-
1
المؤلفون: Henri Xhaard, Erik A.A. Wallén, Jari Yli-Kauhaluoma, Jyrki P. Kukkonen, Teppo O. Leino, Lasse Karhu, Ainoleena Turku
المصدر: ChemMedChem. 14:965-981
مصطلحات موضوعية: Pharmacology, Indole test, Agonist, Bicyclic molecule, 010405 organic chemistry, Stereochemistry, Chemistry, medicine.drug_class, Organic Chemistry, Biological activity, Potentiator, 01 natural sciences, Biochemistry, Orexin receptor, 0104 chemical sciences, 3. Good health, Orexin, 010404 medicinal & biomolecular chemistry, mental disorders, Drug Discovery, medicine, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Binding site, psychological phenomena and processes
-
2
المؤلفون: Jyrki P. Kukkonen, Lasse Karhu, Ainoleena Turku, Teppo O. Leino, Henri Xhaard, Alexandre Borrel
المصدر: Journal of Medicinal Chemistry. 59:8263-8275
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Agonist, medicine.drug_class, Stereochemistry, Pharmacology, Ligands, Cell Line, 03 medical and health sciences, Orexin Receptors, Drug Discovery, medicine, Humans, Receptor, Chemistry, Drug discovery, Small molecule, Orexin receptor, 3. Good health, 030104 developmental biology, Docking (molecular), Molecular Medicine, Calcium, Orexin Receptor Antagonists, Signal transduction, Pharmacophore
-
3
المؤلفون: Aniket Magarkar, Alex Bunker, Henri Xhaard, Lasse Karhu
المساهمون: Division of Pharmaceutical Chemistry and Technology, Division of Pharmaceutical Biosciences, Drug Research Program, Pharmaceutical biophysics group, Pharmaceutical Design and Discovery group, Henri Xhaard / Principal Investigator
المصدر: The Journal of Physical Chemistry. B
مصطلحات موضوعية: STRUCTURAL BASIS, MECHANISM, Agonist, medicine.drug_class, Protein Conformation, 116 Chemical sciences, Allosteric regulation, Molecular Dynamics Simulation, 010402 general chemistry, 01 natural sciences, ALLOSTERIC MODULATION, Article, chemistry.chemical_compound, Molecular dynamics, Orexin Receptors, 0103 physical sciences, Materials Chemistry, medicine, Humans, Amino Acid Sequence, OX1, Physical and Theoretical Chemistry, Receptor, POPC, Orexins, Binding Sites, 010304 chemical physics, CHOLESTEROL, Suvorexant, Antagonist, Water, PEPTIDES, Azepines, Triazoles, Orexin receptor, 0104 chemical sciences, 3. Good health, Surfaces, Coatings and Films, PROTEIN-COUPLED RECEPTOR, MODEL, chemistry, FORCE-FIELD, Biophysics, GUI MEMBRANE-BUILDER, Orexin Receptor Antagonists, Protein Binding
-
4
المؤلفون: Ainoleena, Turku, Teppo O, Leino, Lasse, Karhu, Jari, Yli-Kauhaluoma, Jyrki P, Kukkonen, Erik A A, Wallén, Henri, Xhaard
المصدر: ChemMedChem. 14(9)
مصطلحات موضوعية: Structure-Activity Relationship, Orexin Receptors, Animals, Humans, Hydrogen Bonding, Molecular Dynamics Simulation, Azulenes
-
5Computational analysis of orexin receptors and their interactions with natural and synthetic ligands
المؤلفون: Lasse Karhu
المساهمون: University of Helsinki, Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, Doctoral Programme in Drug Research, Helsingin yliopisto, farmasian tiedekunta, Lääketutkimuksen tohtoriohjelma, Helsingfors universitet, farmaceutiska fakulteten, Doktorandprogrammet i läkemedelsforskning, Kolb, Peter, Xhaard, Henri, Bunker, Alex
المصدر: University of Helsinki
وصف الملف: application/pdf
-
6
المؤلفون: Henri Xhaard, Henri T. Pätsi, Erik A.A. Wallén, Jyrki P. Kukkonen, Janne Weisell, Teppo O. Leino, Lasse Karhu, Pauli M. Turunen
المساهمون: Faculty of Pharmacy, Pharmaceutical Design and Discovery group, Medicum, Veterinary Biosciences, Departments of Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Division of Pharmaceutical Chemistry and Technology, Henri Xhaard / Principal Investigator, Drug Research Program, Jyrki Kukkonen / Principal Investigator, Veterinary Biochemistry and Cell Biology, Department of Physiology, Erik Wallen / Principal Investigator
المصدر: Peptides. 102
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, alpha-Helical, Aminoisobutyric Acids, Physiology, Endogeny, Peptide, Biochemistry, Pseudopeptide, 03 medical and health sciences, Cellular and Molecular Neuroscience, Endocrinology, APPETITE, Orexin Receptors, Orexin Receptor Agonists, BINDING, Humans, G protein-coupled receptor, Amino Acid Sequence, OX1, chemistry.chemical_classification, Orexins, ANALOGS, Chemistry, Peptide stapling, RECOGNITION, Intracellular Signaling Peptides and Proteins, Orexin receptor, Peptide Conformation, Orexin, Amino acid, 030104 developmental biology, orexin, 317 Pharmacy, ACID, Biophysics, 1182 Biochemistry, cell and molecular biology, LIGANDS, 3111 Biomedicine, Peptides, SYSTEM
-
7
المؤلفون: Lasse Karhu, Ainoleena Turku, Henri Xhaard
المساهمون: Faculty of Pharmacy, Henri Xhaard / Principal Investigator, Drug Discovery, Division of Pharmaceutical Biosciences, Division of Pharmaceutical Chemistry and Technology, Computational Adme, Pharmaceutical Design and Discovery group, Drug Research Program
المصدر: BMC Structural Biology
مصطلحات موضوعية: Models, Molecular, STRUCTURAL BASIS, Orexin-A, Peptide docking, Neurotensin receptor 1, OREXIN-1 RECEPTOR, Protein Structure, Secondary, OPIOID RECEPTOR, OX1 receptor, 03 medical and health sciences, GPCR, PROTEIN-COUPLED RECEPTORS, 0302 clinical medicine, Orexin Receptors, Structural Biology, NEUROTENSIN RECEPTOR, Humans, PEPTIDE, G protein-coupled receptor, DOCKING, Neurotensin receptor, ANTAGONIST, 030304 developmental biology, Orexins, 0303 health sciences, Binding Sites, Chemistry, digestive, oral, and skin physiology, Suvorexant, Hydrogen Bonding, Orexin receptor, Orexin, Molecular Docking Simulation, AGONIST, Biochemistry, Structural Homology, Protein, 317 Pharmacy, Docking (molecular), Mutation, Biophysics, Pose selection, Multidimensional scaling, 030217 neurology & neurosurgery, Research Article, Protein Binding
-
8
المؤلفون: Lasse Karhu, Ainoleena Turku, Henri Xhaard
المصدر: University of Helsinki