المؤلفون: Shiri Meron-Sudai, Valeria Asato, Amos Adler, Anya Bialik, Sophy Goren, Ortal Ariel-Cohen, Arava Reizis, Laurence A. Mulard, Armelle Phalipon, Dani Cohen

المصدر: npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2059-0105

URL الوصول: https://doaj.org/article/063fa043e27d4d6bbd83224197fa1938

المؤلفون: Franklin R. Toapanta, Jingping Hu, Shiri Meron-Sudai, Laurence A. Mulard, Armelle Phalipon, Dani Cohen, Marcelo B. Sztein

المصدر: Frontiers in Immunology, Vol 14 (2023)

مصطلحات موضوعية: Shigella, conjugate vaccine, synthetic carbohydrate, memory B cells, antigen-specific B cells, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291664/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/c126aa01bac14aeca8ea6a9a6c1b1b54

المؤلفون: Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Dorian Lefebvre, Mathieu Fanuel, Hélène Rogniaux, David Ropartz, Sophie Barbe, David Guieysse, Laurence A. Mulard, Magali Remaud-Siméon, Claire Moulis, Isabelle André

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/6fca7743f5704259be614afb146d57e5

المؤلفون: Mounir Benkoulouche, Akli Ben Imeddourene, Louis-Antoine Barel, Guillaume Le Heiget, Sandra Pizzut, Hanna Kulyk, Floriant Bellvert, Sophie Bozonnet, Laurence A. Mulard, Magali Remaud-Siméon, Claire Moulis, Isabelle André

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/ef2c88e7c7fc466baca624798a644eb8

المؤلفون: David Ropartz (1686262), Mathieu Fanuel (2629327), Simon Ollivier (7547357), Adrien Lissarrague (11978210), Mounir Benkoulouche (10103334), Laurence A. Mulard (1478686), Isabelle André (1478674), David Guieysse (6315821), Hélène Rogniaux (1686265)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Sociology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, resolving power (<, precise structural characterization, extreme structural complexity, chemoenzymatic glycan synthesis, 14 engineered mutants, eight possible products, eight possible ones, particular microbial glycans, naturally occurring glycans, p , ion mobility made, complementary strategies based, accuracy ms led, ion mobility, r <, >< sub, complex glycans, work illustrates, utilizing α, uhplc coupled, tandem ms, special interest, reaction media, rapid development

Relation: https://figshare.com/articles/journal_contribution/Combination_of_High-Resolution_Multistage_Ion_Mobility_and_Tandem_MS_with_High_Energy_of_Activation_to_Resolve_the_Structure_of_Complex_Chemoenzymatically_Synthesized_Glycans/18785033

الاتاحة: https://doi.org/10.1021/acs.analchem.1c04982.s001

المؤلفون: Armelle Phalipon, Laurence A. Mulard

المصدر: Vaccines; Volume 10; Issue 3; Pages: 403

مصطلحات موضوعية: carbohydrates, conjugate vaccines, glycoconjugates, O-antigens, Shigella, synthetic glycans

وصف الملف: application/pdf

Relation: Vaccines against Infectious Diseases; https://dx.doi.org/10.3390/vaccines10030403

الاتاحة: https://doi.org/10.3390/vaccines10030403

المؤلفون: Louis-Antoine Barel, Laurence A. Mulard

المصدر: Human Vaccines & Immunotherapeutics, Vol 15, Iss 6, Pp 1338-1356 (2019)

مصطلحات موضوعية: bioconjugate, carbohydrate antigen, clinical trial, glycan, glycoconjugate, lipopolysaccharide, o-acetylation, oligosaccharide, shigella, vaccine, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

URL الوصول: https://doaj.org/article/f58451bf2e444caa9a185bf6263f1b82

المؤلفون: Zhaoyu Hu (10103331), Mounir Benkoulouche (10103334), Louis-Antoine Barel (10103337), Guillaume Le Heiget (10103340), Akli Ben Imeddourene (10103343), Yann Le Guen (10103346), Nelly Monties (4454515), Catherine Guerreiro (1478671), Magali Remaud-Siméon (1478683), Claire Moulis (474017), Isabelle André (1478674), Laurence A. Mulard (1478686)

مصطلحات موضوعية: Microbiology, Ecology, Immunology, Marine Biology, Inorganic Chemistry, Space Science, Shigella, concept, transfer glucosyl residues, oligosaccharide, regioselective α- d-glucosylation, flexneri type IV O-antigen, non-natural, acceptor, chemoenzymatic, Convergent Chemoenzymatic Strategy, serotype coverage S, tetrasaccharide, glycoside hydrolase family 70, Protected Tetrasaccharide Core Progress, flexneri glycoconjugate vaccine, α- transglucosylases

Relation: https://figshare.com/articles/journal_contribution/Convergent_Chemoenzymatic_Strategy_to_Deliver_a_Diversity_of_Shigella_flexneri_Serotype-Specific_O_Antigen_Segments_from_a_Unique_Lightly_Protected_Tetrasaccharide_Core/13720665

الاتاحة: https://doi.org/10.1021/acs.joc.0c00777.s001

المؤلفون: Debashis Dhara, Marion Bouchet, Laurence A. Mulard

المصدر: The Journal of Organic Chemistry.

مصطلحات موضوعية: Organic Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6845f562c43dc622c091685b478df0e1
https://doi.org/10.1021/acs.joc.2c03016

المؤلفون: David Ropartz, Mathieu Fanuel, Simon Ollivier, Adrien Lissarrague, Mounir Benkoulouche, Laurence A. Mulard, Isabelle André, David Guieysse, Hélène Rogniaux

المساهمون: Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Chimie des Biomolécules - Chemistry of Biomolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), ANR-15-CE07-0019,CarbUniVax,Synergie entre synthèse chimique et ingénierie d'enzymes pour le développement de vaccins glycoconjugués à large spectre(2015), ANR-18-CE29-0006,ALGAIMS,Analyses de polysaccharides comportant des unités Galf par IRMPD et MS-mobilité ionique(2018)

المصدر: Analytical Chemistry
Analytical Chemistry, 2022, 94 (4), pp.2279-2287. ⟨10.1021/acs.analchem.1c04982⟩

مصطلحات موضوعية: Isomerism, Polysaccharides, Tandem Mass Spectrometry, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Carbohydrates, Oligosaccharides, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95beeec366cdfec2c3e6d6966779927d
https://doi.org/10.1021/acs.analchem.1c04982

المؤلفون: Franklin R. Toapanta, Jingping Hu, Shiri Meron-Sudai, Laurence A. Mulard, Armelle Phalipon, Dani Cohen, Marcelo B. Sztein

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, Shigella, conjugate vaccine, synthetic carbohydrate, memory B cells, antigen-specific B cells

Relation: https://figshare.com/articles/dataset/DataSheet_1_Further_characterization_of_Shigella-specific_memory_B_cells_induced_in_healthy_volunteer_recipients_of_SF2a-TT15_a_Shigella_flexneri_2a_synthetic_glycan-based_vaccine_candidate_docx/24486556

الاتاحة: https://doi.org/10.3389/fimmu.2023.1291664.s001
https://figshare.com/articles/dataset/DataSheet_1_Further_characterization_of_Shigella-specific_memory_B_cells_induced_in_healthy_volunteer_recipients_of_SF2a-TT15_a_Shigella_flexneri_2a_synthetic_glycan-based_vaccine_candidate_docx/24486556

المؤلفون: Hélène B. Pfister, Julie Paoletti, Ana Poveda, Jesus Jimenez-Barbero, Laurence A. Mulard

مصطلحات موضوعية: glycosylation, oligosaccharide synthesis, VACCINE

Relation: https://zenodo.org/communities/cicbiogune_repo; oai:zenodo.org:3332856

الاتاحة: https://doi.org/10.1055/s-0037-1609719

المؤلفون: Sonja Kunstmann, Tom Scheidt, Saskia Buchwald, Alexandra Helm, Laurence A. Mulard, Angelika Fruth, Stefanie Barbirz

المصدر: Viruses; Volume 10; Issue 8; Pages: 431

مصطلحات موضوعية: Shigella flexneri, bacteriophage, tailspike proteins, O-antigen, serotyping, microtiter plate assay, fluorescence sensor

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Bacterial Viruses; https://dx.doi.org/10.3390/v10080431

الاتاحة: https://doi.org/10.3390/v10080431

المؤلفون: Philippe J. Sansonetti, Armelle Phalipon, Jacob Atsmon, Anya Bialik, Alexandra Dorman, Shiri Meron-Sudai, Cecile Artaud, Carla W G Hoitink, Shai Ashkenazi, Valeria Asato, Arava Reizis, Marie-Lise Gougeon, Laurence A. Mulard, Ortal Ariel-Cohen, Dani Cohen, Sophy Goren, Janny Westdijk

المساهمون: Tel Aviv University (TAU), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Institut Pasteur [Paris] (IP), Immunité Innée - Innate Immunity, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Translational Vaccinology (INTRAVACC), Ariel University, Pathogénie microbienne moléculaire, Chimie des Biomolécules - Chemistry of Biomolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This Article is dedicated to the late John B Robbins and to Rachel Schneerson formerly at the National Institute of Child Health and Human Development, National Institutes of Health, for their groundbreaking achievements and inspiring visionary leadership in the field of shigella glycoconjugate vaccine development. We thank the members of the Centre de Recherche Translationnelle—Coordination Clinique, Institut Pasteur: Mohand Ait Ahmed for his help in site trial implementation, Nathalie Jolly for helpful discussions about trial conduct, and Hélène Lafolly for her help at the early stages of the clinical project. We acknowledge Odile Launay (CIC Cochin Pasteur), Beatrice De Vos (Consultant), and Eli Somekh (Wolfson Medical Center) for agreeing to be members of the independent data monitoring committee.

المصدر: The Lancet Infectious Diseases
The Lancet Infectious Diseases, 2021, 21 (4), pp.546-558. ⟨10.1016/S1473-3099(20)30488-6⟩

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Population, Dose-Response Relationship, Immunologic, Placebo-controlled study, Aluminum Hydroxide, Placebo, Injections, Intramuscular, Shigella flexneri, Young Adult, 03 medical and health sciences, Immunogenicity, Vaccine, 0302 clinical medicine, Adjuvants, Immunologic, Shigella Vaccines, Conjugate vaccine, Internal medicine, Humans, Medicine, media_common.cataloged_instance, Single-Blind Method, 030212 general & internal medicine, European union, education, Adverse effect, Dysentery, Bacillary, media_common, Vaccines, Synthetic, education.field_of_study, Vaccines, Conjugate, business.industry, Immunogenicity, O Antigens, Middle Aged, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Antibodies, Bacterial, Healthy Volunteers, 030104 developmental biology, Infectious Diseases, Tolerability, Female, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c837f9fae6f85901c22bf26b9315019
https://doi.org/10.1016/s1473-3099(20)30488-6

المؤلفون: Laurence A. Mulard, Debashis Dhara

المساهمون: Chimie des Biomolécules - Chemistry of Biomolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was funded by the Institut Pasteur, which included a Pasteur Roux Cantarini postdoctoral fellowship to D.D. Financial supports from the Bill & Melinda Gates Foundation (Grant agreement Investment ID OPP1191130), and from the Bill & Melinda Gates Medical Research Institute (Contract ID: Collaboration & License Agreement (Institut Pasteur, Gates MRI), December 2019) are gratefully acknowledged., The authors are very grateful to C. Guerreiro and Dr. F. Baleux (Unité de Chimie des Biomolécules, Institut Pasteur) for the RP-HPLC purification of the final products and to B. Vitorge (Plateforme de RMN Biologique, Institut Pasteur) for providing the 800 MHz NMR spectra of octasaccharide 4. The authors thank F. Bonhomme (UMR3523 CNRS) for performing the HRMS analyses.

المصدر: Chemistry-A European Journal
Chemistry-A European Journal, 2021, 27 (18), pp.5694-5711. ⟨10.1002/chem.202003480⟩
Chemistry (Weinheim an Der Bergstrasse, Germany)

مصطلحات موضوعية: Glycosylation, Stereochemistry, Altrose, Disaccharide, Oligosaccharides, Shigella sonnei, Disaccharides, 010402 general chemistry, 01 natural sciences, Catalysis, chemistry.chemical_compound, Polysaccharides, Total Synthesis, [CHIM]Chemical Sciences, Moiety, Protecting group, Imide, Full Paper, 010405 organic chemistry, Organic Chemistry, zwitterionic polysaccharides, Total synthesis, General Chemistry, Full Papers, AAT, 0104 chemical sciences, chemistry, protecting groups, altrose

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7c17bfe2067d7a02443ad8ffe78a56
https://doi.org/10.1002/chem.202003480

المؤلفون: Debashis Dhara, Ashis Dhara, Paul V. Murphy, Laurence A. Mulard

المصدر: Carbohydrate research. 521

مصطلحات موضوعية: Polysaccharides, Organic Chemistry, Carbohydrates, Oligonucleotides, Oligosaccharides, General Medicine, Glycosides, Sugars, Biochemistry, Analytical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45d1df5c343339b5d3d9454d3fd5a4e
https://pubmed.ncbi.nlm.nih.gov/36030632

المؤلفون: Robert M F, van der Put, Carolien, Smitsman, Alex, de Haan, Martin, Hamzink, Hans, Timmermans, Joost, Uittenbogaard, Janny, Westdijk, Michiel, Stork, Olga, Ophorst, Françoise, Thouron, Catherine, Guerreiro, Philippe J, Sansonetti, Armelle, Phalipon, Laurence A, Mulard

المصدر: ACS central science. 8(4)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::e79d406ac920907ed0232b1a52521e44
https://pubmed.ncbi.nlm.nih.gov/35559427

المؤلفون: Marion Bouchet, Zhaoyu Hu, Laurence A. Mulard, Johan Cornil

المساهمون: Chimie des Biomolécules - Chemistry of Biomolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by Institut Pasteur under grant agreement GPH-FLEXBIVAC (postdoctoral fellowship to J.C.) and by the European Union's seventh Framework Program for research, technological development, and demonstration under grant agreement no 261462-STOPENTERICS (postdoctoral fellowship to Z.H.)., The authors would like to acknowledge Ms Catherine Guerreiro (Chemistry of Biomolecules) for her excellent advice with regard to RP-HPLC. They also thank Mr Frederic Bonhomme (UMR3523 CNRS) for the HRMS spectra., European Project: 261472,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,STOPENTERICS(2010)

المصدر: Organic Chemistry Frontiers
Organic Chemistry Frontiers, 2021, 8 (22), pp.6279-6299. ⟨10.1039/d1qo00761k⟩

مصطلحات موضوعية: chemistry.chemical_classification, Glycan, Glycosylation, biology, Glycoconjugate, Dimer, [SDV]Life Sciences [q-bio], Organic Chemistry, biology.organism_classification, Chemical synthesis, Combinatorial chemistry, chemistry.chemical_compound, Shigella flexneri, chemistry, biology.protein, Moiety, [CHIM]Chemical Sciences, Azide, [SDV.IMM.VAC]Life Sciences [q-bio]/Immunology/Vaccinology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3953bad9a9e5594933827c0e32f6120
https://hal-pasteur.archives-ouvertes.fr/pasteur-03722329/file/OrgChemFront2021-Cornil.pdf

المؤلفون: Akli Ben Imeddourene, Guillaume Le Heiget, Claire Moulis, Isabelle André, Zhaoyu Hu, Nelly Monties, Laurence A. Mulard, Magali Remaud-Simeon, Mounir Benkoulouche, Louis-Antoine Barel, Catherine Guerreiro, Yann Le Guen

المساهمون: Chimie des Biomolécules - Chemistry of Biomolecules, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Université Paris 13, Sorbonne Paris Cité , BPC, This work was funded by the French National Research Agency (grant ANR-15-CE07-0019), which included postdoctoral fellowships to Z.H. and A.B.I. as well as PhD fellowships to M.B. and L.A.B (MTCI doctoral school). Y.L.G. (MTCE doctoral school) and G.L.H. (MTCI doctoral school) were the recipients of a PhD fellowship from their respective doctoral school. Financial support from the TGIR-RMN-THC Fr3050 CNRS (Gif-sur-Yvette) f, ANR-15-CE07-0019,CarbUniVax,Synergie entre synthèse chimique et ingénierie d'enzymes pour le développement de vaccins glycoconjugués à large spectre(2015), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

المصدر: Journal of Organic Chemistry
Journal of Organic Chemistry, 2021, 86 (3), pp.2058-2075. ⟨10.1021/acs.joc.0c00777⟩
Journal of Organic Chemistry, American Chemical Society, 2020, 86 (3), pp.2058-2075. ⟨10.1021/acs.joc.0c00777⟩

مصطلحات موضوعية: chemistry.chemical_classification, Serotype, biology, 010405 organic chemistry, Chemistry, Stereochemistry, Glycoconjugate, Diarrhoeal disease, [SDV]Life Sciences [q-bio], Organic Chemistry, Context (language use), 010402 general chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Shigella flexneri, Antigen, Tetrasaccharide, Glycoside hydrolase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9424a376996bb908628ac2d5c4f976e
https://hal.insa-toulouse.fr/hal-03020947/document

المؤلفون: Zhaoyu, Hu, Mounir, Benkoulouche, Louis-Antoine, Barel, Guillaume, Le Heiget, Akli, Ben Imeddourene, Yann, Le Guen, Nelly, Monties, Catherine, Guerreiro, Magali, Remaud-Siméon, Claire, Moulis, Isabelle, André, Laurence A, Mulard

المصدر: The Journal of organic chemistry. 86(3)

مصطلحات موضوعية: Carbohydrate Sequence, O Antigens, Oligosaccharides, Serogroup, Shigella flexneri

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::fe7e8c5c8624fd9471ff197e5ae0344a
https://pubmed.ncbi.nlm.nih.gov/32700907