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1
المؤلفون: Michelle R. Garnsey, Aaron C. Smith, Jana Polivkova, Autumn L. Arons, Guoyun Bai, Caroline Blakemore, Markus Boehm, Leanne M. Buzon, Sarah N. Campion, Matthew Cerny, Shiao-Chi Chang, Karen Coffman, Kathleen A. Farley, Kari R. Fonseca, Kristen K. Ford, Jeonifer Garren, Jimmy X. Kong, Martin R. M. Koos, Daniel W. Kung, Yajing Lian, Monica M. Li, Qifang Li, Luis A. Martinez-Alsina, Rebecca O’Connor, Kevin Ogilvie, Kiyoyuki Omoto, Brian Raymer, Matthew R. Reese, Tim Ryder, Lacey Samp, Kimberly A. Stevens, Daniel W. Widlicka, Qingyi Yang, Kaicheng Zhu, Jean-Philippe Fortin, Matthew F. Sammons
المصدر: Journal of Medicinal Chemistry. 66:3195-3211
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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2
المؤلفون: Shenping Liu, Bethany L. Kormos, John D. Knafels, Parag V. Sahasrabudhe, Amy Rosado, Ruth F. Sommese, Allan R. Reyes, Jessica Ward, Rachel J. Roth Flach, Xiaochun Wang, Leanne M. Buzon, Matthew R. Reese, Samit K. Bhattacharya, Kiyoyuki Omoto, Kevin J. Filipski
المصدر: Journal of Biological Chemistry. 299:102959
مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry
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3
المؤلفون: Kelly R. Bales, Anabella Villalobos, David Riddell, Shawn D. Doran, Christopher Ryan Butler, Bruce N. Rogers, Lorraine F. Lanyon, Karamjeet Pandher, Claude Ambroise, Ashley Robshaw, Gabriela Barreiro, Christopher Houle, Kevin Ogilvie, Brian T. O’Neill, Erik Alphie Lachapelle, Germaine Boucher, Xinjun Hou, Katherine Hales, David Karanian, Michael Aaron Brodney, Leanne M. Buzon, Kimberly Lapham, Lei Zhang, Luis Martinez-Alsina, Charles E. Nolan, Claire M. Steppan, Cathleen Gonzales, John C. Murray, Cheng Chang, Jason K. Dutra, Elizabeth Mary Beck
المصدر: Journal of Medicinal Chemistry. 61:4476-4504
مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Protein Conformation, Thiazines, Cathepsin D, Skin Pigmentation, Amyloid beta-Protein Precursor, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Protein structure, In vivo, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Cells, Cultured, Pyrans, Melanosome, Hypopigmentation, chemistry.chemical_classification, Molecular Structure, biology, Brain, Phenotype, Mice, Inbred C57BL, Thiazoles, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Drug Design, biology.protein, Melanocytes, Molecular Medicine, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, 030217 neurology & neurosurgery
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4
المؤلفون: Felix Vajdos, Eric Benvenuti, Leanne M. Buzon, Brian T. O’Neill, Gabriela Barreiro, David Riddell, Kevin Atchison, Charles E. Nolan, Ashley Robshaw, Eric F. Johnson, Kevin D. Parris, Shawn D. Doran, Michael Aaron Brodney, Xinjun Hou, Luis Martinez-Alsina, Kimberly Lapham, Mei-Hui Hsu, Elizabeth Mary Beck, Christopher Ryan Butler, Kevin Ogilvie, Cathleen Gonzales, Lorraine F. Lanyon, Christopher John Helal
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Male, 0301 basic medicine, Patch-Clamp Techniques, Stereochemistry, Glycine, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Tandem Mass Spectrometry, Drug Discovery, Animals, Moiety, Potency, Structure–activity relationship, Anilides, Amino Acid Sequence, Enzyme Inhibitors, Binding site, Structural motif, Chromatography, High Pressure Liquid, ADME, biology, Chemistry, Brain, 030104 developmental biology, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Crystallization, Linker, Amyloid precursor protein secretase, 030217 neurology & neurosurgery
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5
المؤلفون: Christopher John Helal, Kevin Atchison, Christopher Ryan Butler, Cathleen Gonzales, Ricardo Lira, Shawn D. Doran, Feng Pan, Felix Vajdos, Alison H. Varghese, Gabriela Barreiro, Michael Aaron Brodney, Jinlong Wang, Elizabeth Mary Beck, Luis Martinez-Alsina, Yong Zhang, Kevin D. Parris, David Riddell, Joseph Michael Young, Leanne M. Buzon, Ashley Robshaw, Kevin Ogilvie, Jason K. Dutra, Brian T. O’Neill, John C. Murray, Charles E. Nolan
المصدر: Journal of Medicinal Chemistry. 58:2678-2702
مصطلحات موضوعية: Male, Models, Molecular, Drug, media_common.quotation_subject, Amidines, Cathepsin D, Plaque, Amyloid, Pharmacology, Mice, Dogs, Alzheimer Disease, Oral administration, mental disorders, Drug Discovery, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Potency, Sulfhydryl Compounds, Enzyme Inhibitors, Rats, Wistar, media_common, ADME, Amyloid beta-Peptides, Retinal pigment epithelium, biology, Chemistry, Brain, medicine.disease, Rats, medicine.anatomical_structure, Drug Design, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase
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6
المؤلفون: Mark W. Bundesmann, David Riddell, Peter Mikochik, Leanne M. Buzon, Brian T. O’Neill, Subas M. Sakya, Jayvardhan Pandit, Christopher Ryan Butler, Xinjun Hou, Ashley Robshaw, Kevin D. Parris, Jason K. Dutra, Ricardo Lira, Loren M. Price, Charles E. Nolan, Elizabeth Mary Beck, Bruce N. Rogers, Gabriela Barreiro, Aijia Yu, Michael Aaron Brodney, Cathleen Gonzales, Erik Alphie Lachapelle, Shawn D. Doran, Luis Martinez-Alsina, Kevin E. Henegar, Ying Fan, Kevin Atchison, Eric F. Johnson, John C. Murray, Kevin Ogilvie, Yong Zhang
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Drug, Male, Models, Molecular, CYP2D6, ERG1 Potassium Channel, media_common.quotation_subject, Molecular Sequence Data, Amyloidogenic Proteins, Mice, Inbred Strains, Pyrazole, Pharmacology, Crystallography, X-Ray, Article, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Aspartic Acid Endopeptidases, Humans, Drug Interactions, Protease Inhibitors, Amino Acid Sequence, media_common, chemistry.chemical_classification, biology, Potential risk, First generation, Ether-A-Go-Go Potassium Channels, 3. Good health, Enzyme, chemistry, Biochemistry, Cytochrome P-450 CYP2D6, Drug Design, biology.protein, Molecular Medicine, Pyrazoles, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
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7
المؤلفون: Charles E. Nolan, Christer Halldin, Anabella Villalobos, Kelly R. Bales, Klaas Schildknegt, Ryosuke Arakawa, Akihiro Takano, Lorraine F. Lanyon, Leanne M. Buzon, Shawn D. Doran, Nahid Amini, Laigao Chen, Brian T. O’Neill, Michael Aaron Brodney, Elizabeth Mary Beck, Lei Zhang, Timothy J. McCarthy, Sangram Nag, Jason K. Dutra
المصدر: Journal of medicinal chemistry. 61(8)
مصطلحات موضوعية: 0301 basic medicine, Male, Fluorine Radioisotopes, Thiazines, Cleavage (embryo), Ligands, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, mental disorders, Drug Discovery, Amyloid precursor protein, Extracellular, medicine, Animals, Aspartic Acid Endopeptidases, Protease Inhibitors, chemistry.chemical_classification, biology, medicine.diagnostic_test, Brain, In vitro, 030104 developmental biology, Enzyme, chemistry, Biochemistry, Positron emission tomography, Positron-Emission Tomography, Pyrazines, Pet ligand, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Radiopharmaceuticals, 030217 neurology & neurosurgery
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المؤلفون: Joseph Michael Young, John C. Murray, Mark W. Bundesmann, Brian T. O’Neill, Leanne M. Buzon, Luis Martinez-Alsina
المصدر: The Journal of organic chemistry. 82(23)
مصطلحات موضوعية: 010405 organic chemistry, Stereochemistry, Organic Chemistry, Late stage, 010402 general chemistry, Ring (chemistry), Metathesis, 01 natural sciences, 0104 chemical sciences, Overman rearrangement, chemistry.chemical_compound, Template, chemistry, Amide, Lactam, Amine gas treating
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9
المؤلفون: Kevin K.-C. Liu, Leanne M. Buzon, Ernie Hamanaka, Xiaojing Yang
المصدر: Tetrahedron: Asymmetry. 11:4447-4450
مصطلحات موضوعية: Inorganic Chemistry, chemistry.chemical_classification, Enzyme, Resolution (mass spectrometry), chemistry, Yield (chemistry), Organic Chemistry, Organic chemistry, Physical and Theoretical Chemistry, Enantiomer, Squalene Synthetase, Catalysis
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10
المؤلفون: Katherine Loomis, Kevin Daniel Freeman-Cook, Zhengrong Zhao, Susan Tapley, Dennis Paul Phillion, Richard L. Elliott, Steven B. Coffey, Christopher S. Jones, Kevin E. Henegar, Kirk McPherson, Chris Limberakis, Scott Bader, Janet A. Houser, Leanne M. Buzon, Angel Guzman-Perez, Shawn D. Doran, Wei Song, Betsy Pierce, Kendra Louise Nelson, Meihua Tu, William P. Esler, Kenneth J. DiRico, Sharad B. Murdande, Jeffrey W. Corbett, Paul A. Amor, Eliot Sugarman
المصدر: Journal of medicinal chemistry. 55(2)
مصطلحات موضوعية: Prioritization, Quantitative structure–activity relationship, Indazoles, Indoles, Quantitative Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Spiro Compounds, Muscle, Skeletal, Chemistry, Acetyl-CoA carboxylase, Pyruvate carboxylase, Rats, Isoenzymes, Biochemistry, Liver, Lipophilic efficiency, Rat liver, Drug Design, Molecular Medicine, Pyrazoles, Benzimidazoles, Acetyl-CoA Carboxylase
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المؤلفون: H. James Harwood, R. Kirk McPherson, Susan Tapley, Leanne M. Buzon, Kevin Daniel Freeman-Cook, Steven B. Coffey, Richard L. Elliott, Darcy Kohls, Liang Tong, Felix Vajdos, Meihua Tu, Eliot Sugarman, Shawn D. Doran, Francis Rajamohan, Eric S. Marr, Hailong Zhang, Wei Song, Kenneth J. DiRico, Jeffrey W. Corbett, Janet A. Houser, Sharad B. Murdande, William P. Esler, Martha L. Minich, Christopher J. Jones
المصدر: Bioorganicmedicinal chemistry letters. 20(7)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Small Molecule Libraries, Structure-Activity Relationship, Drug Discovery, Transferase, Animals, Humans, Enzyme Inhibitors, Molecular Biology, biology, Drug discovery, Chemistry, Organic Chemistry, Acetyl-CoA carboxylase, Acetyl-CoA Carboxylase 1, Small molecule, Pyruvate carboxylase, Rats, Isoenzymes, Enzyme inhibitor, biology.protein, Molecular Medicine, Acetyl-CoA Carboxylase