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1Academic Journal
المؤلفون: Naohiro Yasuda, Satoshi Takenaka, Sho Nakai, Takaaki Nakai, Shutaro Yamada, Yoshinori Imura, Hidetatsu Outani, Kenichiro Hamada, Hideki Yoshikawa, Norifumi Naka
المصدر: FEBS Open Bio, Vol 10, Iss 5, Pp 767-779 (2020)
مصطلحات موضوعية: LM8, lung metastasis, molecular targeted therapy, osteosarcoma, TAS‐115, Biology (General), QH301-705.5
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2211-5463
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2
المؤلفون: Sho Nakai, Naohiro Yasuda, Satoshi Takenaka, Norifumi Naka, Takaaki Nakai, Yoshinori Imura, Shutaro Yamada, Hidetatsu Outani, Hideki Yoshikawa, Kenichiro Hamada
المصدر: FEBS Open Bio, Vol 10, Iss 5, Pp 767-779 (2020)
FEBS Open Bioمصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Receptor, Platelet-Derived Growth Factor alpha, Lung metastasis, TAS‐115, Mice, 0302 clinical medicine, Cell Movement, Medicine, Phosphorylation, lcsh:QH301-705.5, Research Articles, Mice, Inbred C3H, lung metastasis, Thiourea, Proto-Oncogene Proteins c-met, 030220 oncology & carcinogenesis, Quinolines, Osteosarcoma, Female, Signal transduction, Signal Transduction, Research Article, musculoskeletal diseases, molecular targeted therapy, Alpha (ethology), Bone Neoplasms, LM8, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Growth factor receptor, Cell Line, Tumor, Proto-Oncogene Proteins, osteosarcoma, Animals, Humans, Protein Kinase Inhibitors, Survival rate, neoplasms, Cell Proliferation, business.industry, Receptor Protein-Tyrosine Kinases, medicine.disease, Axl Receptor Tyrosine Kinase, 030104 developmental biology, fms-Like Tyrosine Kinase 3, lcsh:Biology (General), Cell culture, Cancer research, business, Proto-Oncogene Proteins c-akt
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3Conference
المؤلفون: Palma Simoniello, Alexander Helm, Walter Tinganelli, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa and Marco Durante.
المساهمون: Palma Simoniello, Alexander Helm , Walter Tinganelli , Fuki Kurosawa , Claudia Fournier , Takashi Shimokawa and Marco Durante ., Simoniello, Palma, Helm, Alexander, Tinganelli, Walter, Kurosawa, Fuki, Fournier, Claudia, Durante., Takashi Shimokawa and Marco
مصطلحات موضوعية: Radiotherapy is one of the main treatments for cancers, which has experienced important improvements in the last year, metastatic disease still remains a problem. It is known that immune system plays a key role in the elimination of primary tumors and preventing tumor recurrence. Ionizing radiation is reported to be immunogenic, i.e. it may induce an immunogenic cell death in tumor cells leading to immunoactivation, in turn resulting in the shrinkage of out-of-field metastases. This phenomenon is known as abscopal effect. The right combination of radiotherapy with immunotherapy could be a strategy to induce durable responses and improve survival. Particle therapy with protons and especially carbon-ions is assumed to further increase the immunogenic effect. The aim of this study was to investigate the efficacy of X-ray and high-energy carbon ion therapy in a combination with immunotherapy. In this work we investigated the combination of radiotherapy, with either carbon ions or X-rays, and immune checkpoint inhibitors (CPI) (anti- CTLA-4 and anti-PD-1), in a syngeneic osteosarcoma mouse model (C3H/He mice, LM8 cells). Tumor cells were injected in both hind limbs of the mice. Following an initial growth period, one of the tumors was irradiated while the other was kept out of the irradiation field, mimicking the abscopal tumor. Macroscopic analysis on out-of-field metastases were carried out to investigate spontaneously formed lung metastases. Immune responses were investigated by histological analyses on the abscopal tumors screening. The results show that combination of carbon ion therapy and CPI lead to a reduced growth of abscopal tumors and reduced formation of lung metastases. In addition, in the abscopal tumors treated with combining therapy an immunogenic response resulting in increasing of infiltration of CD8+ cells was observed. Combination of CPI with high-energy carbon ion radiotherapy could be a promising strategy for the treatment of tumor and metastasis.
Relation: ispartofbook:XIX Congresso nazionale SIRR Società Italiana per le Ricerche sulle Radiazioni; XIX Congresso nazionale SIRR Società Italiana per le Ricerche sulle Radiazioni; lastpage:12; numberofpages:1; http://hdl.handle.net/11367/89111
الاتاحة: http://hdl.handle.net/11367/89111
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4
المؤلفون: Simoniello, Palma, Alexander, Helm, Walter, Tinganelli, Fuki, Kurosawa, Claudia, Fournier, Takashi Shimokawa and Marco, Durante.
مصطلحات موضوعية: Radiotherapy is one of the main treatments for cancers, in turn resulting in the shrinkage of out-of-field metastases. This phenomenon is known as abscopal effect. The right combination of radiotherapy with immunotherapy could be a strategy to induce durable responses and improve survival. Particle therapy with protons and especially carbon-ions is assumed to further increase the immunogenic effect. The aim of this study was to investigate the efficacy of X-ray and high-energy carbon ion therapy in a combination with immunotherapy. In this work we investigated the combination of radiotherapy, i.e. it may induce an immunogenic cell death in tumor cells leading to immunoactivation, LM8 cells). Tumor cells were injected in both hind limbs of the mice. Following an initial growth period, metastatic disease still remains a problem. It is known that immune system plays a key role in the elimination of primary tumors and preventing tumor recurrence. Ionizing radiation is reported to be immunogenic, Radiotherapy is one of the main treatments for cancers, which has experienced important improvements in the last years, metastatic disease still remains a problem. It is known that immune system plays a key role in the elimination of primary tumors and preventing tumor recurrence. Ionizing radiation is reported to be immunogenic, i.e. it may induce an immunogenic cell death in tumor cells leading to immunoactivation, in turn resulting in the shrinkage of out-of-field metastases. This phenomenon is known as abscopal effect. The right combination of radiotherapy with immunotherapy could be a strategy to induce durable responses and improve survival. Particle therapy with protons and especially carbon-ions is assumed to further increase the immunogenic effect. The aim of this study was to investigate the efficacy of X-ray and high-energy carbon ion therapy in a combination with immunotherapy. In this work we investigated the combination of radiotherapy, with either carbon ions or X-rays, and immune checkpoint inhibitors (CPI) (anti- CTLA-4 and anti-PD-1), in a syngeneic osteosarcoma mouse model (C3H/He mice, LM8 cells). Tumor cells were injected in both hind limbs of the mice. Following an initial growth period, one of the tumors was irradiated while the other was kept out of the irradiation field, mimicking the abscopal tumor. Macroscopic analysis on out-of-field metastases were carried out to investigate spontaneously formed lung metastases. Immune responses were investigated by histological analyses on the abscopal tumors screening. The results show that combination of carbon ion therapy and CPI lead to a reduced growth of abscopal tumors and reduced formation of lung metastases. In addition, in the abscopal tumors treated with combining therapy an immunogenic response resulting in increasing of infiltration of CD8+ cells was observed. Combination of CPI with high-energy carbon ion radiotherapy could be a promising strategy for the treatment of tumor and metastasis, in a syngeneic osteosarcoma mouse model (C3H/He mice, one of the tumors was irradiated while the other was kept out of the irradiation field, and immune checkpoint inhibitors (CPI) (anti- CTLA-4 and anti-PD-1), with either carbon ions or X-rays, which has experienced important improvements in the last years, mimicking the abscopal tumor. Macroscopic analysis on out-of-field metastases were carried out to investigate spontaneously formed lung metastases. Immune responses were investigated by histological analyses on the abscopal tumors screening. The results show that combination of carbon ion therapy and CPI lead to a reduced growth of abscopal tumors and reduced formation of lung metastases. In addition, in the abscopal tumors treated with combining therapy an immunogenic response resulting in increasing of infiltration of CD8+ cells was observed. Combination of CPI with high-energy carbon ion radiotherapy could be a promising strategy for the treatment of tumor and metastasis
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5
المؤلفون: Eisuke Ueshima, Kayako Isohashi, Koji Sasaki, Takuya Okada, Koji Maruyama, Masato Yamaguchi, Munenobu Nogami, Takeshi Ueha, Yasukazu Kanai, Hayato Ikeda, Jun Hatazawa, Tomoyuki Gentsu, Takamichi Murakami, Keitaro Sofue, Koji Sugimoto, Yoshitada Sakai
المصدر: Oncology Letters
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, 18F-Fluoromisonidazole, Percutaneous, intratumoral hypoxia, Standardized uptake value, 03 medical and health sciences, 0302 clinical medicine, In vivo, 18F-fluoromisonidazole positron emission tomography-computed tomography, Medicine, PET-CT, business.industry, Therapeutic effect, carbon dioxide, Articles, Hypoxia (medical), LM8 tumor, in vivo, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Room air distribution, medicine.symptom, Nuclear medicine, business
وصف الملف: application/pdf
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6Academic Journal
المؤلفون: Nakamura Atsushi, Aizawa Junichi, Sakayama Kenshi, Kidani Teruki, Takata Tomoyo, Norimatsu Yoshiaki, Miura Hiromasa, Masuno Hiroshi
المصدر: BMC Cell Biology, Vol 13, Iss 1, p 24 (2012)
مصطلحات موضوعية: Genistein, LM8, Cell invasion, Matrix metalloproteinase-2, β-catenin, Cell differentiation, Cytology, QH573-671
Relation: http://www.biomedcentral.com/1471-2121/13/24; https://doaj.org/toc/1471-2121; https://doaj.org/article/1eb5bd9044e74d2193698e293a3436b8
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7Academic Journal
المؤلفون: Nakamura, Atsushi, Aizawa, Junichi, Sakayama, Kenshi, Kidani, Teruki, Takata, Tomoyo, Norimatsu, Yoshiaki, Miura, Hiromasa, Masuno, Hiroshi
مصطلحات موضوعية: Genistein, LM8, Cell invasion, Matrix metalloproteinase-2, β-catenin, Cell differentiation
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8
المؤلفون: Kenta, Watanabe, Yoshihiro, Yui, Satoru, Sasagawa, Kayo, Suzuki, Masahiko, Kanamori, Taketoshi, Yasuda, Tomoatsu, Kimura
المصدر: Oncotarget
مصطلحات موضوعية: osteosarcoma, metastasis, LM8, circulating tumor cells, eribulin, Research Paper
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9
المؤلفون: Kenshi Sakayama, Atsushi Nakamura, Tomoyuki Iwasaki, Tatsuhiko Miyazaki, Hiromasa Miura, Junya Masumoto, Teruki Kidani, Hiroshi Nakata
المصدر: Oncology Reports
مصطلحات موضوعية: Male, Cancer Research, medicine.medical_treatment, Apoptosis, Pharmacology, Benzoates, Mice, chemistry.chemical_compound, Drug Delivery Systems, drug delivery system, Drug Carriers, Mice, Inbred C3H, Ifosfamide, Abnormalities, Drug-Induced, Drug Synergism, Articles, General Medicine, Tumor Burden, Drug Combinations, Oncology, Drug delivery, Osteosarcoma, Female, Drug carrier, Caffeine, medicine.drug, Bone Neoplasms, LM8, Span 80 vesicles, Cell Line, Tumor, osteosarcoma, medicine, Animals, Humans, Spermatogenesis, Antineoplastic Agents, Alkylating, Infertility, Male, Hexoses, Chemotherapy, caffeine-potentiated chemotherapy, business.industry, medicine.disease, In vitro, chemistry, Nanoparticles, Drug Screening Assays, Antitumor, business
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10
المؤلفون: Teruki Kidani, Atsushi Nakamura, Setsuya Kamei, Yoshiaki Norimatsu, Hiromasa Miura, Hiroshi Masuno
المصدر: Cancer Cell International
مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, β-Catenin, Genistein, Metastatic potential, Metastasis, chemistry.chemical_compound, Genetics, medicine, Lung, business.industry, medicine.disease, Primary tumor, Trypsinization, medicine.anatomical_structure, Matrix metalloproteinase-2, Oncology, chemistry, Catenin, LM8 murine osteosarcoma cells, Osteosarcoma, Primary Research, business, Immunostaining
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11
المؤلفون: Atsushi Nakamura, Kenshi Sakayama, Teruki Kidani, Tomoyo Takata, Yoshiaki Norimatsu, Junichi Aizawa, Hiroshi Masuno, Hiromasa Miura
المصدر: BMC Cell Biology, Vol 13, Iss 1, p 24 (2012)
BMC Cell Biologyمصطلحات موضوعية: Beta-catenin, Cellular differentiation, Osteocalcin, Genistein, Motility, LM8, Mice, chemistry.chemical_compound, Cell Movement, Cell Line, Tumor, medicine, Cell differentiation, Animals, Anticarcinogenic Agents, RNA, Messenger, lcsh:QH573-671, beta Catenin, Cell Proliferation, Osteosarcoma, biology, Cell growth, lcsh:Cytology, Cell Biology, β-catenin, medicine.disease, Immunohistochemistry, Cell biology, Cell invasion, chemistry, Matrix metalloproteinase-2, Immunology, biology.protein, Cancer research, Matrix Metalloproteinase 2, Research Article
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12
المؤلفون: Kidani, Teruki, Nakamura, Atsushi, Kamei, Setsuya, Norimatsu, Yoshiaki, Miura, Hiromasa, Masuno, Hiroshi
مصطلحات موضوعية: LM8 murine osteosarcoma cells, Metastatic potential, β-Catenin, Genistein, Matrix metalloproteinase-2
Relation: http://www.cancerci.com/content/14/1/31
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