نتائج البحث - "LIGAND-BINDING DOMAIN"

المصدر: Bay , Y , Cabello , F J M , Koens , C C , Frantsen , S M , Pickering , D S , Frydenvang , K , Francotte , P , Pirotte , B , Kristensen , A S , Bowie , D & Kastrup , J S 2024 , ' Crystal structure of the GluK1 ligand-binding domain with kainate and the full-spanning positive allosteric modulator BPAM538 ' , Journal of Structural Biology , vol. 216 , no. 3 , 108113 . https://doi.org/10.1016/j.jsb.2024.108113

مصطلحات موضوعية: Binding mode, Kainate, Ligand-binding domain of GluK1, Positive allosteric modulator, X-ray crystallography

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/crystal-structure-of-the-gluk1-ligandbinding-domain-with-kainate-and-the-fullspanning-positive-allosteric-modulator-bpam538(df268a28-8a1e-4e7e-9d39-cc934d06f3b1).html
https://doi.org/10.1016/j.jsb.2024.108113
https://curis.ku.dk/ws/files/403255036/1_s2.0_S1047847724000534_main.pdf

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4

Academic Journal

NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models

المؤلفون: Roshan Tumdam, Yara Hussein, Tali Garin-Shkolnik, Shani Stern

المصدر: International Journal of Molecular Sciences ; Volume 25 ; Issue 22 ; Pages: 12366

مصطلحات موضوعية: NDD—neurodevelopmental disorder, EPSCs—excitatory postsynaptic currents, mEPSCs—miniature excitatory postsynaptic currents, ATD—amino-terminal domain, LBD—ligand-binding domain, TMD—transmembrane domain, CTD—C-terminal domain, CNS—central nervous system, SCZ—schizophrenia, ASD—autism spectrum disorder

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms252212366

الاتاحة: https://doi.org/10.3390/ijms252212366

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5

Academic Journal

Disrupted protein interaction dynamics in a genetic neurodevelopmental disorder revealed by structural bioinformatics and genetic code expansion

المؤلفون: Marino, Valerio, Phromkrasae, Wanchana, Bertacchi, Michele, Cassini, Paul, Chakrabandhu, Krittalak, Dell'Orco, Daniele, Studer, Michèle

المساهمون: Marino, Valerio, Phromkrasae, Wanchana, Bertacchi, Michele, Cassini, Paul, Chakrabandhu, Krittalak, Dell'Orco, Daniele, Studer, Michèle

مصطلحات موضوعية: BBSOAS, CRABP2, NR2F1, cellular biology, genetic code expansion, ligand binding domain, pathogenic variants, protein interactions, protein stability and affinity, structural biochemistry

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/38511490; info:eu-repo/semantics/altIdentifier/wos/WOS:001188178500001; volume:33; issue:4; firstpage:1; lastpage:31; numberofpages:31; journal:PROTEIN SCIENCE; https://hdl.handle.net/11562/1123127; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85188323163; https://doi.org/10.1002/pro.4953

الاتاحة: https://hdl.handle.net/11562/1123127
https://doi.org/10.1002/pro.4953

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6

Academic Journal

Selective modulation of the human glucocorticoid receptor compromises GR chromatin occupancy and recruitment of p300/CBP and the Mediator complex

المؤلفون: Van Moortel, Laura, Verhee, Annick, Thommis, Jonathan, Houtman, René, Melchers, Diana, Delhaye, Louis, Van Leene, Chloé, Hellemans, Madeleine, Gevaert, Kris, Eyckerman, Sven, De Bosscher, Karolien

المصدر: MOLECULAR & CELLULAR PROTEOMICS ; ISSN: 1535-9476 ; ISSN: 1535-9484

مصطلحات موضوعية: Medicine and Health Sciences, Biology and Life Sciences, Molecular Biology, Biochemistry, Analytical Chemistry, LIGAND-BINDING DOMAIN, ANDROGEN RECEPTOR, COACTIVATOR TIF2, PROTEIN, ACTIVATION, ACTIVATION-FUNCTION-1, ACETYLTRANSFERASE, PHOSPHORYLATION, TRANSACTIVATION, SEQUENCE

وصف الملف: application/pdf

Relation: https://biblio.ugent.be/publication/01HREZT7ERP7SYYZ099JM0Y3B9; http://doi.org/10.1016/j.mcpro.2024.100741; https://biblio.ugent.be/publication/01HREZT7ERP7SYYZ099JM0Y3B9/file/01HREZXCCJEXGA327C6CVX369X

الاتاحة: https://biblio.ugent.be/publication/01HREZT7ERP7SYYZ099JM0Y3B9
http://hdl.handle.net/1854/LU-01HREZT7ERP7SYYZ099JM0Y3B9
https://doi.org/10.1016/j.mcpro.2024.100741
https://biblio.ugent.be/publication/01HREZT7ERP7SYYZ099JM0Y3B9/file/01HREZXCCJEXGA327C6CVX369X

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7

Academic Journal

Structure and the Anticancer Activity of Vitamin D Receptor Agonists

المؤلفون: Agnieszka Powała, Teresa Żołek, Geoffrey Brown, Andrzej Kutner

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6624 (2024)

مصطلحات موضوعية: vitamin D, vitamin D receptor (VDR), VDR ligand-binding domain, vitamin D metabolites and analogs, vitamin D anticancer analogs, calcitriol, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/25/12/6624; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/3f5ff0348dee46f38a3c547963840cc2

الاتاحة: https://doi.org/10.3390/ijms25126624
https://doaj.org/article/3f5ff0348dee46f38a3c547963840cc2

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8

Academic Journal

The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy.

المؤلفون: Messner, Elisabeth A, Steele, Thomas M, Tsamouri, Maria Malvina, Hejazi, Nazila, Gao, Allen C, Mudryj, Maria, Ghosh, Paramita M

المصدر: Biomedicines. 8(10)

مصطلحات موضوعية: DNA-binding domain, Ligand-binding domain, N-terminal domain, alternatively spliced variants, androgen receptor, castration-resistant prostate cancer

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8x85w1vj

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9

Academic Journal

Safety and clinical activity of BMS-986365 (CC-94676), a dual androgen receptor ligand-directed degrader and antagonist, in heavily pretreated patients with metastatic castration-resistant prostate cancer.

المؤلفون: Rathkopf, D E, Patel, M R, Choudhury, A D, Rasco, D, Lakhani, N, Hawley, J E, Srinivas, S, Aparicio, A, Narayan, V, Runcie, K D, Emamekhoo, H, Reichert, Z R, Nguyen, M H, Wells, A L, Kandimalla, R, Liu, C, Suryawanshi, S, Han, J, Wu, J, Arora, V K, Pourdehnad, M, Armstrong, A J

المصدر: Ann Oncol ; ISSN:1569-8041 ; Volume:36 ; Issue:1

مصطلحات موضوعية: androgen receptor antagonist, androgen receptor pathway inhibitor, ligand binding domain, ligand-directed degrader, mCRPC, protein degradation

Relation: https://doi.org/10.1016/j.annonc.2024.09.005; https://pubmed.ncbi.nlm.nih.gov/39293515

الاتاحة: https://doi.org/10.1016/j.annonc.2024.09.005
https://pubmed.ncbi.nlm.nih.gov/39293515

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10

Academic Journal

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite

المؤلفون: Bruning, John M, Wang, Yan, Oltrabella, Francesca, Tian, Boxue, Kholodar, Svetlana A, Liu, Harrison, Bhattacharya, Paulomi, Guo, Su, Holton, James M, Fletterick, Robert J, Jacobson, Matthew P, England, Pamela M

المصدر: Cell Chemical Biology. 26(5)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Genetics, Neurodegenerative, Brain Disorders, Parkinson's Disease, Neurosciences, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Neurological, Good Health and Well Being, Animals, Binding Sites, Cell Line, Tumor, Crystallography, X-Ray, Dopamine, Humans, Indoles, Larva, Molecular Dynamics Simulation, Nuclear Receptor Subfamily 4, Group A, Member 2, Oxidative Stress, Protein Domains, Recombinant Proteins, Thermodynamics, Transcription, Genetic, Zebrafish, 5, 6-dihydroxyindole, 5, 6-dihydroxyindolequinone, 5, 6-indolequinone, DHI, DHICA, IQ, Nr4A2, Nurr1, Parkinson's disease, cysteine adduct, dopamine homeostasis, dopamine metabolite, dopamine oxidation, ligand-binding domain, ligand-binding pocket, nuclear receptor, nuclear receptor related 1 protein, redox sensor

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0t29b02j
https://escholarship.org/content/qt0t29b02j/qt0t29b02j.pdf

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11

Academic Journal

Structural insights into the ligand binding domain of GluD1 and GluD2 receptors

المؤلفون: Tricoire, Ludovic, Hepp, Régine

المساهمون: Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Réseaux synaptiques et neuroénergétiques = Synaptic and Neuroenegertic Networks (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS)

المصدر: ISSN: 1742-464X.

مصطلحات موضوعية: Ludovic Tricoire Régine Hepp GluD ligand binding domain protein structure receptor biology molecular dynamics, Ludovic Tricoire, Régine Hepp GluD, ligand binding domain, protein structure, receptor biology, molecular dynamics, [SDV]Life Sciences [q-bio]

الاتاحة: https://hal.sorbonne-universite.fr/hal-04290057
https://hal.sorbonne-universite.fr/hal-04290057v1/document
https://hal.sorbonne-universite.fr/hal-04290057v1/file/Comments%20Masternak%201st%20REV%20FINAL.pdf
https://doi.org/10.1111/febs.16883

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12

Academic Journal

A New Tool for Inducible Gene Expression in Caenorhabditis elegans.

المؤلفون: Monsalve, Gabriela, Yamamoto, Keith, Ward, Jordan

المصدر: Genetics. 211(2)

مصطلحات موضوعية: Caenorhabditis elegans, Glucocorticoid receptor, drug inducible, gene expression, ligand-binding domain, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Dexamethasone, Forkhead Transcription Factors, Genetic Techniques, Glucocorticoids, Humans, Receptors, Glucocorticoid, Transcriptional Activation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7gv094vr

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13

Academic Journal

Erratum: Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family

المؤلفون: Frontiers Production Office

المصدر: Frontiers in Endocrinology, Vol 14 (2023)

مصطلحات موضوعية: nuclear receptor, thyroid hormone receptor-like family, ligand-binding domain, sequence conservation, phylogeny, relative entropy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1175369/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/e9872139fb274af298e2e2a67d2a337e

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14

Academic Journal

Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist

المؤلفون: Azam Rashidian, Enni-Kaisa Mustonen, Thales Kronenberger, Matthias Schwab, Oliver Burk, Stefan A. Laufer, Tatu Pantsar

المصدر: Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3004-3018 (2022)

مصطلحات موضوعية: Pregnane X receptor, Molecular dynamics simulation, PXR ligand binding domain, SR12813 (PubChem CID: 446313), BAY-1797 (PubChem CID: 124125214), Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037022002343; https://doaj.org/toc/2001-0370

URL الوصول: https://doaj.org/article/390d4c67451d49668c763e41795e9da7

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15

Academic Journal

The structural analysis of the periplasmic domain of Sinorhizobium meliloti chemoreceptor McpZ reveals a novel fold and suggests a complex mechanism of transmembrane signaling ; Proteins-Structure Function and Bioinformatics

المؤلفون: Salar, Safoura, Ball, Nicolas E., Baaziz, Hiba, Nix, Jay C., Sobe, Richard C., Compton, K. Karl, Zhulin, Igor B., Brown, Anne M., Scharf, Birgit E., Schubot, Florian D.

مصطلحات موضوعية: chemotaxis, helical tri-modular sensor domain, ligand-binding domain, methyl-accepting chemotaxis protein, piston, scissoring, transmembrane signaling

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10919/115555; https://doi.org/10.1002/prot.26510

الاتاحة: http://hdl.handle.net/10919/115555
https://doi.org/10.1002/prot.26510

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16

Academic Journal

Androgen receptor mutations modulate activation by 11-oxygenated androgens and glucocorticoids

المؤلفون: Snaterse, Gido, Mies, Rosinda, van Weerden, Wytske M, French, Pim J, Jonker, Johan W, Houtsmuller, Adriaan B, van Royen, Martin E, Visser, Jenny A, Hofland, Johannes

المصدر: Snaterse , G , Mies , R , van Weerden , W M , French , P J , Jonker , J W , Houtsmuller , A B , van Royen , M E , Visser , J A & Hofland , J 2023 , ' Androgen receptor mutations modulate activation by 11-oxygenated androgens and glucocorticoids ' , Prostate Cancer and Prostatic Diseases , vol. 26 , pp. 293–301 . https://doi.org/10.1038/s41391-022-00491-z

مصطلحات موضوعية: RESISTANT PROSTATE-CANCER, LIGAND-BINDING DOMAIN, INCREASED SURVIVAL, DNA-BINDING, ABIRATERONE, ENZALUTAMIDE, TESTOSTERONE, ASSAY, DEXAMETHASONE, SPECIFICITY