المؤلفون: Markus Ritzefeld, Leran Zhang, Zhangping Xiao, Sebastian A. Andrei, Olivia Boyd, Naoko Masumoto, Ursula R. Rodgers, Markus Artelsmair, Lea Sefer, Angela Hayes, Efthymios-Spyridon Gavriil, Florence I. Raynaud, Rosemary Burke, Julian Blagg, Henry S. Rzepa, Christian Siebold, Anthony I. Magee, Thomas Lanyon-Hogg, Edward W. Tate

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Pharmacology, Biotechnology, Developmental Biology, Hematology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, work identifies imp, three key factors, providing tool compounds, inactive control enantiomer, central amide linkage, active chemical probe, several potent analogues, shh signaling pathway, potential drug target, >- terminal palmitoylation, 50 , potent cell, r <, n <, c <, μm ic, structural data, secondary amine, results show, inhibitory potency

Relation: https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Evaluation_of_Inhibitors_of_Hedgehog_Acyltransferase/24975692

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01363.s001
https://figshare.com/articles/journal_contribution/Design_Synthesis_and_Evaluation_of_Inhibitors_of_Hedgehog_Acyltransferase/24975692

المؤلفون: Milon Mondal, Balazs Pogranyi, Matthew J. Fuchter, Leran Zhang, Christian Siebold, Jake L. Greenfield, Lea Sefer, Sebastian A. Andrei, Thomas Lanyon-Hogg, Markus Ritzefeld, Callum D. Johnston, Joshua Newington, Claire E. Coupland, Anthony I. Magee, Edward W. Tate

المصدر: Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)

مصطلحات موضوعية: 0301 basic medicine, Light, Pyridines, enzymes, membrane-bound O-acyltransferase, MBOAT, Photochemistry, 010402 general chemistry, 01 natural sciences, Catalysis, Homology (biology), Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, HHAT, Acetyltransferases, Hedgehog acyltransferase, Humans, Binding site, photoaffinity labelling, Hedgehog, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Binding Sites, Palmitoyl Coenzyme A, Communication, Affinity Labels, General Chemistry, General Medicine, Small molecule, Communications, 3. Good health, 0104 chemical sciences, Kinetics, 030104 developmental biology, Enzyme, chemistry, Hedgehog signalling, Acyltransferase, Medicinal Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046e3682911cb037adf1cd5c1cfd25f8
https://doi.org/10.1002/ange.202014457

المؤلفون: Claire E. Coupland, Sebastian A. Andrei, T. Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A. Schwab, Eamon F.X. Byrne, Els Pardon, Jan Steyaert, Anthony I. Magee, Thomas Lanyon-Hogg, Mark S.P. Sansom, Edward W. Tate, Christian Siebold

المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels, Cancer Research UK, Biotechnology and Biological Sciences Research Council (BBSRC)

المصدر: Molecular Cell

مصطلحات موضوعية: Biochemistry & Molecular Biology, STRUCTURE VALIDATION, animal structures, PROTEINS, Protein Conformation, Acylation, Hedgehog acyl transferase, membrane-bound O-acyltransferase, Heme, Sonic Hedgehog signaling, Molecular Dynamics Simulation, CRYO-EM, Article, Structure-Activity Relationship, Allosteric Regulation, Catalytic Domain, Chlorocebus aethiops, Animals, Humans, Hedgehog Proteins, Enzyme Inhibitors, PALMITOYLATION, Molecular Biology, 11 Medical and Health Sciences, Science & Technology, IDENTIFICATION, REFINEMENT, Palmitoyl Coenzyme A, ALGORITHMS, Cryoelectron Microscopy, RECOGNITION, Membrane Proteins, small molecule inhibitor, drug, cryo-EM structure, Cell Biology, molecular dynamics simulations, 06 Biological Sciences, palmitoyl co enzyme A, HEK293 Cells, embryonic structures, COS Cells, VISUALIZATION, integral membrane protein, Life Sciences & Biomedicine, Acyltransferases, GENERATION, Developmental Biology, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126d9db15243ce2d4d7d77c45ec15bc
https://pubmed.ncbi.nlm.nih.gov/34890564

المؤلفون: Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D. Johnston, Claire E. Coupland, Sebastian A. Andrei, Joshua Newington, Anthony I. Magee, Christian Siebold, Edward W. Tate

المساهمون: Cancer Research UK, Biotechnology and Biological Sciences Research Council (BBSRC), Engineering & Physical Science Research Council (EPSRC)

مصطلحات موضوعية: Science & Technology, PROTEINS, Chemistry, Multidisciplinary, enzymes, Organic Chemistry, membrane-bound O-acyltransferase, ACYLATION, Chemistry, TARGET, Hedgehog signalling, Physical Sciences, Hedgehog acyltransferase, GHRELIN, photoaffinity labelling, 03 Chemical Sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e59cf7fba46be40356dcde9c651c2d
http://hdl.handle.net/10044/1/87627

المؤلفون: Anthony I. Magee, Nattawadee Panyain, Thomas Lanyon-Hogg, Markus Ritzefeld, Nicola O’Reilly, Ganka Bineva-Todd, Jasmine K. Bickel, Edward W. Tate, Cory A Ocasio, Lea Sefer, Christian Siebold, A.F. Rudolf

المساهمون: Pancreatic Cancer Research Fund, Cancer Research UK

المصدر: Chemical Science

مصطلحات موضوعية: Chemistry, Multidisciplinary, Lipid-anchored protein, 010402 general chemistry, 01 natural sciences, Acylation, Palmitoylation, Hydrolase, medicine, Transferase, PALMITOYLATION, PROBE, Chemical Biology & High Throughput, chemistry.chemical_classification, Science & Technology, HEDGEHOG, 010405 organic chemistry, Chemistry, Drug discovery, Neurodegeneration, General Chemistry, medicine.disease, 0104 chemical sciences, Enzyme, Biochemistry, Physical Sciences, lipids (amino acids, peptides, and proteins), INHIBITORS, 03 Chemical Sciences, Structural Biology & Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac31b40b5b5d89fececdd949daee3aed
https://doi.org/10.1039/c9sc01785b

المؤلفون: Steve Matthews, Yingqi Xu, Fisentzos Stylianou, Lee Sewell, Lea Sefer, Jonathan D. Taylor

المساهمون: Engineering & Physical Science Research Council (EPSRC), Imperial College Trust, Medical Research Council (MRC)

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Amyloid, Magnetic Resonance Spectroscopy, Protein Conformation, Protein subunit, lcsh:Medicine, Plasma protein binding, Biochemistry, Microbiology, Article, 03 medical and health sciences, Protein structure, Bacterial Proteins, Enterobacteriaceae, Secretion, lcsh:Science, Multidisciplinary, 030102 biochemistry & molecular biology, biology, Chemistry, Escherichia coli Proteins, lcsh:R, Biofilm, Membrane Transport Proteins, Periplasmic space, Gene Expression Regulation, Bacterial, 030104 developmental biology, Chaperone (protein), Biofilms, Periplasm, biology.protein, Biophysics, lcsh:Q, Structural biology, Intracellular, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162a59233601e66043afed4f4e801e75
http://hdl.handle.net/10044/1/79248

المؤلفون: Matthew George Chapman, Lea Sefer, Pernilla Wittung-Stafshede, Margery L. Evans, Jörgen Ådén, Anna Götheson, Erik Chorell, Jonathan D. Taylor, Fei Li, Steve Matthews, Fredrik Almqvist, Marion Koch

المصدر: Molecular cell. 57(3)

مصطلحات موضوعية: Amyloid beta-Peptides, biology, Amyloid, Base Sequence, Protein subunit, Escherichia coli Proteins, Amino Acid Motifs, Molecular Sequence Data, Periplasmic space, Cell Biology, Protein aggregation, In Vitro Techniques, Protein Structure, Secondary, Protein Aggregates, Protein structure, Biochemistry, Chaperone (protein), mental disorders, biology.protein, Escherichia coli, alpha-Synuclein, Humans, Secretion, Molecular Biology, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e692c016f5898929a11e09cb8e2004
https://pubmed.ncbi.nlm.nih.gov/25658202

المؤلفون: Rebekka A. Schwab, B Ansell, Loic Carrique, Anthony I. Magee, Lea Sefer, Sebastian A. Andrei, Thomas Lanyon-Hogg, CE Coupland, Byrne Efx., Els Pardon, Christian Siebold, Edward W. Tate, Prem Kumar, Jan Steyaert, Mark S.P. Sansom

المصدر: bioRxiv
bioRxiv 451580

مصطلحات موضوعية: 0303 health sciences, 010304 chemical physics, biology, Chemistry, Wnt signaling pathway, MBOAT, 01 natural sciences, Transmembrane protein, Cell biology, 03 medical and health sciences, HHAT, Acyltransferase, 0103 physical sciences, biology.protein, Sonic hedgehog, Hedgehog, 030304 developmental biology, Morphogen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f367141d8ec3323155a1b9f27dbe4dfd