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المؤلفون: Songsong Wang, Peng Li, Liang Zou, Jianbo Xiao, Feiya Sheng
المصدر: Journal of Advanced Research
مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, SREBPs, sterol regulatory element binding proteins, SREBP2, sterol regulatory element-binding protein 2, SHP, small heterodimer partner, chemistry.chemical_compound, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, LXRα, liver X receptor α, VLDL, very low-density lipoprotein, Multidisciplinary, TG, triglyceride, Bile acid, Chemistry, Fatty liver, FGF15/19, fibroblast growth factor 15/19, Cholesterol, WB, Western blot, ACC, Acetyl-CoA carboxylase, 030220 oncology & carcinogenesis, Lipogenesis, Quercetin, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, Bile acid metabolism, SDS, sodium dodecyl sulfate, TGR5, Takeda G-protein-coupled receptor 5, medicine.drug_class, Hyperoside, LC-MS, the combination of high-performance liquid chromatography and mass spectrometry, Article, Bile Acids and Salts, pACC, phosphorylated ACC, 03 medical and health sciences, Label-free proteomics, FXR, farnesoid X receptor, CYP27A1, sterol 27-hydroxylase, NAFLD, Internal medicine, medicine, Animals, Cholesterol metabolism, Liver X receptor, ComputingMethodologies_COMPUTERGRAPHICS, BAs, bile acids, SREBP1, sterol regulatory element-binding protein 1, Targeted metabolomics, Lipid Metabolism, CYP7A1, cholesterol 7α-hydroxylase, medicine.disease, Rats, TC, total cholesterol, QC, quality control, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, PMSF, phenylmethylsulfonyl fluoride, Apo, apolipoprotein, BSH, bile salt hydrolase, Farnesoid X receptor
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المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress
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المؤلفون: Mingjiang Zhu, Mingming Zhao, Shanshan Zhong, Xinli Xue, Shuyuan Guo, L. L. Li, Jianhong Lu, Yongzhen Tao, Buxing Chen, Qun Chen, Mengqing Xiao, Yujuan Zhuo, Chunzhao Yin, Huiyong Yin, Lemin Zheng, Xia Shen
المصدر: Redox Biology, Vol 21, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: RT, retention time, Male, TLR4, Toll like receptor 4, BEP-CE, Bicyclic endoperoxide and hydroperoxide cholesterol ester, CHD, coronary heart disease, Biochemistry, Mass Spectrometry, Mice, 0302 clinical medicine, LXRα, liver X receptor α, oxLA-CE, oxidized LA-CE, Myocardial infarction, HMGCR, HMG-CoA reductase, CBD, cerebrovascular diseases, lcsh:QH301-705.5, chol-d7, cholesterol-d7, Idol, inducible degrader of the LDL receptor, AMVN, 2, 2′-azobis(2,4-dimethylvaleronitrile), GW, GW 3965, LDLR, LDL receptor, mmLDL, minimally modified LDL, Cholesterol, WT, wide type, Cardiovascular Diseases, Knockout mouse, MI, myocardial infarction, Cholesterol Esters, lcsh:Medicine (General), ch-HpETE, cholesteryl-hydroperoxy-eicosatetraenoate, medicine.medical_specialty, NH4OAc, ammonium acetate, LA-CEOH, LA-CE hydroxide, Lipid peroxidation, CVD, cardiovascular disease, SYK, spleen tyrosine kinase, 03 medical and health sciences, PUFA, polyunsaturated fatty acid, Humans, Aged, TLC, thin layer chromatography, Macrophages, ch-HpODE, cholesteryl-hydroperoxy-octadecadienoate, Lipid Metabolism, medicine.disease, Dil-LDL, 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate labeled LDL, 030104 developmental biology, Endocrinology, LA-CE, cholesteryl linoleate, LDL oxidation, Biomarkers, 030217 neurology & neurosurgery, MRM, multiple reaction monitoring, 0301 basic medicine, CE19:0, cholesteryl nonadecanoate, Clinical Biochemistry, ch-HODE, cholesteryl-hydroxy-octadecadienoate, Endogeny, LDL, low density lipoprotein, Pathogenesis, Cholesterol/metabolism, chemistry.chemical_compound, BSTFA+TMCS, Bis-(trimethylsilyl)-trifluoroacetamide+Trimethylchlorosilane, Cholesterol uptake, IS, internal standard, PPh3, triphenylphosphine, CEOH, CE hydroxide, Liver X Receptors, lcsh:R5-920, CEOOH, cholesterol ester hydroperoxide, Chemistry, BMDM, bone marrow-derived macrophage, Middle Aged, CVD, ch-13c,t-HpODE, cholesteryl-13(cis, trans)-hydroperoxy-octadecadienoate, ch-HETE, cholesteryl-hydroxy-eicosatetraenoate, Metabolome, LXR, Female, lipids (amino acids, peptides, and proteins), oxCE, oxidized CE, Research Paper, IPA, isopropanol, AA-CE, cholesteryl arachidonate, Cholesterol ester hydroperoxides, CE, cholesterol ester, T09, T0901317, ROS, reactive oxygen species, Internal medicine, BHT, butylated hydroxytoluene, medicine, Animals, oxLDL, oxidized LDL, Organic Chemistry, IP, intraperitoneal injection, Disease Models, Animal, LDLR, Receptors, LDL, lcsh:Biology (General), NaOMe, sodium methoxide, Lipidomics, LDL receptor, Hepatocytes, Chromatography, Liquid, Lipoprotein
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المؤلفون: Zhuohong Xie, Haiqiu Huang, Liangli Yu, Wallace Yokoyama, Thomas T. Y. Wang
المصدر: Journal of Nutritional Science
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Very low-density lipoprotein, 7-Dehydrocholesterol reductase, RXR, retinoid X receptor, Endocrinology, Diabetes and Metabolism, Sterol O-acyltransferase, SREBP, sterol regulatory element-binding protein, CYP51, Biology, Cholesterol 7 alpha-hydroxylase, 03 medical and health sciences, 0302 clinical medicine, HF, high-fat, Internal medicine, HMG, 3-hydroxy-3-methyl-glutaryl, LXRα, liver X receptor α, medicine, Cholesterol 24-hydroxylase, Liver X receptor, Circulating cholesterol, Hypercholesterolaemia, IPA, Ingenuity Pathway Analysis, Nutrition and Dietetics, Reverse cholesterol transport, ABCG5/, ATP-binding cassette subfamily G member 5/8, CYP7A1, cholesterol 7α-hydroxylase, HF + CA, high-fat + cholestyramine, 030104 developmental biology, Endocrinology, 030220 oncology & carcinogenesis, HMG-CoA reductase, Hamsters, biology.protein, lipids (amino acids, peptides, and proteins), CYP51, lanosterol 14α-demethylase, CA, cholestyramine, Research Article, Food Science