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1Academic Journal
المؤلفون: Igor B Gubrij, Amanda K Pangle, Li Pang, Larry G Johnson
المصدر: PLoS ONE, Vol 11, Iss 1, p e0147827 (2016)
وصف الملف: electronic resource
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المؤلفون: Harry G M Heijerman, Edward F McKone, Damian G Downey, Eva Van Braeckel, Steven M Rowe, Elizabeth Tullis, Marcus A Mall, John J Welter, Bonnie W Ramsey, Charlotte M McKee, Gautham Marigowda, Samuel M Moskowitz, David Waltz, Patrick R Sosnay, Christopher Simard, Neil Ahluwalia, Fengjuan Xuan, Yaohua Zhang, Jennifer L Taylor-Cousar, Karen S McCoy, Karen McCoy, Scott Donaldson, Seth Walker, James Chmiel, Ronald Rubenstein, Deborah K. Froh, Isabel Neuringer, Manu Jain, Kathryn Moffett, Jennifer L. Taylor-Cousar, Bruce Barnett, Gary Mueller, Patrick Flume, Floyd Livingston, Nighat Mehdi, Charlotte Teneback, John Welter, Raksha Jain, Dana Kissner, Kapilkumar Patel, Francisco J. Calimano, Jimmy Johannes, Cori Daines, Thomas Keens, Herschel Scher, Subramanyam Chittivelu, Sudhakar Reddivalam, Ross Carl Klingsberg, Larry G. Johnson, Stijn Verhulst, Patricia Macedo, Damien Downey, Gary Connett, Edward Nash, Nicholas Withers, Timothy Lee, Marleen Bakker, Harry Heijerman, Francois Vermeulen, Christiane Knoop, Elke De Wachter, Renske van der Meer, Petrus Merkus, Christof Majoor
المساهمون: Pulmonology, AII - Inflammatory diseases, Clinical sciences, Physiotherapy, Human Physiology and Anatomy, Pediatrics
المصدر: Lancet, 394(10212), 1940-1948. Elsevier Limited
VX17-445-103 Trial Group 2019, ' Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial ', Lancet, vol. 394, no. 10212, pp. 1940 . https://doi.org/10.1016/S0140-6736(19)32597-8
Lancet
The Lancet, 394(10212), 1940. Elsevier Limitedمصطلحات موضوعية: Male, Indoles, Pyrrolidines, Cystic Fibrosis, Pyridines, Clinical Trial, Phase III, Phases of clinical research, Cystic Fibrosis Transmembrane Conductance Regulator, 030204 cardiovascular system & hematology, Quinolones, Aminophenols, Cystic fibrosis, law.invention, Ivacaftor, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, 030212 general & internal medicine, Pyridines/administration & dosage, Non-U.S. Gov't, Chloride Channel Agonists, Sweat, Child, Chloride Channel Agonists/administration & dosage, Medicine(all), biology, Research Support, Non-U.S. Gov't, Lumacaftor, General Medicine, Indoles/administration & dosage, Clinical Trial, Cystic fibrosis transmembrane conductance regulator, Pyrrolidines/administration & dosage, Quinolones/administration & dosage, Randomized Controlled Trial, Combination, Drug Therapy, Combination, Female, medicine.drug, medicine.medical_specialty, Adolescent, Research Support, Article, Benzodioxoles/administration & dosage, Sweat/chemistry, N.I.H, 03 medical and health sciences, Phase III, Research Support, N.I.H., Extramural, Double-Blind Method, Drug Therapy, Internal medicine, Journal Article, medicine, Aminophenols/administration & dosage, Humans, Benzodioxoles, business.industry, Extramural, medicine.disease, Pyrazoles/administration & dosage, Clinical trial, Regimen, chemistry, biology.protein, Pyrazoles, Cystic Fibrosis Transmembrane Conductance Regulator/genetics, sense organs, Cystic Fibrosis/drug therapy, business
وصف الملف: application/pdf; text/plain
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3Academic JournalPathological changes in pulmonary circulation in carbon tetrachloride (CCl4)-induced cirrhotic mice.
المؤلفون: Mita Das, Marjan Boerma, Jessica R Goree, Elise G Lavoie, Michel Fausther, Igor B Gubrij, Amanda K Pangle, Larry G Johnson, Jonathan A Dranoff
المصدر: PLoS ONE, Vol 9, Iss 4, p e96043 (2014)
وصف الملف: electronic resource
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المؤلفون: Richard C. Boucher, Larry G. Johnson
المصدر: Gene Therapy for Diseases of the Lung ISBN: 9781003064619
Gene Therapy for Diseases of the Lungمصطلحات موضوعية: Pathology, medicine.medical_specialty, business.industry, medicine, medicine.disease, business, Cystic fibrosis
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5Academic Journal
المؤلفون: Ruth S. Everett, Miriam K. Vanhook, Nadia Barozzi, Istvan Toth, Larry G. Johnson
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.6950; http://espace.library.uq.edu.au/eserv/uq:80909/n1549.pdf
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6Academic Journal
المؤلفون: Larry G. Johnson, Jennifer P. Mewshaw, Hong Ni, Theodore Friedmann, Richard C. Boucher, John C, John C. Olsen
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.7996; http://jvi.asm.org/content/72/11/8861.full.pdf
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المؤلفون: Larry G. Johnson, Amanda K. Pangle, Li Pang, Igor Gubrij
المصدر: PLoS ONE, Vol 11, Iss 1, p e0147827 (2016)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Physiology, Oligonucleotides, lcsh:Medicine, Prostacyclin, 030204 cardiovascular system & hematology, Pathology and Laboratory Medicine, Biochemistry, Rats, Sprague-Dawley, Pathogenesis, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Gene expression, Medicine and Health Sciences, polycyclic compounds, Lipid Hormones, lcsh:Science, Lung, Regulation of gene expression, Monocrotaline, Multidisciplinary, biology, Heart, Hematology, Animal Models, Body Fluids, Intramolecular Oxidoreductases, Nucleic acids, Blood, medicine.anatomical_structure, Hyperexpression Techniques, Female, Anatomy, Research Article, medicine.drug, medicine.medical_specialty, Cardiac Ventricles, Hypertension, Pulmonary, Research and Analysis Methods, Blood Plasma, Prostacyclin synthase, 03 medical and health sciences, Model Organisms, Signs and Symptoms, Internal medicine, microRNA, Genetics, Gene Expression and Vector Techniques, medicine, Animals, Humans, Non-coding RNA, Molecular Biology Techniques, Molecular Biology, Molecular Biology Assays and Analysis Techniques, Biology and life sciences, lcsh:R, Antagomirs, Genetic Therapy, medicine.disease, Pulmonary hypertension, Hormones, Gene regulation, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Cardiovascular Anatomy, Lesions, biology.protein, Cancer research, RNA, lcsh:Q
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المؤلفون: Larry G. Johnson
المصدر: Advanced Drug Delivery Reviews. 57:111-121
مصطلحات موضوعية: Microscopy, Confocal, Tight junction, Pharmaceutical Science, Adhesion, Biology, Cell junction, Epithelium, Permeability, Tight Junctions, Cell biology, Adherens junction, Microscopy, Fluorescence, Cytoplasm, Paracellular transport, Claudin, Molecular Biology, Epithelial polarity
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المؤلفون: Carolyn B. Coyne, Larry G. Johnson, Todd M. Gambling, Richard C. Boucher, Johnny L. Carson
المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 285:L1166-L1178
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Cell Membrane Permeability, endocrine system diseases, Physiology, Bronchi, Respiratory Mucosa, Biology, Transfection, urologic and male genital diseases, digestive system, Cell junction, Tight Junctions, Mice, Physiology (medical), Claudin-1, medicine, Animals, Claudin-3, Humans, Claudin-5, Claudin, Tight junction, Membrane Proteins, 3T3 Cells, Cell Biology, Recombinant Proteins, digestive system diseases, Transmembrane protein, Cell biology, Junctional permeability, Airway, tissues
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المؤلفون: Carolyn B. Coyne, Najwa Haykal-Coates, Stephen H. Gavett, Miriam K. Vanhook, Larry G. Johnson
المصدر: Human Gene Therapy. 14:729-747
مصطلحات موضوعية: Male, Cell Membrane Permeability, Cystic Fibrosis, medicine.medical_treatment, Genetic Vectors, Pulmonary Edema, Respiratory Mucosa, Biology, Pharmacology, Adenoviridae, Tight Junctions, Mice, chemistry.chemical_compound, In vivo, Lactate dehydrogenase, Genetics, medicine, Animals, Humans, Interleukin 8, Egtazic Acid, Lung, Molecular Biology, Cells, Cultured, Serum Albumin, Chelating Agents, Inflammation, L-Lactate Dehydrogenase, medicine.diagnostic_test, Gene Transfer Techniques, Lauric Acids, In vitro, Respiratory Function Tests, Mice, Inbred C57BL, EGTA, Bronchoalveolar lavage, Cytokine, Biochemistry, chemistry, Paracellular transport, Cytokines, Molecular Medicine, lipids (amino acids, peptides, and proteins), Decanoic Acids
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المؤلفون: Richard C. Boucher, Carolyn B. Coyne, Larry G. Johnson, Carla Ribeiro
المصدر: Journal of Pharmacology and Experimental Therapeutics. 305:440-450
مصطلحات موضوعية: Cell Membrane Permeability, Gene Transfer, Horizontal, Respiratory System, Fluorescent Antibody Technique, Biology, complex mixtures, Epithelium, Calcium in biology, Adenovirus Infections, Human, Structure-Activity Relationship, Adenosine Triphosphate, medicine, Humans, Medium chain fatty acid, Receptor, Claudin, Cells, Cultured, Fluorescent Dyes, Pharmacology, Calcium metabolism, Microscopy, Confocal, Tight junction, Fatty Acids, Epithelial Cells, Cell biology, Intercellular Junctions, Xanthenes, Mechanism of action, Biochemistry, Paracellular transport, Molecular Medicine, Calcium, lipids (amino acids, peptides, and proteins), medicine.symptom, Signal Transduction
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المؤلفون: Sridhar, Badireddi, Mohammad F, Siddiqui, Larry G, Johnson
المصدر: The Journal of the Arkansas Medical Society. 111(5)
مصطلحات موضوعية: Hypertension, Pulmonary, Internal Medicine, Prevalence, Humans, Prognosis
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المؤلفون: Johnny L. Carson, Todd M. Gambling, Carolyn B. Coyne, Larry G. Johnson, Miriam K. Vanhook, Richard C. Boucher
المصدر: Molecular Biology of the Cell. 13:3218-3234
مصطلحات موضوعية: Time Factors, Cystic Fibrosis, medicine.medical_treatment, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Inflammation, Biology, Occludin, Article, Permeability, Tight Junctions, Proinflammatory cytokine, Interferon-gamma, Cell Movement, medicine, Humans, RNA, Messenger, Molecular Biology, Cells, Cultured, Protein Kinase C, Barrier function, Microscopy, Confocal, Tight junction, Reverse Transcriptase Polymerase Chain Reaction, Tumor Necrosis Factor-alpha, Sodium, Membrane Proteins, Epithelial Cells, Cell Biology, Phosphoproteins, Cell biology, Electrophysiology, Microscopy, Electron, Cytokine, Microscopy, Fluorescence, Paracellular transport, Zonula Occludens-1 Protein, Cytokines, Respiratory epithelium, Chlorine, medicine.symptom, Interleukin-1
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المؤلفون: Igor Gubrij, Mita Das, Jessica R. Goree, Larry G. Johnson, Amanda K. Pangle, Michel Fausther, Jonathan A. Dranoff, Elise G. Lavoie, Marjan Boerma
المصدر: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e96043 (2014)مصطلحات موضوعية: Liver Cirrhosis, Male, Pathology, Cirrhosis, Pulmonology, Respiratory System, lcsh:Medicine, Blood Pressure, Vascular Medicine, Medicine and Health Sciences, lcsh:Science, Carbon Tetrachloride, Lung, Portopulmonary hypertension, Multidisciplinary, Liver Diseases, Fatty liver, Portal Hypertension, Animal Models, Pathophysiology, 3. Good health, medicine.anatomical_structure, Liver, Research Design, Hypertension, Fatty Acids, Unsaturated, Portal hypertension, Collagen, Anatomy, Research Article, medicine.medical_specialty, Histology, Clinical Research Design, Hypertension, Pulmonary, Cardiology, Mouse Models, Gastroenterology and Hepatology, Research and Analysis Methods, Model Organisms, medicine, Animals, Pulmonary Vascular Diseases, Pulmonary pathology, Animal Models of Disease, business.industry, lcsh:R, Biology and Life Sciences, medicine.disease, Pulmonary hypertension, Mice, Inbred C57BL, Disease Models, Animal, Oxidative Stress, lcsh:Q, business, Hydroxy Acids
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المؤلفون: Richard C. Boucher, L Naldini, John C. Olsen, Larry G. Johnson
المساهمون: Johnson, Lg, Olsen, Jc, Naldini, Luigi, Boucher, Rc
المصدر: Gene Therapy. 7:568-574
مصطلحات موضوعية: Genetic enhancement, Genetic Vectors, Respiratory System, Transfection, Epithelium, Viral vector, Mice, Transduction (genetics), Genetics, Animals, Humans, Molecular Biology, Cells, Cultured, Epithelial polarity, Analysis of Variance, Reporter gene, biology, Lentivirus, Genetic transfer, respiratory system, beta-Galactosidase, biology.organism_classification, Virology, Rats, Cell biology, Evaluation Studies as Topic, Vesicular stomatitis virus, Molecular Medicine, Respiratory epithelium
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المؤلفون: Carla Foy, Rodney Pearlman, Kim R. Jones, Larry G. Johnson, Peadar G. Noone, John Efthimiou, Zhaoqing Zhou, Caryl Schwartzbach, Margaret W. Leigh, Michael R. Knowles, Katherine W. Hohneker, Terry L. Noah, Richard C. Boucher, Clay L. Gipson
المصدر: Molecular Therapy. 1(1):105-114
مصطلحات موضوعية: Adult, Male, DNA, Complementary, Cystic Fibrosis, Nostril, Genetic enhancement, Cystic Fibrosis Transmembrane Conductance Regulator, Mucous membrane of nose, Pharmacology, Cystic fibrosis, Epithelium, Chlorides, Double-Blind Method, Drug Discovery, medicine, Genetics, Humans, Cationic liposome, Molecular Biology, DNA Primers, Base Sequence, biology, Electric Conductivity, Gene Transfer Techniques, Genetic Therapy, Middle Aged, respiratory system, medicine.disease, Cystic fibrosis transmembrane conductance regulator, Nasal Mucosa, medicine.anatomical_structure, Liposomes, Immunology, biology.protein, Nasal Lavage, Molecular Medicine, Female, Safety
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المؤلفون: Larry G. Johnson, Barbara R. Grubb, Richard C. Boucher, David Parsons
المصدر: Human Gene Therapy. 9:2661-2672
مصطلحات موضوعية: Genetic enhancement, Detergents, Genetic Vectors, Polidocanol, Cystic Fibrosis Transmembrane Conductance Regulator, Gene transfer, Nose, Biology, Permeability, Adenoviridae, Polyethylene Glycols, Viral vector, Mice, In vivo, Genetics, Animals, Pseudomonas Infections, Vector (molecular biology), Molecular Biology, Dose-Response Relationship, Drug, Gene Transfer Techniques, Epithelial Cells, Molecular biology, Cell biology, Nasal Mucosa, Intercellular Junctions, Lac Operon, Active agent, Pseudomonas aeruginosa, Molecular Medicine, Airway
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المؤلفون: Theodore Friedmann, Richard C. Boucher, Jennifer P. Mewshaw, John C. Olsen, Hong Ni, Larry G. Johnson
المصدر: Journal of Virology. 72:8861-8872
مصطلحات موضوعية: Cystic Fibrosis, Genetic Vectors, Respiratory System, Immunology, Cystic Fibrosis Transmembrane Conductance Regulator, Biology, Microbiology, Vesicular stomatitis Indiana virus, Cell Line, Mice, chemistry.chemical_compound, Multiplicity of infection, Viral Envelope Proteins, Western blot, Transduction, Genetic, In vivo, Virology, Murine leukemia virus, medicine, Animals, Humans, Sulfur Dioxide, Glycoproteins, Infectivity, Membrane Glycoproteins, medicine.diagnostic_test, Age Factors, Gene Transfer Techniques, Epithelial Cells, Gene Therapy, respiratory system, biology.organism_classification, Molecular biology, In vitro, Leukemia Virus, Murine, Trachea, Lac Operon, chemistry, Cell culture, Insect Science, Bromodeoxyuridine
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المؤلفون: Larry G. Johnson, James R. Yankaskas, Hugh R. Black, Terry L. Noah
المصدر: American Journal of Respiratory Cell and Molecular Biology. 19:210-215
مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Chemokine, Adolescent, Cystic Fibrosis, Clinical Biochemistry, Cystic Fibrosis Transmembrane Conductance Regulator, Stimulation, Biology, Cystic fibrosis, Adenoviridae, medicine, Humans, Interleukin 8, Respiratory system, Child, Molecular Biology, Cell Line, Transformed, Tumor Necrosis Factor-alpha, Interleukin-8, Gene Transfer Techniques, Interleukin, Cell Biology, Middle Aged, medicine.disease, Respiratory Syncytial Viruses, Nasal Mucosa, Child, Preschool, Immunology, biology.protein, Respiratory epithelium, Female, Tumor necrosis factor alpha
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