المؤلفون: Jongkyun Kang, Guodong Huang, Long Ma, Youren Tong, Anu Shahapal, Phoenix Chen, Jie Shen

المصدر: eLife, Vol 12 (2024)

مصطلحات موضوعية: LRRK1, LRRK2, dopaminergic neuron, conditional knock-out mice, substantia nigra pars compacta, Parkinson's disease, Medicine, Science, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://elifesciences.org/articles/92673; https://doaj.org/toc/2050-084X

URL الوصول: https://doaj.org/article/fabed0c9954044a7be4f1170eeaaa540

المؤلفون: Chariklia Pieridou, Ataf Sabir, Jonathan Lancashire, Yifan Liang, Kevin McMillan, Nick Shaw, Suma Uday

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: skeletal dysplasia, sclerotic dysplasia, osteopetrosis, LRRK1, whole-exome sequencing, osteonecrosis, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1258340/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/73494b5096664acb9a84390d4b3d68e5

المؤلفون: Evert F.S. vanVelsen, Serwet Demirdas, David Hanff, M. Carola Zillikens

المصدر: JBMR Plus, Vol 7, Iss 8, Pp n/a-n/a (2023)

مصطلحات موضوعية: fractures, LRRK1, osteopetrosis, osteoporosis, osteosclerotic metaphyseal dysplasia, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2473-4039

URL الوصول: https://doaj.org/article/d22b16d797ba45c290fc2a2b9572e2d3

المؤلفون: Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing

المصدر: Biology; Volume 12; Issue 4; Pages: 511

مصطلحات موضوعية: Lrrk1, osteoclast, osteopetrosis, bone formation, bone resorption, lysosome, knockout, bone mineral density, acidification, cathepsin K, OSTM1

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Cell Biology; https://dx.doi.org/10.3390/biology12040511

الاتاحة: https://doi.org/10.3390/biology12040511

المؤلفون: DEMİRCİOĞLU, SERAP

المساهمون: Turan S.

مصطلحات موضوعية: Ysosteosclerosis, Bone fractures, Osteopetrosis, Osteosclerosis, Osteopenia, Optic atrophy, Jaw necrosis, Metaphyseal osteosclerosis, Osteosclerotic metaphyseal dysplasia, Pyle disease, Brain abnormalities, Neurodegeneration, Dementia, Leukoencephalopathy, SLC29A3, TNFRSF11A, TCIRG1, LRRK1, CSF1R, TNFSF11

وصف الملف: application/pdf

Relation: Bone; Turan S., "Osteopetrosis: Gene-based nosology and significance dysosteosclerosis.", Bone, ss.116615, 2022; 116615; https://reader.elsevier.com/reader/sd/pii/S8756328222002927?token=3F84C33F65099D25B1E6503BF02BA24E861598580B8E81FDCBEC3F04C3B00A9D294A163EBD8518ECCB2850CEEABD29B9&originRegion=eu-west-1&originCreation=20221201123952; https://hdl.handle.net/11424/283475

الاتاحة: https://hdl.handle.net/11424/283475
https://doi.org/10.1016/j.bone.2022.116615
https://reader.elsevier.com/reader/sd/pii/S8756328222002927?token=3F84C33F65099D25B1E6503BF02BA24E861598580B8E81FDCBEC3F04C3B00A9D294A163EBD8518ECCB2850CEEABD29B9&originRegion=eu-west-1&originCreation=20221201123952

المؤلفون: Lejia Xu, Yuki Nagai, Yotaro Kajihara, Genta Ito, Taisuke Tomita

المصدر: Biomolecules; Volume 11; Issue 9; Pages: 1340

مصطلحات موضوعية: Rab, phosphorylation, membrane trafficking, LRRK1, LRRK2, TBK1

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Biology; https://dx.doi.org/10.3390/biom11091340

الاتاحة: https://doi.org/10.3390/biom11091340

المؤلفون: Howaldt, Antonia, Hennig, Anna Floriane, Rolvien, Tim, Rössler, Uta, Stelzer, Nina, Knaus, Alexej, Böttger, Sebastian, Zustin, Jozef, Geißler, Sven, Oheim, Ralf, Amling, Michael, Howaldt, Hans‐Peter, Kornak, Uwe

مصطلحات موضوعية: LRRK1, NEXT GENERATION SEQUENCING, OSTEOPETROSIS, OSTEOSCLEROTIC METAPHYSEAL DYSPLASIA, TRIO-BASED EXOME SEQUENCING, ddc:610

وصف الملف: application/pdf

Relation: https://refubium.fu-berlin.de/handle/fub188/34190; http://dx.doi.org/10.17169/refubium-33908

الاتاحة: https://refubium.fu-berlin.de/handle/fub188/34190
https://doi.org/10.17169/refubium-33908
https://doi.org/10.1002/jbmr.3995

المؤلفون: Helen Goodluck, Mingjue Si, Sandi Shen, Subburaman Mohan, Weirong Xing, Canjun Zeng

المصدر: Aging (Albany NY)

مصطلحات موضوعية: Aging, kinase inhibitor, Drug Evaluation, Preclinical, Osteoclasts, Bone Marrow Cells, 030209 endocrinology & metabolism, Protein Serine-Threonine Kinases, Bone resorption, 03 medical and health sciences, 0302 clinical medicine, Osteoclast, medicine, Animals, Bone Resorption, Actin, bone formation, 030304 developmental biology, 0303 health sciences, Chemistry, Kinase, Cell Differentiation, Osteoblast, LRRK1, Cell Biology, Molecular biology, In vitro, Mice, Inbred C57BL, Molecular Docking Simulation, medicine.anatomical_structure, Docking (molecular), Cytoplasm, osteoclast, Osteoporosis, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e78f0e7ac92c90544d49c9015a6ebc5
https://doi.org/10.18632/aging.101977

المؤلفون: Genta Ito, Yuki Nagai, Taisuke Tomita, Yotaro Kajihara, Lejia Xu

المصدر: Biomolecules
Biomolecules, Vol 11, Iss 1340, p 1340 (2021)

مصطلحات موضوعية: TBK1, GTPase, Review, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Microbiology, Models, Biological, Animals, Humans, Cilia, Molecular Biology, Kinase, Effector, Chemistry, phosphorylation, membrane trafficking, fungi, Intracellular vesicle, LRRK2, LRRK1, QR1-502, Rab, Cell biology, rab GTP-Binding Proteins, alpha-Synuclein, Phosphorylation, Guanine nucleotide exchange factor, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b5f138e8a8dfb5a3de36dffa60ed4a
https://pubmed.ncbi.nlm.nih.gov/34572553

المؤلفون: Howaldt, Antonia

مصطلحات موضوعية: Craniofrontonasal syndrome, Next generation sequencing, SLC29A3, Autosomal recessive osteopetrosis, Osteosclerotic metaphyseal dysplasia, LRRK1, TCIRG1, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Osteonecrosis of the jaws

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b7f75ca1c0a6315ff6b62611d20063
https://refubium.fu-berlin.de/handle/fub188/31372

المؤلفون: Giesert, Florian, Hofmann, Andreas, Bürger, Alexander, Zerle, Julia, Kloos, Karina, Hafen, Ulrich, Ernst, Luise, Zhang, Jingzhong, Vogt-Weisenhorn, Daniela Maria, Wurst, Wolfgang

المصدر: PLOS ONE 8(5), e63778 (2013). doi:10.1371/journal.pone.0063778

مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Alternative Splicing, Animals, Brain: metabolism, Embryonic Development: genetics, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Order, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Mice, Neurons: metabolism, Protein-Serine-Threonine Kinases: genetics, Protein-Serine-Threonine Kinases: metabolism, RNA, Messenger: genetics, Messenger: metabolism, Messenger, Lrrk1 protein, mouse, Lrrk2 protein, Protein-Serine-Threonine Kinases

جغرافية الموضوع: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1932-6203; info:eu-repo/semantics/altIdentifier/pmid/pmid:23675505; https://pub.dzne.de/record/136909; https://pub.dzne.de/search?p=id:%22DZNE-2020-03231%22

الاتاحة: https://pub.dzne.de/record/136909
https://pub.dzne.de/search?p=id:%22DZNE-2020-03231%22

المؤلفون: Shengli Li, Xinxin Xu, Chao Wang, Wenwen Guo, Huayun Geng, Shuige Yang

المصدر: Bioscience Reports

مصطلحات موضوعية: 0301 basic medicine, T cell, Lymphoblastic Leukemia, Biophysics, Apoptosis, Protein Serine-Threonine Kinases, Biology, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Biochemistry, Malignant disease, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, LINC00511, Cell Line, Tumor, medicine, Humans, Neoplasm Invasiveness, Molecular Biology, Research Articles, miR-195-5p, Cell Proliferation, Gene Expression & Regulation, Gene Expression Regulation, Leukemic, Cell growth, Mechanism (biology), Pharmacology & Toxicology, Genomics, LRRK1, Cell Biology, T lymphocyte, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Cardiovascular System & Vascular Biology, 030220 oncology & carcinogenesis, Cancer research, RNA, Long Noncoding, T-cell acute lymphoblastic leukemia, Function (biology), Biotechnology, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83ce86c844a35baaeef5a8600bb9c8c
https://doi.org/10.1042/bsr20193631

المؤلفون: Xuezhong Qin, Elizabeth M. Todd, Sharon Celeste Morley, Mingjue Si, Weirong Xing, Helen Goodluck, Subburaman Mohan, Songqin Pan, Canjun Zeng

المصدر: Journal of Cellular Biochemistry

مصطلحات موضوعية: 0301 basic medicine, Osteoclasts, Protein Serine-Threonine Kinases, Biochemistry, serine phosphorylation, Serine, 03 medical and health sciences, Mice, 0302 clinical medicine, Western blot, Osteoclast, medicine, Animals, Humans, Lrrk1, Phosphorylation, Cytoskeleton, Protein kinase A, Molecular Biology, Actin, Research Articles, Mice, Knockout, Membrane Glycoproteins, medicine.diagnostic_test, Chemistry, Microfilament Proteins, Osteopetrosis, protein kinase, Cell Biology, medicine.disease, Actins, Cell biology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, osteoclast, Cancellous Bone, L‐plastin, Research Article, Protein Binding, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35358b5ca6d60d5e3a6c1a8f25725a75
http://europepmc.org/articles/PMC6218268

المؤلفون: Howaldt, Antonia

المساهمون: female, N.N.

مصطلحات موضوعية: Autosomal recessive osteopetrosis, Osteonecrosis of the jaws, Osteosclerotic metaphyseal dysplasia, Craniofrontonasal syndrome, Next generation sequencing, LRRK1, TCIRG1, SLC29A3, ddc:610

وصف الملف: application/pdf

Relation: https://refubium.fu-berlin.de/handle/fub188/31372; http://dx.doi.org/10.17169/refubium-31106; urn:nbn:de:kobv:188-refubium-31372-7

الاتاحة: https://refubium.fu-berlin.de/handle/fub188/31372
https://doi.org/10.17169/refubium-31106
https://nbn-resolving.org/urn:nbn:de:kobv:188-refubium-31372-7

المؤلفون: Hans-Peter Howaldt, Ralf Oheim, Sebastian Böttger, Nina Stelzer, Michael Amling, Anna Floriane Hennig, Jozef Zustin, Alexej Knaus, Uwe Kornak, Tim Rolvien, Uta Rössler, Sven Geißler, Antonia Howaldt

المصدر: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchReferences. 35(7)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Vacuolar Proton-Translocating ATPases, Endocrinology, Diabetes and Metabolism, Osteoclasts, 030209 endocrinology & metabolism, Protein Serine-Threonine Kinases, Osteochondrodysplasias, Bone resorption, TCIRG1, 03 medical and health sciences, Osteosclerosis, 0302 clinical medicine, Osteoclast, medicine, Humans, Orthopedics and Sports Medicine, Bone Resorption, NEXT GENERATION SEQUENCING, biology, business.industry, OSTEOSCLEROTIC METAPHYSEAL DYSPLASIA, Osteonecrosis, Osteopetrosis, LRRK1, medicine.disease, Resorption, 030104 developmental biology, medicine.anatomical_structure, Jaw, Dysplasia, Mutation, biology.protein, CLCN7, business, TRIO-BASED EXOME SEQUENCING, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02676ec9467fd0ebe11b9db2fa696dc2
https://pubmed.ncbi.nlm.nih.gov/32119750

المؤلفون: Elzbieta Kania, Jan B. Parys

مصطلحات موضوعية: 0301 basic medicine, Kinase, Endoplasmic reticulum, Autophagy, LRRK2, Cell Biology, GTPase, LRRK1, Biology, Cell biology, DAPK, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Ca(2+), Kinase activity, Protein kinase A, Molecular Biology, 030217 neurology & neurosurgery, Intracellular

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7450fe9b9260023757bad4ffd3bab866
https://lirias.kuleuven.be/handle/123456789/633033

المؤلفون: Taymans, Jean-Marc, Chartier-Harlin, Marie-Christine

المساهمون: CHU Lille, Inserm, Université de Lille

مصطلحات موضوعية: LRRK2, MASL1, DAPK1, LRRK1

Relation: Proteomics; http://hdl.handle.net/20.500.12210/39968

الاتاحة: https://hdl.handle.net/20.500.12210/39968

المؤلفون: Wang, Guan

Thesis Advisors: Sorbonne Paris Cité, Galli, Thierry

مصطلحات موضوعية: VAMP2, VAMP7, LRRK1, Tension membranaire, Membrane tension

الاتاحة: http://www.theses.fr/2016USPCC195

المؤلفون: Subburaman Mohan, Weirong Xing, Helen Goodluck, Canjun Zeng, Xuezhong Qin, Bo Liu

المصدر: American Journal of Physiology-Endocrinology and Metabolism

مصطلحات موضوعية: 0301 basic medicine, Male, rac1 GTP-Binding Protein, Physiology, Endocrinology, Diabetes and Metabolism, Osteoclasts, Protein Serine-Threonine Kinases, Serine, 03 medical and health sciences, Mice, Physiology (medical), Animals, Protein phosphorylation, Small GTPase, Threonine, Bone Resorption, Phosphorylation, Protein kinase A, Mice, Knockout, Chemistry, Lrrk1, bone resorption, osteoclast, RAC1, Cdc42, protein kinase, protein phosphorylation, GTPase-Activating Proteins, Neuropeptides, RANK Ligand, Molecular biology, Ankyrin Repeat, 030104 developmental biology, RAW 264.7 Cells, Protein kinase domain, Mutation, Call for Papers, Ankyrin repeat

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10813399bdb0637dcadc700e3cda82d
https://pubmed.ncbi.nlm.nih.gov/27600824

المؤلفون: Klein, Christian

المساهمون: Gasser, Thomas (Prof. Dr.)

مصطلحات موضوعية: Parkinson-Krankheit , Dimerisierung , MAP-Kinase, LRRK1 , LRRK2 , ROCO-Proteine , Kinase-Inhibition, LRRK1 , LRRK2 , ROCO-proteins , Kinase-inhibition, nervous system diseases

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______707::ff13a1dba5fbd9556d4b73a123058487
https://hdl.handle.net/10900/45349