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1
المؤلفون: Stuart L. Schreiber, Michael Foley, Andrew Germain, Willmen Youngsaye, Timothy A. Lewis, Lawrence MacPherson, Michelle Palmer, Marek M. Nagiec, Christina Scherer, Han-Je Kim, Partha P. Nag, Michel Weïwer, BenjaminZ. Stanton, Chris Dockendorff, Melissa Bennion, Amal Ting, Jose Perez, Sara J. Buhrlage, Linlong Xue
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: Purmorphamine, Patched, Letter, Stereochemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, C3H10T1/2, GLI1, Drug Discovery, Mode of action, Hedgehog, Smoothened antagonist, Sonic Hedgehog pathway, biology, 010405 organic chemistry, Organic Chemistry, Combinatorial chemistry, Hedgehog signaling pathway, 0104 chemical sciences, 3. Good health, biology.protein, Alkaline phosphatase, macrocycle, Smoothened, diversity-oriented synthesis (DOS)
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2
المؤلفون: Kevin J. Embrey, Julie Demeritt, Joanna Bryant, Beth Andrews, George B. Mullen, Ning Gao, Lawrence Macpherson, James T. Loch, Ken Hull, Bryan Prince, Brian Sherer, Alok Singh, P. Ann Boriack-Sjodin, Sheila Irene Hauck, Oluyinka Green, Ann E. Eakin, Haihong Ni, Ruth Illingworth, Dave Timms, Maria Uria-Nickelsen, Grant K. Walkup, Neil James Hales, Alexander L. Breeze, April E. Blodgett, Shanta Bist
المصدر: Antimicrobial Agents and Chemotherapy. 56:1240-1246
مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Magnetic Resonance Spectroscopy, Mutant, Microbial Sensitivity Tests, Biology, Crystallography, X-Ray, medicine.disease_cause, DNA gyrase, DNA sequencing, Inhibitory Concentration 50, Mice, Nuclear magnetic resonance, Drug Resistance, Bacterial, medicine, Animals, Humans, Topoisomerase II Inhibitors, Pyrroles, Experimental Therapeutics, Pharmacology (medical), Enzyme Inhibitors, Binding site, Pharmacology, chemistry.chemical_classification, Mutation, Binding Sites, DNA synthesis, Staphylococcal Infections, Amides, Molecular biology, Anti-Bacterial Agents, Streptococcus pneumoniae, Infectious Diseases, Enzyme, chemistry, Biochemistry, DNA Gyrase, Antibacterial activity, Protein Binding
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3
المؤلفون: Michelle Palmer, Sivaraman Dandapani, Cristina Galan-Rodriguez, Leigh C. Carmody, Chris Dockendorff, Ana Rodriguez, Andrew R. Germain, Lawrence MacPherson, Stephen Johnston, Benito Munoz, Joshua A. Bittker, Stuart L. Schreiber
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7197-7200
مصطلحات موضوعية: Chagas disease, Molecular Structure, Trypanosoma cruzi, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biology, medicine.disease, Trypanocidal Agents, Biochemistry, Virology, Small molecule, Small Molecule Libraries, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Molecular Medicine, Molecular Biology
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4Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor
المؤلفون: Chris Dockendorff, Lynn VerPlank, Joseph Negri, Daniel A. Smith, Robert Flaumenhaft, Stuart L. Schreiber, James R. Dilks, Louisa Dowal, Michelle Palmer, Lawrence MacPherson, Omozuanvbo Aisiku, Susanna F. Gunnink
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: Agonist, Letter, medicine.drug_class, 1,3-diaminobenzene, Allosteric regulation, Peptide, ML161, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Drug Discovery, medicine, platelet activation, Platelet, Platelet activation, Receptor, PAR1 inhibitor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, allosteric inhibitor, business.industry, Organic Chemistry, MLPCN MLSMR, 3. Good health, Protease-Activated Receptor 1, chemistry, cardiovascular system, business, medicine.drug
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5
المؤلفون: Michelle Palmer, Kenichi Shimada, Sivaraman Dandapani, Brent R. Stockwell, Timothy A. Lewis, Benito Munoz, Lawrence MacPherson, Michel Weïwer, Joshua A. Bittker, Wan Seok Yang, Stuart L. Schreiber
المصدر: Bioorganicmedicinal chemistry letters. 22(4)
مصطلحات موضوعية: Clinical Biochemistry, Chemical biology, Pharmaceutical Science, Apoptosis, Thiophenes, Biochemistry, Article, Cell Line, Proto-Oncogene Proteins p21(ras), Small Molecule Libraries, Inhibitory Concentration 50, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Animals, Humans, HRAS, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Fibroblasts, Molecular biology, Small molecule, Rats, Cell culture, Cancer cell, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor, Molecular probe, PubChem
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المؤلفون: Michelle Palmer, Stuart L. Schreiber, Benjamin Vincent, Barbara Morgan, Benito Munoz, Sara J. Buhrlage, Sivaraman Dandapani, Willmen Youngsaye, Luke Whitesell, Cathy L Hartland, Joshua A. Bittker, Susan Lindquist, Stephen Johnston, Lawrence MacPherson
المساهمون: Massachusetts Institute of Technology. Department of Biology, Lindquist, Susan
المصدر: PMC
مصطلحات موضوعية: Antifungal, Antifungal Agents, medicine.drug_class, Calcineurin Inhibitors, Clinical Biochemistry, Antifungal drug, Chemosensitizer, Pharmaceutical Science, Microbial Sensitivity Tests, Drug resistance, Pharmacology, Biochemistry, Article, Microbiology, Small Molecule Libraries, Structure-Activity Relationship, Candida albicans, Drug Discovery, medicine, Structure–activity relationship, HSP90 Heat-Shock Proteins, Fluconazole, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Calcineurin, Organic Chemistry, Stereoisomerism, biology.organism_classification, Quinolines, Molecular Medicine, medicine.drug
وصف الملف: application/pdf
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7
المؤلفون: Alexander Satz, Lawrence Macpherson, Gregory S. Basarab, Bolin Geng, Ekundayo Osimboni, Pamela Hill, Charles J. Eyermann, Janelle Comita-Prevoir, Madhusudhan Reddy Gowravaram, George B. Mullen, Tomas Lundqvist, Marshall Morningstar, Andrew Kiely, James T. Loch
المصدر: Bioorganicmedicinal chemistry letters. 19(3)
مصطلحات موضوعية: Chemistry, Pharmaceutical, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Plasma protein binding, Muri, Biochemistry, Binding, Competitive, Helicobacter Infections, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Non-competitive inhibition, Anti-Infective Agents, Drug Discovery, Structure–activity relationship, Glutamate racemase, Animals, Humans, Amines, Molecular Biology, Antibacterial agent, Amino Acid Isomerases, chemistry.chemical_classification, biology, Helicobacter pylori, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Dimerization
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8
المؤلفون: Jason Burbank, Lynn VerPlank, James R. Dilks, Price S. Blair, Robert Gould, Albert Mairuhu, Michelle Palmer, Robert Flaumenhaft, Lawrence MacPherson, Gil Walzer, Tyler Aldredge, Chris Dockendorff, Joseph Negri
المصدر: Blood. 114:4009-4009
مصطلحات موضوعية: Protease, Chemistry, medicine.medical_treatment, Immunology, Allosteric regulation, Cell Biology, Hematology, Biochemistry, Small molecule, medicine, Platelet, Luciferase, Platelet activation, Chemical genetics, PubChem