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1Academic Journal
المؤلفون: Guillaume Lapointe (2168788), Colin K. Skepper (1897093), Lauren M. Holder (9095337), Duncan Armstrong (9095325), Cornelia Bellamacina (1570933), Johanne Blais (3417245), Dirksen Bussiere (2153530), Jianwei Bian (1523959), Cody Cepura (10732121), Helen Chan (2084524), Charles R. Dean (7338677), Gianfranco De Pascale (8456487), Bhavesh Dhumale (9095328), L. Mark Fisher (9095331), Mangesh Fulsunder (9095334), Bhavin Kantariya (9095340), Julie Kim (10332175), Sean King (821002), Lauren Kossy (10732124), Upendra Kulkarni (10732127), Jay Lakshman (10732130), Jennifer A. Leeds (2055931), Xiaolan Ling (10732133), Anatoli Lvov (9095343), Sylvia Ma (1570936), Swapnil Malekar (9095349), David McKenney (2105656), Wosenu Mergo (1730602), Louis Metzger (6518129), Keshav Mhaske (10732136), Heinz E. Moser (2437708), Mina Mostafavi (5100065), Sunil Namballa (10732139), Jonas Noeske (24784), Colin Osborne (2105632), Ashish Patel (6913259), Darshit Patel (9095352), Tushar Patel (235052), Philippe Piechon (8850452), Valery Polyakov (1612567), Krunal Prajapati (9095355), Katherine R. Prosen (8456490), Folkert Reck (2694517), Daryl L. Richie (9095358), Mark R. Sanderson (9095361), Shailesh Satasia (9095364), Bhautik Savani (10732142), Jogitha Selvarajah (9095367), Vijay Sethuraman (1742821), Wei Shu (319155), Kyuto Tashiro (6518141), Katherine V. Thompson (3253005), Krishniah Vaarla (10732145), Lakhan Vala (9095376), Dennis A. Veselkov (9095379), Jason Vo (8456493), Bhavesh Vora (10732148), Trixie Wagner (1639117), Laura Wedel (10732151), Sarah L. Williams (13547), Satya Yendluri (10732154), Qin Yue (1505008), Aregahegn Yifru (1730641), Yong Zhang (5893), Alexey Rivkin (1730611)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Virology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, series, mouse thigh model, DNA cleavage complexes, QRDR, X-ray crystal structure, Fluoroquinolone-Resistant Gram-Posi., vivo pharmacokinetic properties, Optimization, Topoisomerase IV Inhibitors, topoisomerase IV, fluoroquinolone-sensitive Staphyloc., compound 25
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المؤلفون: Marie-Gabrielle Braun, Georgette Castanedo, Samantha A. Green, Mingshuo Zeng, Joseph Carpenter, Antonella Converso, Izzat T. Raheem, Anthony J. Roecker, Akshay A. Shah, Laurent Debien, T.G. Murali Dhar, Lauren M. Holder, J. Robert Merritt, Kevin M. Peese, Denise G. Grünenfelder, Julian C. Lo
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المؤلفون: David McKenney, Louis E. Metzger, Dirksen E. Bussiere, Sylvia Ma, Ashish Patel, Bhavesh Dhumale, Upendra Kulkarni, Jay Parthiban Lakshman, Sean King, Duncan Armstrong, Kyuto Tashiro, Lauren Kossy, Tushar Patel, Lauren M. Holder, Jogitha Selvarajah, Sarah Williams, Satya Yendluri, Colin Osborne, Jason Vo, Mangesh Fulsunder, Xiaolan Ling, Laura Wedel, Gianfranco De Pascale, Jennifer A. Leeds, Cody Cepura, Heinz E. Moser, Alexey Rivkin, Sunil Namballa, Colin K. Skepper, Bhavin Kantariya, Mina Mostafavi, Bhautik Savani, Anatoli Lvov, Guillaume Lapointe, Cornelia Bellamacina, Bhavesh Vora, Daryl L. Richie, Helen Chan, Wosenu Mergo, Jianwei Bian, Wei Shu, Keshav Mhaske, Aregahegn Yifru, Mark R. Sanderson, Swapnil Malekar, Johanne Blais, Qin Yue, Yong Zhang, Katherine V. Thompson, Julie Kim, Charles R. Dean, Vijay Sethuraman, Trixie Wagner, L. Mark Fisher, Dennis A. Veselkov, Darshit Patel, Folkert Reck, Jonas Noeske, Krishniah Vaarla, Lakhan Vala, Shailesh Satasia, Krunal Prajapati, Philippe Piechon, Valery Polyakov, Katherine R Prosen
المصدر: Lapointe, G, Skepper, C K, Holder, L M, Armstrong, D, Bellamacina, C, Blais, J, Bussiere, D, Bian, J, Cepura, C, Chan, H, Dean, C R, De Pascale, G, Dhumale, B, Fisher, L M, Fulsunder, M, Kantariya, B, Kim, J, King, S, Kossy, L, Kulkarni, U, Lakshman, J, Leeds, J A, Ling, X, Lvov, A, Ma, S, Malekar, S, McKenney, D, Mergo, W, Metzger, L, Mhaske, K, Moser, H E, Mostafavi, M, Namballa, S, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Piechon, P, Polyakov, V, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Sanderson, M R, Satasia, S, Savani, B, Selvarajah, J, Sethuraman, V, Shu, W, Tashiro, K, Thompson, K V, Vaarla, K, Vala, L, Veselkov, D A, Vo, J, Vora, B, Wagner, T, Wedel, L, Williams, S L, Yendluri, S, Yue, Q, Yifru, A, Zhang, Y & Rivkin, A 2021, ' Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria ', Journal of Medicinal Chemistry, vol. 64, no. 9, pp. 6329-6357 . https://doi.org/10.1021/acs.jmedchem.1c00375
مصطلحات موضوعية: DNA Topoisomerase IV, Staphylococcus aureus, Topoisomerase IV, Klebsiella pneumoniae, Gram-positive bacteria, 01 natural sciences, DNA gyrase, 03 medical and health sciences, chemistry.chemical_compound, Mice, Moxifloxacin, Drug Discovery, Drug Resistance, Bacterial, medicine, Animals, Topoisomerase II Inhibitors, Ternary complex, 030304 developmental biology, 0303 health sciences, biology, Chemistry, biology.organism_classification, 0104 chemical sciences, Anti-Bacterial Agents, 010404 medicinal & biomolecular chemistry, Biochemistry, DNA Gyrase, Drug Design, biology.protein, Molecular Medicine, Bacteria, DNA, medicine.drug, Fluoroquinolones
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المؤلفون: Xiaolin Li, Martin Traebert, David McKenney, Dirksen E. Bussiere, Sylvia Ma, Katherine V. Thompson, Nirav Shah, Douglas C. Bauer, Wosenu Mergo, Duncan Armstrong, Richard Zang, Bhavin Kantariya, Jennifer A. Leeds, Bo Zhou, Ashish Patel, John Fuller, Tushar Patel, Alice Rico, William S. Sawyer, Colin Osborne, Heinz E. Moser, Mangesh Fulsunder, Yongjin Xu, Bret Benton, Swapnil Malekar, Shravanthi Madhavan, Jason Vo, Cheng Hu, Daniel Mutnick, Krunal Prajapati, Michael Wang, Katherine R Prosen, Louis E. Metzger, Carl J. Balibar, Darshit Patel, Jogitha Selvarajah, Sarah Williams, Shailesh Satasia, Peichao Lu, Bhavesh Dhumale, Kartik Shanghavi, Alexey Rivkin, Javier de Vicente, Wei Shu, Jonas Noeske, Anand Vala, Mark R. Sanderson, Cornelia Bellamacina, L. Mark Fisher, Lakhan Vala, Qin Yue, Charles R. Dean, Gianfranco De Pascale, Dennis A. Veselkov, Marcella Widya, Folkert Reck, Lauren M. Holder, Guillaume Lapointe, Colin K. Skepper, Daryl L. Richie, Anatoli Lvov
المصدر: Skepper, C K, Armstrong, D, Balibar, C J, Bauer, D, Bellamacina, C, Benton, B M, Bussiere, D, De Pascale, G, De Vicente, J, Dean, C R, Dhumale, B, Fisher, L M, Fuller, J, Fulsunder, M, Holder, L M, Hu, C, Kantariya, B, Lapointe, G, Leeds, J A, Li, X, Lu, P, Lvov, A, Ma, S, Madhavan, S, Malekar, S, Mckenney, D, Mergo, W, Metzger, L, Moser, H E, Mutnick, D, Noeske, J, Osborne, C, Patel, A, Patel, D, Patel, T, Prajapati, K, Prosen, K R, Reck, F, Richie, D L, Rico, A, Sanderson, M R, Satasia, S, Sawyer, W S, Selvarajah, J, Shah, N, Shanghavi, K, Shu, W, Thompson, K V, Veselkov, D A, Williams, S L, Xu, Y, Yue, Q, Zang, R, Zho, B & Rivkin, A 2020, ' Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria ', Journal of Medicinal Chemistry, vol. 63, no. 14, pp. 7773-7816 . https://doi.org/10.1021/acs.jmedchem.0c00347
مصطلحات موضوعية: DNA Topoisomerase IV, Gram-negative bacteria, medicine.drug_class, Topoisomerase IV, Antibiotics, Microbial Sensitivity Tests, 01 natural sciences, DNA gyrase, Microbiology, 03 medical and health sciences, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Drug Resistance, Bacterial, Gram-Negative Bacteria, medicine, Humans, Topoisomerase II Inhibitors, Binding site, 030304 developmental biology, 0303 health sciences, Binding Sites, biology, Molecular Structure, Chemistry, Topoisomerase, biology.organism_classification, Quinolone, 0104 chemical sciences, Anti-Bacterial Agents, 010404 medicinal & biomolecular chemistry, DNA Gyrase, biology.protein, Molecular Medicine, Topoisomerase inhibitor, Fluoroquinolones
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