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المؤلفون: Richard Marais, Grazia Saturno, Robert McLeary, Cyril Fisher, Udai Banerji, Alfonso Zambon, Lawrence Davies, Rebecca Lee, J.M.G. Larkin, Natasha Preece, Emma Dean, Paul Lorigan, Dan Niculescu-Duvaz, Matthew G Krebs, Amaya Viros, Nathalie Dhomen, Malin Pedersen, L. Johnson, Filipa Lopes, Caroline J. Springer, D. Holovanchuk, M. E. Gore, Ion Niculescu-Duvaz
المصدر: Annals of Oncology
Saturno, G, Lopes, F, Niculescu-Duvaz, I, Niculescu-Duvaz, D, Zambon, A, Davies, L, Johnson, L, Preece, N, Lee, R, Viros Usandizaga, A, Holovanchuk, D, Pedersen, M, Mcleary, R, Lorigan, P, Dhomen, N, Fisher, C, Banerji, U, Dean, E, Krebs, M, Gore, M, Larkin, J, Marais, R & Springer, C 2021, ' The paradox-breaking panRAF plus SRC family kinase inhibitor, CCT3833, is effective in mutant KRAS-driven cancers ', Annals of Oncology, vol. 32, no. 2, pp. 269-278 . https://doi.org/10.1016/j.annonc.2020.10.483مصطلحات موضوعية: 0301 basic medicine, Drug, Lung Neoplasms, media_common.quotation_subject, Phases of clinical research, medicine.disease_cause, NSCLC, CRC, KRAS, panRAF/SRC inhibitor, PDAC, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Mice, 0302 clinical medicine, Pancreatic tumor, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Medicine, Animals, Humans, Src family kinase, Protein Kinase Inhibitors, media_common, Cell Proliferation, business.industry, Kinase, Hematology, medicine.disease, digestive system diseases, 030104 developmental biology, src-Family Kinases, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, Original Article, Spindle cell sarcoma, business, Proto-oncogene tyrosine-protein kinase Src
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المؤلفون: Lawrence Davies, Alfonso Zambon, Michael Brown, Leo Leung, Caroline J. Springer, Miller Natalie, Mohammed Aljarah, Deborah A. Smithen, Gabor Nemeth, Dan Niculescu-Duvaz, Hannah Asiki
المصدر: Organic Process Research & Development
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Chemistry, Continuous flow, Communication, continuous-flow, Organic Chemistry, oxaziridine, Schmidt, 010402 general chemistry, microreactor, 01 natural sciences, Oxaziridine, 0104 chemical sciences, Safety profile, chemistry.chemical_compound, Computational chemistry, SCALE-UP, homopiperazine, Physical and Theoretical Chemistry, Microreactor, photochemical
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المؤلفون: Lawrence Davies
المصدر: Jazz Research Journal. 13:110-129
مصطلحات موضوعية: History, Rhythm, British jazz, Narrative, Musical, Club, Consumption (sociology), Jazz, Music, Critical vocabulary, Visual arts
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4eBook
المؤلفون: Lawrence Davies
Resource Type: eBook.
الموضوعات: Boxing--Wales--History, Boxers (Sports)--Wales
Categories: SPORTS & RECREATION / Boxing
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المؤلفون: Lawrence Davies
المصدر: Journal of World Popular Music. 3:126-131
مصطلحات موضوعية: History, common, common.demographic_type, Media studies, British jazz, Art history, Transnationalism, Performance art, Blues, Colonialism, Jazz, Black British, Music
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المؤلفون: Lawrence Davies
مصطلحات موضوعية: 1030269:Music:topical, 982165:Jazz:topical, 982179:Jazz--Instruction and study:topical, 1154884:Transnationalism:topical, 958221:Historiography:topical, 1245064:Europe:geographic, 958235:History:topical
Relation: http://dx.doi.org/10.17613/zkem-dq21
الاتاحة: https://doi.org/10.17613/zkem-dq21
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المؤلفون: Grazia Saturno, Laura Fish, Filipa Lopes, Margaret C. Frame, Alberto Fusi, Paul Lorigan, Bart M. J. M. Suijkerbuijk, John Brognard, Alfonso Zambon, L. Johnson, Delphine Menard, Robert McLeary, Richard Marais, Anna A. Marusiak, Juliane Hohloch, Dan Niculescu-Duvaz, Malin Pedersen, Lawrence Davies, Berta Sanchez-Laorden, Amaya Viros, Natasha Preece, Neil O. Carragher, Caroline J. Springer, Kenneth G. MacLeod, Steven R. Whittaker, Maria Romina Girotti, Sarah Ejiama, Garry Ashton
المصدر: Cancer Cell
Girotti, M R, Lopes, F, Preece, N, Niculescu-Duvaz, D, Zambon, A, Davies, L, Whittaker, S, Saturno, G, Viros, A, Pedersen, M, Suijkerbuijk, B M J M, Menard, D, McLeary, R, Johnson, L, Fish, L, Ejiama, S, Sanchez-Laorden, B, Hohloch, J, Carragher, N, Macleod, K, Ashton, G, Marusiak, A A, Fusi, A, Brognard, J, Frame, M, Lorigan, P, Marais, R & Springer, C 2015, ' Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma ', Cancer Cell, vol. 27, no. 1, pp. 85-96 . https://doi.org/10.1016/j.ccell.2014.11.006
Girotti, MR, Lopes, F, Preece, N, Niculescu-Duvaz, D, Zambon, A, Davies, L, Whittaker, S, Saturno, G, Viros, A, Pedersen, M, Suijkerbuijk, BM J M, Menard, D, McLeary, R, Johnson, L, Fish, L, Ejiama, S, Sanchez-Laorden, B, Hohloch, J, Carragher, N, Macleod, K, Ashton, G, Marusiak, AA, Fusi, A, Brognard, J, Frame, M, Lorigan, P, Marais, R & Springer, C 2015, ' Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma. ', Cancer Cell, vol. 27, no. 1, pp. 85-96 . https://doi.org/10.1016/j.ccell.2014.11.006, https://doi.org/10.1016/j.ccell.2014.11.006مصطلحات موضوعية: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, MAPK/ERK pathway, Cancer Research, endocrine system diseases, HOMOLOG B1 BRAF, Cell, Mutant, Nude, POTENT INHIBITORS, Drug Resistance, Melanoma, Experimental, Drug resistance, VEMURAFENIB, Receptor tyrosine kinase, Proto-Oncogene Proteins B-raf, PATHWAY, Mice, 0302 clinical medicine, METASTATIC MELANOMA, Vemurafenib, Melanoma, 0303 health sciences, Tumor, Manchester Cancer Research Centre, Kinase, 3. Good health, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, src-Family Kinases, Oncology, 030220 oncology & carcinogenesis, Pyrazines, Female, medicine.drug, Proto-oncogene tyrosine-protein kinase Src, Mice, Nude, Antineoplastic Agents, Biology, Article, Cell Line, 03 medical and health sciences, Experimental, Cell Line, Tumor, medicine, Animals, Humans, MEK INHIBITION, OPTIMIZATION, Protein Kinase Inhibitors, neoplasms, 030304 developmental biology, Neoplastic, MUTATIONS, ResearchInstitutes_Networks_Beacons/mcrc, Phenylurea Compounds, KINASE INHIBITORS, Drug Resistance, Neoplasm, Xenograft Model Antitumor Assays, Cell Biology, Melanoma cancer, medicine.disease, digestive system diseases, 030104 developmental biology, Gene Expression Regulation, biology.protein, Cancer research, Neoplasm, ACQUIRED-RESISTANCE
وصف الملف: application/pdf
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المؤلفون: Lawrence Davies
المصدر: Notes. 72:517-519
مصطلحات موضوعية: History, White (horse), media_common.quotation_subject, Art history, Blues, Musical, Library and Information Sciences, Legend, Genealogy, Ballad, Popular music, White supremacy, Country, Music, media_common
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المؤلفون: Lawrence Davies
المصدر: Studies in Theatre and Performance. 35:262-264
مصطلحات موضوعية: Visual Arts and Performing Arts, Aesthetics, media_common.quotation_subject, Framing (construction), Art, Blues, Tourism, media_common
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المؤلفون: Lawrence Davies
المصدر: Notes. 72:376-378
مصطلحات موضوعية: White (horse), History, media_common.quotation_subject, Art history, Espionage, Library and Information Sciences, Populism, Politics, Patriotism, Criticism, Theology, Music, Folk music, Period (music), media_common
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المؤلفون: Ion Niculescu-Duvaz, Alfonso Zambon, Natasha Preece, Delphine Menard, Lawrence Davies, Steven R. Whittaker, Lesley Ogilvie, Arnaud Nourry, Dan Niculescu-Duvaz, Bart M. J. M. Suijkerbuijk, Richard Marais, Filipa Lopes, Caroline J. Springer, Ruth Kirk, Helen A. Manne, Douglas Hedley
المصدر: Journal of Medicinal Chemistry. 53:5639-5655
مصطلحات موضوعية: Models, Molecular, Oral, Niacinamide, Proto-Oncogene Proteins B-raf, Pyridines, Transplantation, Heterologous, Administration, Oral, Biological Availability, Antineoplastic Agents, Plasma protein binding, Crystallography, X-Ray, Serine, Mice, Structure-Activity Relationship, Models, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Threonine, Inbred BALB C, Mice, Inbred BALB C, Transplantation, Heterologous, Crystallography, Kinase, Chemistry, Phenylurea Compounds, Drug Discovery3003 Pharmaceutical Science, Benzenesulfonates, Imidazoles, Molecular, Hydrogen Bonding, Sorafenib, Biochemistry, Pyrazines, Administration, X-Ray, Molecular Medicine, Female, Neoplasm Transplantation, Protein Binding
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المؤلفون: Laura Mancini, Andrzej S. K. Dzik-Jurasz, Geoffrey S. Payne, Martin O. Leach, Lawrence Davies, Frank Friedlos, Caroline J. Springer, Maria Falck-Miniotis
المصدر: NMR in Biomedicine. 22:561-566
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Buffers, Gene delivery, In vivo, Cell Line, Tumor, Carboxypeptidase-G2, Humans, Prodrugs, Radiology, Nuclear Medicine and imaging, Bovine serum albumin, Spectroscopy, chemistry.chemical_classification, biology, Genes, Transgenic, Suicide, Fluorine, Genetic Therapy, gamma-Glutamyl Hydrolase, Prodrug, Suicide gene, Solutions, Kinetics, Enzyme, chemistry, Biochemistry, biology.protein, Molecular Medicine, Gamma-glutamyl hydrolase
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المؤلفون: Florence I. Raynaud, Ion Niculescu-Duvaz, Catherine Gaulon, Douglas Hedley, Bart M. J. M. Suijkerbuijk, Caroline J. Springer, Ruth Kirk, Arnaud Nourry, Frank Friedlos, Javier Moreno-Farre, Richard Marais, Lesley Ogilvie, Dan Niculescu-Duvaz, Alfonso Zambon, Delphine Menard, Harmen P. Dijkstra, Adrian Liam Gill, Helen A. Manne, Richard D. Taylor, Lawrence Davies, Steven R. Whittaker
المصدر: Journal of Medicinal Chemistry. 52:2255-2264
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, endocrine system diseases, Pyridines, Transplantation, Heterologous, Mutant, Melanoma, Experimental, Viral Oncogene, Mice, Nude, Antineoplastic Agents, In Vitro Techniques, Serine, Mice, Structure-Activity Relationship, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Animals, Drug Screening Assays, Antitumor, Female, Humans, Imidazoles, Microsomes, Liver, Mutation, Neoplasm Transplantation, Molecular Medicine, Drug Discovery3003 Pharmaceutical Science, Potency, Threonine, neoplasms, Chemistry, Kinase, Methylation, digestive system diseases, Biochemistry, Cancer research
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المؤلفون: Luke Chisolm, Zohra Ali, Lawrence Davies, Caroline Dive, Ion Niculescu-Duvaz, Caroline J. Springer, James Larkin, Brent O’Carrigan, Natalie Dhomen, Filipa Lopes, Louise Carter, Martin Gore, Emma Dean, Dan Niculescu-Duvaz, Paul Lorigan, Romina Girotti, Sally Ellis, Udai Banerji, Heidi Lane, Richard Marais
المصدر: Dean, E, Banerji, U, Girotti, R, Niculescu-Duvaz, I, Lopes, F, Davies, L, Niculescu-Duvaz, D, Dhomen, N, Ellis, S, Ali, Z, O'Carrigan, B, Carter, L, Chisolm, L, Dive, C, Lane, HA, Lorigan, P, Gore, ME, Larkin, J, Marais, R & Springer, C 2016, A Phase 1 first-in-human trial to evaluate the safety and tolerability of CCT3833, an oral panRAF inhibitor, in patients with advanced solid tumours, including metastatic melanoma. in Journal of Clinical Oncology . suppl; abstr TPS9597 edn, vol. 34 . < http://meetinglibrary.asco.org/content/168123-176 >
University of Manchester-PUREمصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Metastatic melanoma, business.industry, Melanoma, First in human, medicine.disease, 03 medical and health sciences, 030104 developmental biology, Tolerability, Internal medicine, medicine, In patient, business, neoplasms
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057282b741c26db40ba83e5f37dd8a1c
https://www.research.manchester.ac.uk/portal/en/publications/a-phase-1-firstinhuman-trial-to-evaluate-the-safety-and-tolerability-of-cct3833-an-oral-panraf-inhibitor-in-patients-with-advanced-solid-tumours-including-metastatic-melanoma(1d7642ef-34e1-4438-a1af-acbdcf3d4653).html -
15Novel Inhibitors of B-RAF Based on a Disubstituted Pyrazine Scaffold. Generation of a Nanomolar Lead
المؤلفون: Esteban Roman, Richard Marais, Ion Niculescu-Duvaz, Frank Friedlos, Ian Scanlon, Dan Niculescu-Duvaz, Steven R. Whittaker, Caroline J. Springer, Ruth Kirk, Lawrence Davies
المصدر: Journal of Medicinal Chemistry. 49:407-416
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyrazine, medicine.drug_class, Stereochemistry, Carboxamide, Chemical synthesis, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Humans, Moiety, Threonine, Protein kinase A, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Enzyme inhibitor, Pyrazines, biology.protein, Molecular Medicine, Acetanilides, Drug Screening Assays, Antitumor
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المؤلفون: Frank Friedlos, Lesley Ogilvie, Douglas Hedley, Caroline J. Springer, Jan Martin, Lawrence Davies, Ian Scanlon
المصدر: Journal of Medicinal Chemistry. 48:5321-5328
مصطلحات موضوعية: Mustard Compounds, Stereochemistry, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Glutamate carboxypeptidase, In vivo, Cell Line, Tumor, Drug Discovery, Carboxypeptidase-G2, Animals, Humans, Prodrugs, Cytotoxicity, Benzoic acid, chemistry.chemical_classification, Fluorine, gamma-Glutamyl Hydrolase, Prodrug, In vitro, Enzyme, chemistry, Biochemistry, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation
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المؤلفون: Richard Marais, Janet L. Martin, Lawrence Davies, Frank Friedlos, Robert A. Spooner, Stephen M. Stribbling, Caroline J. Springer
المصدر: Human Gene Therapy. 11:285-292
مصطلحات موضوعية: Time Factors, Genetic enhancement, Mice, Nude, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Biology, Mice, Glutamate carboxypeptidase, Glutamates, Carboxypeptidase-G2, Genetics, Carcinoma, medicine, Bystander effect, Animals, Humans, Prodrugs, Molecular Biology, Mice, Inbred BALB C, Body Weight, Genetic Therapy, gamma-Glutamyl Hydrolase, Prodrug, Suicide gene, medicine.disease, Nitrogen Mustard Compounds, Immunology, Cancer research, Molecular Medicine, Female, Breast carcinoma, Neoplasm Transplantation
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المؤلفون: Richard Marais, Caroline J. Springer, Dan Niculescu-Duvaz, Janet Martin, Robert A. Spooner, Frank Friedlos, Lawrence Davies, Ion Niculescu-Duvaz
المصدر: Journal of Medicinal Chemistry. 41:5297-5309
مصطلحات موضوعية: Stereochemistry, Transfection, Chemical synthesis, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Aniline, Drug Discovery, Carboxypeptidase-G2, Tumor Cells, Cultured, Animals, Phenol, Prodrugs, Mechlorethamine, Bifunctional, Antineoplastic Agents, Alkylating, Fluoroethyl, biology, Genetic Therapy, gamma-Glutamyl Hydrolase, Prodrug, chemistry, Mutation, Carboxypeptidase A, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Colorectal Neoplasms
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المؤلفون: Robert McLeary, Bart M. J. M. Suijkerbuijk, John Brognard, Paul Lorigan, Steven R. Whittaker, Natasha Preece, Dan Niculescu-Duvaz, Margaret C. Frame, Grazia Saturno, Alfonso Zambon, Laura Fish, Delphine Menard, Anna A. Marusiak, Filipa Lopes, Amaya Viros, Kenneth G. MacLeod, Maria Romina Girotti, Sarah Ejiama, Alberto Fusi, Neil O. Carragher, Richard Marais, Lawrence Davies, Malin Pedersen, Garry Ashton, Berta Sanchez-Laorden, Caroline J. Springer, L. Johnson
مصطلحات موضوعية: MAPK/ERK pathway, Neuroblastoma RAS viral oncogene homolog, Gerontology, Cancer Research, Mutation, business.industry, MEK inhibitor, Melanoma, Mutant, Cancer, medicine.disease, medicine.disease_cause, Oncology, Cancer research, medicine, Protein kinase A, business, neoplasms
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المؤلفون: Alfonso Zambon, Delphine Menard, Richard Marais, Bart M. J. M. Suijkerbuijk, Ion Niculescu-Duvaz, Lawrence Davies, Jean-François Pons, Caroline J. Springer, Dan Niculescu-Duvaz, Steven R. Whittaker
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Triarylimidazole, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Naphthols, Thiophenes, Biochemistry, BRAF, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Imidazole, Humans, Anticancer, Kinase inhibitors, Melanoma, Benzofurans, Imidazoles, Protein Kinase Inhibitors, 3003, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Molecular Medicine, Molecular Biology, neoplasms, Tumor, Chemistry, Kinase, Benzothiophene, medicine.disease, Molecular medicine, Cell culture, Cancer research