المؤلفون: Lüth, Theresa, Gabbert, Carolin, Koch, Sebastian, König, Inke R, Caliebe, Amke, Laabs, Björn-Hergen, Hentati, Faycel, Sassi, Samia Ben, Amouri, Rim, Spielmann, Malte, Klein, Christine, GRÜNEWALD, Anne, Farrer, Matthew J, Trinh, Joanne

المصدر: Movement Disorders, 38 (10), 1837 - 1849 (2023-10)

مصطلحات موضوعية: gene-environment interaction, mitochondrial genes, polygenic score, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, LRRK2 protein, human, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Age of Onset, Risk Factors, Life Style, Mutation, Protein Serine-Threonine Kinases/genetics, Parkinson Disease/complications, Parkinson Disease, Neurology, Neurology (clinical), Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

Relation: urn:issn:0885-3185; urn:issn:1531-8257; https://orbilu.uni.lu/handle/10993/57728; info:hdl:10993/57728; info:pmid:37482924; wos:001033699200001

الاتاحة: https://orbilu.uni.lu/handle/10993/57728
https://orbilu.uni.lu/bitstream/10993/57728/1/Movement%20Disorders%20-%202023%20-%20L%20th%20-%20Interaction%20of%20Mitochondrial%20Polygenic%20Score%20and%20Lifestyle%20Factors%20in%20LRRK2%20p%20Gly2019Ser.pdf
https://doi.org/10.1002/mds.29563

المؤلفون: OLEKSY, Christiane, Massart, François, Goldwurm, Stefano, Arado, Alessia, ARENA, Giuseppe, BOUSSAAD, Ibrahim, Krüger, Rejko

المصدر: Stem Cell Research, 72, 103212 (2023-10)

مصطلحات موضوعية: LRRK2 protein, human, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Humans, Mutation/genetics, Fibroblasts/metabolism, Dopaminergic Neurons/metabolism, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Induced Pluripotent Stem Cells/metabolism, Parkinson Disease/genetics, Parkinson Disease/metabolism, Dopaminergic Neurons, Fibroblasts, Induced Pluripotent Stem Cells, Mutation, Parkinson Disease, Developmental Biology, Cell Biology, General Medicine, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques

Relation: https://api.elsevier.com/content/article/PII:S1873506123001988?httpAccept=text/xml; urn:issn:1873-5061; urn:issn:1876-7753; https://orbilu.uni.lu/handle/10993/58996; info:hdl:10993/58996; https://orbilu.uni.lu/bitstream/10993/58996/1/Oleksy%20et%20al.%2c%202023.pdf; info:pmid:37832355; wos:001099165300001

الاتاحة: https://orbilu.uni.lu/handle/10993/58996
https://orbilu.uni.lu/bitstream/10993/58996/1/Oleksy%20et%20al.%2c%202023.pdf
https://doi.org/10.1016/j.scr.2023.103212

المؤلفون: Singh, Ranjan K, Soliman, Ahmed, David, Joshua A, Pardon, Els, Schwartz, Thomas U, Knapp, Stefan, Kennedy, Eileen J, Steyaert, Jan, Herberg, Friedrich W, Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim, Guaitoli, Giambattista, Störmer, Eliza, Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H, Chatterjee, Deep

المصدر: Proceedings of the National Academy of Sciences of the United States of America 119(9), e2112712119 (2022). doi:10.1073/pnas.2112712119

مصطلحات موضوعية: info:eu-repo/classification/ddc/500, Adenosine Triphosphate: metabolism, Allosteric Regulation, Animals, Binding Sites, Epitope Mapping, HEK293 Cells, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: metabolism, Mice, Microtubules: metabolism, Parkinson Disease: metabolism, Phosphorylation, Protein Binding, RAW 264.7 Cells, Single-Domain Antibodies, rab GTP-Binding Proteins: metabolism, LRRK2, Parkinson’s disease, allosteric inhibitor, drug design, nanobody, Adenosine Triphosphate, LRRK2 protein, human, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, rab GTP-Binding Proteins

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/0027-8424; info:eu-repo/semantics/altIdentifier/pmid/pmid:35217606; info:eu-repo/semantics/altIdentifier/issn/1091-6490; https://pub.dzne.de/record/163406; https://pub.dzne.de/search?p=id:%22DZNE-2022-00168%22

الاتاحة: https://pub.dzne.de/record/163406
https://pub.dzne.de/search?p=id:%22DZNE-2022-00168%22

المؤلفون: Marrone, Lara, Bus, Christine, Meixner, Andrea, Klink, Barbara, Glatza, Michael, Gloeckner, Christian Johannes, Gasser, Thomas, Sterneckert, Jared, Schöndorf, David, Fitzgerald, Julia Catherine, Kübler, Manuela, Schmid, Benjamin, Reinhardt, Peter, Reinhardt, Lydia, Deleidi, Michela, Levin, Tanya

المصدر: PLOS ONE 13(3), e0192497 (2018). doi:10.1371/journal.pone.0192497

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Aged, Alleles, Cell Differentiation: genetics, Cells, Cultured, Female, Humans, Induced Pluripotent Stem Cells: metabolism, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: genetics, Male, Middle Aged, Models, Genetic, Parkinson Disease: genetics, Parkinson Disease: pathology, Pilot Projects, Polymorphism, Single Nucleotide, Risk Factors, LRRK2 protein, human, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1932-6203; info:eu-repo/semantics/altIdentifier/pmid/pmid:29513666; https://pub.dzne.de/record/139842; https://pub.dzne.de/search?p=id:%22DZNE-2020-06164%22

الاتاحة: https://pub.dzne.de/record/139842
https://pub.dzne.de/search?p=id:%22DZNE-2020-06164%22

المؤلفون: Ranjan K. Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H. Schmidt, Deep Chatterjee, Joshua A. David, Els Pardon, Thomas U. Schwartz, Stefan Knapp, Eileen J. Kennedy, Jan Steyaert, Friedrich W. Herberg, Arjan Kortholt, Christian Johannes Gloeckner, Wim Versées

المساهمون: Cell Biochemistry, Molecular Pharmacology, Department of Bio-engineering Sciences, Faculty of Medicine and Pharmacy, Structural Biology Brussels

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 119(9):e2112712119. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America 119(9), e2112712119 (2022). doi:10.1073/pnas.2112712119

مصطلحات موضوعية: drug design, metabolism [Microtubules], Parkinson's disease, metabolism [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], metabolism [Parkinson Disease], Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Microtubules, Mice, Adenosine Triphosphate, Allosteric Regulation, Animals, Humans, LRRK2 protein, human, Phosphorylation, LRKK2, allosteric inhibitor, Multidisciplinary, Binding Sites, LRRK2, Parkinson Disease, Single-Domain Antibodies, metabolism [rab GTP-Binding Proteins], nervous system diseases, nanobody, HEK293 Cells, RAW 264.7 Cells, rab GTP-Binding Proteins, metabolism [Adenosine Triphosphate], Parkinson’s disease, ddc:500, Epitope Mapping, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec9137a034b6629ae019cb5b5d3957f
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98457

المؤلفون: Valerie Tokars, Chuyu Chen, Loukia Parisiadou

المصدر: Trends in biochemical sciences. 47(3)

مصطلحات موضوعية: LRRK2 Gene, Parkinson's disease, Structure (category theory), Parkinson Disease, Computational biology, Biology, medicine.disease, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, LRRK2, nervous system diseases, Mutation, medicine, LRRK2 Protein, Humans, Closing (morphology), Molecular Biology, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c84df6bc70779f24896c37923065da79
https://pubmed.ncbi.nlm.nih.gov/34756665

المؤلفون: Brown, Emmeline E, Blauwendraat, Cornelis, Hassin-Baer, Sharon, Brockmann, Kathrin, Infante, Jon, Tolosa, Eduardo, Ezquerra, Mario, Ben Romdhan, Sawssan, Benmahdjoub, Mustapha, Arezki, Mohamed, Mhiri, Chokri, Hardy, John, Trinh, Joanne, Singleton, Andrew B, Alcalay, Roy N, Gasser, Thomas, Grosset, Donald G, Williams, Nigel M, Pittman, Alan, Gan-Or, Ziv, Fernández-Santiago, Rubén, Brice, Alexis, Lesage, Suzanne, Rizig, Mie, Farrer, Matthew, Wood, Nicholas, Morris, Huw R, Consortium, International Parkinson Disease Genomics, Nalls, Mike A, Leveille, Etienne, Ruskey, Jennifer A, Jonvik, Hallgeir, Tan, Manuela M X, Bandres-Ciga, Sara

المصدر: Neurobiology of aging 97, 148.e17 - 148.e24 (2021). doi:10.1016/j.neurobiolaging.2020.07.002

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Age of Onset, Aged, Cohort Studies, Dynamin III: genetics, Epistasis, Genetic: genetics, Female, Genetic Association Studies, Genetic Predisposition to Disease: genetics, Genetic Variation: genetics, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: genetics, Linkage Disequilibrium: genetics, Male, Middle Aged, Parkinson Disease: epidemiology, Parkinson Disease: ethnology, Parkinson Disease: genetics, R-SNARE Proteins: genetics, Risk, Genetic modifiers, Leucine-rich repeat kinase 2, Parkinsonism, Parkinson’s disease, R-SNARE Proteins, VAMP4 protein, human, LRRK2 protein, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/0197-4580; info:eu-repo/semantics/altIdentifier/pmid/pmid:32873436; info:eu-repo/semantics/altIdentifier/issn/1558-1497; https://pub.dzne.de/record/155708; https://pub.dzne.de/search?p=id:%22DZNE-2021-00876%22

الاتاحة: https://pub.dzne.de/record/155708
https://pub.dzne.de/search?p=id:%22DZNE-2021-00876%22

المؤلفون: Giesert, Florian, Hofmann, Andreas, Bürger, Alexander, Zerle, Julia, Kloos, Karina, Hafen, Ulrich, Ernst, Luise, Zhang, Jingzhong, Vogt-Weisenhorn, Daniela Maria, Wurst, Wolfgang

المصدر: PLOS ONE 8(5), e63778 (2013). doi:10.1371/journal.pone.0063778

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Alternative Splicing, Animals, Brain: metabolism, Embryonic Development: genetics, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Order, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mice, Neurons: metabolism, Protein-Serine-Threonine Kinases: genetics, Protein-Serine-Threonine Kinases: metabolism, RNA, Messenger: genetics, Messenger: metabolism, Messenger, Lrrk1 protein, mouse, Lrrk2 protein, Protein-Serine-Threonine Kinases

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1932-6203; info:eu-repo/semantics/altIdentifier/pmid/pmid:23675505; https://pub.dzne.de/record/136909; https://pub.dzne.de/search?p=id:%22DZNE-2020-03231%22

الاتاحة: https://pub.dzne.de/record/136909
https://pub.dzne.de/search?p=id:%22DZNE-2020-03231%22

المؤلفون: Reinhardt, Peter, Glatza, Michael, Wu, Guangming, Schmid, Benjamin, Röpke, Albrecht, Klingauf, Jürgen, Schwamborn, Jens C, Gasser, Thomas, Schöler, Hans R, Sterneckert, Jared, Hemmer, Kathrin, Tsytsyura, Yaroslav, Thiel, Cora S, Höing, Susanne, Moritz, Sören, Parga, Juan A, Wagner, Lydia, Bruder, Jan M

المصدر: PLOS ONE 8(3), e59252 (2013). doi:10.1371/journal.pone.0059252

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Cell Differentiation: genetics, Cell Differentiation: physiology, Cells, Cultured, Electrophysiology, Epithelial Cells: cytology, Epithelial Cells: metabolism, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Motor Neurons: cytology, Motor Neurons: metabolism, Neural Crest: cytology, Neural Crest: metabolism, Neural Stem Cells: cytology, Neural Stem Cells: metabolism, Neurodegenerative Diseases: genetics, Neurodegenerative Diseases: metabolism, Neurons: cytology, Neurons: metabolism, Protein-Serine-Threonine Kinases: genetics, Protein-Serine-Threonine Kinases: metabolism, LRRK2 protein, human, Protein-Serine-Threonine Kinases

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1932-6203; info:eu-repo/semantics/altIdentifier/pmid/pmid:23533608; https://pub.dzne.de/record/136849; https://pub.dzne.de/search?p=id:%22DZNE-2020-03171%22

الاتاحة: https://pub.dzne.de/record/136849
https://pub.dzne.de/search?p=id:%22DZNE-2020-03171%22

المؤلفون: Haebig, Karina, Gloeckner, Christian Johannes, Garcia-Miralles, Marta, Gillardon, Frank, Schulte, Claudia, Riess, Olaf, Ueffing, Marius, Biskup, Saskia, Bonin, Michael

المصدر: PLOS ONE 5(10), e13762 (2010). doi:10.1371/journal.pone.0013762

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Cell Line, Guanine Nucleotide Exchange Factors: metabolism, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Phosphorylation, Protein-Serine-Threonine Kinases: metabolism, Recombinant Proteins: metabolism, Rho Guanine Nucleotide Exchange Factors, ARHGEF7 protein, human, Guanine Nucleotide Exchange Factors, Recombinant Proteins, LRRK2 protein, Protein-Serine-Threonine Kinases

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1932-6203; info:eu-repo/semantics/altIdentifier/pmid/pmid:21048939; https://pub.dzne.de/record/136127; https://pub.dzne.de/search?p=id:%22DZNE-2020-02449%22

الاتاحة: https://pub.dzne.de/record/136127
https://pub.dzne.de/search?p=id:%22DZNE-2020-02449%22

المؤلفون: Ying, Fan, Andrew J M, Howden, Adil R, Sarhan, Pawel, Lis, Genta, Ito, Terina N, Martinez, Kathrin, Brockmann, Thomas, Gasser, Dario R, Alessi, Esther M, Sammler

المصدر: Biochemical Journal
Biochemical journal 475(1), 23-44 (2017). doi:10.1042/BCJ20170803

مصطلحات موضوعية: pharmacology [Protein Kinase Inhibitors], pathology [Leukocytes, Mononuclear], antagonists & inhibitors [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], Parkinson's disease, Epitopes, neutrophils, Antibody Specificity, genetics [Parkinson Disease], immunology [Gyrus Cinguli], diagnostics, antibodies, Phosphorylation, Research Articles, Clinical Trials as Topic, immunology [Neutrophils], pathology [Neutrophils], isolation & purification [Antibodies, Phospho-Specific], Antibodies, Monoclonal, Parkinson Disease, LRRK2, immunology [Epitopes], ddc:540, Rabbits, Rab10 protein, human, Signal Transduction, Research Article, monoclonal, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Gyrus Cinguli, immunology [Parkinson Disease], leucine-rich repeat kinase, immunology [Leukocytes, Mononuclear], Commentaries, chemistry [Epitopes], immunology [rab GTP-Binding Proteins], Animals, Humans, chemistry [Antibodies, Monoclonal], Genetic Predisposition to Disease, chemistry [rab GTP-Binding Proteins], LRRK2 protein, human, chemistry [Antibodies, Phospho-Specific], Protein Kinase Inhibitors, physiopathology [Gyrus Cinguli], Enzyme Assays, biomarkers, nervous system diseases, immunology [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], Gene Expression Regulation, Rab proteins, rab GTP-Binding Proteins, Case-Control Studies, Mutation, Rab10, Leukocytes, Mononuclear, Commentary, genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], genetics [rab GTP-Binding Proteins], enzymology [Parkinson Disease], Antibodies, Phospho-Specific, isolation & purification [Antibodies, Monoclonal]

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::65f956fa3c03c86699d3e431da15e234
http://europepmc.org/articles/PMC5748842

المؤلفون: Wim Versées, Bernd K Gilsbach, Panagiotis S Athanasopoulos, Giambattista Guaitoli, Arjan Kortholt, Alfred Wittinghofer, Margaux Leemans, Lina Wauters, Christian Johannes Gloeckner, Susanne Terheyden

المساهمون: Cell Biochemistry, Faculty of Sciences and Bioengineering Sciences, Department of Bio-engineering Sciences, Structural Biology Brussels

المصدر: Biological Chemistry, 399(12), 1447-1456. Walter de Gruyter GmbH
Biological chemistry 399(12), 1447-1456 (2018). doi:10.1515/hsz-2018-0227

مصطلحات موضوعية: 0301 basic medicine, metabolism [Guanosine Triphosphate], genetics [GTP-Binding Proteins], GTP', Protein family, G protein, Roco proteins, unconventional G-protein, Clinical Biochemistry, chemistry [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], metabolism [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], GTPase, leucine-rich repeat kinase 2, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, GTP-Binding Proteins, ddc:570, Humans, LRRK2 protein, human, metabolism [GTP-Binding Proteins], Molecular Biology, Gene, chemistry [Guanosine Triphosphate], Kinase, Chemistry, Hydrolysis, LRRK2, chemistry [GTP-Binding Proteins], Kinetics, 030104 developmental biology, Mutation, genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], Guanosine Triphosphate, 030217 neurology & neurosurgery, Function (biology)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e672c529f33ef47219f161c39b38691
https://research.rug.nl/en/publications/3e5d696b-48d5-402c-adb1-f50a20fa9880

المؤلفون: Karina Häbig, Thomas Hentrich, Birgit Heim, Florian Giesert, Carolin Walter, Olaf Riess, Michael Bonin, Wolfgang Wurst, Sandra Gellhaar, Verena Djuric

المصدر: Biochimica et biophysica acta / Molecular basis of disease 1832(12), 2352-2367 (2013). doi:10.1016/j.bbadis.2013.09.009

مصطلحات موضوعية: genetics [Neuroblastoma], Parkinson's disease, metabolism [Rho Guanine Nucleotide Exchange Factors], Fluorescent Antibody Technique, Arp2/3 complex, metabolism [Hippocampus], genetics [RNA, Small Interfering], Tropomyosin, Hippocampus, Immunoenzyme Techniques, Mice, Neuroblastoma, antagonists & inhibitors [Rho Guanine Nucleotide Exchange Factors], pathology [Neuroblastoma], Guanine Nucleotide Exchange Factors, metabolism [Actin Cytoskeleton], genetics [Tropomyosin], RNA, Small Interfering, metabolism [Tropomyosin], TPM4 protein, human, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Mice, Knockout, Neurons, Reverse Transcriptase Polymerase Chain Reaction, Neurite outgrowth, metabolism [Protein-Serine-Threonine Kinases], metabolism [Neurites], Protein-Serine-Threonine Kinases, LRRK2, Cell biology, Actin Cytoskeleton, metabolism [Neurons], Molecular Medicine, Lrrk2 protein, mouse, antagonists & inhibitors [Protein-Serine-Threonine Kinases], metabolism [Biomarkers], Growth cone, Neurite, metabolism [Growth Cones], Blotting, Western, Growth Cones, metabolism [Neuroblastoma], macromolecular substances, genetics [Rho Guanine Nucleotide Exchange Factors], Protein Serine-Threonine Kinases, Biology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Real-Time Polymerase Chain Reaction, genetics [Protein-Serine-Threonine Kinases], Filamentous actin, genetics [RNA, Messenger], Neurites, Animals, Humans, ddc:610, LRRK2 protein, human, RNA, Messenger, Molecular Biology, Actin, Cell Proliferation, physiology [Protein-Serine-Threonine Kinases], Gene Expression Profiling, Actin cytoskeleton, nervous system diseases, ARHGEF7 protein, human, cytology [Hippocampus], cytology [Neurons], NIH 3T3 Cells, biology.protein, Biomarkers, Rho Guanine Nucleotide Exchange Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ba353f29c2943ab3f209bd31a5e546
https://doi.org/10.1016/j.bbadis.2013.09.009

المؤلفون: Caesar, Mareike

مصطلحات موضوعية: Inflammation, Progranulin, Entzündung, LRRK2, Zellskelett, Parkinson disease, Parkinson-Krankheit, ddc:610, LRRK2 protein, human, Microglia, DDC 610 / Medicine & health, Cytoskeleton, LRRK2 protein, mouse

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb18303a994f4677ca7865aa50ef09c5

المؤلفون: Wauters, Lina, Terheyden, Susanne, Gilsbach, Bernd K, Leemans, Margaux, Athanasopoulos, Panagiotis S, Guaitoli, Giambattista, Wittinghofer, Alfred, Gloeckner, Christian Johannes, Versées, Wim, Kortholt, Arjan

المصدر: Biological chemistry 399(12), 1447-1456 (2018). doi:10.1515/hsz-2018-0227

مصطلحات موضوعية: info:eu-repo/classification/ddc/570, GTP-Binding Proteins: chemistry, GTP-Binding Proteins: genetics, GTP-Binding Proteins: metabolism, Guanosine Triphosphate: chemistry, Guanosine Triphosphate: metabolism, Humans, Hydrolysis, Kinetics, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: chemistry, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: genetics, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: metabolism, Mutation, Guanosine Triphosphate, LRRK2 protein, human, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, GTP-Binding Proteins

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/0018-4888; info:eu-repo/semantics/altIdentifier/issn/1431-6730; info:eu-repo/semantics/altIdentifier/pmid/pmid:30067506; info:eu-repo/semantics/altIdentifier/issn/0177-3593; info:eu-repo/semantics/altIdentifier/issn/1437-4315; info:eu-repo/semantics/altIdentifier/issn/0372-9672; https://pub.dzne.de/record/140329; https://pub.dzne.de/search?p=id:%22DZNE-2020-06651%22

الاتاحة: https://pub.dzne.de/record/140329
https://pub.dzne.de/search?p=id:%22DZNE-2020-06651%22

المؤلفون: Gilsbach, Bernd K, Eckert, Marita, Gloeckner, Christian Johannes

المصدر: Biological chemistry 399(7), 637-642 (2018). doi:10.1515/hsz-2018-0132

مصطلحات موضوعية: info:eu-repo/classification/ddc/570, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: chemistry, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: genetics, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: metabolism, Parkinson Disease: metabolism, LRRK2 protein, human, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/0018-4888; info:eu-repo/semantics/altIdentifier/issn/1431-6730; info:eu-repo/semantics/altIdentifier/pmid/pmid:29894291; info:eu-repo/semantics/altIdentifier/issn/0177-3593; info:eu-repo/semantics/altIdentifier/issn/1437-4315; info:eu-repo/semantics/altIdentifier/issn/0372-9672; https://pub.dzne.de/record/140007; https://pub.dzne.de/search?p=id:%22DZNE-2020-06329%22

الاتاحة: https://pub.dzne.de/record/140007
https://pub.dzne.de/search?p=id:%22DZNE-2020-06329%22

المؤلفون: Jerry A Darsey

المصدر: Current Trends in Biomedical Engineering & Biosciences. 9

مصطلحات موضوعية: Parkinson's disease, Chemistry, Mechanism (biology), medicine, General Earth and Planetary Sciences, LRRK2 Protein, medicine.disease, Neuroscience, General Environmental Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eda04449eebbdefe5c02b94c06184c71
https://doi.org/10.19080/ctbeb.2017.09.555754

المؤلفون: Brockmann, K., Lohmann, K.

المصدر: Der Nervenarzt 88(7), 713-719 (2017). doi:10.1007/s00115-017-0348-5

مصطلحات موضوعية: diagnosis [Dystonia], Essential Tremor, DNA Mutational Analysis, diagnosis [Movement Disorders], Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, genetics [Glucosylceramidase], genetics [Parkinson Disease], Risk Factors, Restless Legs Syndrome, Humans, ddc:610, LRRK2 protein, human, Genetic Association Studies, genetics [Genetic Diseases, Inborn], Movement Disorders, diagnosis [Essential Tremor], genetics [Restless Legs Syndrome], Genetic Carrier Screening, Genetic Diseases, Inborn, Genetic Variation, Parkinson Disease, genetics [Movement Disorders], diagnosis [Genetic Diseases, Inborn], genetics [Genetic Variation], genetics [Dystonia], Dystonia, genetics [Essential Tremor], diagnosis [Restless Legs Syndrome], Glucosylceramidase, genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], diagnosis [Parkinson Disease], Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::908d120f6938e7248bc4659934c1ebbd
https://pubmed.ncbi.nlm.nih.gov/28536875

المؤلفون: Jansen, IE, Gibbs, JR, Nalls, MA, Price, T R, Lubbe, S, van Rooij, J, Uitterlinden, André, Kraaij, Robert, Williams, NM, Brice, A, Hardy, J, Wood, NW, Morris, HR, Gasser, T, Singleton, AB, Heutink, P, Sharma, M, Int Parkinsons Genomics, C

المساهمون: Internal Medicine, Erasmus MC other, Neurology, Amsterdam Neuroscience - Neurodegeneration

المصدر: Neurobiol Aging
Neurobiology of Aging, 59:220.e11. Elsevier Inc.
Neurobiology of Aging, 59, 220.e11-220.e18. Elsevier Inc.
Jansen, I E, Gibbs, J R, Nalls, M A, Price, T R, Lubbe, S, van Rooij, J, Uitterlinden, A G, Kraaij, R, Williams, N M, Brice, A, Hardy, J, Wood, N W, Morris, H R, Gasser, T, Singleton, A B, Heutink, P, Sharma, M & International Parkinson's Disease Genomics Consortium 2017, ' Establishing the role of rare coding variants in known Parkinson's disease risk loci ', Neurobiology of Aging, vol. 59, pp. 220.e11-220.e18 . https://doi.org/10.1016/j.neurobiolaging.2017.07.009
Neurobiology of aging 59, 220.e11-220.e18 (2017). doi:10.1016/j.neurobiolaging.2017.07.009

مصطلحات موضوعية: 0301 basic medicine, Risk, Aging, Datasets as Topic, Muscle Proteins, Genomics, Genome-wide association study, Disease, genetics [Genetic Loci], Biology, genetics [Muscle Proteins], Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Article, Mitochondrial Proteins, 03 medical and health sciences, genetics [Parkinson Disease], Humans, Genetic Predisposition to Disease, ddc:610, genetics [Seminal Plasma Proteins], LRRK2 protein, human, genetics [Genetic Predisposition to Disease], Gene, Exome sequencing, Genetic association, Genetics, SPATA19 protein, human, General Neuroscience, Seminal Plasma Proteins, Genetic Variation, Membrane Proteins, Parkinson Disease, LRRK2, genetics [Genetic Variation], genetics [Membrane Proteins], 030104 developmental biology, Genetic Loci, genetics [Leucine-Rich Repeat Serine-Threonine Protein Kinase-2], genetics [Mitochondrial Proteins], GENX-3414 protein, human, Neurology (clinical), Geriatrics and Gerontology, Developmental Biology, Common disease-common variant, Genome-Wide Association Study

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5495dbd7e750fdfd558871130548175
https://pubmed.ncbi.nlm.nih.gov/28867149

المؤلفون: Raquel Revilla, Diana Alarcón-Arís, Analía Bortolozzi, Rubén Pavia-Collado, V. Cóppola, M. Andrés, Francesc Artigas, Esther Ruiz-Bronchal

المصدر: European Neuropsychopharmacology. 29:S250-S251

مصطلحات موضوعية: Pharmacology, Psychiatry and Mental health, Neurology, Chemistry, Wild type, LRRK2 Protein, Pharmacology (medical), α synuclein, Neurology (clinical), Neurotransmission, Differential effects, Biological Psychiatry, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1d8fac89d9416ef17257a446bbc61f90
https://doi.org/10.1016/j.euroneuro.2018.11.398