المؤلفون: Joglekar, Tejashree, Chin, Alexander, Voskanian-Kordi, Alin, Seungchul, Baek, Raja, Azim, Rege, Apurv, Huang, Weiliang, Kane, Maureen A, Laiho, Marikki, Webb, Thomas, Fan, Xiaoxuan, Rubenstein, Michael, Bieberich, Charles J., Li, Xiang

الاتاحة: https://dx.doi.org/10.13016/m2fkyb-awsg
https://mdsoar.org/handle/11603/34606

المؤلفون: Ford, Brittany, Wei, Ting, Liu, Hester, Scull, Catherine E., Najmi, Saman M., Pitts, Stephanie, Fan, Wenjun, Schneider, David A., Laiho, Marikki

المساهمون: Division of Pharmaceutical Biosciences, Faculty of Pharmacy

مصطلحات موضوعية: Medical biotechnology, Immunofluorescence, small interfering RNA, co-immunoprecipitation, chromatin immunoprecipitation, polymerase chain reaction, Biochemistry, cell and molecular biology, rRNA, RNA polymerase I, yeast, rDNA

وصف الملف: application/pdf

Relation: Ford , B , Wei , T , Liu , H , Scull , C E , Najmi , S M , Pitts , S , Fan , W , Schneider , D A & Laiho , M 2023 , ' Expression of RNA polymerase I catalytic core is influenced by RPA12 ' , PLoS One , vol. 18 , no. 5 , e028566 . https://doi.org/10.1371/journal.pone.0285660; http://hdl.handle.net/10138/357804; 85159609789; 001022249000001

الاتاحة: http://hdl.handle.net/10138/357804

المؤلفون: Pitts, Stephanie, Liu, Hester, Ibrahim, Adel, Garg, Amit, Felgueira, Catarina Mendes, Begum, Asma, Fan, Wenjun, Teh, Selina, Low, Jin Yih, Ford, Brittany, Schneider, David A., Hay, Ronald, Laiho, Marikki

المساهمون: Drug Research Program, TRIMM - Translational Immunology Research Program, Doctoral Programme in Drug Research, Faculty of Pharmacy

مصطلحات موضوعية: cancer, proteasome, small molecule, transcription, ubiquitin, Biomedicine, Cancers

وصف الملف: application/pdf

Relation: This work was supported by grants from the National Cancer Institute , National Institutes of Health (NIH; grant nos.: F31CA247077 to S. P. and P30CA006973 to M. L.) and National Institute of General Medical Sciences , NIH (grant no.: R01GM121404 to M. L. and D. A. S.). The content in this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.; Pitts , S , Liu , H , Ibrahim , A , Garg , A , Felgueira , C M , Begum , A , Fan , W , Teh , S , Low , J Y , Ford , B , Schneider , D A , Hay , R & Laiho , M 2022 , ' Identification of an E3 ligase that targets the catalytic subunit of RNA Polymerase I upon transcription stress ' , Journal of Biological Chemistry , vol. 298 , no. 12 , 102690 . https://doi.org/10.1016/j.jbc.2022.102690; http://hdl.handle.net/10138/354858; 7ca57775-5b1d-45dc-ad09-6f8981c89981; 85143584740

الاتاحة: http://hdl.handle.net/10138/354858

المؤلفون: Fan, Wenjun, Eklund, Eetu, Sherman, Rachel M., Liu, Hester, Pitts, Stephanie, Ford, Brittany, Rajeshkumar, N., Laiho, Marikki

المساهمون: TRIMM - Translational Immunology Research Program, Drug Research Program, Faculty of Pharmacy

مصطلحات موضوعية: rRNA, ribosome, rDNA array, 1000 Genomes Project, DNA, GENOME, VARIANTS, SEQUENCE, RDNA, Pharmacy

وصف الملف: application/pdf

Relation: ACKNOWLEDGMENTS This work was supported in part by National Institute of General Medical Sciences (NIGMS) R01GM121404 and National Cancer Institute (NCI) P30 CA006973. We thank Dr. Steven Salzberg for helpful discussions and the Maryland Advanced Research Computing Center (MARCC) for access to the high computing resource.; Fan , W , Eklund , E , Sherman , R M , Liu , H , Pitts , S , Ford , B , Rajeshkumar , N & Laiho , M 2022 , ' Widespread genetic heterogeneity of human ribosomal RNA genes ' , RNA , vol. 28 , no. 4 , pp. 478-492 . https://doi.org/10.1261/rna.078925.121; http://hdl.handle.net/10138/356760; f2448493-8492-49f7-a5e5-5aa27c98f2f5; 000779015100001

الاتاحة: http://hdl.handle.net/10138/356760

المؤلفون: Ford, Brittany L., Wei, Ting, Liu, Hester, Scull, Catherine E., Najmi, Saman M., Pitts, Stephanie, Fan, Wenjun, Schneider, David A., Laiho, Marikki

المساهمون: Roy, Arunava, National Cancer Institute

المصدر: PLOS ONE ; volume 18, issue 5, page e0285660 ; ISSN 1932-6203

الاتاحة: http://dx.doi.org/10.1371/journal.pone.0285660
https://dx.plos.org/10.1371/journal.pone.0285660

المؤلفون: Pitts, Stephanie, Liu, Hester, Ibrahim, Adel, Garg, Amit, Felgueira, Catarina Mendes, Begum, Asma, Fan, Wenjun, Teh, Selina, Low, Jin-Yih, Ford, Brittany, Schneider, David A., Hay, Ronald, Laiho, Marikki

المصدر: Pitts , S , Liu , H , Ibrahim , A , Garg , A , Felgueira , C M , Begum , A , Fan , W , Teh , S , Low , J-Y , Ford , B , Schneider , D A , Hay , R & Laiho , M 2022 , ' Identification of an E3 ligase that targets the catalytic subunit of RNA polymerase I upon transcription stress ' , Journal of Biological Chemistry , vol. 298 , no. 12 , 102690 . https://doi.org/10.1016/j.jbc.2022.102690

مصطلحات موضوعية: transcription, ubiquitin, proteasome, small molecule, cancer, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology

وصف الملف: application/pdf

الاتاحة: https://discovery.dundee.ac.uk/en/publications/5139ce3d-9a30-44e1-846e-edab0948cb5b
https://doi.org/10.1016/j.jbc.2022.102690
https://discovery.dundee.ac.uk/ws/files/91564430/PIIS0021925822011334.pdf
http://www.scopus.com/inward/record.url?scp=85143584740&partnerID=8YFLogxK

المؤلفون: Jacobs, Ruth Q., Huffines, Abigail K., Laiho, Marikki, Schneider, David A.

المساهمون: National Institutes of Health, National Institute of General Medical Sciences

المصدر: Journal of Biological Chemistry ; volume 298, issue 1, page 101450 ; ISSN 0021-9258

الاتاحة: http://dx.doi.org/10.1016/j.jbc.2021.101450
https://api.elsevier.com/content/article/PII:S002192582101259X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S002192582101259X?httpAccept=text/plain

المؤلفون: Hämäläinen, Riikka H., Landoni, Juan C., Ahlqvist, Kati J., Goffart, Steffi, Ryytty, Sanna, Rahman, M. Obaidur, Brilhante, Virginia, Icay, Katherine, Hautaniemi, Sampsa, Wang, Liya, Laiho, Marikki, Suomalainen, Anu

المساهمون: STEMM - Stem Cells and Metabolism Research Program, Research Programs Unit, University of Helsinki, HUSLAB, Research Program in Systems Oncology, Sampsa Hautaniemi / Principal Investigator, Bioinformatics, Department of Biochemistry and Developmental Biology, HUS Helsinki and Uusimaa Hospital District, Neurologian yksikkö, Helsinki University Hospital Area, Neuroscience Center

مصطلحات موضوعية: PHENOTYPES, MUTATIONS, DISTINCT, MICE, Biomedicine, Biochemistry, cell and molecular biology, Neurosciences

وصف الملف: application/pdf

Relation: Hämäläinen , R H , Landoni , J C , Ahlqvist , K J , Goffart , S , Ryytty , S , Rahman , M O , Brilhante , V , Icay , K , Hautaniemi , S , Wang , L , Laiho , M & Suomalainen , A 2020 , ' Reply to : Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos ' , Nature metabolism , vol. 2 , no. 8 , pp. 676-677 . https://doi.org/10.1038/s42255-020-0265-y; ORCID: /0000-0002-7749-2694/work/80576245; ORCID: /0000-0002-0318-6707/work/80577591; http://hdl.handle.net/10138/326256; 58886eb0-f009-4a46-9cef-b81b18199feb; 000561178600009

الاتاحة: http://hdl.handle.net/10138/326256

المؤلفون: Joglekar, Tejashree, Chin, Alexander, Voskanian-Kordi, Alin, Baek, Seungchul, Raja, Azim, Rege, Apurv, Huang, Weiliang, Kane, Maureen, Laiho, Marikki, Webb, Thomas R., Fan, Xiaoxuan, Rubenstein, Michael, Bieberich, Charles J., Li, Xiang

المصدر: Blood Advances; August 2024, Vol. 8 Issue: 15 p3880-3892, 13p

المؤلفون: Wright, Jean L., Alcorn, Sara R., McNutt, Todd, Han-Oh, Sarah, Gonzalez, Raul, Lin, Lan, Anderson, Roberta, Wieworka, Jennifer, Deville, Curtiland, Ladra, Matthew, Meyer, Jeffrey, Hales, Russel, Voong, Ranh, Narang, Amol, Vogel, Jennifer, Asrari, Fariba, Kiess, Ana, Song, Daniel, Tran, Phuoc, Kleinberg, Lawrence, Redmond, Kristin, Tsien, Christina, Quon, Harry, Page, Brandi, Croog, Victoria, Walker, Amanda, Greco, Stephen, Laiho, Marikki, Viswanathan, Akila

المصدر: Advances in Radiation Oncology ; volume 5, issue 4, page 666-672 ; ISSN 2452-1094

الاتاحة: http://dx.doi.org/10.1016/j.adro.2020.03.014
https://api.elsevier.com/content/article/PII:S2452109420300671?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2452109420300671?httpAccept=text/plain

المؤلفون: GÜNER, GÜNEŞ, Laiho, Marikki, Bieberich, Charles, De Marzo, Angelo M., Yang, Zhiming, Liu, Hester, Rege, Apurv, Agarwal, Shreya, Moubarek, Michael, Sirajuddin, Paul, Low, Jin-Yih

الاتاحة: https://doi.org/10.1002/pros.23909
https://avesis.hacettepe.edu.tr/publication/details/5f952c5e-cc49-4cdf-911c-00c807c3c286/oai

المؤلفون: Wei, Ting, Najmi, Saman M., Liu, Hester, Peltonen, Karita, Kucerova, Alena, Schneider, David A., Laiho, Marikki

المساهمون: Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Institute of Biotechnology, Drug Research Program, ImmunoViroTherapy Lab

مصطلحات موضوعية: transcription, elongation, cancer therapeutics, rRNA, nucleolus, yeast, G-QUADRUPLEX, CANCER, MACHINERY, PROMOTER, PATHWAY, STRESS, GENES, STEPS, DRUG, P53, Pharmacy, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

Relation: Wei , T , Najmi , S M , Liu , H , Peltonen , K , Kucerova , A , Schneider , D A & Laiho , M 2018 , ' Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint ' , Cell Reports , vol. 23 , no. 2 , pp. 404-414 . https://doi.org/10.1016/j.celrep.2018.03.066; RIS: urn:0DB0930C98107F8D2B27638971487CF4; ORCID: /0000-0002-3063-451X/work/44189199; http://hdl.handle.net/10138/234589; 2759d909-592c-46e3-92d4-823bf22f326c; 85045021180; 000429866600007

الاتاحة: http://hdl.handle.net/10138/234589

المؤلفون: GÜNER, GÜNEŞ, De Marzo, Angelo M., Laiho, Marikki, Kulac, Ibrahim, af Hallstrom, Taija, Liu, Hester, Brodie, Alexandra, Bai, Baoyan, Zheng, Qizhi, Sirajuddin, Paul

الاتاحة: https://doi.org/10.1158/1541-7786.mcr-16-0246
https://avesis.hacettepe.edu.tr/publication/details/bee26d2e-f258-4fb5-a52e-852632d6440a/oai

المؤلفون: Colis, Laureen, Ernst, Glen, Sanders, Sara, Liu, Hester, Sirajuddin, Paul, Peltonen, Karita, DePasquale, Michael, Barrow, James C., Laiho, Marikki

المساهمون: Faculty of Pharmacy, Cancer Molecular biology and Therapeutics

مصطلحات موضوعية: CANCER, TRANSCRIPTION, DISCOVERY, NUCLEOLUS, MECHANISM, STRATEGY, Pharmacy

وصف الملف: application/pdf

Relation: This work has been supported by NIH Grants P30 CA006973 and 1R01CA172069 (M.L.) and Johns Hopkins University start-up funds.; Colis , L , Ernst , G , Sanders , S , Liu , H , Sirajuddin , P , Peltonen , K , DePasquale , M , Barrow , J C & Laiho , M 2014 , ' Design, Synthesis, and Structure-Activity Relationships of Pyridoquinazolinecarboxamides as RNA Polymerase I Inhibitors ' , Journal of Medicinal Chemistry , vol. 57 , no. 11 , pp. 4950-4961 . https://doi.org/10.1021/jm5004842; ORCID: /0000-0002-3063-451X/work/39897485; http://hdl.handle.net/10138/224460; e85efa02-815e-4d01-8d44-a964114b53e4; 84902476120; 000337336600039

الاتاحة: http://hdl.handle.net/10138/224460

المؤلفون: Kara, Bülent, Köroğlu, Çiğdem, Peltonen, Karita, Steinberg, Ruchama C, Maraş Genç, Hülya, Hölttä-Vuori, Maarit, Güven, Ayşe, Kanerva, Kristiina, Kotil, Tuğba, Solakoğlu, Seyhun, Zhou, You, Olkkonen, Vesa M, Ikonen, Elina, Laiho, Marikki, Tolun, Aslıhan

المصدر: European Journal of Human Genetics ; volume 25, issue 3, page 315-323 ; ISSN 1018-4813 1476-5438

الاتاحة: http://dx.doi.org/10.1038/ejhg.2016.183
http://www.nature.com/articles/ejhg2016183.pdf
http://www.nature.com/articles/ejhg2016183

المؤلفون: Anklesaria, Pervin, Teixido, Joaquin, Laiho, Marikki, Pierce, Jacalyn H., Greenberger, Joel S., Massague, Joan

المساهمون: Department of Radiation Oncology

المصدر: Proceedings of the National Academy of Sciences of the United States of America ; 87 ; 9 ; 3289-93

مصطلحات موضوعية: Animals, Cell Adhesion, Cell Division, Cell Line, Cell Nucleus, Epidermal Growth Factor, Genetic Vectors, Growth Substances, Hematopoietic Stem Cells, Kinetics, Mice, Protein Precursors, RNA, Messenger, Receptor, Transfection, Transforming Growth Factor alpha, Transforming Growth Factors, Life Sciences, Medicine and Health Sciences

Relation: Link to Article in PubMed; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53885/; Proc Natl Acad Sci U S A. 1990 May;87(9):3289-93.; 0027-8424 (Print); 2333283; http://hdl.handle.net/20.500.14038/39007; https://escholarship.umassmed.edu/oapubs/1832; 808598; oapubs/1832

الاتاحة: https://hdl.handle.net/20.500.14038/39007
https://escholarship.umassmed.edu/oapubs/1832

المؤلفون: Pitts, Stephanie, Liu, Hester, Ibrahim, Adel, Garg, Amit, Mendes Felgueira, Catarina, Begum, Asma, Fan, Wenjun, Teh, Selina, Low, Jin-Yih, Ford, Brittany, Schneider, David A., Hay, Ronald, Laiho, Marikki

المصدر: SSRN Electronic Journal ; ISSN 1556-5068

الاتاحة: http://dx.doi.org/10.2139/ssrn.4073012

المؤلفون: Dorado, Tony E., de León, Pablo, Begum, Asma, Liu, Hester, Chen, Daming, Rajeshkumar, N. V., Rey-Rodriguez, Romain, Hoareau-Aveilla, Coralie, Alcouffe, Chantal, Laiho, Marikki, Barrow, James C.

المساهمون: National Cancer Institute, Lieber Institute for Brain Development, National Institute of General Medical Sciences, Bluefield Innovations LLC

المصدر: ACS Medicinal Chemistry Letters ; volume 13, issue 4, page 608-614 ; ISSN 1948-5875 1948-5875

الاتاحة: http://dx.doi.org/10.1021/acsmedchemlett.1c00660
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.1c00660

المؤلفون: Claiborne, Michael D., Sengupta, Srona, Zhao, Liang, Arwood, Matthew L., Sun, Im-Meng, Wen, Jiayu, Thompson, Elizabeth A., Mitchell-Flack, Marisa, Laiho, Marikki, Powell, Jonathan D.

المصدر: Science Immunology ; volume 7, issue 71 ; ISSN 2470-9468

الاتاحة: http://dx.doi.org/10.1126/sciimmunol.abh4271
https://www.science.org/doi/pdf/10.1126/sciimmunol.abh4271

المؤلفون: Balistreri, Giuseppe, Viiliainen, Johanna, Turunen, Mikko, Diaz, Raquel, Lyly, Lauri, Pekkonen, Pirita, Rantala, Juha, Ojala, Krista, Sarek, Grzegorz, Teesalu, Mari, Denisova, Oxana, Peltonen, Karita, Julkunen, Ilkka, Varjosalo, Markku, Kainov, Denis, Kallioniemi, Olli, Laiho, Marikki, Taipale, Jussi, Hautaniemi, Sampsa, Ojala, Paivi M.

المساهمون: Research Programs Unit, Translational Cancer Biology (TCB) Research Programme, Genome-Scale Biology (GSB) Research Program, Department of Pathology, Medicum, Nutrient sensing laboratory, Institute for Molecular Medicine Finland, Faculty of Pharmacy, Molecular Systems Biology, Denis Kainov / Principal Investigator, Olli-Pekka Kallioniemi / Principal Investigator, Jussi Taipale / Principal Investigator, Sampsa Hautaniemi / Principal Investigator, Bioinformatics, Drug Research Program, ImmunoViroTherapy Lab

مصطلحات موضوعية: SARCOMA-ASSOCIATED HERPESVIRUS, EPSTEIN-BARR-VIRUS, MITOTIC CHROMOSOME CONDENSATION, HISTONE H3 PHOSPHORYLATION, DNA-DAMAGE CHECKPOINT, BREAST-CANCER CELLS, KAPOSIS-SARCOMA, GENE-EXPRESSION, NUCLEAR ANTIGEN, INDUCED LYMPHOMAS, Biomedicine

وصف الملف: application/pdf

Relation: Research reported in this publication was supported by Academy of Finland (http://www.aka.fi/en), University of Helsinki (https://www.helsinki.fi/en), Cancer Society of Finland, (http://www.cancer.fi/en), and K. Albin Johansson Foundation (http://www.foundationweb.net/johansson/), Sigrid Juselius Foundation (www.sigridjuselius.fi/foundation) to PMO. GB was supported by Finnish Cancer Foundation (http://syopasaatio.fi/). JV was supported by Doctoral Program for Biomedicine (www.helsinki.fi/dpbm/), K. Albin Johansson Foundation, and Instrumentarium Science Foundation (http://www.instrufoundation.fi/index.php?k=18077). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; Balistreri , G , Viiliainen , J , Turunen , M , Diaz , R , Lyly , L , Pekkonen , P , Rantala , J , Ojala , K , Sarek , G , Teesalu , M , Denisova , O , Peltonen , K , Julkunen , I , Varjosalo , M , Kainov , D , Kallioniemi , O , Laiho , M , Taipale , J , Hautaniemi , S & Ojala , P M 2016 , ' Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication ' , PLoS Pathogens , vol. 12 , no. 2 , 1005424 . https://doi.org/10.1371/journal.ppat.1005424; ORCID: /0000-0002-3063-451X/work/39897487; ORCID: /0000-0002-7749-2694/work/29942478; ORCID: /0000-0002-1340-9732/work/37568881; ORCID: /0000-0001-5033-3223/work/75466435; http://hdl.handle.net/10138/165104; 78168259-960e-4e08-b88f-d3a361d090e4; 84959487038; 000378152900024

الاتاحة: http://hdl.handle.net/10138/165104