institutes of Health (NIH), USA

المصدر: Nature Cancer ; volume 1, issue 5, page 507-517 ; ISSN 2662-1347

الاتاحة: http://dx.doi.org/10.1038/s43018-020-0061-3
https://www.nature.com/articles/s43018-020-0061-3.pdf
https://www.nature.com/articles/s43018-020-0061-3

المؤلفون: Duke-Cohan, Jonathan, Ishikawa, Yuki, Yoshizawa, Akihiro, Choi, Young-Il, Lee, Chin-Nien, Acuto, Oreste, Kissler, Stephan, Reinherz, Ellis L.

المصدر: Sci. Signal.

مصطلحات موضوعية: Cell Biology, Biochemistry, Molecular Biology

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf; application/octet-stream; image/tiff

Relation: Science Signaling; Duke-Cohan, Jonathan S, Yuki Ishikawa, Akihiro Yoshizawa, Young-Il Choi, Chin-Nien Lee, Oreste Acuto, Stephan Kissler, and Ellis L Reinherz. "Regulation of Thymocyte Trafficking by Tagap, a GAP Domain Protein Linked to Human Autoimmunity." Science Signaling 11, no. 534 (2018).; http://nrs.harvard.edu/urn-3:HUL.InstRepos:42656538

الاتاحة: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42656538
https://doi.org/10.1126/scisignal.aan8799

المؤلفون: Sun, Honghong, Lin, Mei, Zamani, Ali, Goldsmith, Jason R., Boggs, Amanda E., Li, Mingyue, Lee, Chin-Nien, Chen, Xu, Li, Xinyuan, Li, Ting, Dorrity, Brigid L., Li, Ning, Lou, Yunwei, Shi, Songlin, Wang, Wei, Chen, Youhai H.

المصدر: Scientific Reports; 4/20/2020, Vol. 10 Issue 1, p1-13, 13p

مصطلحات موضوعية: LYMPHOCYTES, CHEMOKINES, INFLAMMATION, PHOSPHOINOSITIDES, GUANOSINE triphosphatase

المؤلفون: Lin, Ruei-Zeng, Lee, Chin Nien, Moreno-Luna, Rafael, Neumeyer, Joseph, Piekarski, Breanna, Zhou, Pingzhu, Moses, Marsha A., Sachdev, Monisha, Pu, William T., Emani, Sitaram, Melero-Martin, Juan M.

وصف الملف: application/pdf

Relation: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578427/pdf/; Nature biomedical engineering; Lin, R., C. N. Lee, R. Moreno-Luna, J. Neumeyer, B. Piekarski, P. Zhou, M. A. Moses, et al. 2017. “Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks.” Nature biomedical engineering 1 (1): 0081. doi:10.1038/s41551-017-0081. http://dx.doi.org/10.1038/s41551-017-0081.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651811

الاتاحة: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651811
https://doi.org/10.1038/s41551-017-0081

المؤلفون: Lin, Ruei-Zeng, Lee, Chin Nien, Moreno-Luna, Rafael, Neumeyer, Joseph, Piekarski, Breanna, Zhou, Pingzhu, Moses, Marsha A., Sachdev, Monisha, Pu, William T., Emani, Sitaram, Melero-Martin, Juan M.

المصدر: Nature Biomedical Engineering ; volume 1, issue 7 ; ISSN 2157-846X

الاتاحة: https://doi.org/10.1038/s41551-017-0099
https://www.nature.com/articles/s41551-017-0099.pdf
https://www.nature.com/articles/s41551-017-0099
http://www.nature.com/articles/s41551-017-0099

المؤلفون: Lee Chin-Nien, Lew Andrew M, Shortman Ken, Wu Li

المساهمون: Molecular Immunology Division of The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Immunology Division of The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., 1 Molecular Immunology Division of The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia 2 Tsinghua University-Peking University Joint Center for Life Sciences, Tsinghua University School of Medicine, Beijing, China.

المصدر: PubMed

Relation: Immunology and cell biology.2015.; 650524; http://hdl.handle.net/20.500.11897/341537

الاتاحة: https://hdl.handle.net/20.500.11897/341537
https://doi.org/10.1038/icb.2014.119

المؤلفون: Lee, Chin-Nien, Lew, Andrew M., Wu, Li

المساهمون: Wu, L (reprint author), Walter & Eliza Hall Inst Med Res, Mol Immunol Div, 1G Royal Parade, Parkville, Vic 3052, Australia., Walter & Eliza Hall Inst Med Res, Mol Immunol Div, Parkville, Vic 3052, Australia., Univ Melbourne, Australia Immunol Div, Walter Eliza Hall Inst Med Res, Dept Med Biol, Parkville, Vic 3052, Australia., Tsinghua Univ, Sch Med, Peking Univ, Joint Ctr Life Sci, Beijing 100084, Peoples R China., Walter & Eliza Hall Inst Med Res, Mol Immunol Div, 1G Royal Parade, Parkville, Vic 3052, Australia.

المصدر: SCI

مصطلحات موضوعية: autoimmunity, dendritic cells, immunotherapy, tolerance, Type 1 diabetes, REGULATORY T-CELLS, SYSTEMIC-LUPUS-ERYTHEMATOSUS, GLUTAMIC-ACID DECARBOXYLASE, C-TYPE LECTIN, JOINT GENETIC SUSCEPTIBILITY, COMPLETE FREUND ADJUVANT, GENOME-WIDE ASSOCIATION, TOLERANCE IN-VIVO, NOD MICE, AUTOIMMUNE-DISEASE

Relation: IMMUNOTHERAPY.2013,5,(6),591-606.; 822710; http://hdl.handle.net/20.500.11897/391495; WOS:000319818300012

الاتاحة: https://hdl.handle.net/20.500.11897/391495
https://doi.org/10.2217/IMT.13.48

المؤلفون: 李錦年, Lee, Chin-Nien

المساهمون: 賴明宗, 臺灣大學：免疫學研究所

مصطلحات موضوعية: ATM, Ataxia Telangiectasia Mutated, Ataxia Telangiectasia, T細胞活化, TCR訊息傳遞, T cell activation, TCR signal transduction

وصف الملف: 1449436 bytes; application/pdf

Relation: Alcover, A., and Alarcon, B. (2000). Internalization and intracellular fate of TCR-CD3 complexes. Crit Rev Immunol 20, 325-346. Ariumi, Y., Turelli, P., Masutani, M., and Trono, D. (2005). DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. J Virol 79, 2973-2978. Bakkenist, C. J., and Kastan, M. B. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506. Barlow, C., Hirotsune, S., Paylor, R., Liyanage, M., Eckhaus, M., Collins, F., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D., and Wynshaw-Boris, A. (1996). Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159-171. Barzilai, A., Rotman, G., and Shiloh, Y. (2002). ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair (Amst) 1, 3-25. Benmerah, A., Gagnon, J., Begue, B., Megarbane, B., Dautry-Varsat, A., and Cerf-Bensussan, N. (1995). The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2. J Cell Biol 131, 1831-1838. Brown, K. D., Ziv, Y., Sadanandan, S. N., Chessa, L., Collins, F. S., Shiloh, Y., and Tagle, D. A. (1997). The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage. Proc Natl Acad Sci U S A 94, 1840-1845. Chen, G., and Lee, E. (1996). The product of the ATM gene is a 370-kDa nuclear phosphoprotein. J Biol Chem 271, 33693-33697. Chen, S., Wang, G., Makrigiorgos, G. M., and Price, B. D. (2004). Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells. Biochem Biophys Res Commun 317, 1037-1044. Downward, J. (1998). Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10, 262-267. Duden, R., Griffiths, G., Frank, R., Argos, P., and Kreis, T. E. (1991). Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell 64, 649-665. Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., and Naldini, L. (1998). A third-generation lentivirus vector with a conditional packaging system. J Virol 72, 8463-8471. Easton, D. F. (1994). Cancer risks in A-T heterozygotes. Int J Radiat Biol 66, S177-182. Elson, A., Wang, Y., Daugherty, C. J., Morton, C. C., Zhou, F., Campos-Torres, J., and Leder, P. (1996). Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A 93, 13084-13089. Fischer, A., and Malissen, B. (1998). Natural and engineered disorders of lymphocyte development. Science 280, 237-243. Fukao, T., Kaneko, H., Birrell, G., Gatei, M., Tashita, H., Yoshida, T., Cross, S., Kedar, P., Watters, D., Khana, K. K., et al. (1999). ATM is upregulated during the mitogenic response in peripheral blood mononuclear cells. Blood 94, 1998-2006. Gaffen, S. L., and Liu, K. D. (2004). Overview of interleukin-2 function, production and clinical applications. Cytokine 28, 109-123. Ghaffari-Tabrizi, N., Bauer, B., Villunger, A., Baier-Bitterlich, G., Altman, A., Utermann, G., Uberall, F., and Baier, G. (1999). Protein kinase Ctheta, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells. Eur J Immunol 29, 132-142. Goldstone, S. D., Fragonas, J. C., Jeitner, T. M., and Hunt, N. H. (1995). Transcription factors as targets for oxidative signalling during lymphocyte activation. Biochim Biophys Acta 1263, 114-122. Gueven, N., Keating, K. E., Chen, P., Fukao, T., Khanna, K. K., Watters, D., Rodemann, P. H., and Lavin, M. F. (2001). Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. J Biol Chem 276, 8884-8891. Hildeman, D. A., Mitchell, T., Teague, T. K., Henson, P., Day, B. J., Kappler, J., and Marrack, P. C. (1999). Reactive oxygen species regulate activation-induced T cell apoptosis. Immunity 10, 735-744. Hsieh, C. L., Arlett, C. F., and Lieber, M. R. (1993). V(D)J recombination in ataxia telangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem 268, 20105-20109. Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004). Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431, 997-1002. Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., and Suda, T. (2006). Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 12, 446-451. Khanna, K. K., Keating, K. E., Kozlov, S., Scott, S., Gatei, M., Hobson, K., Taya, Y., Gabrielli, B., Chan, D., Lees-Miller, S. P., and Lavin, M. F. (1998). ATM associates with and phosphorylates p53: mapping the region of interaction. Nat Genet 20, 398-400. Kozlov, S., Gueven, N., Keating, K., Ramsay, J., and Lavin, M. F. (2003). ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J Biol Chem 278, 9309-9317. Kuo, C. T., and Leiden, J. M. (1999). Transcriptional regulation of T lymphocyte development and function. Annu Rev Immunol 17, 149-187. Kurz, E. U., and Lees-Miller, S. P. (2004). DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst) 3, 889-900. Lakin, N. D., Weber, P., Stankovic, T., Rottinghaus, S. T., Taylor, A. M., and Jackson, S. P. (1996). Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene 13, 2707-2716. Laposa, R. R., Henderson, J. T., Xu, E., and Wells, P. G. (2004). Atm-null mice exhibit enhanced radiation-induced birth defects and a hybrid form of embryonic programmed cell death indicating a teratological suppressor function for ATM. Faseb J 18, 896-898. Lavin, M. F., Delia, D., and Chessa, L. (2006). ATM and the DNA damage response. Workshop on ataxia-telangiectasia and related syndromes. EMBO Rep 7, 154-160. Lee, K., and Esselman, W. J. (2002). Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways. Free Radic Biol Med 33, 1121-1132. Li, Y., Wu, D., Chen, B., Ingram, A., He, L., Liu, L., Zhu, D., Kapoor, A., and Tang, D. (2004). ATM activity contributes to the tumor-suppressing functions of p14ARF. Oncogene 23, 7355-7365. Liao, M. J., and Van Dyke, T. (1999). Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma. Genes Dev 13, 1246-1250. Lim, D. S., Kirsch, D. G., Canman, C. E., Ahn, J. H., Ziv, Y., Newman, L. S., Darnell, R. B., Shiloh, Y., and Kastan, M. B. (1998). ATM binds to beta-adaptin in cytoplasmic vesicles. Proc Natl Acad Sci U S A 95, 10146-10151. Liu, H., Rhodes, M., Wiest, D. L., and Vignali, D. A. (2000a). On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 13, 665-675. Liu, Y., Witte, S., Liu, Y. C., Doyle, M., Elly, C., and Altman, A. (2000b). Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation. J Biol Chem 275, 3603-3609. Liyanage, M., Weaver, Z., Barlow, C., Coleman, A., Pankratz, D. G., Anderson, S., Wynshaw-Boris, A., and Ried, T. (2000). Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice. Blood 96, 1940-1946. Llorca, O., Rivera-Calzada, A., Grantham, J., and Willison, K. R. (2003). Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA. Oncogene 22, 3867-3874. Los, M., Droge, W., Stricker, K., Baeuerle, P. A., and Schulze-Osthoff, K. (1995a). Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur J Immunol 25, 159-165. Los, M., Schenk, H., Hexel, K., Baeuerle, P. A., Droge, W., and Schulze-Osthoff, K. (1995b). IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. Embo J 14, 3731-3740. Lu, B., Wang, L., Stehlik, C., Medan, D., Huang, C., Hu, S., Chen, F., Shi, X., and Rojanasakul, Y. (2006). Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. J Immunol 176, 6785-6793. Lumsden, J. M., McCarty, T., Petiniot, L. K., Shen, R., Barlow, C., Wynn, T. A., Morse, H. C., 3rd, Gearhart, P. J., Wynshaw-Boris, A., Max, E. E., and Hodes, R. J. (2004). Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med 200, 1111-1121. Matei, I. R., Guidos, C. J., and Danska, J. S. (2006). ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection. Immunol Rev 209, 142-158. Miyoshi, H., Blomer, U., Takahashi, M., Gage, F. H., and Verma, I. M. (1998). Development of a self-inactivating lentivirus vector. J Virol 72, 8150-8157. Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., and Trono, D. (1996). In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267. Newman, L. S., McKeever, M. O., Okano, H. J., and Darnell, R. B. (1995). Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell 82, 773-783. Nicholson, K. M., and Anderson, N. G. (2002). The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14, 381-395. Pani, G., Colavitti, R., Borrello, S., and Galeotti, T. (2000). Endogenous oxygen radicals modulate protein tyrosine phosphorylation and JNK-1 activation in lectin-stimulated thymocytes. Biochem J 347 Pt 1, 173-181. Panka, D. J., Mano, T., Suhara, T., Walsh, K., and Mier, J. W. (2001). Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J Biol Chem 276, 6893-6896. Perkins, E. J., Nair, A., Cowley, D. O., Van Dyke, T., Chang, Y., and Ramsden, D. A. (2002). Sensing of intermediates in V(D)J recombination by ATM. Genes Dev 16, 159-164. Petiniot, L. K., Weaver, Z., Barlow, C., Shen, R., Eckhaus, M., Steinberg, S. M., Ried, T., Wynshaw-Boris, A., and Hodes, R. J. (2000). Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Proc Natl Acad Sci U S A 97, 6664-6669. Plas, D. R., Talapatra, S., Edinger, A. L., Rathmell, J. C., and Thompson, C. B. (2001). Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem 276, 12041-12048. Reichenbach, J., Schubert, R., Schwan, C., Muller, K., Bohles, H. J., and Zielen, S. (1999). Anti-oxidative capacity in patients with ataxia telangiectasia. Clin Exp Immunol 117, 535-539. Robey, E., and Fowlkes, B. J. (1994). Selective events in T cell development. Annu Rev Immunol 12, 675-705. Rotman, G., and Shiloh, Y. (1998). ATM: from gene to function. Hum Mol Genet 7, 1555-1563. Samelson, L. E. (2002). Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu Rev Immunol 20, 371-394. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., and et al. (1995). A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268, 1749-1753. Savitsky, K., Platzer, M., Uziel, T., Gilad, S., Sartiel, A., Rosenthal, A., Elroy-Stein, O., Shiloh, Y., and Rotman, G. (1997). Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression. Nucleic Acids Res 25, 1678-1684. Scollay, R. (1991). T-cell subset relationships in thymocyte development. Curr Opin Immunol 3, 204-209. Shan, X., Czar, M. J., Bunnell, S. C., Liu, P., Liu, Y., Schwartzberg, P. L., and Wange, R. L. (2000). Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol 20, 6945-6957. Shi, Y., Dodson, G. E., Shaikh, S., Rundell, K., and Tibbetts, R. S. (2005). Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem 280, 40195-40200. Shirata, N., Kudoh, A., Daikoku, T., Tatsumi, Y., Fujita, M., Kiyono, T., Sugaya, Y., Isomura, H., Ishizaki, K., and Tsurumi, T. (2005). Activation of ataxia telangiectasia-mutated DNA damage checkpoint signal transduction elicited by herpes simplex virus infection. J Biol Chem 280, 30336-30341. Shortman, K., and Wu, L. (1996). Early T lymphocyte progenitors. Annu Rev Immunol 14, 29-47. Simpson, F., Peden, A. A., Christopoulou, L., and Robinson, M. S. (1997). Characterization of the adaptor-related protein complex, AP-3. J Cell Biol 137, 835-845. Smith, G. C., d'Adda di Fagagna, F., Lakin, N. D., and Jackson, S. P. (1999). Cleavage and inactivation of ATM during apoptosis. Mol Cell Biol 19, 6076-6084. Suhara, T., Mano, T., Oliveira, B. E., and Walsh, K. (2001). Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP). Circ Res 89, 13-19. Sun, Z., Arendt, C. W., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., Annes, J., Petrzilka, D., Kupfer, A., Schwartzberg, P. L., and Littman, D. R. (2000). PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 404, 402-407. Swift, M., Morrell, D., Cromartie, E., Chamberlin, A. R., Skolnick, M. H., and Bishop, D. T. (1986). The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 39, 573-583. Swift, M., Morrell, D., Massey, R. B., and Chase, C. L. (1991). Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325, 1831-1836. Tatla, S., Woodhead, V., Foreman, J. C., and Chain, B. M. (1999). The role of reactive oxygen species in triggering proliferation and IL-2 secretion in T cells. Free Radic Biol Med 26, 14-24. Teague, T. K., Hildeman, D., Kedl, R. M., Mitchell, T., Rees, W., Schaefer, B. C., Bender, J., Kappler, J., and Marrack, P. (1999). Activation changes the spectrum but not the diversity of genes expressed by T cells. Proc Natl Acad Sci U S A 96, 12691-12696. Traven, A., and Heierhorst, J. (2005). SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins. Bioessays 27, 397-407. Viniegra, J. G., Martinez, N., Modirassari, P., Losa, J. H., Parada Cobo, C., Lobo, V. J., Luquero, C. I., Alvarez-Vallina, L., Ramon y Cajal, S., Rojas, J. M., and Sanchez-Prieto, R. (2005). Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 280, 4029-4036. von Boehmer, H., and Fehling, H. J. (1997). Structure and function of the pre-T cell receptor. Annu Rev Immunol 15, 433-452. Wang, X., Gjorloff-Wingren, A., Saxena, M., Pathan, N., Reed, J. C., and Mustelin, T. (2000). The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase. J Immunol 164, 1934-1939. Watters, D., Khanna, K. K., Beamish, H., Birrell, G., Spring, K., Kedar, P., Gatei, M., Stenzel, D., Hobson, K., Kozlov, S., et al. (1997). Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene 14, 1911-1921. Werlen, G., Jacinto, E., Xia, Y., and Karin, M. (1998). Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. Embo J 17, 3101-3111. Williams, M. S., and Henkart, P. A. (1996). Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas. J Immunol 157, 2395-2402. Wonerow, P., and Watson, S. P. (2001). The transmembrane adapter LAT plays a central role in immune receptor signalling. Oncogene 20, 6273-6283. Wu, Z. H., Shi, Y., Tibbetts, R. S., and Miyamoto, S. (2006). Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science 311, 1141-1146. Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., and Baltimore, D. (1996). Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10, 2411-2422. Young, D. B., Jonnalagadda, J., Gatei, M., Jans, D. A., Meyn, S., and Khanna, K. K. (2005). Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem 280, 27587-27594. Zakian, V. A. (1995). ATM-related genes: what do they tell us about functions of the human gene? Cell 82, 685-687. Zhang, L., Tie, Y., Tian, C., Xing, G., Song, Y., Zhu, Y., Sun, Z., and He, F. (2006). CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM. Cell Signal 18, 1386-1395.; zh-TW; http://ntur.lib.ntu.edu.tw/handle/246246/63327; http://ntur.lib.ntu.edu.tw/bitstream/246246/63327/1/ntu-95-R93449004-1.pdf

الاتاحة: http://ntur.lib.ntu.edu.tw/handle/246246/63327
http://ntur.lib.ntu.edu.tw/bitstream/246246/63327/1/ntu-95-R93449004-1.pdf

المؤلفون: Lee, Chin‐Nien, Lew, Andrew M, Shortman, Ken, Wu, Li

المصدر: Immunology & Cell Biology; Jul2015, Vol. 93 Issue 6, p548-557, 10p

مصطلحات موضوعية: CD8 antigen, DENDRITIC cells, GENETICS of diabetes, MAJOR histocompatibility complex, T cell receptors

المؤلفون: Huang, Tzu-Hsuan, Wu, Pin-Yi, Lee, Chin-Nien, Huang, Hsing-I, Hsieh, Shie-Liang, Kung, John, Tao, Mi-Hua

المصدر: Blood; December 2000, Vol. 96 Issue: 12 p3663-3670, 8p

المؤلفون: Lee, Chin Nien

مصطلحات موضوعية: dendritic cells, DC, DCs, type 1 diabetes, T1D, non-obese diabetic, NOD, cross-presentation, CD8+ cDC, cDC, pDC, plasmacytoid DC

Relation: Lee, C. N. (2012). Functional studies of dendritic cells in type 1 diabetes: non-obese diabetic (NOD) mouse model. PhD thesis, Medicine, Dentistry & Health Sciences - Medical Biology, Walter & Eliza Hall Institute of Medical Research and The University of Melbourne.; http://hdl.handle.net/11343/37473

الاتاحة: http://hdl.handle.net/11343/37473