المؤلفون: Zhuming Zhang (1846087), Avijit Ghosh (1428496), Peter J. Connolly (2456890), Peter King (234747), Thomas Wilde (6057116), Jianyao Wang (640348), Yawei Dong (2365990), Xueliang Li (585599), Daohong Liao (1393399), Hao Chen (5190), Gaochao Tian (2465608), Javier Suarez (2289811), William G. Bonnette (11173075), Vineet Pande (2538973), Karen A. Diloreto (11154645), Yifan Shi (4269262), Shefali Patel (11154648), Beth Pietrak (1940869), Lawrence Szewczuk (11154651), Carlo Sensenhauser (2181964), Shannon Dallas (7945637), James P. Edwards (2428411), Kurtis E. Bachman (5679542), David C. Evans (203487)

مصطلحات موضوعية: Biochemistry, Medicine, Physiology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, adenoma progression, Colorectal Cancer, vivo 18 F-FDG uptake attenuation, efficacy proxy, survival extension, COX -2 inhibitors, COX -2-mediated CRC disease chemopr., colorectal adenomas, APC, exposure, chemoprotective effects, COX -2 inhibition, vivo dose-dependent inhibition

Relation: https://figshare.com/articles/journal_contribution/Gut-Restricted_Selective_Cyclooxygenase_2_COX-2_Inhibitors_for_Chemoprevention_of_Colorectal_Cancer/15019026

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00890.s003

المؤلفون: Shannon Dallas, Thomas Wilde, Avijit Ghosh, Jianyao Wang, Yawei Dong, Gaochao Tian, Daohong Liao, Xueliang Li, Lawrence Szewczuk, Peter King, David C. Evans, Yifan Shi, Kurtis E. Bachman, Javier Suarez, Beth Pietrak, James P. Edwards, Carlo Sensenhauser, Hao Chen, Vineet Pande, Peter J. Connolly, Karen DiLoreto, William G Bonnette, Shefali Patel, Zhuming Zhang

المصدر: Journal of Medicinal Chemistry. 64:11570-11596

مصطلحات موضوعية: Male, Adenoma, Cell Survival, Colorectal cancer, Antineoplastic Agents, Disease, Etoricoxib, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Cell Proliferation, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, medicine.disease, Mice, Inbred C57BL, Celecoxib, Cyclooxygenase 2, biology.protein, Cancer research, Chemoprotective, Molecular Medicine, Cyclooxygenase, Drug Screening Assays, Antitumor, Colorectal Neoplasms, Ex vivo, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b02dbb581a1a9ad484e13ee726c09b
https://doi.org/10.1021/acs.jmedchem.1c00890

المؤلفون: Michael R. Brandt, Pascal Bonaventure, Christine Dugovic, William G Bonnette, Lawrence Szewczuk, Ryan M Wyatt, Kristen M. Chevalier, Timothy W. Lovenberg, Brian Lord, Tatiana Koudriakova, Allison White, Ian Fraser, Peter J. Connolly, Kay Ahn, Michelle Wennerholm, Javier Suarez, Sujin Yun, Steven W. Sutton, Brahma Ghosh, Natalie Welty, Leslie Nguyen, Bin Zhu, Sui-Po Zhang, Gaochao Tian, Mark J. Macielag, Michael K. Ameriks, Christopher M. Flores

المصدر: Journal of Pharmacology and Experimental Therapeutics. 372:339-353

مصطلحات موضوعية: Male, 0301 basic medicine, Cannabinoid receptor, Pain, Sleep, REM, Pharmacology, Binding, Competitive, Piperazines, Substrate Specificity, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, In vivo, Escherichia coli, Animals, Humans, Enzyme Inhibitors, Receptor, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Brain, Long-term potentiation, Serine hydrolase, Endocannabinoid system, Monoacylglycerol Lipases, Mice, Inbred C57BL, Monoacylglycerol lipase, Kinetics, 030104 developmental biology, Leukocytes, Mononuclear, Molecular Medicine, 030217 neurology & neurosurgery, Endogenous agonist, HeLa Cells, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425d2e399b62ec058deb114196dce30
https://doi.org/10.1124/jpet.119.262139

المؤلفون: Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar

المصدر: Cancer Research. 82:2133-2133

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d26c71d6d913e202af7c340f376b66d7
https://doi.org/10.1158/1538-7445.am2022-2133

المؤلفون: Dennis S. Yamashita, Christopher S. Brook, Lawrence Szewczuk, David G. Tew, Thaddeus A. Tomaszek, Xiaoyang Dong, Daniel F. Veber, Hye-Ja Oh

المصدر: Journal of Combinatorial Chemistry. 1:207-215

مصطلحات موضوعية: Models, Molecular, Ketone, Stereochemistry, Cathepsin L, Cathepsin K, Cysteine Proteinase Inhibitors, Structure-Activity Relationship, Solid-phase synthesis, Endopeptidases, Combinatorial Chemistry Techniques, Structure–activity relationship, Cathepsin, chemistry.chemical_classification, biology, General Chemistry, Cathepsins, Cysteine protease, Butanones, Cysteine Endopeptidases, Kinetics, chemistry, Drug Design, biology.protein, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5251a985cb5d63e818e7c56359d8cab8
https://doi.org/10.1021/cc9800374

المؤلفون: Thomas Joseph Carr, Mary J. Bossard, Alison M. Badger, Thaddeus A. Tomaszek, Fred H. Drake, Mark Alan Levy, Lawrence Szewczuk, Scott K. Thompson, Ian E. James, Bartholomew J. Votta, Daniel F. Veber, Maxine Gowen, Janice R. Connor, R.A. Dodds, Bradbeer Jeremy N

المصدر: Journal of Bone and Mineral Research. 12:1396-1406

مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Cathepsin K, Parathyroid hormone, Bone resorption, Rats, Sprague-Dawley, Pregnancy, Osteoclast, Internal medicine, Tumor Cells, Cultured, medicine, Animals, Humans, Orthopedics and Sports Medicine, RNA, Messenger, Bone Resorption, Enzyme Inhibitors, Cellular localization, Parathyroidectomy, Cathepsin, Aldehydes, Chemistry, Arthritis, Experimental, Cathepsins, Recombinant Proteins, Rats, Resorption, medicine.anatomical_structure, Endocrinology, Parathyroid Hormone, Thyroidectomy, Calcium, Cattle, Female, Cortical bone, Oligopeptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4955992b9c29efcb62ab66cb1b50dee7
https://doi.org/10.1359/jbmr.1997.12.9.1396