نتائج البحث - "Leach, Andrew R"

1

Academic Journal

CACHE (Critical Assessment of Computational Hit-finding Experiments): A public–private partnership benchmarking initiative to enable the development of computational methods for hit-finding

المؤلفون: Ackloo, Suzanne, Al-awar, Rima, Amaro, Rommie E, Arrowsmith, Cheryl H, Azevedo, Hatylas, Batey, Robert A, Bengio, Yoshua, Betz, Ulrich AK, Bologa, Cristian G, Chodera, John D, Cornell, Wendy D, Dunham, Ian, Ecker, Gerhard F, Edfeldt, Kristina, Edwards, Aled M, Gilson, Michael K, Gordijo, Claudia R, Hessler, Gerhard, Hillisch, Alexander, Hogner, Anders, Irwin, John J, Jansen, Johanna M, Kuhn, Daniel, Leach, Andrew R, Lee, Alpha A, Lessel, Uta, Morgan, Maxwell R, Moult, John, Muegge, Ingo, Oprea, Tudor I, Perry, Benjamin G, Riley, Patrick, Rousseaux, Sophie AL, Saikatendu, Kumar Singh, Santhakumar, Vijayaratnam, Schapira, Matthieu, Scholten, Cora, Todd, Matthew H, Vedadi, Masoud, Volkamer, Andrea, Willson, Timothy M

المصدر: Nature Reviews Chemistry. 6(4)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, 5.1 Pharmaceuticals, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6v9825wx
https://escholarship.org/content/qt6v9825wx/qt6v9825wx.pdf

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2

Academic Journal

The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods

المصدر: Nucleic Acids Research, 52 (D1)

وصف الملف: application/application/pdf

Relation: info:eu-repo/semantics/altIdentifier/wos/001097735600001; info:eu-repo/grantAgreement/EC/H2020/875510; http://hdl.handle.net/20.500.11850/643774

الاتاحة: https://hdl.handle.net/20.500.11850/643774
https://doi.org/10.3929/ethz-b-000643774

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3

Academic Journal

Overview of the Knowledge Management Center for Illuminating the Druggable Genome

المؤلفون: Oprea, Tudor I., Bologa, Cristian, Holmes, Jayme, Mathias, Stephen, Metzger, Vincent T., Waller, Anna, Yang, Jeremy J., Leach, Andrew R., Jensen, Lars Juhl, Kelleher, Keith J., Sheils, Timothy K., Mathé, Ewy, Avram, Sorin, Edwards, Jeremy S.

المصدر: Oprea , T I , Bologa , C , Holmes , J , Mathias , S , Metzger , V T , Waller , A , Yang , J J , Leach , A R , Jensen , L J , Kelleher , K J , Sheils , T K , Mathé , E , Avram , S & Edwards , J S 2024 , ' Overview of the Knowledge Management Center for Illuminating the Druggable Genome ' , Drug Discovery Today , vol. 29 , no. 3 , 103882 . https://doi.org/10.1016/j.drudis.2024.103882

مصطلحات موضوعية: database, druggable genome, knowledge management, pharos

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/overview-of-the-knowledge-management-center-for-illuminating-the-druggable-genome(eca22382-aacb-430c-ac1f-8dd1f665602e).html
https://doi.org/10.1016/j.drudis.2024.103882
https://curis.ku.dk/ws/files/382499950/1_s2.0_S1359644624000072_main.pdf

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4

Academic Journal

Occurrence of “Natural Selection” in Successful Small Molecule Drug Discovery

المؤلفون: Heinzke, A. Lina, Pahl, Axel, Zdrazil, Barbara, Leach, Andrew R., Waldmann, Herbert, Young, Robert J., Leeson, Paul D.

المساهمون: Wellcome Trust, European Molecular Biology Laboratory

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 13, page 11226-11241 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.4c00811
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00811

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5

Academic Journal

The Global Phosphorylation Landscape of SARS-CoV-2 Infection.

المؤلفون: Bouhaddou, Mehdi, Memon, Danish, Meyer, Bjoern, White, Kris M, Rezelj, Veronica V, Correa Marrero, Miguel, Polacco, Benjamin J, Melnyk, James E, Ulferts, Svenja, Kaake, Robyn M, Batra, Jyoti, Richards, Alicia L, Stevenson, Erica, Gordon, David E, Rojc, Ajda, Obernier, Kirsten, Fabius, Jacqueline M, Soucheray, Margaret, Miorin, Lisa, Moreno, Elena, Koh, Cassandra, Tran, Quang Dinh, Hardy, Alexandra, Robinot, Rémy, Vallet, Thomas, Nilsson-Payant, Benjamin E, Hernandez-Armenta, Claudia, Dunham, Alistair, Weigang, Sebastian, Knerr, Julian, Modak, Maya, Quintero, Diego, Zhou, Yuan, Dugourd, Aurelien, Valdeolivas, Alberto, Patil, Trupti, Li, Qiongyu, Hüttenhain, Ruth, Cakir, Merve, Muralidharan, Monita, Kim, Minkyu, Jang, Gwendolyn, Tutuncuoglu, Beril, Hiatt, Joseph, Guo, Jeffrey Z, Xu, Jiewei, Bouhaddou, Sophia, Mathy, Christopher JP, Gaulton, Anna, Manners, Emma J, Félix, Eloy, Shi, Ying, Goff, Marisa, Lim, Jean K, McBride, Timothy, O'Neal, Michael C, Cai, Yiming, Chang, Jason CJ, Broadhurst, David J, Klippsten, Saker, De Wit, Emmie, Leach, Andrew R, Kortemme, Tanja, Shoichet, Brian, Ott, Melanie, Saez-Rodriguez, Julio, tenOever, Benjamin R, Mullins, R Dyche, Fischer, Elizabeth R, Kochs, Georg, Grosse, Robert, García-Sastre, Adolfo, Vignuzzi, Marco, Johnson, Jeffery R, Shokat, Kevan M, Swaney, Danielle L, Beltrao, Pedro, Krogan, Nevan J

المصدر: Cell. 182(3)

مصطلحات موضوعية: Caco-2 Cells, Vero Cells, Animals, Humans, Pneumonia, Viral, Coronavirus Infections, Peptidyl-Dipeptidase A, Casein Kinase II, Cyclin-Dependent Kinases, p38 Mitogen-Activated Protein Kinases, Receptor Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Protein Kinase Inhibitors, Antiviral Agents, Drug Evaluation, Preclinical, Proteomics, Phosphorylation, Host-Pathogen Interactions, Phosphatidylinositol 3-Kinases, HEK293 Cells, Pandemics, Spike Glycoprotein, Coronavirus, A549 Cells, Betacoronavirus, Phosphoinositide-3 Kinase Inhibitors, Chlorocebus aethiops, COVID-19, Angiotensin-Converting Enzyme 2, SARS-CoV-2, AXL, CDK, MAPK, PIKFYVE, antiviral, casein kinase II, mass spectrometry, p38, phosphoproteomics, Infectious Diseases, Prevention, Biodefense, Emerging Infectious Diseases, Vaccine Related, Lung, Infection, Developmental Biology, Biological Sciences, Medical and Health Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4431p9mq

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6

Academic Journal

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

المؤلفون: West, Clare E., Karim, Mohd, Falaguera, Maria J., Speidel, Leo, Green, Charlotte J., Logie, Lisa, Schwartzentruber, Jeremy, Ochoa, David, Lord, Janet M., Ferguson, Michael A. J., Bountra, Chas, Wilkinson, Graeme F., Vaughan, Beverley, Leach, Andrew R., Dunham, Ian, Marsden, Brian D.

المصدر: West , C E , Karim , M , Falaguera , M J , Speidel , L , Green , C J , Logie , L , Schwartzentruber , J , Ochoa , D , Lord , J M , Ferguson , M A J , Bountra , C , Wilkinson , G F , Vaughan , B , Leach , A R , Dunham , I & Marsden , B D 2023 , ' Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity ' , Scientific Data , vol. 10 , 655 . https://doi.org/10.1038/s41597-023-02513-4

مصطلحات موضوعية: Computational biology and bioinformatics, Diseases, Genomics, Target identification, /dk/atira/pure/subjectarea/asjc/2600/2613, name=Statistics and Probability, /dk/atira/pure/subjectarea/asjc/1700/1710, name=Information Systems, /dk/atira/pure/subjectarea/asjc/3300/3304, name=Education, /dk/atira/pure/subjectarea/asjc/1700/1706, name=Computer Science Applications, /dk/atira/pure/subjectarea/asjc/1800/1804, name=Statistics, Probability and Uncertainty, /dk/atira/pure/subjectarea/asjc/3300/3309, name=Library and Information Sciences

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/2503727e-1551-4af4-9672-a6c018abaf57
https://doi.org/10.1038/s41597-023-02513-4
https://discovery.dundee.ac.uk/ws/files/108771833/s41597-023-02513-4.pdf
http://www.scopus.com/inward/record.url?scp=85172269856&partnerID=8YFLogxK

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7

Academic Journal

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.

مصطلحات موضوعية: Humans, Genome-Wide Association Study, Mendelian Randomization Analysis, Proteomics, Heart Failure

وصف الملف: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/354036

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/354036

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8

Academic Journal

Illuminating the druggable genome through patent bioactivity data

المؤلفون: Magariños, Maria P., Gaulton, Anna, Félix, Eloy, Kiziloren, Tevfik, Arcila, Ricardo, Oprea, Tudor I., Leach, Andrew R.

المساهمون: US National Institutes of Health, Illuminating the Druggable Genome Knowledge Management Center (IDG KMC) at the University of New Mexico, Novo Nordisk Foundation Center for Protein Research, European Bioinformatics Institute (EBI) and University of Miami, Wellcome Trust, Member States of the European Molecular Biology Laboratory

المصدر: PeerJ ; volume 11, page e15153 ; ISSN 2167-8359

الاتاحة: http://dx.doi.org/10.7717/peerj.15153
https://peerj.com/articles/15153.pdf
https://peerj.com/articles/15153.xml
https://peerj.com/articles/15153.html

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9

Academic Journal

The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods

المساهمون: Wellcome Trust, Member States of the European Molecular Biology Laboratory, US National Institutes of Health, University of New Mexico, European Bioinformatics Institute, University of Miami, Innovative Medicines Initiative 2 Joint Undertaking

المصدر: Nucleic Acids Research ; volume 52, issue D1, page D1180-D1192 ; ISSN 0305-1048 1362-4962

الاتاحة: https://doi.org/10.1093/nar/gkad1004
https://academic.oup.com/nar/article-pdf/52/D1/D1180/55040046/gkad1004.pdf

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10

Academic Journal

EMBL’s European Bioinformatics Institute (EMBL-EBI) in 2023

المساهمون: EMBL, European Commission, Wellcome, UK Research and Innovation, US National Institutes of Health

المصدر: Nucleic Acids Research ; volume 52, issue D1, page D10-D17 ; ISSN 0305-1048 1362-4962

الاتاحة: http://dx.doi.org/10.1093/nar/gkad1088
https://academic.oup.com/nar/article-pdf/52/D1/D10/55040618/gkad1088.pdf

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11

Academic Journal

MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity

المؤلفون: Bosc, Nicolas, Felix, Eloy, Gardner, J. Mark F., Mills, James, Timmerman, Martijn, Asveld, Dennis, Rensen, Kim, Mukherjee, Partha, Das, Rishi, Chenu, Elodie, Besson, Dominique, Burrows, Jeremy N., Duffy, James, Laleu, Benoît, Guantai, Eric M., Leach, Andrew R.

المساهمون: European Molecular Biology Laboratory, Bill and Melinda Gates Foundation

المصدر: ACS Medicinal Chemistry Letters ; volume 14, issue 12, page 1733-1741 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.3c00369
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00369

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12

Academic Journal

A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds.

المؤلفون: Heinzke, A. Lina, Zdrazil, Barbara, Leeson, Paul D., Young, Robert J., Pahl, Axel, Waldmann, Herbert, Leach, Andrew R.

المصدر: Scientific Data; 10/21/2024, Vol. 11 Issue 1, p1-9, 9p

مصطلحات موضوعية: DRUG discovery, DRUG interactions, DOSAGE forms of drugs, DATABASES, BIOACTIVE compounds

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13

Report

EUbOPEN Data Management Plan

المؤلفون: Muller-Knapp, Susanne, Marsden, Brian, Leach, Andrew R, Zdrazil, Barbara, Mendez, David, Felix, Eloy, Manners, Emma, Blackshaw, James, Mosquera, Juan Felipe, Hartley, Matthew, Corbett, Sybilla, Sarkans, Ugis, Günther, Judith, Häberle, Sandra, Menge, Amelie, Ferreira, Lucas, Szommer, Tamas, Edfeldt, Kristina, Roehm, Sandra

المساهمون: Muller-Knapp, Susanne, Juty, Nick, Rocca-Serra, Philippe, Giessmann, Robert

Relation: https://zenodo.org/communities/eu; https://doi.org/10.5281/zenodo.8278990; https://doi.org/10.5281/zenodo.8278991; oai:zenodo.org:8278991

الاتاحة: https://doi.org/10.5281/zenodo.8278991

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14

Academic Journal

Target 2035-update on the quest for a probe for every protein

المؤلفون: Mueller, Susanne, Ackloo, Suzanne, Al Chawaf, Arij, Al-Lazikani, Bissan, Antolin, Albert, Baell, Jonathan B., Beck, Hartmut, Beedie, Shaunna, Betz, Ulrich A. K., Bezerra, Gustavo Arruda, Brennan, Paul E., Brown, David, Brown, Peter J., Bullock, Alex N., Carter, Adrian J., Chaikuad, Apirat, Chaineau, Mathilde, Ciulli, Alessio, Collins, Ian, Dreher, Jan, Drewry, David, Edfeldt, Kristina, Edwards, Aled M., Egner, Ursula, Frye, Stephen, V, Fuchs, Stephen M., Hall, Matthew D., Hartung, Ingo, V, Hillisch, Alexander, Hitchcock, Stephen H., Homan, Evert, Kannan, Natarajan, Kiefer, James R., Knapp, Stefan, Kostic, Milka, Kubicek, Stefan, Leach, Andrew R., Lindemann, Sven, Marsden, Brian D., Matsui, Hisanori, Meier, Jordan L., Merk, Daniel, Michel, Maurice, Morgan, Maxwell R., Mueller-Fahrnow, Anke, Owen, Dafydd R., Perry, Benjamin G., Rosenberg, Saul H., Saikatendu, Kumar Singh, Schapira, Matthieu, Scholten, Cora, Sharma, Sujata, Simeonov, Anton, Sundstrom, Michael, Superti-Furga, Giulio, Todd, Matthew H., Tredup, Claudia, Vedadi, Masoud, von Delft, Frank, Willson, Timothy M., Winter, Georg E., Workman, Paul, Arrowsmith, Cheryl H.

المصدر: Mueller , S , Ackloo , S , Al Chawaf , A , Al-Lazikani , B , Antolin , A , Baell , J B , Beck , H , Beedie , S , Betz , U A K , Bezerra , G A , Brennan , P E , Brown , D , Brown , P J , Bullock , A N , Carter , A J , Chaikuad , A , Chaineau , M , Ciulli , A , Collins , I , Dreher , J , Drewry , D , Edfeldt , K , Edwards , ....

مصطلحات موضوعية: /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1313, name=Molecular Medicine, /dk/atira/pure/subjectarea/asjc/3000/3004, name=Pharmacology, /dk/atira/pure/subjectarea/asjc/3000/3003, name=Pharmaceutical Science, /dk/atira/pure/subjectarea/asjc/3000/3002, name=Drug Discovery, /dk/atira/pure/subjectarea/asjc/1600/1605, name=Organic Chemistry