المؤلفون: Young Chen, Brandon Whitefield, Erin Nevius, Mark Hill, Joselyn DelRosario, Nadia Sinitsyna, Veerabahu Shanmugasundaram, Debarati Mukherjee, Lihong Shi, Christopher Glenn Mayne, Anne-Marie Rousseau, Steffen M. Bernard, Jennifer Buenviaje, Gody Khambatta, Miriam El Samin, Michael Wallace, Zhe Nie, Pallavur Sivakumar, Lawrence G. Hamann, Donald P. McDonnell, Laura Akullian D’Agostino

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, tumor intrinsic biology, several syngeneic models, report herein selective, potential therapeutic benefits, myeloid cells results, bone mass accrual, small molecule inhibitors, generate selective inhibitors, several biological targets, inhibiting catalytic activity, increased antitumor immunity, ablating camkk2 signaling, ligand directed degraders, efficient inhibitors, directed degraders, biological roles, biological impact, targeting camkk2, probe immune

Relation: https://figshare.com/articles/journal_contribution/Identification_of_Small_Molecule_Inhibitors_and_Ligand_Directed_Degraders_of_Calcium_Calmodulin_Dependent_Protein_Kinase_Kinase_1_and_2_CaMKK1_2_/24638599

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01137.s004
https://figshare.com/articles/journal_contribution/Identification_of_Small_Molecule_Inhibitors_and_Ligand_Directed_Degraders_of_Calcium_Calmodulin_Dependent_Protein_Kinase_Kinase_1_and_2_CaMKK1_2_/24638599

المؤلفون: Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis

المصدر: PLoS ONE, Vol 16, Iss 11 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577775/?tool=EBI; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/c77d178e9fdf4a27bb6fc2263243c22d

المؤلفون: Jake Axford (6081920), Moo Je Sung (2085337), John Manchester (2303572), Donovan Chin (1612576), Monish Jain (1948042), Youngah Shin (6059), Ina Dix (1639147), Lawrence G. Hamann (1436563), Atwood K. Cheung (1920859), Rajeev Sivasankaran (264843), Karin Briner (2725954), Natalie A. Dales (2990565), Brian Hurley (6081917)

مصطلحات موضوعية: Biochemistry, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 2- fluorophenyl thiadiazole motif, exon -7 inclusion, survival motor neuron protein, gene SMN 2, SMA, 2- hydroxyphenyl pyridazine core, SMN protein, intramolecular hydrogen bond, survival motor neuron 1

Relation: https://figshare.com/articles/journal_contribution/Use_of_Intramolecular_1_5-Sulfur_Oxygen_and_1_5-Sulfur_Halogen_Interactions_in_the_Design_of_i_N_i_Methyl-5-aryl_i_N_i_2_2_6_6-tetramethylpiperidin-4-yl_-1_3_4-thiadiazol-2-amine_SMN2_Splicing_Modulators/14378625

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02173.s002

المؤلفون: Philip R. D. Murray (1909783), Willem M. M. Bussink (10261306), Geraint H. M. Davies (4232329), Farid W. van der Mei (8180598), Alyssa H. Antropow (9921239), Jacob T. Edwards (1407445), Laura Akullian D’Agostino (8633694), J. Michael Ellis (1648321), Lawrence G. Hamann (1436563), Fedor Romanov-Michailidis (1563847), Robert R. Knowles (1367934)

مصطلحات موضوعية: Biochemistry, Microbiology, Genetics, Molecular Biology, Biotechnology, Evolutionary Biology, Cancer, Inorganic Chemistry, Infectious Diseases, Plant Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Expedient Access, energy transfer pathway, electron-deficient alkenes, light irradiation, access, transformation, carbonyl bioisosteres, exocyclic arylidene oxetanes, reaction proceeds, DFT calculations, 2-, Mechanistic experiments, Visible-Light Triplet Photosensitiz.

Relation: https://figshare.com/articles/journal_contribution/Intermolecular_Crossed_2_2_Cycloaddition_Promoted_by_Visible-Light_Triplet_Photosensitization_Expedient_Access_to_Polysubstituted_2_Oxaspiro_3_3_heptanes/14170237

الاتاحة: https://doi.org/10.1021/jacs.1c01173.s002

المؤلفون: Claire G. Page (9921230), Simon J. Cooper (9921233), Jacob S. DeHovitz (9921236), Daniel G. Oblinsky (1417888), Kyle F. Biegasiewicz (1617133), Alyssa H. Antropow (9921239), Kurt W. Armbrust (1672966), J. Michael Ellis (1648321), Lawrence G. Hamann (1436563), Evan J. Horn (1420897), Kevin M. Oberg (1685617), Gregory D. Scholes (1272651), Todd K. Hyster (1323081)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Pharmacology, Biotechnology, Developmental Biology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, α- chloroamide, flavin-dependent, biocatalysi, photoexcitation, alkene, Olefin, protein, ene, olefins, hydroalkylation, initiation, electron transfer mechanisms, synthesis, biocatalytic transformations, Quaternary Charge-Transfer Complex ., bond-forming, high-order enzyme-templated charge-., flavin hydroquinone, photoenzymatic catalysis, substrate

Relation: https://figshare.com/articles/journal_contribution/Quaternary_Charge-Transfer_Complex_Enables_Photoenzymatic_Intermolecular_Hydroalkylation_of_Olefins/13491296

الاتاحة: https://doi.org/10.1021/jacs.0c11462.s001

المؤلفون: Georg E. Winter, Klemens Hoegenauer, Karl Heinz Krawinkler, Tobias Ritter, Vicky Steadman, Wolfgang Jahnke, Lawrence G. Hamann, Alessio Ciulli, Scott D. Williams, Amit S. Kalgutkar, Thomas Magauer, Antonia F. Stepan

المصدر: ChemMedChem. 16:2417-2423

مصطلحات موضوعية: Pharmacology, 010404 medicinal & biomolecular chemistry, History, 010405 organic chemistry, Organic Chemistry, Drug Discovery, Molecular Medicine, Library science, General Pharmacology, Toxicology and Pharmaceutics, 01 natural sciences, Biochemistry, 0104 chemical sciences

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4e478fc57346eb3701565d11a2aef0c1
https://doi.org/10.1002/cmdc.202100372

المؤلفون: Youngah Shin, Moo Je Sung, Monish Jain, Jake Axford, Natalie Dales, Ina Dix, Brian Hurley, Lawrence G. Hamann, Karin Briner, Atwood K. Cheung, John I. Manchester, Donovan N. Chin, Rajeev Sivasankaran

المصدر: Journal of Medicinal Chemistry. 64:4744-4761

مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Hydrogen bond, Stereochemistry, Aryl, SMN1, 01 natural sciences, nervous system diseases, 0104 chemical sciences, Pyridazine, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, RNA splicing, Molecular Medicine, Non-covalent interactions, Amine gas treating, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4cb500bf78e4fb0857bfdd9a64443fed
https://doi.org/10.1021/acs.jmedchem.0c02173

المؤلفون: Mary E Matyskiela, Thomas Clayton, Philip P Chamberlain, Aaron Carpenter, Mark Rolfe, Barbra Pagarigan, Joseph J. McDonald, Gang Lu, Eileen Tran, Christopher Mayne, Lawrence G Hamann, Xinde Zheng

المصدر: Nature Structural & Molecular Biology. 27:319-322

مصطلحات موضوعية: Zinc finger, 0303 health sciences, biology, Chemistry, Cereblon, Rational design, Pomalidomide, eye diseases, Cell biology, Ubiquitin ligase, Thalidomide, 03 medical and health sciences, DDB1, 0302 clinical medicine, Structural Biology, medicine, biology.protein, Molecular Biology, Transcription factor, 030217 neurology & neurosurgery, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7210984ec5e6072f87bb4c0493f947fc
https://doi.org/10.1038/s41594-020-0405-9

المؤلفون: Courtney G. Havens, Correa Matthew D, Rama K. Narla, Frans Baculi, Kercher Timothy S, Thomas O. Daniel, Roy L. Harris, Brian E. Cathers, Matt Alexander, Mehran F. Moghaddam, Grant Virginia Heather Sharron, Veronique Plantevin, James Carmichael, Katalin Ebinger, Antonia Lopez-Girona, Gody Khambatta, Derek Mendy, Lawrence G Hamann, Joshua Hansen, Katerina Leftheris, Brandon Wade Whitefield, Joseph Piccotti, Nagy Mark A, Rupert Vessey, Yang Tang, Laurie LeBrun, Jim Leisten, Dehua Huang

المصدر: Journal of Medicinal Chemistry. 63:6648-6676

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Ubiquitin-Protein Ligases, Antineoplastic Agents, Protein degradation, 01 natural sciences, Inhibitory Concentration 50, Mice, 03 medical and health sciences, Refractory, Recurrence, Cell Line, Tumor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Treatment Failure, Multiple myeloma, Adaptor Proteins, Signal Transducing, Cell Proliferation, 030304 developmental biology, Lenalidomide, 0303 health sciences, biology, Chemistry, Cereblon, Stereoisomerism, Pomalidomide, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Ubiquitin ligase, 010404 medicinal & biomolecular chemistry, Proteasome, biology.protein, Molecular Medicine, Female, Multiple Myeloma, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7c02cb54b83623d7f5d29645738bcd
https://doi.org/10.1021/acs.jmedchem.9b01928

المؤلفون: Jean B. Regard, Tyler J. Harrison, Jake Axford, Laura Axford, Lac Lee, Xianglin Ren, Lin Deng, Aimee Reynolds, Justin Mao, Qian Liu, Anup Patnaik, Evan Cohick, Micah Hollis-Symynkywicz, Sally Loi, Simone Riek, Una McKeever, David Dunstan, MooJe Sung, Nathaniel F. Ware, Alan P. Brown, Lawrence G. Hamann, Jovita Marcinkeviciene, Andrew W. Patterson, Martin L. Marro

المصدر: Biochemical Pharmacology. 209:115418

مصطلحات موضوعية: Pharmacology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca359f22e4e005b5d162fd46603ee41
https://doi.org/10.1016/j.bcp.2023.115418

المؤلفون: Jean B. Regard, Tyler J. Harrison, Jake Axford, Laura Axford, Lac Lee, Xianglin Ren, Lin Deng, Aimee Reynolds, Justin Mao, Qian Liu, Anup Patnaik, Evan Cohick, Micah Hollis-Symynkywicz, Sally Loi, Simone Riek, David Dunstan, MooJe Sung, Nathaniel F. Ware, Lawrence G. Hamann, Jovita Marcinkeviciene, Andrew W. Patterson, Martin L. Marro

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e1104177874617840d976f7da34edc3f
https://doi.org/10.2139/ssrn.4198908

المؤلفون: Lawrence G Hamann, Philip P Chamberlain

المصدر: Nature Chemical Biology. 15:937-944

مصطلحات موضوعية: Proteasome Endopeptidase Complex, 0303 health sciences, Binding Sites, biology, Computer science, Ubiquitin-Protein Ligases, Cereblon, 030302 biochemistry & molecular biology, Cell Biology, Computational biology, Plasma protein binding, Protein degradation, Small molecule, Ubiquitin ligase, Small Molecule Libraries, 03 medical and health sciences, Ubiquitin, Proteolysis, biology.protein, Humans, Molecular Biology, Function (biology), Repurposing, Protein Binding, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3393a81a2f4bcc08fe46e5fdb8e8db
https://doi.org/10.1038/s41589-019-0362-y

المؤلفون: Jake, Axford, Moo Je, Sung, John, Manchester, Donovan, Chin, Monish, Jain, Youngah, Shin, Ina, Dix, Lawrence G, Hamann, Atwood K, Cheung, Rajeev, Sivasankaran, Karin, Briner, Natalie A, Dales, Brian, Hurley

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: Male, Motor Neurons, RNA Splicing, Molecular Conformation, Survival of Motor Neuron 1 Protein, Rats, Muscular Atrophy, Spinal, Oxygen, Pyridazines, Rats, Sprague-Dawley, Survival of Motor Neuron 2 Protein, Mice, Structure-Activity Relationship, Halogens, Drug Design, Thiadiazoles, Animals, Humans, Sulfur, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::13330dc0c7e19f69d4bd3cf1bf193353
https://pubmed.ncbi.nlm.nih.gov/33822618

المؤلفون: Philip R. D. Murray, Geraint Davies, J. Michael Ellis, Farid W. van der Mei, Willem M. M. Bussink, Alyssa H. Antropow, Laura Akullian D’Agostino, Fedor Romanov-Michailidis, Jacob T. Edwards, Robert R. Knowles, Lawrence G. Hamann

المصدر: Journal of the American Chemical Society. 143(10)

مصطلحات موضوعية: Cyclobutanes, Heptane, Chemistry, Energy transfer, Intermolecular force, General Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, Cycloaddition, 0104 chemical sciences, chemistry.chemical_compound, Colloid and Surface Chemistry, Computational chemistry, Photosensitizer, Epimer, Visible spectrum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baabfab15f34d6ff58bf2ada9fb3002
https://pubmed.ncbi.nlm.nih.gov/33666086

المؤلفون: Shivsmriti Koul, John Malona, Lisa Beebe, Laure Escoubet, Meghan Clements, Arvind Shakya, Veerabahu Shanmugasundaram, Lan Jiang, Lawrence G. Hamann, Matt M. Kreilein, Jenna Malley, C. Eric Schwartz, Roman Shimanovich, Ganesh Rajaraman, Alex Dubrovskiy, Laura Akullian D’Agostino, Justin Stedman, Andrea Local, J. Michael Ellis, Tiffany Carr, Steven A. Saenz, Haiqing Hu, John Cho, Lisa Chourb

المصدر: PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE, Vol 16, Iss 11, p e0248034 (2021)
PLoS ONE

مصطلحات موضوعية: Carcinogenesis, Physiology, Cell, Cancer Treatment, Retinoic acid, Gene Expression, Mice, chemistry.chemical_compound, RAR-related orphan receptor gamma, Immune Physiology, Medicine and Health Sciences, Organ Cultures, Immune Response, Innate Immune System, Multidisciplinary, Interleukin-17, Nuclear Receptor Subfamily 1, Group F, Member 1, Animal Models, Organoids, medicine.anatomical_structure, Oncology, Experimental Organism Systems, Cytokines, Medicine, Biological Cultures, Anatomy, medicine.symptom, Signal Transduction, Research Article, Science, Immunology, Allosteric regulation, Mouse Models, Inflammation, Research and Analysis Methods, Pancreatic Cancer, Model Organisms, Signs and Symptoms, Immune system, In vivo, Gastrointestinal Tumors, Genetics, medicine, Animals, Transcription factor, Biology and Life Sciences, Cancers and Neoplasms, Molecular Development, Nuclear receptor, chemistry, Ears, Immune System, Animal Studies, Cancer research, Th17 Cells, Clinical Medicine, Head, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fdb7715b2c933851e25206e28f0210
https://doi.org/10.1101/2021.02.19.431952

المؤلفون: Kyle F. Biegasiewicz, Claire G. Page, Lawrence G. Hamann, Kevin M. Oberg, Gregory D. Scholes, Evan J. Horn, Simon J. Cooper, Daniel G. Oblinsky, Alyssa H. Antropow, Jacob S. Dehovitz, J. Michael Ellis, Todd K. Hyster, Kurt W. Armbrust

المصدر: Journal of the American Chemical Society, vol 143, iss 1
J Am Chem Soc

مصطلحات موضوعية: Alkylation, Light, Dinitrocresols, Chemical, Flavin group, Alkenes, 010402 general chemistry, Photochemistry, 01 natural sciences, Biochemistry, Catalysis, Article, Electron transfer, Colloid and Surface Chemistry, Models, Catalytic Domain, Ene reaction, chemistry.chemical_classification, biology, Flavoproteins, Chemistry, Alkene, Intermolecular force, Active site, General Chemistry, Charge-transfer complex, Amides, 0104 chemical sciences, Models, Chemical, Biocatalysis, Chemical Sciences, biology.protein, Oxidoreductases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453e3684efab0c71e9d3671a592869b
https://escholarship.org/uc/item/4j59h787

المؤلفون: Claire Page, Simon Cooper, Jacob DeHovitz, Daniel G. Oblinsky, Kyle Biegasiewicz, Alyssa Antropow, Kurt Armbrust, Michael Ellis, Lawrence G. Hamann, Evan Horn, Kevin Oberg, Gregory Scholes, Todd Hyster

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167073089719a35eec3ae69927cfb172
https://doi.org/10.26434/chemrxiv.13173596.v1

المؤلفون: Lawrence G Hamann, J. Michael Ellis, Fedor Romanov-Michailidis, Noah B. Bissonnette

المصدر: Chemical Science

مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Radical, chemistry.chemical_element, General Chemistry, Alkylation, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Aldehyde, Nitrogen, 0104 chemical sciences, LITHIUM PHOSPHATE, Photocatalysis, Molecule, Iridium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd588e77e0364242bfd11f27f893a1a
https://doi.org/10.1039/c9sc03429c

المؤلفون: Natalie Dales, Monish Jain, Sanchez Carina Cristina, Ryan Kerrigan, Atwood K. Cheung, Cary Fridrich, Donovan N. Chin, Brian Hurley, Keith Hoffmaster, Lin Deng, Ronald Tomlinson, Marc Hild, Rajeev Sivasankaran, Jake Axford, Aleem Fazal, Gary O’Brien, Christopher Towler, Mailin Van Hoosear, Youngah Shin, Dione Kobayashi, Shen Yiping, Lei Shu, William F. Dietrich, Karen S. Chen, Lawrence G. Hamann, Karin Briner, Rebecca Servais, Cheng Song, Emma Cody, Robert Sun, Daniel Curtis, Moo Je Sung, Ying Hou

المصدر: Journal of Medicinal Chemistry. 61:11021-11036

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Spliceosome, RNA Splicing, Phenotypic screening, Drug Evaluation, Preclinical, Administration, Oral, Quantitative Structure-Activity Relationship, SMN1, Crystallography, X-Ray, Cell Line, Muscular Atrophy, Spinal, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Gene, Motor Neurons, Dose-Response Relationship, Drug, Chemistry, Brain, Spinal muscular atrophy, Motor neuron, medicine.disease, SMA, Survival of Motor Neuron 1 Protein, nervous system diseases, Mice, Inbred C57BL, Pyridazines, Survival of Motor Neuron 2 Protein, 030104 developmental biology, medicine.anatomical_structure, RNA splicing, Molecular Medicine, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a86b835f8a7bec6e7356af0b03dae4
https://doi.org/10.1021/acs.jmedchem.8b01291

المؤلفون: Mariko Riley, Katie Stamp, Xinde Zheng, Yan Ren, Kate Blease, Chin-Chun Lu, Julia Hui, Lawrence G Hamann, Philip P Chamberlain, Gang Lu, Polat Abdubek, Mary E Matyskiela, Gondi Kumar, Maria Wang, Wei Fang, Aaron Carpenter, Thomas Clayton, Clifton Drew, Suzana Couto, Chung-Wein Lee, Mark Rolfe, Rupert Vessey, James Hartke

المصدر: Nature Chemical Biology. 14:981-987

مصطلحات موضوعية: Male, 0301 basic medicine, Ubiquitin-Protein Ligases, Transgene, Induced Pluripotent Stem Cells, Mice, Transgenic, Nerve Tissue Proteins, Phocomelia, Protein degradation, Ligands, medicine.disease_cause, 01 natural sciences, Mice, 03 medical and health sciences, SALL4, Testis, Animals, Humans, Medicine, Molecular Biology, Adaptor Proteins, Signal Transducing, Zinc finger, Mutation, 010405 organic chemistry, business.industry, Cereblon, Homozygote, Zinc Fingers, Cell Biology, medicine.disease, Immunohistochemistry, eye diseases, Thalidomide, 0104 chemical sciences, DNA-Binding Proteins, Teratogens, 030104 developmental biology, Gene Expression Regulation, Proteolysis, Cancer research, Rabbits, business, Peptide Hydrolases, Transcription Factors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f5299ace6c6c8aa0af7dbee0692fbc
https://doi.org/10.1038/s41589-018-0129-x