المؤلفون: Alexander Vugler, James O’connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicolas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian

المصدر: Frontiers in Pharmacology, Vol 15 (2024)

مصطلحات موضوعية: TNF, rheumatoid arthritis, small molecule, TNF trimer, immunogenicity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1479557/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/7c28a2cfd57b43f5bbbad3d413464f30

المؤلفون: Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: TNF, rheumatoid arthritis, small molecule, TNF trimer, immunogenicity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1037983/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/1ee03f08f53b498dba01c240aad2ca37

المؤلفون: Elias Abedelnour, Stephanie Ognier, Olivier Venier, Laurent Schio, Michael Tatoulian, Janine Cossy

المصدر: Chemical Communications. 59:4213-4216

مصطلحات موضوعية: Materials Chemistry, Metals and Alloys, Ceramics and Composites, General Chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::675d6327071d1554adf3c5d0c4fd93dd
https://doi.org/10.1039/d3cc00942d

المؤلفون: Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b86af78b2f4b0ea0bc017ba86b84056
https://doi.org/10.1158/1535-7163.c.6542763

المؤلفون: Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10eddd92e318753beaf14063960214f
https://doi.org/10.1158/1535-7163.22520766

المؤلفون: Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3813137435b6e50ede54df16b76c6dfc
https://doi.org/10.1158/1535-7163.22520769.v1

المؤلفون: Elias Abedelnour, Stephanie Ognier, Mengxue Zhang, Laurent Schio, Olivier Venier, Janine Cossy, Michael Tatoulian

المصدر: Chemical Communications. 58:7281-7284

مصطلحات موضوعية: Materials Chemistry, Metals and Alloys, Ceramics and Composites, General Chemistry, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2191fb6122d7523dabe7f2dd831cf8e2
https://doi.org/10.1039/d2cc01940j

المؤلفون: Youssef El-Ahmad, Veronique Croq, Christian Wehrey, Maysoun Shomali, Laurent Schio

المصدر: ACS Symposium Series ISBN: 9780841297333

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9d926dc0916fc9b48c711bcdc18b28b0
https://doi.org/10.1021/bk-2022-1423.ch007

المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud

المصدر: Journal of Medicinal Chemistry. 63:512-528

مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
https://doi.org/10.1021/acs.jmedchem.9b01293

المؤلفون: Youssef El-Ahmad, Hong Cheng, Fabienne Thompson, Monsif Bouaboula, Jack Pollard, Gary Mccort, Andrew Hebert, Carlos Garcia-Echeverria, Michel Tabart, Fangxian Sun, Laurent Schio, Joon Sang Lee, Dinesh S. Bangari, Jane Cheng, Laurent Besret, Hui Cao, Dietmar Hoffmann, Maysoun Shomali, Rosalia Arrebola, Zhuyan Guo, Anne Caron, Laurent Debussche, Frank Halley, Bruno Filoche-Romme, Albane Courjaud, Mikhail Levit, Malvika Koundinya, Jessica McManus, Victor Certal, Pierre-Yves Abecassis

المصدر: Molecular cancer therapeutics. 20(2)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, medicine.drug_class, Estrogen receptor, Breast Neoplasms, 03 medical and health sciences, Mice, 0302 clinical medicine, Breast cancer, In vivo, medicine, Animals, Humans, Receptor, Fulvestrant, business.industry, Wild type, medicine.disease, Disease Models, Animal, 030104 developmental biology, Oncology, Receptors, Estrogen, Estrogen, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Female, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a793f8b26300e48375f0775740c17d0
https://pubmed.ncbi.nlm.nih.gov/33310762

المؤلفون: Jaan A. Pesti, Ahmed F. Abdel-Magid, Rajappa Vaidyanathan, Matthew Maddess, John McIntosh, Wonsuk Chang, Trung Cao, Natalia Dyatkina, Sébastien Lemaire, Marija Prhavc, Simon Wagschal, Jun Liang, Jie Xu, Scott H. Watterson, Steven R. Wisniewski, Seb Caille, Brian S. Lucas, T. G. Murali Dhar, William P. Gallagher, John R. Coombs, F. González-Bobes, Youssef El-Ahmad, Veronique Croq, Christian Wehrey, Maysoun Shomali, Laurent Schio, Christian Moessner, Fabienne Hoffmann-Emery, Jean-Michel Adam, Serena Fantasia, Daniel Fishlock, Roland Meier, Georg Wuitschik, Hasane Ratni, John Studley

Resource Type: eBook.

Categories: SCIENCE / Chemistry / Organic, SCIENCE / Chemistry / Industrial & Technical

المؤلفون: Céline Prévost, Eric Brohan, Odile Angouillant-Boniface, G.Andrees Böhme, Sylvie Houtmann, Céline Chantoiseau, Thierry Carriot, Veronique Ballet, Sophie Fouconnier, Laurent Schio, Michel Partiseti, Rachid Boukaiba, Jean-Marie Chambard, Brigitte Schombert

المصدر: European Journal of Pharmacology. 915:174670

مصطلحات موضوعية: Patch-Clamp Techniques, Purkinje fibers, hERG, Action Potentials, Pharmacology, Ion Channels, Membrane Potentials, Afterdepolarization, Purkinje Fibers, Antimalarials, Electrocardiography, medicine, Animals, Humans, Ion channel, biology, Chemistry, Arrhythmias, Cardiac, Heart, Stereoisomerism, Cardiac action potential, Resting potential, Ether-A-Go-Go Potassium Channels, Potassium channel, Electrophysiology, medicine.anatomical_structure, biology.protein, Rabbits, Electrophysiologic Techniques, Cardiac, Hydroxychloroquine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2889049ef9d687d5261e5fde9ce6f50
https://doi.org/10.1016/j.ejphar.2021.174670

المؤلفون: Jérôme Marrot, Laurent Schio, Patrick Bernardelli, Elsa Anselmi, Cédric Simon, Bruce Pégot, Emmanuel Magnier

المصدر: European Journal of Organic Chemistry. 2017:6319-6326

مصطلحات موضوعية: chemistry.chemical_classification, Solid-state chemistry, 010405 organic chemistry, Organic Chemistry, Halide, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Nucleophile, Reagent, Ionic liquid, Functional group, Nucleophilic substitution, Organic chemistry, Physical and Theoretical Chemistry, Alkyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::759890a95ef12730f41153142dc91900
https://doi.org/10.1002/ejoc.201701222

المؤلفون: Laurent Schio, Hervé Minoux

المصدر: Proteinkinase Inhibitors ISBN: 9783030681791

مصطلحات موضوعية: Lead finding, Clinical trial, Kinase, business.industry, medicine.medical_treatment, Medicine, Context (language use), business, Bioinformatics, Targeted therapy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dbab100de802797a4246f17b8f2168a9
https://doi.org/10.1007/7355_2020_99

المؤلفون: Fangxian Sun, Youssef El-Ahmed, Monsif Bouaboula, Vasiliki Pelekanou, Marina Celanovic, Laurent Debussche, Christina I. Herold, Chris Soria, Joon Sang Lee, Jack Pollard, Patrick Cohen, Maysoun Shomali, Laurent Schio, Laurent Besret, Anne Caron

المصدر: Cancer Research. 81:739-739

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Oncology, business.industry, Internal medicine, medicine, Bioinformatics, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e1ac31d42db3a4bdafe580b1765bf581
https://doi.org/10.1158/1538-7445.am2021-739

المؤلفون: Alexey Rak, Eric Bacqué, Mireille Kenigsberg, Hélène Goulaouic, Cécile Capdevila, Loreley Calvet, Laurent Schio, Jean Khider, Conception Nemecek, Nathalie Martinet, Eva Albert, Dorothée Semiond, Christine Delaisi, Fabrice Bonche, Jacques Houtmann, Antonio Ugolini, Maryse Lowinski, Sandrine Grapinet, François Vallée, Coumaran Egile, Manfred Roesner

المصدر: Journal of Medicinal Chemistry. 59:7066-7074

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Urea, Structure–activity relationship, Benzothiazoles, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, CYP3A4, Kinase, Drug discovery, Cell growth, Chemistry, Cancer, Neoplasms, Experimental, Proto-Oncogene Proteins c-met, medicine.disease, Small molecule, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb960d63d4c0d5f4ac1aabc2f57745aa
https://doi.org/10.1021/acs.jmedchem.6b00280

المؤلفون: Magali Mathieu, Benoît Robert, Jean-Christophe Carry, Andreas Karlsson, Thomas Bertrand, Laurent Schio, Woody Sherman, Daniel D. Robinson, Hervé Minoux, Marc-Antoine Perrin, Frank Halley

المصدر: Journal of Chemical Information and Modeling. 56:886-894

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, General Chemical Engineering, Molecular Dynamics Simulation, Library and Information Sciences, Ligands, 010402 general chemistry, 01 natural sciences, Substrate Specificity, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Molecular dynamics, Transferase, Binding site, Beta (finance), Drug discovery, Chemistry, Water, General Chemistry, Ligand (biochemistry), 0104 chemical sciences, Computer Science Applications, Solvent, Protein Subunits, 030104 developmental biology, Solvents, Thermodynamics, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7062d3dd30a4dff5b85c631a6da61290
https://doi.org/10.1021/acs.jcim.5b00641

المؤلفون: Joon Sang Lee, Youssef El-Ahmad, Fangxian Sun, Mikhail Levit, Laurent Schio, Laurent Debussche, Chris Soria, Patrick Cohen, Jack Pollard, Monsif Bouaboula, Maysoun Shomali

المصدر: Cancer Research. 81:PS17-16

مصطلحات موضوعية: Cancer Research, Fulvestrant, business.industry, medicine.drug_class, Wild type, Cancer, Estrogen receptor, medicine.disease, Breast cancer, Oncology, In vivo, Tumor progression, Estrogen, Cancer research, Medicine, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5e186a43c98094949abb92927c9ade84
https://doi.org/10.1158/1538-7445.sabcs20-ps17-16

المؤلفون: Fangxian Sun, Laurent Schio, Carlos Garcia-Echeverria, Dietmar Hoffmann, Shih Min A Huang, Christoph Lengauer, Bailin Zhang, Vinod F. Patel, Francisco Adrian, Michel Tabart, Hong Cheng, Weidong Zhang, Anlai Wang, Qiang Gao, Zhuyan Guo, Jingxin Zhang, Claude Barberis, Stefan Gross, Josh Murtie, Jennifer Rocnik, Mikhail Levit, Dmitri Wiederschain, Marion Dorsch

المصدر: Blood. 124:1777-1789

مصطلحات موضوعية: Male, Myeloid, Immunology, Antineoplastic Agents, HL-60 Cells, Biology, Biochemistry, Proto-Oncogene Proteins c-myc, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, STAT5 Transcription Factor, medicine, Humans, IL-2 receptor, Oncogene, Gene Expression Regulation, Leukemic, Interleukin-2 Receptor alpha Subunit, Cancer, Myeloid leukemia, Cell Biology, Hematology, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Proteolysis, Cancer cell, Cancer research, Female, Blast Crisis, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fd20272c355acdbc0ebc55c54bddc6
https://doi.org/10.1182/blood-2014-01-551234

المؤلفون: Shih-Min A. Huang, Anlai Wang, Rita Greco, Zhifang Li, Fangxian Sun, Claude Barberis, Michel Tabart, Vinod Patel, Laurent Schio, Raelene Hurley, Bo Chen, Hong Cheng, Christoph Lengauer, Jack Pollard, James Watters, Carlos Garcia-Echeverria, Dmitri Wiederschain, Francisco Adrian, JingXin Zhang

المصدر: Oncotarget. 5:3362-3374

مصطلحات موضوعية: Janus kinase 2, biology, Kinase, Cell growth, food and beverages, Molecular biology, Small hairpin RNA, chemistry.chemical_compound, Myeloproliferative Disorders, Oncology, chemistry, hemic and lymphatic diseases, biology.protein, Cancer research, Growth inhibition, Kinase activity, Transcription factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5ea866e86d0a32dbdc183085b972904b
https://doi.org/10.18632/oncotarget.1951