المؤلفون: Luisa M. Bachmann, Maria Hanl, Felix Feller, Laura Sinatra, Andrea Schöler, Jens Pietzsch, Markus Laube, Finn K. Hansen

المصدر: Molecules, Vol 28, Iss 3, p 1061 (2023)

مصطلحات موضوعية: cancer, COX, HDAC, multi-target drugs, solid-phase synthesis, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/3/1061; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/a993f8708aee4b61881355d9607e89a7

المؤلفون: Laura Sinatra, Jing Yang, Julian Schliehe-Diecks, Niklas Dienstbier, Melina Vogt, Philip Gebing, Luisa M. Bachmann, Melf Sönnichsen, Thomas Lenz, Kai Stühler, Andrea Schöler, Arndt Borkhardt, Sanil Bhatia, Finn K. Hansen

المصدر: Journal of medicinal chemistry. 65(24)

مصطلحات موضوعية: Ubiquitin-Protein Ligases, Drug Discovery, Proteolysis, Molecular Medicine, Antineoplastic Agents, Histone Deacetylase 6, Solid-Phase Synthesis Techniques, Proteolysis Targeting Chimera, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58716a1204f43910128642bef4d0b507
https://pubmed.ncbi.nlm.nih.gov/36473103

المؤلفون: Christoph Selg, Andrea Schöler, Finn K. Hansen, Maria Hanl, Menyhárt B. Sárosi, Sanil Bhatia, Evamarie Hey-Hawkins, Laura Sinatra, Arndt Borkhardt, Julian Schliehe-Diecks

المصدر: Chemical Science

مصطلحات موضوعية: biology, Chemistry, General Chemistry, HDAC6, Combinatorial chemistry, Solid-phase synthesis, Histone, biology.protein, Moiety, Carborane, Histone deacetylase, Pharmacophore, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bd63bb25621a6645d3528558af501e
https://doi.org/10.1039/d1sc02268g

المؤلفون: Finn K. Hansen, Alexandra Hamacher, Jens Meiler, Jan J. Bandolik, Martin Roatsch, Clara T. Schoeder, Andrea Schöler, Laura Sinatra, Sanil Bhatia, Matthias U. Kassack, Melf Sönnichsen, Arndt Borkhardt

المصدر: Sinatra, L, Bandolik, J J, Roatsch, M, Soennichsen, M, Schoeder, C T, Hamacher, A, Schoeler, A, Borkhardt, A, Meiler, J, Bhatia, S, Kassack, M U & Hansen, F K 2020, ' Hydroxamic Acids Immobilized on Resins (HAIRs) : Synthesis of Dual-Targeting HDAC Inhibitors and HDAC Degraders (PROTACs) ', Angewandte Chemie International Edition, vol. 59, no. 50, pp. 22494-22499 . https://doi.org/10.1002/anie.202006725
Angewandte Chemie (International Ed. in English)

مصطلحات موضوعية: MULTITARGET DRUGS, solid-phase synthesis, Dual targeting, DNA damage, Antineoplastic Agents, Apoptosis, Caspase 3, Hydroxamic Acids, 010402 general chemistry, 01 natural sciences, Histone Deacetylases, Catalysis, PROTAC, Chimera (genetics), Solid-phase synthesis, Cell Line, Tumor, Humans, POLYPHARMACOLOGY, Multi‐Target Drugs | Hot Paper, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Communication, TEMOZOLOMIDE, General Chemistry, Anticancer drug, Communications, multi-target drugs, 0104 chemical sciences, Cell biology, Histone Deacetylase Inhibitors, Resins, Synthetic, Histone, histone deacetylase, biology.protein, Histone deacetylase

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d75b9c011e7cc21cadd59c1622e90e
https://doi.org/10.1002/anie.202006725

المؤلفون: Finn K. Hansen, Jens Meiler, Martin Roatsch, Andrea Schöler, Laura Sinatra, Melf Sönnichsen, Arndt Borkhardt, Alexandra Hamacher, Clara T. Schoeder, Jan J. Bandolik, Sanil Bhatia, Matthias U. Kassack

المصدر: Angewandte Chemie. 132:22681-22687

مصطلحات موضوعية: Dual target, Solid-phase synthesis, Biochemistry, DNA damage, Chemistry, General Medicine, Histone deacetylase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b4867fc7e7a0e82fba47440de7f06ae3
https://doi.org/10.1002/ange.202006725

المؤلفون: Ines Gockel, Finn K. Hansen, Stefan R. Fritzsche, Maik Icker, Daniela Volke, Laura Sinatra, Ralf Hoffmann, Lisa Kolano, René Thieme

المصدر: ChemPlusChem. 86(6)

مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Stereochemistry, Peptidomimetic, Cationic polymerization, Peptide, General Chemistry, Random hexamer, 010402 general chemistry, Antimicrobial, 01 natural sciences, 0104 chemical sciences, Chain length, Side chain, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7f929fa0d7bdf8875090151c187352
https://pubmed.ncbi.nlm.nih.gov/33656810

المؤلفون: Bruno L. Oliveira, Benjamin J Stenton, Gonçalo J. L. Bernardes, Maria João Matos, Laura Sinatra

المساهمون: Stenton, Benjamin J [0000-0001-5852-2803], Oliveira, Bruno L [0000-0002-7687-4746], Matos, Maria J [0000-0002-3470-8299], Sinatra, Laura [0000-0002-2467-3803], Bernardes, Gonçalo JL [0000-0001-6594-8917], Apollo - University of Cambridge Repository

المصدر: Chemical Science

مصطلحات موضوعية: inorganic chemicals, Biomedical, 010405 organic chemistry, Chemistry, General Chemistry, Prodrug, 010402 general chemistry, 0601 Biochemistry and Cell Biology, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, Cell killing, Thioether, 5.1 Pharmaceuticals, Bioorthogonal chemistry, Bifunctional, Linker, Conjugate, Cysteine, Cancer, Biotechnology

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1fc3adfe5c1e6cd18d88e12d6b4402